BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and fracture.Type 2 diabetes mellitus(T2DM)co...BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and fracture.Type 2 diabetes mellitus(T2DM)complicated with osteoporosis is a common systemic metabolic bone disease,and reduced bone mass and bone strength are considered the main clinical features;however,the pathogenesis of this disease has not been fully clarified.Its occurrence is considered related to sex,age,and genetic factors.There are many risk factors for diabetes complicated with osteoporosis.Therefore,exploring these risk factors will help prevent it.AIM To investigate the relationships among serum glucagon-like peptide-1(GLP-1)levels,matrix Gla protein(MGP)levels,and diabetes with osteoporosis.METHODS Sixty patients with T2DM complicated with osteoporosis confirmed by the endocrinology department of our hospital were selected as the case group.Sixty T2DM patients with bone loss were selected as the control group.Sixty healthy participants were selected as the healthy group.The general data,bone mineral density index,and bone metabolic markers of the three groups were compared.The relationships among GLP-1 levels,MGP levels,and the bone mineral density index of the case group were analyzed using linear correlation analysis and a logistic regression model.RESULTS Differences in sex,smoking,and drinking among the case group,control group,and healthy group were not statistically significant(P>0.05).The mean age of the case group was older than those of the control and healthy groups(P<0.05).The body mass index,fasting plasma glucose level,HbA1c level,hypertension rate,and coronary heart disease rate of the case and control groups were higher than those of the healthy group(P<0.05).The serum GLP-1 and MGP levels of the case group were lower than those of the control and healthy groups;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the control group were lower than those of the healthy group;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the case group were significantly positively correlated with the bone mineral density values of the hip and lumbar spine(P<0.05).The results of the logistic regression model showed that age and duration of diabetes were independent risk factors for osteoporosis in diabetic patients(P<0.05)and that increased GLP-1 and MGP values were protective factors against osteoporosis in diabetic patients(P<0.05).CONCLUSION Serum GLP-1 and MGP levels of diabetic patients with osteoporosis were significantly decreased and positively correlated with bone mineral density and were independent risk factors for osteoporosis in diabetic patients.展开更多
