Residential energy-use behavior and energy-saving awareness play a crucial role in sustainable urban energy planning and building energy efficiency,particularly under the pressures of climate change.However,existing s...Residential energy-use behavior and energy-saving awareness play a crucial role in sustainable urban energy planning and building energy efficiency,particularly under the pressures of climate change.However,existing studies often lack comparative analysis of urban-rural differences and tend to focus excessively on behavior patterns while neglecting the dimension of energysaving awareness.With China’s urbanization rate reaching 66.16%,understanding such regional disparities has become increasingly important.To address these research gaps,this study conducts a large-scale survey on space cooling behaviors among residents in Beijing,a representative Chinese megacity.It should be noted that living standards in such megacities are generally higher than the national average,which may shape distinctive energy-use profiles.Analyzing 1573valid samples(1064 urban/442 rural)in 2024,this study employed K-Prototypes and K-Modes clustering to identify typical cooling behavior and energy-saving awareness pattems,followed by Kendall/Chi-square correlation tests and XGBoost importance analysis to determine key influencing factors,with subsequent urban-rural comparative analysis.Results indicate that urban residents are primarily heat-sensitive or heat-tolerant,with a secondary patten of mid-low temperature preference,and generally exhibit long cooling durations;rural behavior is dominated by heat-tolerant type,followed by heat-sensitive,mid-low temperature preference,and never-on types as secondary patterns;both urban and rural areas exhibit energy-savingawareness characterized by low consumption-lowwillingness,though urban areas show marginally higher motivation;energy-saving awareness correlates with cooling behavior in rural areas,but this relationship weakens significantly in urban contexts.展开更多
AIM:To investigate the sex-specific correlation between systemic factors and retinal neurovascular alterations in individuals with type 1 diabetes mellitus(T1DM)who do not exhibit signs of diabetic retinopathy(DR).MET...AIM:To investigate the sex-specific correlation between systemic factors and retinal neurovascular alterations in individuals with type 1 diabetes mellitus(T1DM)who do not exhibit signs of diabetic retinopathy(DR).METHODS:A cohort participant without DR diagnosed with T1DM,underwent comprehensive ophthalmologic evaluation,optical coherence tomography angiography retinal structural and microvascular density analysis,and systemic parameter assessment.Multiple linear regression analysis was used to investigate the impact of systemic parameters on retinal alterations in distinct gender groups.RESULTS:A total of 182 individuals were included,consisting of 85 males(mean age 23.28±12.75y)and 97 females(mean age 22.98±13.68y).Males exhibited significantly greater thickness in both the internal retinal layer and the entire retina compared to females(P<0.01),whereas females had higher densities of deep retinal vessels and choroidal capillaries(P<0.05).Additionally,glycemic control was found to have a notable influence on retinal thickness in males(P<0.05),while insulin function had a more pronounced impact on retinal structure in females(P<0.01).Furthermore,a significant correlation was observed between thyroid function markers and retinal parameters in both male and female(P<0.05).CONCLUSION:Sex differences in alterations in retinal structure and microcirculation are observed in individuals with T1DM prior to the development of clinical DR,with a noted association between these changes and systemic parameters.展开更多
In this paper,we propose and analyze two second-order accurate finite difference schemes for the one-dimensional heat equation with concentrated capacity on a computa-tional domain=[a,b].We first transform the target ...In this paper,we propose and analyze two second-order accurate finite difference schemes for the one-dimensional heat equation with concentrated capacity on a computa-tional domain=[a,b].We first transform the target equation into the standard heat equation on the domain excluding the singular point equipped with an inner interface matching(IIM)condition on the singular point x=ξ∈(a,b),then adopt Taylor’s ex-pansion to approximate the IIM condition at the singular point and apply second-order finite difference method to approximate the standard heat equation at the nonsingular points.This discrete procedure allows us to choose different grid sizes to partition the two sub-domains[a,ξ]and[ξ,b],which ensures that x=ξ is a grid point,and hence the pro-posed schemes can be generalized to the heat equation with more than one concentrated capacities.We prove that the two proposed schemes are uniquely solvable.And through in-depth analysis of the local truncation errors,we rigorously prove that the two schemes are second-order accurate both in temporal and spatial directions in the maximum norm without any constraint on the grid ratio.Numerical experiments are carried out to verify our theoretical conclusions.展开更多
BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structu...BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.展开更多
A method combining finite difference method(FDM)and k-means clustering algorithm which can determine the threshold of rock bridge generation is proposed.Jointed slope models with different joint coalescence coefficien...A method combining finite difference method(FDM)and k-means clustering algorithm which can determine the threshold of rock bridge generation is proposed.Jointed slope models with different joint coalescence coefficients(k)are constructed based on FDM.The rock bridge area was divided through k-means algorithm and the optimal number of clusters was determined by sum of squared errors(SSE)and elbow method.The influence of maximum principal stress and stress change rate as clustering indexes on the clustering results of rock bridges was compared by using Euclidean distance.The results show that using stress change rate as clustering index is more effective.When the joint coalescence coefficient is less than 0.6,there is no significant stress concentration in the middle area of adjacent joints,that is,no generation of rock bridge.In addition,the range of rock bridge is affected by the coalescence coefficient(k),the relative position of joints and the parameters of weak interlayer.展开更多
By extending the concept of diffusion to the potential energy landscapes(PELs), we introduce the meansquared energy difference(MSED) as a novel quantity to investigate the intrinsic properties of supercooled liquids. ...By extending the concept of diffusion to the potential energy landscapes(PELs), we introduce the meansquared energy difference(MSED) as a novel quantity to investigate the intrinsic properties of supercooled liquids. MSED can provide a clear description of the “energy relaxation” process on a PEL. Through MSED analysis, we have obtained a characteristic time similar to that derived from structure analysis, namely τ_(α)^(*).Further, we establish a connection between MSED and the feature of PELs, providing a concise and quantitative description of PELs. The relaxation behavior of energy has been found to follow a stretched exponential form.As the temperature decreases, the roughness of the accessible PEL changes significantly around a characteristic temperature T_(x), which is 20% higher than the glass transition temperature T_(g) and is comparable to the critical temperature of the mode-coupling theory. More importantly, one of the PEL parameters is closely related to the Adam–Gibbs configurational entropy. The present research, which directly links the PEL to the relaxation process, provides avenues for further research of glasses.展开更多
Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological p...Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological problems and suicidal ideation compared to their non-left-behind peers.The aim of the current study was to examine two potential protective factors,negotiable fate belief and coping self-efficacy,and to test the mediating role of coping self-efficacy in the relationship between negotiable fate belief and suicidal ideation.We also analyzed gender differences in this mediation model.Methods:Across-sectional survey was conducted in rural areas ofChina.A sample of 526 left-behind children(285 males,54.18%;241 females,45.82%;Meanage=13.29 years,SD=0.97 years)was recruited to complete the Negotiable Fate Belief Scale,Coping Self-Efficacy Scale,and the Positive and Negative Suicide Ideation Inventory-Negative Scale.We used structural equation modeling to test the mediation model and multigroup analysis to test the moderation effect of gender.Results:Negotiable fate belief is negatively correlated with suicidal ideation(r=-0.13,p<0.01).Moreover,coping self-efficacy mediates the relationship between negotiable fate belief and suicidal ideation(β=-0.06,95%confidence interval(CI)[-0.12,-0.02]),accounting for 35.29%of the total effect.Finally,the mediating effect of coping self-efficacy was found to be significant only for female left-behind children(male:95%CI[-0.09,0.07];female:95%CI[-0.16,-0.01]).For female left-behind children,the mediating effect was complete,with a coefficient of-0.06,accounting for 85.71%of the total effect.Conclusions:The relationship between negotiable fate belief and suicidal ideation among rural left-behind children is mediated by coping self-efficacy,and this mediation effect was moderated by gender.This study provides a theoretical explanation for how cultivating the belief in negotiable fate and coping self-efficacy is effective for reducing suicidal ideation of rural left-behind children.展开更多
Equations(2)and(6)and the corresponding discussion in the paper[Chin.Phys.Lett.42,056301(2025)]have been corrected.These modiffcations do not affect the results derived in the paper.
