Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected ...Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected that it will make a greater contribution to the world ophthalmology.展开更多
Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO PressProf.Xiu-Wen Hu,Chief Editor of IJO,and Prof.Yan-Nian Hui,Editor-in-Chief of IJO,introduced the current situation o...Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO PressProf.Xiu-Wen Hu,Chief Editor of IJO,and Prof.Yan-Nian Hui,Editor-in-Chief of IJO,introduced the current situation of IJ O to Prof.Peter Wiedemann,President of ICOProf.Xiu-Wen Hu(left),Chief Editor of IJO,and Prof.Yan-Nian Hui(right),Editor-in-Chief of IJO.展开更多
The soil-water retention curve(SWRC)plays a pivotal role in understanding water movement across numerous geological engineering applications.Despite significant advancements in theoretical modeling approaches,accurate...The soil-water retention curve(SWRC)plays a pivotal role in understanding water movement across numerous geological engineering applications.Despite significant advancements in theoretical modeling approaches,accurate prediction of SWRCs remains challenging due to the inherently sparse and incomplete nature of site-specific data.This study compiled a comprehensive dataset of SWRCs spanning a wide suction range from various published literature sources.Based on this dataset,multiple machine learning(ML)algorithms were employed to predict SWRCs.The performance of each algorithm was evaluated and ranked using four statistical indicators that quantify simulation accuracy.Feature importance analysis was subsequently conducted to reduce dimensionality by eliminating weakly correlated variables,thereby enhancing both model adaptability and computational efficiency.Following dimensionality reduction,a base learner pool was constructed and integrated through stacked generalization to create a multi-algorithm ensemble model.The proposed stacked model demonstrated robust performance in simulating SWRCs across diverse soil types,using only basic physical properties as inputs,achieving accuracy comparable to or marginally superior to the LightGBM model.The principal advantage of the stacked approach lies in its substantially improved accuracy within high suction ranges,effectively overcoming the limitations observed in LightGBM and enhancing the estimation under these conditions.This study provides valuable insights for researchers evaluating SWRCs through ML algorithms and demonstrates the potential of ensemble techniques in geotechnical prediction tasks.展开更多
Accurate state of health(SOH)estimation is essential for the safe and reliable operation of lithium-ion batteries.However,existing methods face significant challenges,primarily because they rely on complete charge–di...Accurate state of health(SOH)estimation is essential for the safe and reliable operation of lithium-ion batteries.However,existing methods face significant challenges,primarily because they rely on complete charge–discharge cycles and fixed-form physical constraints,which limit adaptability to different chemistries and real-world conditions.To address these issues,this study proposes an approach that extracts features from segmented state of charge(SOC)intervals and integrates them into an enhanced physics-informed neural network(PINN).Specifically,voltage data within the 25%–75%SOC range during charging are used to derive statistical,time–frequency,and mechanism-based features that capture degradation trends.A hybrid PINN-Lasso-Transformer-BiLSTM architecture is developed,where Lasso regression enables sparse feature selection,and a nonlinear empirical degradation model is embedded as a learnable physical term within a dynamically scaled composite loss.This design adaptively balances data-driven accuracy with physical consistency,thereby enhancing estimation precision,robustness,and generalization.The results show that the proposed method outperforms conventional neural networks across four battery chemistries,achieving root mean square error and mean absolute error below 1%.Notably,features from partial charging segments exhibit higher robustness than those from full cycles.Furthermore,the model maintains strong performance under high temperatures and demonstrates excellent generalization capacity in transfer learning across chemistries,temperatures,and C-rates.This work establishes a scalable and interpretable solution for accurate SOH estimation under diverse practical operating conditions.展开更多
In mixture experiments,the observed response is determined by the relative proportions of the components,consequently rendering the experimental region a simplex.This paper focuses primarily on the optimal designs of ...In mixture experiments,the observed response is determined by the relative proportions of the components,consequently rendering the experimental region a simplex.This paper focuses primarily on the optimal designs of mixture experiments that involve process variables.Prior research has extensively delved into optimal orthogonal block designs for some classic mixture models with process variables.Based on the framework of general blending models,this paper proposes a class of symmetric linear mixture models,which can be regarded as a generalization of many existing ones.Under the orthogonal blocking conditions,orthogonal block designs are devised through Latin squares in the presence of process variables.TheD-,A-,and E-optimality criteria are utilized to obtain optimal designs at the boundary of the simplex in the case of 3 components.As the values of the exponents change,numerically derived optimal design points are presented to illustrate the pattern of their variations,and to verify the consistency of the results with previous research on some specific symmetric general blending models.展开更多
