全名:哥白尼期刊数据库(ICI World of Journal)、哥白尼精选期刊数据库(ICI Master List)所属国家及机构:波兰哥白尼国际数据机构(Index Copernicus International,简称ICI)收录形式及规模:创建于1999年,由波兰的Index Copernicus Inter...全名:哥白尼期刊数据库(ICI World of Journal)、哥白尼精选期刊数据库(ICI Master List)所属国家及机构:波兰哥白尼国际数据机构(Index Copernicus International,简称ICI)收录形式及规模:创建于1999年,由波兰的Index Copernicus International(ICI)组织运营。ICI World of Journals是全球第三大国际数据库。目前,数据库中注册的期刊超过4.5万种,每月使用人次超过7万,来自150个国家。期刊需先进入ICI World of Journals,方可申请ICI Master List的录入。展开更多
Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapie...Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapies,chemotherapy,radiotherapy,and surgery,focusing on the development of drug resistance and significant toxicity that often hinder their efficacy.Thereafter,advancements in targeted therapies,such as immune checkpoint inhibitors(ICIs)and tyrosine kinase inhibitors(TKIs),are discussed,highlighting their impact on improving outcomes for patients with specific genetic mutations,including c-ros oncogene 1 receptor tyrosine kinase(ROS1),anaplastic lymphoma kinase(ALK),and epidermal growth factor receptor(EGFR).Additionally,the emergence of novel immunotherapies and phytochemicals is examined,emphasizing their potential to overcome therapeutic resistance,particularly in advanced-stage diseases.The review also delves into the role of next-generation sequencing(NGS)in enabling personalized treatment approaches and explores the clinical potential of innovative agents,such as bispecific T-cell engagers(BiTEs)and antibody-drug conjugates(ADCs).Finally,we address the socioeconomic barriers that limit the accessibility of these therapies in low-resource settings and propose future research directions aimed at improving the long-term efficacy and accessibility of these treatments.展开更多
文摘全名:哥白尼期刊数据库(ICI World of Journal)、哥白尼精选期刊数据库(ICI Master List)所属国家及机构:波兰哥白尼国际数据机构(Index Copernicus International,简称ICI)收录形式及规模:创建于1999年,由波兰的Index Copernicus International(ICI)组织运营。ICI World of Journals是全球第三大国际数据库。目前,数据库中注册的期刊超过4.5万种,每月使用人次超过7万,来自150个国家。期刊需先进入ICI World of Journals,方可申请ICI Master List的录入。
文摘Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapies,chemotherapy,radiotherapy,and surgery,focusing on the development of drug resistance and significant toxicity that often hinder their efficacy.Thereafter,advancements in targeted therapies,such as immune checkpoint inhibitors(ICIs)and tyrosine kinase inhibitors(TKIs),are discussed,highlighting their impact on improving outcomes for patients with specific genetic mutations,including c-ros oncogene 1 receptor tyrosine kinase(ROS1),anaplastic lymphoma kinase(ALK),and epidermal growth factor receptor(EGFR).Additionally,the emergence of novel immunotherapies and phytochemicals is examined,emphasizing their potential to overcome therapeutic resistance,particularly in advanced-stage diseases.The review also delves into the role of next-generation sequencing(NGS)in enabling personalized treatment approaches and explores the clinical potential of innovative agents,such as bispecific T-cell engagers(BiTEs)and antibody-drug conjugates(ADCs).Finally,we address the socioeconomic barriers that limit the accessibility of these therapies in low-resource settings and propose future research directions aimed at improving the long-term efficacy and accessibility of these treatments.