Low ionic conductivity is a major obstacle for polymer solid-state electrolytes.In response to this issue,a design concept of enhanced regional electric potential difference(EREPD)is proposed to modulate the interacti...Low ionic conductivity is a major obstacle for polymer solid-state electrolytes.In response to this issue,a design concept of enhanced regional electric potential difference(EREPD)is proposed to modulate the interaction of nanofillers with other components in the composite polymer solid-state electrolytes(CPSEs).While ensuring the periodic structure of the graphdiyne(GDY)backbone,methoxysubstituted GDY(OGDY)is prepared by an asymmetric substitution strategy,which increases the electric potential differences within each repeating unit of GDY.The staggered distributed electron-rich regions and electron-deficient regions on the two-dimensional plane of OGDY increase the free Li^(+)concentration through Lewis acid-base pair interaction.The adjacent ERRs and EDRs form uniformly distributed EREPDs,creating a continuous potential gradient that synergistically facilitates the efficient migration of Li^(+).Impressively,the OGDY/poly(ethylene oxide)(PEO)exhibits a high ionic conductivity(1.1×10^(-3)S cm^(−1))and ion mobility number(0.71).In addition,the accelerated Li^(+)migration promotes the formation of uniform and dense SEI layers and inhibits the growth of lithium dendrites.As a proof of concept,Li||Li symmetric cell and Li||LiFePO_(4)full cell and pouch cell assembled with OGDY/PEO exhibit good performance,highlighting the effectiveness of our EREPD design strategy for improving CPSEs performance.展开更多
Compared with other migration methods, reverse-time migration is based on a precise wave equation, not an approximation, and performs extrapolation in the depth domain rather than the time domain. It is highly accurat...Compared with other migration methods, reverse-time migration is based on a precise wave equation, not an approximation, and performs extrapolation in the depth domain rather than the time domain. It is highly accurate and not affected by strong subsurface structure complexity and horizontal velocity variations. The difference method based on triangular grids maintains the simplicity of the difference method and the precision of the finite element method. It can be used directly for forward modeling on models with complex top surfaces and migration without statics preprocessing. We apply a finite difference method based on triangular grids for post-stack reverse-time migration for the first time. Tests on model data verify that the combination of the two methods can achieve near-perfect results in application.展开更多
[Objective] This study aimed to analyze the difference in the contents of gallic acid and catechins of tea resources from Yunnan Province. [Method] By using high performance liquid chromatography （HPLC）, the content...[Objective] This study aimed to analyze the difference in the contents of gallic acid and catechins of tea resources from Yunnan Province. [Method] By using high performance liquid chromatography （HPLC）, the contents of gallic acid （GA）, catechins （C）, epicatechin （EC）, epigallocatechin （EGC）, epicatechin gallate （ECG） and epigallocatechin gallate （EGCG） of 121 tea germplasms from the China National Germplasm Tea Repositories （CNGTR） at the Tea Research Institute of Yunnan Academy of Agricultural Sciences （TRIYAAS） were measured. [Result] The content of GA ranged from 0.210% to 1.902%, with an average of 0.834%, explaining rela- tively low GA content among tea germplasms. The content of C ranged from 0.069% to 8.865%, with an average of 1.916%. The content of EC ranged from 0.126% to 2.865%, with an average of 1.112%. The content of EGC ranged from 0.00% to 3.709%, with an average of 0.954%. The content of ECG ranged from 0.739% to 8.957%, with an average of 4.063%. The content of EGCG ranged from 0.819% to 11.77%, with an average of 5.939%. The content of total C ranged from 6.354% to 22.654%, with an average of 14.042%. [Conclusion] There was relatively big difference of catechin contents among different tea resources, indicating that there was plentiful biodiversity of Yunnan tea germplasms. At the same time, three tea germplasms with high epigallocatechin gallate content （≥10%） was selected preliminarily, which would provide important materials for breeding tea cultivars with high EGCG content in the future.展开更多
[Objective]The aim was to compare the silencing effect of three vectors containing shRNA quartet of different lengths at cellular level and individual level.[Method]To silence EGFP gene,three shRNA quartets of 21,27 a...[Objective]The aim was to compare the silencing effect of three vectors containing shRNA quartet of different lengths at cellular level and individual level.[Method]To silence EGFP gene,three shRNA quartets of 21,27 and 29 bp composed of hU6,mU6,h7SK and hH1 promoters were constructed and then cloned into silencing vectors.After the vectors were transfected into Vero cells or injected into mouse muscle,real-time fluorescence quantitative PCR was conducted to detect the mRNA level of EGFP gene.[Result]All the three vectors showed better silencing effect;in which,the silencing effect at the cellular level was far higher than that at individual level.[Conclusion]Multi-site tandem expression shRNA may show better silencing effect;intramuscular injection maybe a transgenic method for baby mouse.展开更多
To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine in...To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.展开更多
To the most of velocity fields, the traveltimes of the first break that seismic waves propagate along rays can be computed on a 2-D or 3-D numerical grid by finite-difference extrapolation. Under ensuring accuracy, to...To the most of velocity fields, the traveltimes of the first break that seismic waves propagate along rays can be computed on a 2-D or 3-D numerical grid by finite-difference extrapolation. Under ensuring accuracy, to improve calculating efficiency and adaptability, the calculation method of first-arrival traveltime of finite-difference is de- rived based on any rectangular grid and a local plane wavefront approximation. In addition, head waves and scat- tering waves are properly treated and shadow and caustic zones cannot be encountered, which appear in traditional ray-tracing. The testes of two simple models and the complex Marmousi model show that the method has higher accuracy and adaptability to complex structure with strong vertical and lateral velocity variation, and Kirchhoff prestack depth migration based on this method can basically achieve the position imaging effects of wave equation prestack depth migration in major structures and targets. Because of not taking account of the later arrivals energy, the effect of its amplitude preservation is worse than that by wave equation method, but its computing efficiency is higher than that by total Green′s function method and wave equation method.展开更多