Clouds play an important role in global atmospheric energy and water vapor budgets, and the low cloud simulations suffer from large biases in many atmospheric general circulation models. In this study, cloud microphys...Clouds play an important role in global atmospheric energy and water vapor budgets, and the low cloud simulations suffer from large biases in many atmospheric general circulation models. In this study, cloud microphysical processes such as raindrop evaporation and cloud water accretion in a double-moment six-class cloud microphysics scheme were revised to enhance the simulation of low clouds using the Global-Regional Integrated Forecast System(GRIST)model. The validation of the revised scheme using a single-column version of the GRIST demonstrated a reasonable reduction in liquid water biases. The revised parameterization simulated medium-and low-level cloud fractions that were in better agreement with the observations than the original scheme. Long-term global simulations indicate the mitigation of the originally overestimated low-level cloud fraction and cloud-water mixing ratio in mid-to high-latitude regions,primarily owing to enhanced accretion processes and weakened raindrop evaporation. The reduced low clouds with the revised scheme showed better consistency with satellite observations, particularly at mid-and high-latitudes. Further improvements can be observed in the simulated cloud shortwave radiative forcing and vertical distribution of total cloud cover. Annual precipitation in mid-latitude regions has also improved, particularly over the oceans, with significantly increased large-scale and decreased convective precipitation.展开更多
The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture majo...The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture major.The"integration of general and specialized education"is the key path to solve the problems of"prominent disciplinary barriers,fragmented knowledge structure,and weak practical ability"in the traditional curriculum system.In this paper,the College of Smart Agriculture from Yulin Normal University is taken as the research object.Based on the characteristics of regional agricultural industry and the positioning of professional education,the prominent problems in the current professional curriculum system of smart agriculture are analyzed,the construction concept of"strong foundation in general education,precise core in professional education,and breaking through boundaries in integrated education"is proposed,and a"three dimensions and four layers"integrated curriculum system framework for general and specialized education is constructed.Moreover,practical exploration is conducted from the aspects of curriculum module design,teaching mode innovation,and guarantee mechanism construction.Practice has shown that this curriculum system effectively enhances students'interdisciplinary application abilities and industry adaptability,and provides a practical sample for the reform of smart agriculture courses in local universities under the background of new agricultural science.展开更多
The overgeneralization of fear is associated with psychiatric disorders and cognitive decline.Recent studies have shown that engram cells in the dorsal dentate gyrus are integrated into functionally heterogeneous ense...The overgeneralization of fear is associated with psychiatric disorders and cognitive decline.Recent studies have shown that engram cells in the dorsal dentate gyrus are integrated into functionally heterogeneous ensembles that are involved in contextual fear memory generalization and discrimination.However,the intracellular signals that promote fear generalization remain to be fully elucidated.In this study,we labeled and manipulated the c-Fos+and Npas4+ensembles in the dorsal dentate gyrus that are activated by contextual fear conditioning using a robust activity marking system.The results showed that increasing the excitability of Fos-dependent robust activity marking by overexpressing NaChBac or decreasing the excitability of Npas4-dependent robust activity marking by overexpressing Kir2.1 promoted fear memory generalization.Furthermore,CRISPR-mediated downregulation of the autophagy-related Atg5 or Atg7 genes in dorsal dentate gyrus neurons inhibited activation of c-Fos,but not Npas4.Knockdown of Atg5 or Atg7 in the Fos-dependent robust activity marking or Npas4-dependent robust activity marking ensemble led to an increase in neuronal excitability and a decrease in spine density in both ensembles.However,Atg7 knockdown in the Fos-dependent robust activity marking ensemble promoted memory generalization,while knockdown of Atg5 or Atg7 in the Npas4-dependent robust activity marking ensemble increased anxiety levels.These results contribute to our understanding of how the varying plasticity of memory engrams is involved in regulating fear memory generalization and anxiety.展开更多
