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Towards Net Zero Resilience: A Futuristic Architectural Strategy for Cyber-Attack Defence in Industrial Control Systems (ICS) and Operational Technology (OT) 被引量:1
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作者 Hariharan Ramachandran Richard Smith +2 位作者 Kenny Awuson David Tawfik Al-Hadhrami Parag Acharya 《Computers, Materials & Continua》 2025年第2期3619-3641,共23页
This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA f... This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals. 展开更多
关键词 ics/OT cyber Programmable Logic Controllers(PLC)security detection safety reliability proof testing gas compressor station ics resilience security architecture ics
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Numerical Study on the Icing Characteristics of Flat Plates and Its Influencing Factors
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作者 Jin Zhu Yanxin Xu 《Computer Modeling in Engineering & Sciences》 2025年第9期2849-2872,共24页
Ice accretion on structures such as aircraft wings and wind turbine blades poses serious risks to aerodynamic performance and operational safety,particularly in cold and humid environments.This study conducts numerica... Ice accretion on structures such as aircraft wings and wind turbine blades poses serious risks to aerodynamic performance and operational safety,particularly in cold and humid environments.This study conducts numerical simulations of ice formation on thin flat plates using CFD and FENSAP-ICE,exploring how air temperature,wind velocity,and angle of attack(AOA)affect icing behavior and aerodynamic characteristics.Results indicate that ice thickness increases linearly over time.Rime ice forms at low temperatures due to immediate droplet freezing,whereas glaze ice develops at higher temperatures when a water film forms and subsequently refreezes into protruding ice horns;under identical conditions,rime ice consistently produces thicker ice layers than glaze ice.Increasing wind speed substantially enhances ice growth and coverage,while speeds as low as 1 m/s result in minimal accretion.Changes in AOA shift the icing region toward the pressure side,and AOAs of equal magnitude but opposite sign yield symmetrical ice accretion patterns and identical maximum thickness values.After icing,the plate’s leading edge becomes smoother,slightly reducing drag while increasing lift and moment coefficients.These findings highlight the dominant roles of temperature,wind speed,and AOA in determining ice morphology,extent,and aerodynamic impact,providing valuable insights for predicting icing effects and developing mitigation strategies for structures operating in icing-prone regions. 展开更多
关键词 Icing characteristics flat plate computational fluid dynamics(CFD) influencing factors
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油桐VfICS2基因的克隆和功能分析
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作者 李俊倩 杨程博 +1 位作者 张琳 刘美兰 《植物生理学报》 北大核心 2025年第9期1271-1283,共13页
油桐(Vernicia fordii)是我国特有的经济林木,具有重要的经济价值。水杨酸(SA)在调节植物生长发育中发挥着重要作用,而异分支酸合酶(isochorismate synthase,ICS)在植物SA合成途径中能够催化分支酸生成异分支酸,正向调控SA的合成。本研... 油桐(Vernicia fordii)是我国特有的经济林木,具有重要的经济价值。水杨酸(SA)在调节植物生长发育中发挥着重要作用,而异分支酸合酶(isochorismate synthase,ICS)在植物SA合成途径中能够催化分支酸生成异分支酸,正向调控SA的合成。本研究利用基因克隆、生物信息学分析、表达模式分析和生物学功能分析等方法,全面探究了油桐中VfICS2基因的功能。结果表明,油桐中仅有1个ICS2成员,编码序列长为1656 bp,编码551个氨基酸,是一种无跨膜结构域的亲水性蛋白,含12个α螺旋和16个β折叠,β折叠上包含Ile292、Ala357、Pro448等3个保守位点;表达模式分析发现,VfICS2主要表达于根、茎、叶中,且在茎中的表达量分别是根和叶的21.44倍、18.62倍;功能研究发现外源SA可抑制油桐花序轴伸长和减少花序轴数量及其花数量,拟南芥中过表达VfICS2可以抑制根毛生长发育和增强植株的抗旱抗盐能力,烟草中过表达VfICS2可减少烟草花数量和降低结实率。以上研究为进一步探索VfICS2功能奠定了基础,同时也为油桐遗传改良提供了基因资源。 展开更多