Idioms are the essence and gems of human wisdom and an important carrier of national culture. As a special form of language, they play an important role in intercultural communication. Due to the uniqueness of each cu...Idioms are the essence and gems of human wisdom and an important carrier of national culture. As a special form of language, they play an important role in intercultural communication. Due to the uniqueness of each culture, English and Chinese idioms are different in many aspects, values included. The present paper attempts to analyze the different values in English and Chinese idioms from three aspects: dependence vs independence, past-time orientation vs future-time orientation, and harmony vs competition. And the authors hope that it will be of some practical significance in people's intercultural communication.展开更多
Objective Urine is a promising biomarker source for clinical proteomics studies.Regional physiological differences are common in multi-center clinical studies.In this study,we investigate whether significant differenc...Objective Urine is a promising biomarker source for clinical proteomics studies.Regional physiological differences are common in multi-center clinical studies.In this study,we investigate whether significant differences are present in the urinary proteomes of individuals from different regions in China.Methods In this study,morning urine samples were collected from healthy urban residents in three regions of China(Haikou,Xi’an and Xining)and urinary proteins were preserved using a membrane-based method(Urimem).The urine proteomes of 27 normal samples were analyzed using LC-MS/MS and compared among three regions.Functional annotation of the differential proteins among the three areas was analyzed using the DAVID online database,and pathway enrichment of the differential urinary proteins was analyzed using KEGG.Results We identified 1898 proteins from Urimem samples using label-free proteome quantification,of which 56 urine proteins were differentially expressed among the three regions(P<0.05).Hierarchical clustering analysis showed that inter-regional differences caused less significant changes in the urine proteome than intersex differences.After gender stratification,16 differential proteins were identified in male samples and 84 differential proteins were identified in female samples.Among these differential proteins,several proteins have been previously reported as urinary disease biomarkers.Conclusions Urimem will facilitate urinary protein storage for large-scale urine sample collection.Regional differences are a confounding factor influencing the urine proteome and should be considered in future multicenter biomarker studies.展开更多
Learners differ,so does their language acquisition.Studies show there are several personality factors affecting the process of language of learning.This paper attempts to indicate these factors to help learners have a...Learners differ,so does their language acquisition.Studies show there are several personality factors affecting the process of language of learning.This paper attempts to indicate these factors to help learners have a better understanding of their own learning.展开更多
Some learners' personal factors, such as gender, major, motivation and language proficiency, influence the use of language learn- ing strategies. This paper reports the results of a survey study which investigates...Some learners' personal factors, such as gender, major, motivation and language proficiency, influence the use of language learn- ing strategies. This paper reports the results of a survey study which investigates the individual differences and the employment of English learning strategies, examines the association between enjoyment and strategy use, motivation and strategy use, gender and strategy use, major and strategy use, English proficiency and strategy use.展开更多
文摘Residential energy-use behavior and energy-saving awareness play a crucial role in sustainable urban energy planning and building energy efficiency,particularly under the pressures of climate change.However,existing studies often lack comparative analysis of urban-rural differences and tend to focus excessively on behavior patterns while neglecting the dimension of energysaving awareness.With China’s urbanization rate reaching 66.16%,understanding such regional disparities has become increasingly important.To address these research gaps,this study conducts a large-scale survey on space cooling behaviors among residents in Beijing,a representative Chinese megacity.It should be noted that living standards in such megacities are generally higher than the national average,which may shape distinctive energy-use profiles.Analyzing 1573valid samples(1064 urban/442 rural)in 2024,this study employed K-Prototypes and K-Modes clustering to identify typical cooling behavior and energy-saving awareness pattems,followed by Kendall/Chi-square correlation tests and XGBoost importance analysis to determine key influencing factors,with subsequent urban-rural comparative analysis.Results indicate that urban residents are primarily heat-sensitive or heat-tolerant,with a secondary patten of mid-low temperature preference,and generally exhibit long cooling durations;rural behavior is dominated by heat-tolerant type,followed by heat-sensitive,mid-low temperature preference,and never-on types as secondary patterns;both urban and rural areas exhibit energy-savingawareness characterized by low consumption-lowwillingness,though urban areas show marginally higher motivation;energy-saving awareness correlates with cooling behavior in rural areas,but this relationship weakens significantly in urban contexts.