Making full use of the operator ordering method and the integration within ordered products,we obtain the analytical evolution law of a general quadratic state in the amplitude decay channel,and find that it is determ...Making full use of the operator ordering method and the integration within ordered products,we obtain the analytical evolution law of a general quadratic state in the amplitude decay channel,and find that it is determined not only by the decay rate of the amplitude decay channel but also by the coefficients of the initial quadratic state.Further,the quantum statistical properties of the initial quadratic state for amplitude decay are investigated via its average photon number and photon-counting distribution,and its Wigner distribution function evolution is discussed in detail.展开更多
Modern apprenticeship emphasizes strengthening school-enterprise cooperation,deepening the integration of production and education,and promoting the combination of work and study to achieve seamless connection between...Modern apprenticeship emphasizes strengthening school-enterprise cooperation,deepening the integration of production and education,and promoting the combination of work and study to achieve seamless connection between professional education and industrial needs,thereby improving the quality of talent training.This paper analyzes the current problems in the nursing talent training system,elaborates on the significance of cultivating nursing talents based on modern apprenticeship,and proposes new ideas for constructing a modern apprenticeship training model for nursing talents from the perspectives of“integrating general and specialized education,merging virtue and skills,and linking specialization and innovation”.The aim is to further promote the organic combination of nursing talent training goals and post needs,for reference only.展开更多
Bruce E,Spivey,M.D.,was President of the International Council of Ophthalmology (ICO)from 2006 to 2014 and served as ICO Secretary-General from1994 to 2006;and is general scientific advisor of International Journal of...Bruce E,Spivey,M.D.,was President of the International Council of Ophthalmology (ICO)from 2006 to 2014 and served as ICO Secretary-General from1994 to 2006;and is general scientific advisor of International Journal of Ophthalmology (IJO)from 2003 to present.Professor Spivey trained as an ophthalmologist and medical educator.He has worked extensively to enhance ophthalmic education and eye care internationally.展开更多
This paper proposes a nonmonotonic backtracking trust region algorithm via bilevel linear programming for solving the general multicommodity minimal cost flow problems.Using the duality theory of the linear programmin...This paper proposes a nonmonotonic backtracking trust region algorithm via bilevel linear programming for solving the general multicommodity minimal cost flow problems.Using the duality theory of the linear programming and convex theory,the generalized directional derivative of the general multicommodity minimal cost flow problems is derived.The global convergence and superlinear convergence rate of the proposed algorithm are established under some mild conditions.展开更多
BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for ...BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.AIM To investigate the analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.METHODS In this retrospective study,94 patients scheduled for laparoscopic minimally invasive surgery for inguinal hernia,admitted to Yiwu Central Hospital between May 2022 and May 2023,were divided into a control group(inhalation combined general anesthesia)and a treatment group(dexmedetomidine-assisted intrave-nous-inhalation combined general anesthesia).Perioperative indicators,analgesic effect,preoperative and postoperative 24-hours blood pressure(BP)and heart rate(HR),stress indicators,immune function levels,and adverse reactions were com-pared between the two groups.RESULTS Baseline data,including age,hernia location,place of residence,weight,monthly income,education level,and underlying diseases,were not significantly different between the two groups,indicating comparability(P>0.05).No significant difference was found in operation time and anesthesia time between the two groups(P>0.05).However,the treatment group exhibited a shorter postoperative urinary catheter removal time and hospital stay than the control group(P<0.05).Preoperatively,no significant differences were found in the visual analog scale(VAS)scores between the two groups(P>0.05).However,at 12,18,and 24 hours postoper-atively,the treatment group had significantly lower VAS scores than the control group(P<0.05).Although no significant differences in preoperative hemodynamic indicators were found between the two groups(P>0.05),both