关键词 油桐 ics2基因 水杨酸 基因克隆 功能分析
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Macro-and Microphysical Characteristics of Freezing Rain and Their Impacts on Wire Icing Mechanisms in the Southwestern Mountainous Areas of China 被引量:1
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作者 Yue ZHOU Chunsong LU +3 位作者 Jingjing Lü Xiaoyun SUN Lingli ZHOU Hui XIAO 《Advances in Atmospheric Sciences》 2025年第8期1620-1635,共16页
Based on comprehensive observations of 20 wire icing events during winter from 2019 to 2021,we investigated the characteristics of the icing properties,the atmospheric boundary layer structure,the raindrop size distri... Based on comprehensive observations of 20 wire icing events during winter from 2019 to 2021,we investigated the characteristics of the icing properties,the atmospheric boundary layer structure,the raindrop size distribution,and their associated effects on the ice accretion mechanism in the mountainous region of Southwest China.The maximum ice weight was positively correlated with the duration of ice accretion in the mountainous area.The duration of precipitation accounted for less than 20%of the icing period in the mountainous area,with solid-phase hydrometeors being predominant.Icing events,dominated by freezing rain(FR)and mixed rain–graupel(more than 70%),were characterized by glaze or highdensity mixed icing.The relationship between the melting energy and refreezing energy reflected the distribution characteristics of the proportion of FR under mixed-phase precipitation.The intensity of the warm layer and the dominant precipitation phase significantly affected the variations in the microphysical properties of FR.The melting of large dry snowflakes significantly contributed to FR in the mountainous areas,resulting in smaller generalized intercepts and larger mass-weighted mean diameters in the presence of a stronger warm layer.Under a weaker warm layer,the value of the massweighted mean diameter was significantly smaller because of the inability of large solid particles to melt.Finally,FR in the mountainous area dominated the ice weight during the rapid ice accumulation period.A numerical simulation of FR icing on wires effectively revealed the evolution of disaster-causing icing in mountainous areas. 展开更多
关键词 freezing rain wire icing macro-and microphysical characteristics mountainous area
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The ICS international chronostratigraphic chart this decade
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作者 Kim Cohen David Harper +1 位作者 Philip Gibbard Nicholas Car 《Episodes》 2025年第1期105-115,共11页
The International Commission on Stratigraphy(ICS)has been producing and updating its International Chro-nostratigraphic Chart for several decades.The chart communicates higher-order divisions of geological time and ac... The International Commission on Stratigraphy(ICS)has been producing and updating its International Chro-nostratigraphic Chart for several decades.The chart communicates higher-order divisions of geological time and actual knowledge on the numerical ages of their bound-aries.Distributed via the ICS website www.stratigraphy.org the chart promotes use in graphic,tabulated and further digital forms in multiple languages.This paper is a status update,eleven years since the last such publication,cov-ering activities between 2012 and 2024.Chart updates during the past decade have echoed the ICS’s primary objective of precisely defining a global standard set of time-correlative