目的:检测人参皂甙对牙周炎大鼠牙周组织中白介素6(interleukin-6,IL-6)及骨钙素(bone gla protein,BGP)的表达的影响并探讨其治疗牙周炎的机制。方法:选用100只体重160～200 g Wistar大白鼠,随机分成10组,每组10只。A组:正常对照组,0...目的:检测人参皂甙对牙周炎大鼠牙周组织中白介素6(interleukin-6,IL-6)及骨钙素(bone gla protein,BGP)的表达的影响并探讨其治疗牙周炎的机制。方法:选用100只体重160～200 g Wistar大白鼠,随机分成10组,每组10只。A组:正常对照组,0周时处死。B-J组建立牙周炎大鼠模型。B-E组:人参皂甙Rg-1治疗组,第1、2、3、4周处死。F-J组:牙周炎对照组,第0、1、2、3、4周处死。取大鼠上颌磨牙牙周组织标本作切片,光镜观察,免疫组化方法对IL-6、BGP进行染色,测量灰度值,进行统计学分析。结果:F组BGP水平明显低于A组,IL-6水平明显高于A组(P<0.05);C-E组BGP的水平明显高于H-J组,D-E组IL-6的水平明显低于I-J组(P<0.05)。结论:人参皂甙Rg-1可以抑制牙周炎大鼠牙周组织中IL-6的水平,同时升高BGP的水平,具有治疗牙周炎并改善全身状况的作用。展开更多
利用ICESat-1、CryoSat-2测高数据与水文站实测数据,分析了1970-2020年巴尔喀什湖水位变化特征,结合MOD09A1数据及相关资料分析了巴尔喀什湖长时间序列面积和水量变化状况,并利用巴尔喀什湖流域灌溉数据及Climatic Research Unit(CRU)...利用ICESat-1、CryoSat-2测高数据与水文站实测数据,分析了1970-2020年巴尔喀什湖水位变化特征,结合MOD09A1数据及相关资料分析了巴尔喀什湖长时间序列面积和水量变化状况,并利用巴尔喀什湖流域灌溉数据及Climatic Research Unit(CRU)气象数据,简要探究了气候变化及人类活动对湖泊长期变化的影响。结果表明:巴尔喀什湖水位在研究时段内总体呈现先下降后波动上升的趋势,1987年水位值达到最低(340.64 m),年内水位增长主要发生在2月底至6月初,且暖季(4-10月)水位波动比冷季(11月-次年3月)更剧烈;1970-2020年巴尔喀什湖面积从19996 km^(2)减少到16641.93 km^(2),湖面缩小约16.77%;在此期间巴尔喀什湖水量损失约为12.33 km^(3)。湖泊动态变化为多种因素共同作用的结果,1970-1987年湖泊动态变化主要由卡普恰盖水库蓄水和哈萨克斯坦境内灌区耕地扩张等人类活动引起;气温与降水在总体趋势上与湖泊的动态变化并无明显相关性,定量讨论各因素对湖泊动态变化的影响,还需进一步研究。展开更多
目的探讨莆田地区畲族健康人群骨密度与骨生化指标、睾酮以及雌二醇之间的关系,并与汉族人群比较,为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地40岁以上健康成年人,其中畲族532人,汉族563人,应用美国Osteometer Medi Tech...目的探讨莆田地区畲族健康人群骨密度与骨生化指标、睾酮以及雌二醇之间的关系,并与汉族人群比较,为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地40岁以上健康成年人,其中畲族532人,汉族563人,应用美国Osteometer Medi Tech公司生产的DTX-200骨密度吸收仪检测骨密度,以及用罗氏公司的骨生化指标仪器及试剂盒,测量骨密度以及25羟维生素D(25(OH)D3)、骨钙素(BGP)、雌二醇(E2)、睾酮(T)、甲状旁腺激素(PTH)、1型前胶原氨基末端肽(P1NP)、碱性磷酸酶(ALP)。把上述检测的数据结果输入电脑,应用SPSS17.0软件包进行数据分析。结果不管畲族和汉族的骨密度均随着年龄的增大而下降,同年龄段男性均高于女性。畲族女性除在40~49岁年龄段稍高于汉族外,其他年龄组汉族女性均高于畲族。而畲族男性在60~69岁年龄段稍高于汉族男性,其他年龄组汉族男性均高于畲族,但汉族与畲族间都没有显著性差异(P>0.05)。汉族的25(OH)D3明显高于畲族,尤其女性在40~60岁年龄段、男性在50~69岁年龄段为正相关(P<0.05);汉族的BGP高于畲族(P<0.05),汉族男的E2指标均高于畲族男,且40~59年龄段尤为明显(P<0.05)。P1NP在汉族男女性高于畲族男女性(P<0.05)。经皮尔森相关分析,骨密度与E2、25OHD3、T成正相关,而与PTH、BGP、ALP成负相关,与ALP无相关。结论本研究25(OH)D3、BGP、P1NP、E2测定可以作为汉族、畲族健康人群早期检测指标,畲族的25(OH)D3水平普遍偏低,可能与他们的生活方式或者维生素D基因有关,值得进一步研究。骨密度与25(OH)D3、E2、T有明显正相关,而与PTH、PINP、BCG负相关,与ALP无明显相关。展开更多
基金Supported by Jiangxi Provincial Health and Family Planning Commission“Science and Technology Plan”.