groups experienced some extent of changes in postoperative HR,diastolic BP(DBP),and systolic BP(SBP).Nevertheless,the treatment group showed smaller changes in HR,DBP,and SBP than the control group(P<0.05).Preoperative immune function indicators showed no significant differences between the two groups(P>0.05).However,postoperatively,the treatment group demonstrated higher levels of CD3+,CD4+,and CD4+/CD8+and lower levels of CD8+than the control group(P<0.05).The rates of adverse reactions were 6.38%and 23.40%in the treatment and control groups,respectively,revealing a significant difference(χ2=5.371,P=0.020).CONCLUSION Dexmedetomidine-assisted intravenous-inhalation combined general anesthesia can promote early recovery of patients undergoing laparoscopic minimally invasive surgery for inguinal hernia.It ensures stable blood flow,improves postoperative analgesic effects,reduces postoperative pain intensity,alleviates stress response,improves immune function,facilitates anesthesia recovery,and enhances safety.展开更多
Background: The seroepidemiology of Helicobacter pylori infection in general population in Durango City, Mexico has not been previously studied. Aims: To determine the seroprevalence of anti-H. pylori antibodies in th...Background: The seroepidemiology of Helicobacter pylori infection in general population in Durango City, Mexico has not been previously studied. Aims: To determine the seroprevalence of anti-H. pylori antibodies in the general population in Durango City, Mexico;and to determine socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seropositivity. Methods: The prevalence of anti-H. pylori IgG antibodies was examined in 345 individuals in Durango City, Mexico, using enzyme-linked immunoassays. Socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seroprevalence were also investigated. Results: In total, 231 (67%) of the 345 participants (mean age, 45.3. ± 17.5 years) had H. pylori IgG antibodies, 146 (63.2%) of whom had H. pylori IgG antibody levels higher than 100 U/mL. Both H. pylori seroprevalence and antibody levels increased significantly with age, and were similar in males and females. An increased H. pylori seroprevalence was found in subjects with low education and employed. In contrast, a low seroprevalence was found in subjects living in suburban areas. One of four subjects with gastritis symptoms had anti-H. pylori antibodies. The seroprevalence of H. pylori was significantly higher among women with abortion history than among those without such history. Multivariate analysis of behavioral variables showed that H. pylori seropositivity was negatively associated with raising farm animals (OR = 0.48;95% CI: 0.25-0.91;P = 0.02). Conclusions: In the general population studied, H. pylori seroreactivity increased significantly with age, not only in frequency but also in intensity. Residence, education, and occupation of the study population influenced the seropositivity rate of H. pylori.展开更多
BACKGROUND Subcutaneous implantable cardioverter-defibrillator(S-ICD)implantation requires effective anesthesia.General anesthesia(GA)carries risks like hemodynamic instability,while ultrasound-guided intercostal nerv...BACKGROUND Subcutaneous implantable cardioverter-defibrillator(S-ICD)implantation requires effective anesthesia.General anesthesia(GA)carries risks like hemodynamic instability,while ultrasound-guided intercostal nerve block(US-ICNB)may offer better pain control.This study hypothesized US-ICNB is superior in perioperative safety and pain management.AIM To compare perioperative outcomes of GA and US-ICNB in S-ICD implantation.METHODS This retrospective single-center study included 64 patients who received S-ICD implantation between February 2021 and December 2024.They were divided into GA and US-ICNB groups based on anesthesia type.Demographic data,perioperative parameters(operation time,pain scores,analgesic usage),and postoperative outcomes(complications,defibrillation events)were collected and analyzed.Statistical tests were used to compare the two groups.RESULTS This study included 64 patients(20 in the GA group and 44 in the US-ICNB group).Baseline left ventricular ejection fraction was significantly lower in the US-ICNB group(39.20%±12.00%vs 56.20%±11.50%in GA,P<0.001),while American Society of Anesthesiologists scores and comorbidities were comparable.US-ICNB showed superior pain control,with significantly lower numeric rating scale scores at 6-48 hours(P<0.001)and fewer patients requiring analgesics(P=0.02).The US-ICNB group had shorter operation times(P<0.001),total hospital stays(P<0.001),and later first analgesia times(P<0.001).No anesthesia-related complications occurred in either group.CONCLUSION Both anesthetic methods were safe in the short term.However,US-ICNB was superior in reducing operation and hospital stay times and alleviating peri-operative pain.It has high safety in S-ICD implantation and deserves further clinical promotion,though large-scale,multi-center,randomized controlled trials are needed to confirm these findings.展开更多
文摘Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected that it will make a greater contribution to the world ophthalmology.