units(Systems,Series,Stages)for stratigraphic successions worldwide.These units are,in turn,the basis for the Periods,Epochs,and Ages of the Geological Time Scale.Their standardization is fundamental for expressing geological knowledge,in application and education,out-reach and continuing research.The chart offers a frame-work through which regional-scale higher-resolution divisions can be linked,equated and collated.Likewise it offers a framework for digital representation of the Geological Time Scale.Maintenance and distribution of chart versions on the web has been a manual endeavour,a process that ICS is upgrading to serve an increasingly digital world. 展开更多
关键词 digital representation geological knowledge education standard time correlative units commission stratigraphy ics chronostratigraphic chart geological time scale international commission stratigraphy
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基于CEEMADAN-GRNN-ICS的水资源预测及配置优化方法
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作者 林湫 《水利科学与寒区工程》 2025年第9期91-94,共4页
本文以H县为研究对象,采用集合经验模态分解法与广义神经网络模型CEEMADAN-GRNN法对该县需水量进行预测,基于预测结果完成该县水资源供需分析。考虑各水源供给能力及各用水户需水量,构建经济、社会和生态综合效益最大化的多目标水资源... 本文以H县为研究对象,采用集合经验模态分解法与广义神经网络模型CEEMADAN-GRNN法对该县需水量进行预测,基于预测结果完成该县水资源供需分析。考虑各水源供给能力及各用水户需水量,构建经济、社会和生态综合效益最大化的多目标水资源配置优化模型,并通过改进布谷鸟ICS算法完成求解。结果表明:该方法能有效预测H县供需水量,并能根据实际约束,完成水资源的有效配置。研究结果可为城市水资源规划提供依据。 展开更多
关键词 水资源需求预测 水资源配置优化 CEEMADAN模型 GRNN模型 ics算法
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慢阻肺病闭合三联药物ICS/LABA/LAMA吸入疗法应用研究进展
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作者 萧转花 金跃玲 《智慧健康》 2025年第21期22-24,27,共4页
慢阻肺为呼吸科常见病,药物治疗为该疾病的首选方案,ICS/LABA/LAMA均属于支气管扩张剂,ICS/LABA/LAMA吸入疗法为慢阻肺代表性用药方案之一。基于此,文章对ICS/LABA/LAMA的药物作用机制进行了论述分析,探讨了闭合三联药物ICS/LABA/LAMA... 慢阻肺为呼吸科常见病,药物治疗为该疾病的首选方案,ICS/LABA/LAMA均属于支气管扩张剂,ICS/LABA/LAMA吸入疗法为慢阻肺代表性用药方案之一。基于此,文章对ICS/LABA/LAMA的药物作用机制进行了论述分析,探讨了闭合三联药物ICS/LABA/LAMA吸入疗法在慢阻肺治疗中的应用方法及临床效果,并对其后续临床应用进行了分析展望。 展开更多
关键词 慢阻肺病 闭合 三联药物ics/LABA/LAMA 吸入疗法
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Impingement Characteristics Investigation of Supercooled Large Droplets Based on Eulerian Method
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作者 YE Zekun SHEN Xiaobin +1 位作者 ZHAO Jingyu LIN Guiping 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第2期191-200,共10页
This numerical simulation investigates the two⁃phase flow under the condition of supercooled large droplets impinging on the aircraft surface.Based on Eulerian framework,a method for calculating supercooled water drop... This numerical simulation investigates the two⁃phase flow under the condition of supercooled large droplets impinging on the aircraft surface.Based on Eulerian framework,a method for calculating supercooled water droplet impingement characteristics is established.Then,considering the deformation and breaking effects during the movement,this method is extended to calculate the impingement characteristics of supercooled large droplets,as well as the bouncing and splashing effects during impingement.The impingement characteristics of supercooled large droplets is then investigated by this method.The results demonstrate that the deformation and breaking effects of supercooled large droplets have negligible influence on the impingement characteristics under the experimental conditions of this paper.In addition,the results of the impingement range and collection efficiency decrease when considering the bouncing and splashing effects.The bouncing effect mainly affects the mass loss near the impingement limits,while the splashing effect influences the result around the stagnation point.This investigation is beneficial for the analysis of aircraft icing and the design of anti⁃icing system with supercooled large droplet conditions. 展开更多