文摘BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and fracture.Type 2 diabetes mellitus(T2DM)complicated with osteoporosis is a common systemic metabolic bone disease,and reduced bone mass and bone strength are considered the main clinical features;however,the pathogenesis of this disease has not been fully clarified.Its occurrence is considered related to sex,age,and genetic factors.There are many risk factors for diabetes complicated with osteoporosis.Therefore,exploring these risk factors will help prevent it.AIM To investigate the relationships among serum glucagon-like peptide-1(GLP-1)levels,matrix Gla protein(MGP)levels,and diabetes with osteoporosis.METHODS Sixty patients with T2DM complicated with osteoporosis confirmed by the endocrinology department of our hospital were selected as the case group.Sixty T2DM patients with bone loss were selected as the control group.Sixty healthy participants were selected as the healthy group.The general data,bone mineral density index,and bone metabolic markers of the three groups were compared.The relationships among GLP-1 levels,MGP levels,and the bone mineral density index of the case group were analyzed using linear correlation analysis and a logistic regression model.RESULTS Differences in sex,smoking,and drinking among the case group,control group,and healthy group were not statistically significant(P>0.05).The mean age of the case group was older than those of the control and healthy groups(P<0.05).The body mass index,fasting plasma glucose level,HbA1c level,hypertension rate,and coronary heart disease rate of the case and control groups were higher than those of the healthy group(P<0.05).The serum GLP-1 and MGP levels of the case group were lower than those of the control and healthy groups;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the control group were lower than those of the healthy group;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the case group were significantly positively correlated with the bone mineral density values of the hip and lumbar spine(P<0.05).The results of the logistic regression model showed that age and duration of diabetes were independent risk factors for osteoporosis in diabetic patients(P<0.05)and that increased GLP-1 and MGP values were protective factors against osteoporosis in diabetic patients(P<0.05).CONCLUSION Serum GLP-1 and MGP levels of diabetic patients with osteoporosis were significantly decreased and positively correlated with bone mineral density and were independent risk factors for osteoporosis in diabetic patients.
文摘目的:检测人参皂甙对牙周炎大鼠牙周组织中白介素6(interleukin-6,IL-6)及骨钙素(bone gla protein,BGP)的表达的影响并探讨其治疗牙周炎的机制。方法:选用100只体重160～200 g Wistar大白鼠,随机分成10组,每组10只。A组:正常对照组,0周时处死。B-J组建立牙周炎大鼠模型。B-E组:人参皂甙Rg-1治疗组,第1、2、3、4周处死。F-J组:牙周炎对照组,第0、1、2、3、4周处死。取大鼠上颌磨牙牙周组织标本作切片,光镜观察,免疫组化方法对IL-6、BGP进行染色,测量灰度值,进行统计学分析。结果:F组BGP水平明显低于A组,IL-6水平明显高于A组(P<0.05);C-E组BGP的水平明显高于H-J组,D-E组IL-6的水平明显低于I-J组(P<0.05)。结论:人参皂甙Rg-1可以抑制牙周炎大鼠牙周组织中IL-6的水平,同时升高BGP的水平,具有治疗牙周炎并改善全身状况的作用。
文摘目的探讨莆田地区畲族健康人群骨密度与骨生化指标、睾酮以及雌二醇之间的关系,并与汉族人群比较,为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地40岁以上健康成年人,其中畲族532人,汉族563人,应用美国Osteometer Medi Tech公司生产的DTX-200骨密度吸收仪检测骨密度,以及用罗氏公司的骨生化指标仪器及试剂盒,测量骨密度以及25羟维生素D(25(OH)D3)、骨钙素(BGP)、雌二醇(E2)、睾酮(T)、甲状旁腺激素(PTH)、1型前胶原氨基末端肽(P1NP)、碱性磷酸酶(ALP)。把上述检测的数据结果输入电脑,应用SPSS17.0软件包进行数据分析。结果不管畲族和汉族的骨密度均随着年龄的增大而下降,同年龄段男性均高于女性。畲族女性除在40~49岁年龄段稍高于汉族外,其他年龄组汉族女性均高于畲族。而畲族男性在60~69岁年龄段稍高于汉族男性,其他年龄组汉族男性均高于畲族,但汉族与畲族间都没有显著性差异(P>0.05)。汉族的25(OH)D3明显高于畲族,尤其女性在40~60岁年龄段、男性在50~69岁年龄段为正相关(P<0.05);汉族的BGP高于畲族(P<0.05),汉族男的E2指标均高于畲族男,且40~59年龄段尤为明显(P<0.05)。P1NP在汉族男女性高于畲族男女性(P<0.05)。经皮尔森相关分析,骨密度与E2、25OHD3、T成正相关,而与PTH、BGP、ALP成负相关,与ALP无相关。结论本研究25(OH)D3、BGP、P1NP、E2测定可以作为汉族、畲族健康人群早期检测指标,畲族的25(OH)D3水平普遍偏低,可能与他们的生活方式或者维生素D基因有关,值得进一步研究。骨密度与25(OH)D3、E2、T有明显正相关,而与PTH、PINP、BCG负相关,与ALP无明显相关。