文摘Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO PressProf.Xiu-Wen Hu,Chief Editor of IJO,and Prof.Yan-Nian Hui,Editor-in-Chief of IJO,introduced the current situation of IJ O to Prof.Peter Wiedemann,President of ICOProf.Xiu-Wen Hu(left),Chief Editor of IJO,and Prof.Yan-Nian Hui(right),Editor-in-Chief of IJO.
基金the National Natural Science Foundation of China(Grant No.42272312)Ningbo Youth Science and Technology Innovation Talent Project(Grant No.2024QL057)the Zhejiang Provincial Xinmiao Talents Program(Grant No.2024R405B093).
文摘The soil-water retention curve(SWRC)plays a pivotal role in understanding water movement across numerous geological engineering applications.Despite significant advancements in theoretical modeling approaches,accurate prediction of SWRCs remains challenging due to the inherently sparse and incomplete nature of site-specific data.This study compiled a comprehensive dataset of SWRCs spanning a wide suction range from various published literature sources.Based on this dataset,multiple machine learning(ML)algorithms were employed to predict SWRCs.The performance of each algorithm was evaluated and ranked using four statistical indicators that quantify simulation accuracy.Feature importance analysis was subsequently conducted to reduce dimensionality by eliminating weakly correlated variables,thereby enhancing both model adaptability and computational efficiency.Following dimensionality reduction,a base learner pool was constructed and integrated through stacked generalization to create a multi-algorithm ensemble model.The proposed stacked model demonstrated robust performance in simulating SWRCs across diverse soil types,using only basic physical properties as inputs,achieving accuracy comparable to or marginally superior to the LightGBM model.The principal advantage of the stacked approach lies in its substantially improved accuracy within high suction ranges,effectively overcoming the limitations observed in LightGBM and enhancing the estimation under these conditions.This study provides valuable insights for researchers evaluating SWRCs through ML algorithms and demonstrates the potential of ensemble techniques in geotechnical prediction tasks.
基金supported by the Shanghai Pilot Program for Basic Research(22T01400100-18)the National Natural Science Foundation of China(22278127 and 12447149)+1 种基金the Fundamental Research Funds for the Central Universities(2022ZFJH004)the Postdoctoral Fellowship Program of CPSF(GZB20250159).
文摘Accurate state of health(SOH)estimation is essential for the safe and reliable operation of lithium-ion batteries.However,existing methods face significant challenges,primarily because they rely on complete charge–discharge cycles and fixed-form physical constraints,which limit adaptability to different chemistries and real-world conditions.To address these issues,this study proposes an approach that extracts features from segmented state of charge(SOC)intervals and integrates them into an enhanced physics-informed neural network(PINN).Specifically,voltage data within the 25%–75%SOC range during charging are used to derive statistical,time–frequency,and mechanism-based features that capture degradation trends.A hybrid PINN-Lasso-Transformer-BiLSTM architecture is developed,where Lasso regression enables sparse feature selection,and a nonlinear empirical degradation model is embedded as a learnable physical term within a dynamically scaled composite loss.This design adaptively balances data-driven accuracy with physical consistency,thereby enhancing estimation precision,robustness,and generalization.The results show that the proposed method outperforms conventional neural networks across four battery chemistries,achieving root mean square error and mean absolute error below 1%.Notably,features from partial charging segments exhibit higher robustness than those from full cycles.Furthermore,the model maintains strong performance under high temperatures and demonstrates excellent generalization capacity in transfer learning across chemistries,temperatures,and C-rates.This work establishes a scalable and interpretable solution for accurate SOH estimation under diverse practical operating conditions.
基金supported by the National Natural Science Foundation of China[grant numbers 12071329,12471246].