关键词 aircraft icing droplet impingement characteristics supercooled large droplet(SLD) Eulerian method numerical simulation
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Icing Characteristics and Anti⁃icing Research of Supercooled Large Droplet Impact on Epoxy Composite Surfaces
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作者 LI Xiaofei WANG Xiangzhao +2 位作者 JI Zemin HUANG Xiaobin LIU Hong 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第2期178-190,共13页
The icing characteristics of supercooled large droplet(SLD)impacting carbon fiber-reinforced composites(CFRCs)remain poorly understood,hindering the enhancement of ice protection capabilities and the certification of ... The icing characteristics of supercooled large droplet(SLD)impacting carbon fiber-reinforced composites(CFRCs)remain poorly understood,hindering the enhancement of ice protection capabilities and the certification of ice-accreted composite aircraft.The paper systematically investigates the effects of the supercooling degree,the surface temperature,and the impact velocity on the ice accretion behavior of SLDs impacting carbon fiber-reinforced epoxy composite surfaces.To address the ice-prone nature of CFRCs,nanoparticle-modified anti-icing coatings are developed,and the icing characteristics of SLD-impacted modified carbon fiber-reinforced epoxy composite surfaces are analyzed.Results demonstrate that surface-modified carbon fiber-reinforced epoxy composite exhibits significantly delayed ice formation.Under conditions of droplet temperature(−15℃)and surface temperature(−18℃),the icing time of hydrophobic-modified CFRCs was delayed by over 1100 ms,representing a 5.4-fold improvement compared to the unmodified carbon fiber-reinforced epoxy composite. 展开更多
关键词 aircraft icing carbon fiber-reinforced epoxy composites supercooled large droplets hydrophobic modification icing protection
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The physics of icing drops under complex conditions
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作者 Feng Wang Hao Zeng +3 位作者 Sergio Peralta Julien Sebilleau Chao Sun Dominique Legendre 《Acta Mechanica Sinica》 2025年第7期180-196,共17页
Icing of water droplets is a ubiquitous phenomenon with significant implications across natural systems and industrial applications.Despite extensive research,the intricate interplay among heat transfer,mass transport... Icing of water droplets is a ubiquitous phenomenon with significant implications across natural systems and industrial applications.Despite extensive research,the intricate interplay among heat transfer,mass transport,and phase change during droplet freezing remains incompletely understood,particularly in the context of multiscale dynamics and environmental dependencies.This review critically examines recent advances in uncovering the fundamental mechanisms of droplet icing through experimental,theoretical,and computational approaches.We begin by revisiting the classical tip singularity problem in the freezing of pure water droplets,analyzing its mathematical formulation and physical significance.Subsequent sections explore how environmental boundary conditions and multicomponent effects influence freezing kinetics,solute redistribution,and ice morphology.Furthermore,we evaluate emerging hybrid numerical frameworks that resolve coupled multiphase physics during solidification processes.Finally,we identify key challenges and open questions that require further investigation in this field. 展开更多