基金Supported by Natural Science Foundation of Hunan Province(No.2023JJ70017No.2025JJ50627)Peak Climbing Project of Optometry Hospital Affiliated to Wenzhou Medical University。
文摘AIM:To investigate the sex-specific correlation between systemic factors and retinal neurovascular alterations in individuals with type 1 diabetes mellitus(T1DM)who do not exhibit signs of diabetic retinopathy(DR).METHODS:A cohort participant without DR diagnosed with T1DM,underwent comprehensive ophthalmologic evaluation,optical coherence tomography angiography retinal structural and microvascular density analysis,and systemic parameter assessment.Multiple linear regression analysis was used to investigate the impact of systemic parameters on retinal alterations in distinct gender groups.RESULTS:A total of 182 individuals were included,consisting of 85 males(mean age 23.28±12.75y)and 97 females(mean age 22.98±13.68y).Males exhibited significantly greater thickness in both the internal retinal layer and the entire retina compared to females(P<0.01),whereas females had higher densities of deep retinal vessels and choroidal capillaries(P<0.05).Additionally,glycemic control was found to have a notable influence on retinal thickness in males(P<0.05),while insulin function had a more pronounced impact on retinal structure in females(P<0.01).Furthermore,a significant correlation was observed between thyroid function markers and retinal parameters in both male and female(P<0.05).CONCLUSION:Sex differences in alterations in retinal structure and microcirculation are observed in individuals with T1DM prior to the development of clinical DR,with a noted association between these changes and systemic parameters.
基金supported by the National Natural Science Foundation of China(Grant No.11571181)by the Natural Science Foundation of Jiangsu Province(Grant No.BK20171454).
文摘In this paper,we propose and analyze two second-order accurate finite difference schemes for the one-dimensional heat equation with concentrated capacity on a computa-tional domain=[a,b].We first transform the target equation into the standard heat equation on the domain excluding the singular point equipped with an inner interface matching(IIM)condition on the singular point x=ξ∈(a,b),then adopt Taylor’s ex-pansion to approximate the IIM condition at the singular point and apply second-order finite difference method to approximate the standard heat equation at the nonsingular points.This discrete procedure allows us to choose different grid sizes to partition the two sub-domains[a,ξ]and[ξ,b],which ensures that x=ξ is a grid point,and hence the pro-posed schemes can be generalized to the heat equation with more than one concentrated capacities.We prove that the two proposed schemes are uniquely solvable.And through in-depth analysis of the local truncation errors,we rigorously prove that the two schemes are second-order accurate both in temporal and spatial directions in the maximum norm without any constraint on the grid ratio.Numerical experiments are carried out to verify our theoretical conclusions.
基金Supported by The Sanming Project of Medicine in Shenzhen,No.SZSM202211003Shenzhen-Hong Kong Jointly Funded Project,Shenzhen Science and Technology Program,No.SGDX20230116093645007+1 种基金Shenzhen Second People's Hospital Clinical Project,No.20243357003Shenzhen Medical Research Fund,No.B2303005.
文摘BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.
基金supported by the National Natural Science Foundation of China(No.42277175)Guangxi Emergency Management Department 2024 Innovation and Technology Research Project,China(No.2024GXYJ006)+2 种基金Hunan Provincial Department of Natural Resources Geological Exploration Project,China(No.2023ZRBSHZ056)The First National Natural Disaster Comprehensive Risk Survey in Hunan Province,China(No.2022-70)Guizhou Provincial Major Scientific and Technological Program,China(No.2023-425).