文摘In mixture experiments,the observed response is determined by the relative proportions of the components,consequently rendering the experimental region a simplex.This paper focuses primarily on the optimal designs of mixture experiments that involve process variables.Prior research has extensively delved into optimal orthogonal block designs for some classic mixture models with process variables.Based on the framework of general blending models,this paper proposes a class of symmetric linear mixture models,which can be regarded as a generalization of many existing ones.Under the orthogonal blocking conditions,orthogonal block designs are devised through Latin squares in the presence of process variables.TheD-,A-,and E-optimality criteria are utilized to obtain optimal designs at the boundary of the simplex in the case of 3 components.As the values of the exponents change,numerically derived optimal design points are presented to illustrate the pattern of their variations,and to verify the consistency of the results with previous research on some specific symmetric general blending models.
基金National Natural Science Foundation of China(42375153,42105153,42205157)Development of Science and Technology at Chinese Academy of Meteorological Sciences(2023KJ038)。
文摘Clouds play an important role in global atmospheric energy and water vapor budgets, and the low cloud simulations suffer from large biases in many atmospheric general circulation models. In this study, cloud microphysical processes such as raindrop evaporation and cloud water accretion in a double-moment six-class cloud microphysics scheme were revised to enhance the simulation of low clouds using the Global-Regional Integrated Forecast System(GRIST)model. The validation of the revised scheme using a single-column version of the GRIST demonstrated a reasonable reduction in liquid water biases. The revised parameterization simulated medium-and low-level cloud fractions that were in better agreement with the observations than the original scheme. Long-term global simulations indicate the mitigation of the originally overestimated low-level cloud fraction and cloud-water mixing ratio in mid-to high-latitude regions,primarily owing to enhanced accretion processes and weakened raindrop evaporation. The reduced low clouds with the revised scheme showed better consistency with satellite observations, particularly at mid-and high-latitudes. Further improvements can be observed in the simulated cloud shortwave radiative forcing and vertical distribution of total cloud cover. Annual precipitation in mid-latitude regions has also improved, particularly over the oceans, with significantly increased large-scale and decreased convective precipitation.
基金Supported by the Autonomous Region-level Research and Practice Projects for New Engineering,New Medicine,New Agriculture,and New Humanities of Guangxi Department of Education(XNK202409)the Undergraduate Teaching Reform Project of Guangxi Higher Education(2024JGB332+1 种基金2024JGA304)the Guangxi Degree and Graduate Education Reform Project(JGY2025382).
文摘The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture major.The"integration of general and specialized education"is the key path to solve the problems of"prominent disciplinary barriers,fragmented knowledge structure,and weak practical ability"in the traditional curriculum system.In this paper,the College of Smart Agriculture from Yulin Normal University is taken as the research object.Based on the characteristics of regional agricultural industry and the positioning of professional education,the prominent problems in the current professional curriculum system of smart agriculture are analyzed,the construction concept of"strong foundation in general education,precise core in professional education,and breaking through boundaries in integrated education"is proposed,and a"three dimensions and four layers"integrated curriculum system framework for general and specialized education is constructed.Moreover,practical exploration is conducted from the aspects of curriculum module design,teaching mode innovation,and guarantee mechanism construction.Practice has shown that this curriculum system effectively enhances students'interdisciplinary application abilities and industry adaptability,and provides a practical sample for the reform of smart agriculture courses in local universities under the background of new agricultural science.
基金the STI2030-Major Projects,Nos.2021ZD0203500(to FW),2021ZD0202100(to XL)the National Natural Science Foundation of China,Nos.32222033(to FW),32330041(to LM)and 82021002(to LM),32171041(to XL)and 32450102(to XL)CAMS Innovation Fund for Medical Sciences,No.2021-I2M-5-009(to LM and XL).