关键词 Icing droplet Multiphase flow Interfacial flow Numerical simulation
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Experimental Investigation of Saltwater Ice Accretion Characteristics on the Marine Gas Turbine Shroud
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作者 LIU Xiao-gang WANG Bao-sheng +2 位作者 WANG Meng WANG Zhong-yi Boo Cheong KHOO 《China Ocean Engineering》 2025年第4期780-790,共11页
Polar ships face significant risks from ice accretion on decks,superstructures,and power systems.Ice formation on the power intake system particularly affects vessel stability and safety.While freshwater icing has bee... Polar ships face significant risks from ice accretion on decks,superstructures,and power systems.Ice formation on the power intake system particularly affects vessel stability and safety.While freshwater icing has been extensively researched,comprehensive multi-parameter studies on ice accretion for intake structures remain insufficient.This investigation examines the icing characteristics of the air shroud,a critical component of marine gas turbines,resulting from saltwater droplet freezing.The study utilized a custom-built cyclic ice wind tunnel,with flow field quality verified through Five-hole probe and Hot wire anemometer methods,and droplet field quality validated using Laser,Flowmeter,Ice blade,and Icing calibration grid techniques.The research analyzes ice distribution and thickness on the shroud under varying NaCl concentrations,considering temperature,liquid water content(LWC),and median volume diameter(MVD).The findings reveal that decreased salinity facilitates rime ice formation,resulting in rough ice texture.Temperature reduction,increased LWC,and larger MVD enhanced salinity's influence on ice thickness.The shroud exhibits substantial radial ice accretion,with coverage extending to approximately 90%.These results establish a foundation for further investigation of saltwater icing mechanisms and pioneer icing research in marine gas turbine intake systems. 展开更多
关键词 ice accretion saltwater droplet icing gas turbine shroud experimental investigation
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基于ICS算法的列车运动模型参数辨识
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作者 刘杨 尤思博 方洲宇 《电力机车与城轨车辆》 2024年第1期14-19,共6页
列车运动模型参数辨识对其运行控制至关重要,文章采用单质点列车模型,对运行列车进行受力分析,建立列车运动模型,并提出利用改进的布谷鸟搜索(ICS)算法对列车基本阻力参数进行辨识;基于真实的列车运行数据,对基本阻力参数辨识进行仿真分... 列车运动模型参数辨识对其运行控制至关重要,文章采用单质点列车模型,对运行列车进行受力分析,建立列车运动模型,并提出利用改进的布谷鸟搜索(ICS)算法对列车基本阻力参数进行辨识;基于真实的列车运行数据,对基本阻力参数辨识进行仿真分析,并基于TD3算法对参数辨识的有效性进行仿真验证。仿真结果表明,基本阻力参数辨识对列车运行控制十分必要,相对于经验参数,辨识参数下的列车基本阻力更为准确,且辨识参数下的牵引能耗有一定的降低。 展开更多
关键词 列车 参数辨识 基本阻力 改进的布谷鸟搜索(ics)算法
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白葡奈氏菌片联合ICS+LABA治疗中重度COPD急性发作
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作者 张玄 陈园园 +3 位作者 张国英 王静 李姗姗 王建春 《中国卫生标准管理》 2024年第1期147-151,共5页
目的探究及观察白葡奈氏菌片联合吸入糖皮质激素+长效β2受体激动剂(inhaled corticosteroid+long-acting β_(2)-agonist,ICS+LABA)治疗中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性发作的疗效及对生活质... 目的探究及观察白葡奈氏菌片联合吸入糖皮质激素+长效β2受体激动剂(inhaled corticosteroid+long-acting β_(2)-agonist,ICS+LABA)治疗中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性发作的疗效及对生活质量的影响。方法将2020年6月—2021年12月山东第一医科大学附属省立医院的80例中重度COPD急性发作患者根据随机数字表法分为2组。对照组的40例采用ICS+LABA进行治疗,观察组的40例则在对照组的基础上加用白葡奈氏菌片。比较2组的COPD治疗总有效率、不良反应发生率、治疗前后的症状体征积分、疾病状态[慢性阻塞性肺疾病评分(COPD assessment test,CAT评分)]及生活质量[世界卫生组织生存质量测定量表简表(World Health Organization on quality of life brief scale,WHOQOL-BREF评分)]。结果治疗1、2周后观察组的COPD治疗总有效率显著高于对照组,差异有统计学意义(P<0.05),2组的不良反应发生率比较,差异无统计学意义(P>0.05),治疗1、2周后观察组的COPD相关症状体征积分显著低于对照组,CAT评分构成则显著优于对照组,WHOQOL-BREF评分显著高于对照组,差异有统计学意义(P<0.05)。结论白葡奈氏菌片联合ICS+LABA治疗中重度COPD急性发作的疗效较好,且可显著改善患者的生活质量。 展开更多