文摘A method combining finite difference method(FDM)and k-means clustering algorithm which can determine the threshold of rock bridge generation is proposed.Jointed slope models with different joint coalescence coefficients(k)are constructed based on FDM.The rock bridge area was divided through k-means algorithm and the optimal number of clusters was determined by sum of squared errors(SSE)and elbow method.The influence of maximum principal stress and stress change rate as clustering indexes on the clustering results of rock bridges was compared by using Euclidean distance.The results show that using stress change rate as clustering index is more effective.When the joint coalescence coefficient is less than 0.6,there is no significant stress concentration in the middle area of adjacent joints,that is,no generation of rock bridge.In addition,the range of rock bridge is affected by the coalescence coefficient(k),the relative position of joints and the parameters of weak interlayer.
基金supported by the National Key Research and Development Program of China (Grant No. 2022YFA1404603)by the National Natural Science Foundation of China (Grant Nos. 12274127 and 12188101)。
文摘By extending the concept of diffusion to the potential energy landscapes(PELs), we introduce the meansquared energy difference(MSED) as a novel quantity to investigate the intrinsic properties of supercooled liquids. MSED can provide a clear description of the “energy relaxation” process on a PEL. Through MSED analysis, we have obtained a characteristic time similar to that derived from structure analysis, namely τ_(α)^(*).Further, we establish a connection between MSED and the feature of PELs, providing a concise and quantitative description of PELs. The relaxation behavior of energy has been found to follow a stretched exponential form.As the temperature decreases, the roughness of the accessible PEL changes significantly around a characteristic temperature T_(x), which is 20% higher than the glass transition temperature T_(g) and is comparable to the critical temperature of the mode-coupling theory. More importantly, one of the PEL parameters is closely related to the Adam–Gibbs configurational entropy. The present research, which directly links the PEL to the relaxation process, provides avenues for further research of glasses.
基金funded by the 2023Laibin City Philosophy and Social Science Research Project(No.2023LBZS035)2024Guangxi Student Innovation and Entrepreneurship Training Program Project(No.S202411546046X)2025 Research Project of Guangxi Science&Technology Normal University(No.GXKS2025YB020).
文摘Objectives:Suicidal ideation is a strong predictor of suicide deaths,which refers to the consideration or desire to give up one's own life.Left-behind children in rural China are more vulnerable to psychological problems and suicidal ideation compared to their non-left-behind peers.The aim of the current study was to examine two potential protective factors,negotiable fate belief and coping self-efficacy,and to test the mediating role of coping self-efficacy in the relationship between negotiable fate belief and suicidal ideation.We also analyzed gender differences in this mediation model.Methods:Across-sectional survey was conducted in rural areas ofChina.A sample of 526 left-behind children(285 males,54.18%;241 females,45.82%;Meanage=13.29 years,SD=0.97 years)was recruited to complete the Negotiable Fate Belief Scale,Coping Self-Efficacy Scale,and the Positive and Negative Suicide Ideation Inventory-Negative Scale.We used structural equation modeling to test the mediation model and multigroup analysis to test the moderation effect of gender.Results:Negotiable fate belief is negatively correlated with suicidal ideation(r=-0.13,p<0.01).Moreover,coping self-efficacy mediates the relationship between negotiable fate belief and suicidal ideation(β=-0.06,95%confidence interval(CI)[-0.12,-0.02]),accounting for 35.29%of the total effect.Finally,the mediating effect of coping self-efficacy was found to be significant only for female left-behind children(male:95%CI[-0.09,0.07];female:95%CI[-0.16,-0.01]).For female left-behind children,the mediating effect was complete,with a coefficient of-0.06,accounting for 85.71%of the total effect.Conclusions:The relationship between negotiable fate belief and suicidal ideation among rural left-behind children is mediated by coping self-efficacy,and this mediation effect was moderated by gender.This study provides a theoretical explanation for how cultivating the belief in negotiable fate and coping self-efficacy is effective for reducing suicidal ideation of rural left-behind children.
文摘Equations(2)and(6)and the corresponding discussion in the paper[Chin.Phys.Lett.42,056301(2025)]have been corrected.These modiffcations do not affect the results derived in the paper.
基金supported by the National Key Research and Development Project of China(2022YFA1204500,2022YFA1204503,2018YFA0703501)the National Natural Science Foundation of China(22275115,21875274,11704024)+4 种基金the Natural Science Foundation of Shandong Province(ZR2024ZD02)Natural Science Foundation of Hebei Province(B2020201006)Hebei Province Innovation Capability Enhancement Plan Project(22567620H)Young Scholarship Funding of Shandong University.Post-graduate Innovation Fund Project of Open Laboratory Project Fund of Hebei University(HBU2025SS010)Basic Research Project of Shandong University-Xin’an Group Silicon-Based High-End New Materials Institute.