文摘The overgeneralization of fear is associated with psychiatric disorders and cognitive decline.Recent studies have shown that engram cells in the dorsal dentate gyrus are integrated into functionally heterogeneous ensembles that are involved in contextual fear memory generalization and discrimination.However,the intracellular signals that promote fear generalization remain to be fully elucidated.In this study,we labeled and manipulated the c-Fos+and Npas4+ensembles in the dorsal dentate gyrus that are activated by contextual fear conditioning using a robust activity marking system.The results showed that increasing the excitability of Fos-dependent robust activity marking by overexpressing NaChBac or decreasing the excitability of Npas4-dependent robust activity marking by overexpressing Kir2.1 promoted fear memory generalization.Furthermore,CRISPR-mediated downregulation of the autophagy-related Atg5 or Atg7 genes in dorsal dentate gyrus neurons inhibited activation of c-Fos,but not Npas4.Knockdown of Atg5 or Atg7 in the Fos-dependent robust activity marking or Npas4-dependent robust activity marking ensemble led to an increase in neuronal excitability and a decrease in spine density in both ensembles.However,Atg7 knockdown in the Fos-dependent robust activity marking ensemble promoted memory generalization,while knockdown of Atg5 or Atg7 in the Npas4-dependent robust activity marking ensemble increased anxiety levels.These results contribute to our understanding of how the varying plasticity of memory engrams is involved in regulating fear memory generalization and anxiety.
文摘Making full use of the operator ordering method and the integration within ordered products,we obtain the analytical evolution law of a general quadratic state in the amplitude decay channel,and find that it is determined not only by the decay rate of the amplitude decay channel but also by the coefficients of the initial quadratic state.Further,the quantum statistical properties of the initial quadratic state for amplitude decay are investigated via its average photon number and photon-counting distribution,and its Wigner distribution function evolution is discussed in detail.
基金2025 Shanghai Secondary Vocational School Curriculum and Teaching Reform Research Project(Project No.:2025K-03)。
文摘Modern apprenticeship emphasizes strengthening school-enterprise cooperation,deepening the integration of production and education,and promoting the combination of work and study to achieve seamless connection between professional education and industrial needs,thereby improving the quality of talent training.This paper analyzes the current problems in the nursing talent training system,elaborates on the significance of cultivating nursing talents based on modern apprenticeship,and proposes new ideas for constructing a modern apprenticeship training model for nursing talents from the perspectives of“integrating general and specialized education,merging virtue and skills,and linking specialization and innovation”.The aim is to further promote the organic combination of nursing talent training goals and post needs,for reference only.
文摘Bruce E,Spivey,M.D.,was President of the International Council of Ophthalmology (ICO)from 2006 to 2014 and served as ICO Secretary-General from1994 to 2006;and is general scientific advisor of International Journal of Ophthalmology (IJO)from 2003 to present.Professor Spivey trained as an ophthalmologist and medical educator.He has worked extensively to enhance ophthalmic education and eye care internationally.
基金the National Natural Science Foundation of China ( 1 0 4 71 0 94) ,the ScienceFoundation of Shanghai Technical Sciences Committee ( 0 2 ZA1 40 70 ) and the Science Foundation ofShanghai Education Committee( 0 2 DK0 6)
文摘This paper proposes a nonmonotonic backtracking trust region algorithm via bilevel linear programming for solving the general multicommodity minimal cost flow problems.Using the duality theory of the linear programming and convex theory,the generalized directional derivative of the general multicommodity minimal cost flow problems is derived.The global convergence and superlinear convergence rate of the proposed algorithm are established under some mild conditions.
文摘BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.AIM To investigate the analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.METHODS In this retrospective study,94 patients scheduled for laparoscopic minimally invasive surgery for inguinal hernia,admitted to Yiwu Central Hospital between May 2022 and May 2023,were divided into a control group(inhalation combined general anesthesia)and a treatment group(dexmedetomidine-assisted intrave-nous-inhalation combined general anesthesia).Perioperative indicators,analgesic effect,preoperative and postoperative 24-hours blood pressure(BP)and heart rate(HR),stress indicators,immune function levels,and adverse reactions were com-pared between the two groups.RESULTS Baseline data,including age,hernia location,place of residence,weight,monthly income,education level,and underlying diseases,were not significantly different between the two groups,indicating comparability(P>0.05).No significant difference was found in operation time and anesthesia time between the two groups(P>0.05).However,the treatment group exhibited a shorter postoperative urinary catheter removal time and hospital stay than the control group(P<0.05).Preoperatively,no significant differences were found in the visual analog scale(VAS)scores between the two groups(P>0.05).However,at 12,18,and 24 hours postoper-atively,the treatment group had significantly lower VAS scores than the control group(P<0.05).Although no significant differences in preoperative hemodynamic indicators were found between the two groups(P>0.05),both groups experienced some extent of changes in postoperative HR,diastolic BP(DBP),and systolic BP(SBP).Nevertheless,the treatment group showed smaller changes in HR,DBP,and SBP than the control group(P<0.05).Preoperative immune function indicators showed no significant differences between the two groups(P>0.05).However,postoperatively,the treatment group demonstrated higher levels of CD3+,CD4+,and CD4+/CD8+and lower levels of CD8+than the control group(P<0.05).The rates of adverse reactions were 6.38%and 23.40%in the treatment and control groups,respectively,revealing a significant difference(χ2=5.371,P=0.020).CONCLUSION Dexmedetomidine-assisted intravenous-inhalation combined general anesthesia can promote early recovery of patients undergoing laparoscopic minimally invasive surgery for inguinal hernia.It ensures stable blood flow,improves postoperative analgesic effects,reduces postoperative pain intensity,alleviates stress response,improves immune function,facilitates anesthesia recovery,and enhances safety.