关键词 白葡奈氏菌片 ics LABA 中重度COPD 急性发作 疗效 生活质量
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Ratification of the base of the ICS Geological Time Scale:the Global Standard Stratigraphic Age(GSSA)for the Hadean lower boundary
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作者 Jaana Halla Nora Noffke +29 位作者 Humberto Reis Stanley Awramik Andrey Bekker Alexander Brasier Flávia Callefo Adrita Choudhury Jan-Peter Duda Christopher Fedo Douglas Galante Jessica Haddock Peter Haines Linda Hinnov Axel Hofmann Martin Homann David Huston Simon Johnson Linda Kah Alan Kaufman Alex Kovalick Matheus Kuchenbecker Juha Köykkä Donald Lowe Noah Nhleko Barry Reno Evelyn Sanchez Yogmaya Shukla Albertus Smith Mark Van Zuilen Frances Westall Martin Whitehouse 《Episodes》 2024年第2期381-389,共9页
The base of the ICS(International Commission on Stratigraphy)Geological Time Scale was ratified in 2022 by defining a new Global Stratigraphic Standard Age(GSSA)for the lower boundary of the Hadean Eon(formerly 4000–... The base of the ICS(International Commission on Stratigraphy)Geological Time Scale was ratified in 2022 by defining a new Global Stratigraphic Standard Age(GSSA)for the lower boundary of the Hadean Eon(formerly 4000–3600 Ma);the age of the Solar System based on the oldest solids,calcium-aluminium inclusions(CAIs),generated in the protoplanetary disk.The formal GSSA for the Hadean base is the oldest reliable,weighted mean Ucorrected Pb–Pb age of 4567.30±0.16 Ma obtained for CAIs in primitive meteorites Allende and Efremovka.This age is supported by the 4568–4567 Ma U-corrected Pb–Pb ages of chondrules in Northwest African meteorites.The boundary sets an upper lifetime for the protoplanetary disk and timing of planet formation. 展开更多
关键词 global stratigraphic standard age gssa Hadean lower boundary RATIFICATION ics primitive meteorites geological time scale time scale GSSA
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应用于ICS PCIE Gen2的扩频时钟模块电路
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作者 葛浩正 韩国旋 许培元 《信息技术与信息化》 2024年第3期162-165,共4页
为了满足ICS(internet connection sharing,因特网连接共享)PCIE Gen2协议,可提供输入时钟信号给PC、PCIE桥芯片以及以太网等芯片,利用时钟扩频技术的研究来减少系统的电磁干扰问题。基于应用于ICS PCIE Gen2协议的设计要求,通过采用SMI... 为了满足ICS(internet connection sharing,因特网连接共享)PCIE Gen2协议,可提供输入时钟信号给PC、PCIE桥芯片以及以太网等芯片,利用时钟扩频技术的研究来减少系统的电磁干扰问题。基于应用于ICS PCIE Gen2协议的设计要求,通过采用SMIC 0.18μm工艺设计传统锁相环结构,包括鉴频鉴相器、电荷泵、环路滤波器、环形振荡器、分频器以及相位插值器所设计的扩频时钟模块电路,实现了在满足指标400 MHz输出频率的基础上对扩频深度控制在-5×10-3以内,频谱峰值能量降低了10.32 dB,输出相位噪声在1 MHz频偏下为-107.378 dBc/Hz。未扩频模式下输出时钟的确定性抖动为31.6 ps,周期间RMS抖动为5.1 ps;进行扩频后,周期间RMS抖动为8.6 ps,满足了ICS PCIE Gen2的协议要求。 展开更多
关键词 ics PCIE Gen2协议 扩频时钟模块电路 电磁干扰 振荡器 相位插值器
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吸入性糖皮质激素(ICS)对咳嗽变异性哮喘(CVA)的气道高反应性和诱导痰中炎性介质的影响 被引量:54
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作者 刘美璇 朱柠 陈小东 《复旦学报(医学版)》 CAS CSCD 北大核心 2013年第1期76-79,87,共5页
目的探讨吸入糖皮质激素(inhaled corticosteroid,ICS)对咳嗽变异性哮喘(cough variant asthma,CVA)患者的气道高反应性和诱导痰中炎性介质的影响。方法本实验纳入28例CVA患者作为实验CVA组及22例健康体检者作为对照组。所有研究对象治... 目的探讨吸入糖皮质激素(inhaled corticosteroid,ICS)对咳嗽变异性哮喘(cough variant asthma,CVA)患者的气道高反应性和诱导痰中炎性介质的影响。方法本实验纳入28例CVA患者作为实验CVA组及22例健康体检者作为对照组。所有研究对象治疗前均进行基础肺功能、支气管激发试验(bronchial provocating test,BPT)和诱导痰检查,入组后所有CVA患者接受正规糖皮质激素,治疗方案为布地奈德粉吸入剂400μg/d,随访观察12个月。评估治疗前后0、3、6、9、12月PD20-FEV1值,通过酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)法检测CVA组治疗前和治疗后3、6、9、12个月诱导痰IL-5、IL-10的含量,用瑞氏吉姆萨染色法计数诱导痰中的嗜酸性粒细胞(eosinophils,EOS)百分比(%)。结果治疗前CVA患者的诱导痰中IL-5含量和EOS(%)明显高于健康对照组,IL-10含量低于健康组(P<0.05)。短期(3个月)ICS即可有效提高CVA患者PD20-FEV1,ICS干预12个月后,CVA组气道高反应性达极轻度水平。CVA组诱导痰IL-5、IL-10及EOS水平分别在ICS干预3个月、6个月后较基线水平出现明显变化(P<0.05),干预12个月后CVA组各炎症观察指标皆有不同程度的恢复,但与健康对照组比较差异仍有统计学意义(P<0.05)。结论 ICS治疗可以显著降低CVA患者的AHR和气道炎症,但CVA治疗12个月也仅有50%(14例)的AHR转阴率,且气道炎症未完全消退,因此CVA的ICS疗程大多数需要12个月以上,提示ICS对CVA的疗程也需要坚持长期的原则。 展开更多