文摘Low ionic conductivity is a major obstacle for polymer solid-state electrolytes.In response to this issue,a design concept of enhanced regional electric potential difference(EREPD)is proposed to modulate the interaction of nanofillers with other components in the composite polymer solid-state electrolytes(CPSEs).While ensuring the periodic structure of the graphdiyne(GDY)backbone,methoxysubstituted GDY(OGDY)is prepared by an asymmetric substitution strategy,which increases the electric potential differences within each repeating unit of GDY.The staggered distributed electron-rich regions and electron-deficient regions on the two-dimensional plane of OGDY increase the free Li^(+)concentration through Lewis acid-base pair interaction.The adjacent ERRs and EDRs form uniformly distributed EREPDs,creating a continuous potential gradient that synergistically facilitates the efficient migration of Li^(+).Impressively,the OGDY/poly(ethylene oxide)(PEO)exhibits a high ionic conductivity(1.1×10^(-3)S cm^(−1))and ion mobility number(0.71).In addition,the accelerated Li^(+)migration promotes the formation of uniform and dense SEI layers and inhibits the growth of lithium dendrites.As a proof of concept,Li||Li symmetric cell and Li||LiFePO_(4)full cell and pouch cell assembled with OGDY/PEO exhibit good performance,highlighting the effectiveness of our EREPD design strategy for improving CPSEs performance.
基金sponsored by National Natural Science Foundation(40474041)National Symposium of 863(2006AA06Z206)+1 种基金National Symposium of 973(2007CB209605)CNPC Geophysical Key Laboratory of the China University of Petroleum (East China) Research Department
文摘Compared with other migration methods, reverse-time migration is based on a precise wave equation, not an approximation, and performs extrapolation in the depth domain rather than the time domain. It is highly accurate and not affected by strong subsurface structure complexity and horizontal velocity variations. The difference method based on triangular grids maintains the simplicity of the difference method and the precision of the finite element method. It can be used directly for forward modeling on models with complex top surfaces and migration without statics preprocessing. We apply a finite difference method based on triangular grids for post-stack reverse-time migration for the first time. Tests on model data verify that the combination of the two methods can achieve near-perfect results in application.
基金Supported by National Natural Science Foundation of China(31160175)Technology Innovation Talents Project of Yunnan Province(2011CI068)+1 种基金Special Fund for National Modern Agricultural Industrial Technology System Construction(nycytx-23)Seed Preservation Project of Ministry of Agriculture(NB2012-2130135)~~
文摘[Objective] This study aimed to analyze the difference in the contents of gallic acid and catechins of tea resources from Yunnan Province. [Method] By using high performance liquid chromatography （HPLC）, the contents of gallic acid （GA）, catechins （C）, epicatechin （EC）, epigallocatechin （EGC）, epicatechin gallate （ECG） and epigallocatechin gallate （EGCG） of 121 tea germplasms from the China National Germplasm Tea Repositories （CNGTR） at the Tea Research Institute of Yunnan Academy of Agricultural Sciences （TRIYAAS） were measured. [Result] The content of GA ranged from 0.210% to 1.902%, with an average of 0.834%, explaining rela- tively low GA content among tea germplasms. The content of C ranged from 0.069% to 8.865%, with an average of 1.916%. The content of EC ranged from 0.126% to 2.865%, with an average of 1.112%. The content of EGC ranged from 0.00% to 3.709%, with an average of 0.954%. The content of ECG ranged from 0.739% to 8.957%, with an average of 4.063%. The content of EGCG ranged from 0.819% to 11.77%, with an average of 5.939%. The content of total C ranged from 6.354% to 22.654%, with an average of 14.042%. [Conclusion] There was relatively big difference of catechin contents among different tea resources, indicating that there was plentiful biodiversity of Yunnan tea germplasms. At the same time, three tea germplasms with high epigallocatechin gallate content （≥10%） was selected preliminarily, which would provide important materials for breeding tea cultivars with high EGCG content in the future.