文摘Background: The seroepidemiology of Helicobacter pylori infection in general population in Durango City, Mexico has not been previously studied. Aims: To determine the seroprevalence of anti-H. pylori antibodies in the general population in Durango City, Mexico;and to determine socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seropositivity. Methods: The prevalence of anti-H. pylori IgG antibodies was examined in 345 individuals in Durango City, Mexico, using enzyme-linked immunoassays. Socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seroprevalence were also investigated. Results: In total, 231 (67%) of the 345 participants (mean age, 45.3. ± 17.5 years) had H. pylori IgG antibodies, 146 (63.2%) of whom had H. pylori IgG antibody levels higher than 100 U/mL. Both H. pylori seroprevalence and antibody levels increased significantly with age, and were similar in males and females. An increased H. pylori seroprevalence was found in subjects with low education and employed. In contrast, a low seroprevalence was found in subjects living in suburban areas. One of four subjects with gastritis symptoms had anti-H. pylori antibodies. The seroprevalence of H. pylori was significantly higher among women with abortion history than among those without such history. Multivariate analysis of behavioral variables showed that H. pylori seropositivity was negatively associated with raising farm animals (OR = 0.48;95% CI: 0.25-0.91;P = 0.02). Conclusions: In the general population studied, H. pylori seroreactivity increased significantly with age, not only in frequency but also in intensity. Residence, education, and occupation of the study population influenced the seropositivity rate of H. pylori.
文摘BACKGROUND Subcutaneous implantable cardioverter-defibrillator(S-ICD)implantation requires effective anesthesia.General anesthesia(GA)carries risks like hemodynamic instability,while ultrasound-guided intercostal nerve block(US-ICNB)may offer better pain control.This study hypothesized US-ICNB is superior in perioperative safety and pain management.AIM To compare perioperative outcomes of GA and US-ICNB in S-ICD implantation.METHODS This retrospective single-center study included 64 patients who received S-ICD implantation between February 2021 and December 2024.They were divided into GA and US-ICNB groups based on anesthesia type.Demographic data,perioperative parameters(operation time,pain scores,analgesic usage),and postoperative outcomes(complications,defibrillation events)were collected and analyzed.Statistical tests were used to compare the two groups.RESULTS This study included 64 patients(20 in the GA group and 44 in the US-ICNB group).Baseline left ventricular ejection fraction was significantly lower in the US-ICNB group(39.20%±12.00%vs 56.20%±11.50%in GA,P<0.001),while American Society of Anesthesiologists scores and comorbidities were comparable.US-ICNB showed superior pain control,with significantly lower numeric rating scale scores at 6-48 hours(P<0.001)and fewer patients requiring analgesics(P=0.02).The US-ICNB group had shorter operation times(P<0.001),total hospital stays(P<0.001),and later first analgesia times(P<0.001).No anesthesia-related complications occurred in either group.CONCLUSION Both anesthetic methods were safe in the short term.However,US-ICNB was superior in reducing operation and hospital stay times and alleviating peri-operative pain.It has high safety in S-ICD implantation and deserves further clinical promotion,though large-scale,multi-center,randomized controlled trials are needed to confirm these findings.