关键词 咳嗽变异性哮喘(CVA) 气道炎症 气道高反应性 吸入性糖皮质激素(ics)
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我国标准化与专利的关系:基于ICS分类的实证分析 被引量:4
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作者 张继宏 姚宪弟 赵锐 《科技进步与对策》 CSSCI 北大核心 2012年第4期94-99,共6页
专利与标准(化)在一国创新系统中发挥着越来越重要的作用。国内外现有研究标准(化)与专利之间相互关系的实证文献很少,基于我国的宏观经验数据来分析专利和标准(化)之间关系的实证研究,在变量设定以及数据收集方面存在较大的缺陷。首先... 专利与标准(化)在一国创新系统中发挥着越来越重要的作用。国内外现有研究标准(化)与专利之间相互关系的实证文献很少,基于我国的宏观经验数据来分析专利和标准(化)之间关系的实证研究,在变量设定以及数据收集方面存在较大的缺陷。首先在变量的设定方面纠正了现有研究的不足之处,其次严格按照布莱德的标准的国际分类(ICS)和国际专利分类(IPC)之间的对应关系收集数据,从而在变量的选择和收集以及样本量方面保证了数据分析结果的有效性。经过实证分析,研究结果表明:我国的专利申请与标准之间具有积极的相互影响的关系;同时,在不同的行业中,专利申请和标准之间的关系是不同的。 展开更多
关键词 标准 专利 ics分类 相关性
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基于ICS-INC的局部阴影下光伏最大功率点追踪研究 被引量:6
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作者 朱娟娟 刘新宇 +1 位作者 闫群民 郭阳 《陕西科技大学学报》 北大核心 2023年第2期184-190,共7页
传统最大功率点追踪技术(Maximum Power Point Tracking, MPPT)存在收敛速度慢、精度差、易陷入局部最优等缺点.针对上述问题,提出一种基于改进布谷鸟算法(Improved Cuckoo Search, ICS)和电导增量法(Incremental Conductancemethod, I... 传统最大功率点追踪技术(Maximum Power Point Tracking, MPPT)存在收敛速度慢、精度差、易陷入局部最优等缺点.针对上述问题,提出一种基于改进布谷鸟算法(Improved Cuckoo Search, ICS)和电导增量法(Incremental Conductancemethod, INC)的联合MPPT控制方式.首先对布谷鸟算法(Cuckoo Search, CS)中莱维步长和毁巢率进行了自适应变化增加了迭代收敛速度和全局寻优能力,其次通过判断鸟巢间最大位置差ξ切换INC防止其陷入局部极小值,最后分别进行静态对比和动态光照仿真实验.静态对比仿真结果表明此控制方式在追踪速度和精度上更有优越性;动态仿真测试结果证明该方法在复杂环境下具有鲁棒性. 展开更多
关键词 太阳能发电 最大功率点追踪 ics算法 INC算法
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Improved Geochronologic Accuracy and Precision for the ICS Chronostratigraphic Charts:Examples from the late Cambrian-Early Ordovician
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作者 E.Landing A.W.A.Rushton +1 位作者 R.A.Fortey S.A.Bowring 《Episodes》 2015年第3期154-161,共8页
The utility of ICS International Chronostratigraphic Charts(ICS Charts)relies on the accuracy and precision of reported geochronologic dates and their relationship to the bases of global chronostratigraphic units.Howe... The utility of ICS International Chronostratigraphic Charts(ICS Charts)relies on the accuracy and precision of reported geochronologic dates and their relationship to the bases of global chronostratigraphic units.However,an examination of some early Paleozoic dates(i.e.,Cambrian-Ordovician boundary and lowest Ordovician)on the ICS Charts shows that they differ from originally reported and late recalculated dates.Thus,they record a numerical precision that differs from these revised dates.The dates assigned to the bases of formal early Paleozoic chronostratigraphic units may be interpreted by the lay reader as precise determinations. 展开更多
关键词 ics charts ics chronostratigraphic charts ics international chronostratigraphic charts ics charts relies early paleozoic dates iecambrian ordovician geochronologic dates PRECISION record numerical precision late cambrian early ordovician
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相关医学人才培养“ICS”模式的探索与实践 被引量:2
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作者 吕俊峰 丁旭红 孙小娅 《教育与职业》 北大核心 2009年第15期41-42,共2页
文章通过苏州卫生职业技术学院相关医学专业人才培养模式的研究与实践,总结了相关医学人才培养的“ICS”模式,以期推进我国相关医学类专业人才培养的研究。
关键词 相关医学 人才培养 ics”模式
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