基金Supported by the National Natural Science Foundation of China(30671495)Project for Breeding New Varieties(2008ZX08006-003)+1 种基金Project for Breeding New Varieties(2009ZX08011-030B)International Cooperation Project(2009BFA012)~~
文摘[Objective]The aim was to compare the silencing effect of three vectors containing shRNA quartet of different lengths at cellular level and individual level.[Method]To silence EGFP gene,three shRNA quartets of 21,27 and 29 bp composed of hU6,mU6,h7SK and hH1 promoters were constructed and then cloned into silencing vectors.After the vectors were transfected into Vero cells or injected into mouse muscle,real-time fluorescence quantitative PCR was conducted to detect the mRNA level of EGFP gene.[Result]All the three vectors showed better silencing effect;in which,the silencing effect at the cellular level was far higher than that at individual level.[Conclusion]Multi-site tandem expression shRNA may show better silencing effect;intramuscular injection maybe a transgenic method for baby mouse.
基金National Science and Technology Support Program of China(Grant No.2008BAI49B01)the National Basic Research Program of China(Grant No.2009CB522000)
文摘To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.
基金National Natural Science Foundation of China (49894190-024) and Geophysical Prospecting Key Laboratory Foun- dation of China National Petroleum Corporation.
文摘To the most of velocity fields, the traveltimes of the first break that seismic waves propagate along rays can be computed on a 2-D or 3-D numerical grid by finite-difference extrapolation. Under ensuring accuracy, to improve calculating efficiency and adaptability, the calculation method of first-arrival traveltime of finite-difference is de- rived based on any rectangular grid and a local plane wavefront approximation. In addition, head waves and scat- tering waves are properly treated and shadow and caustic zones cannot be encountered, which appear in traditional ray-tracing. The testes of two simple models and the complex Marmousi model show that the method has higher accuracy and adaptability to complex structure with strong vertical and lateral velocity variation, and Kirchhoff prestack depth migration based on this method can basically achieve the position imaging effects of wave equation prestack depth migration in major structures and targets. Because of not taking account of the later arrivals energy, the effect of its amplitude preservation is worse than that by wave equation method, but its computing efficiency is higher than that by total Green′s function method and wave equation method.
文摘Idioms are the essence and gems of human wisdom and an important carrier of national culture. As a special form of language, they play an important role in intercultural communication. Due to the uniqueness of each culture, English and Chinese idioms are different in many aspects, values included. The present paper attempts to analyze the different values in English and Chinese idioms from three aspects: dependence vs independence, past-time orientation vs future-time orientation, and harmony vs competition. And the authors hope that it will be of some practical significance in people's intercultural communication.
基金supported by the Key Basic Research Program of the Ministry of Science and Technology of China(No.2013FY114100)the National Key Research and Development Program of China(No.2018YFC0910202,2016YFC1306300)+3 种基金the Beijing Natural Science Foundation(No.7172076)the Beijing Cooperative Construction Project(No.110651103)Beijing Normal University(No.11100704)Peking Union Medical College Hospital(2016-2.27)
文摘Objective Urine is a promising biomarker source for clinical proteomics studies.Regional physiological differences are common in multi-center clinical studies.In this study,we investigate whether significant differences are present in the urinary proteomes of individuals from different regions in China.Methods In this study,morning urine samples were collected from healthy urban residents in three regions of China(Haikou,Xi’an and Xining)and urinary proteins were preserved using a membrane-based method(Urimem).The urine proteomes of 27 normal samples were analyzed using LC-MS/MS and compared among three regions.Functional annotation of the differential proteins among the three areas was analyzed using the DAVID online database,and pathway enrichment of the differential urinary proteins was analyzed using KEGG.Results We identified 1898 proteins from Urimem samples using label-free proteome quantification,of which 56 urine proteins were differentially expressed among the three regions(P<0.05).Hierarchical clustering analysis showed that inter-regional differences caused less significant changes in the urine proteome than intersex differences.After gender stratification,16 differential proteins were identified in male samples and 84 differential proteins were identified in female samples.Among these differential proteins,several proteins have been previously reported as urinary disease biomarkers.Conclusions Urimem will facilitate urinary protein storage for large-scale urine sample collection.Regional differences are a confounding factor influencing the urine proteome and should be considered in future multicenter biomarker studies.
文摘Learners differ,so does their language acquisition.Studies show there are several personality factors affecting the process of language of learning.This paper attempts to indicate these factors to help learners have a better understanding of their own learning.
文摘Some learners' personal factors, such as gender, major, motivation and language proficiency, influence the use of language learn- ing strategies. This paper reports the results of a survey study which investigates the individual differences and the employment of English learning strategies, examines the association between enjoyment and strategy use, motivation and strategy use, gender and strategy use, major and strategy use, English proficiency and strategy use.
