肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存...肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联(Cross-talk)及其对肿瘤生物学特性的影响,有助于更好地调控肿瘤细胞的恶性行为。展开更多
肠道菌群对结直肠癌免疫检查点抑制剂(ICB)治疗的作用日益受到重视,调节肠道菌群成为了优化ICB治疗效果的一个重要研究方向,目前还缺乏既往有关肠道菌群对结直肠癌ICB治疗的研究成果的整合,并且也没有统一的临床治疗指南。本文系统、全...肠道菌群对结直肠癌免疫检查点抑制剂(ICB)治疗的作用日益受到重视,调节肠道菌群成为了优化ICB治疗效果的一个重要研究方向,目前还缺乏既往有关肠道菌群对结直肠癌ICB治疗的研究成果的整合,并且也没有统一的临床治疗指南。本文系统、全面地探讨了肠道菌群对结直肠癌ICB治疗的影响,包括治疗机制、面临的挑战、肠道菌群与ICB治疗效果的关联、影响ICB治疗效果的肠道菌群特征等内容,并通过梳理相关文献进行了总结。本文研究表明肠道菌群在维持人体健康和疾病进程中扮演着关键角色,肠道菌群的不同组成能够显著影响ICB的治疗效果,通过粪便微生物移植、抗生素的合理使用、益生菌补充等方法调节肠道菌群成为了优化结直肠癌ICB治疗效果的一个重要研究方向。本文能够为临床制定肠道菌群干预结直肠癌ICB治疗提供一定的参考,并为更深入地探讨肠道菌群与ICB治疗之间的相互作用机制提供借鉴。The role of the gut microbiome in immunotherapy for colorectal cancer, particularly with immune checkpoint inhibitors (ICB), is increasingly being recognized. Modulating the gut microbiome has become an important area of research for optimizing the effects of ICB therapy. Currently, there is a lack of comprehensive integration of research findings on the gut microbiome’s impact on colorectal cancer ICB treatment, as well as a lack of unified clinical treatment guidelines. This article systematically and comprehensively explores the influence of the gut microbiome on colorectal cancer ICB treatment, including the mechanisms of therapy, challenges faced, the association between the gut microbiome and ICB treatment outcomes, and the characteristics of the gut microbiome that affect ICB treatment efficacy, summarized through a review of relevant literature. The study indicates that the gut microbiome plays a key role in maintaining human health and the disease process, with different compositions of the gut microbiome significantly impacting the efficacy of ICB treatment. Methods such as fecal microbiota transplantation, rational use of antibiotics, and probiotic supplementation to modulate the gut microbiome have become important research directions for optimizing colorectal cancer ICB treatment outcomes. This article provides references for the clinical development of gut microbiome interventions in colorectal cancer ICB treatment and offers insights for further exploration of the interaction mechanisms between the gut microbiome and ICB therapy.展开更多
国际电工委员会于2003年出版低压断路器国际标准IEC60947—2第3版，其中刊出附录L无过电流保护要求的断路器的标准。无过电流保护要求的断路器简称CBI（circuit—breakers not fulfilling requirements for over current protection）...国际电工委员会于2003年出版低压断路器国际标准IEC60947—2第3版，其中刊出附录L无过电流保护要求的断路器的标准。无过电流保护要求的断路器简称CBI（circuit—breakers not fulfilling requirements for over current protection），是一种在原体断路器基础上省去过电流保护装置的断路器（但可有不可调的瞬时短路脱扣器）。展开更多
文摘肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联(Cross-talk)及其对肿瘤生物学特性的影响,有助于更好地调控肿瘤细胞的恶性行为。
文摘肠道菌群对结直肠癌免疫检查点抑制剂(ICB)治疗的作用日益受到重视,调节肠道菌群成为了优化ICB治疗效果的一个重要研究方向,目前还缺乏既往有关肠道菌群对结直肠癌ICB治疗的研究成果的整合,并且也没有统一的临床治疗指南。本文系统、全面地探讨了肠道菌群对结直肠癌ICB治疗的影响,包括治疗机制、面临的挑战、肠道菌群与ICB治疗效果的关联、影响ICB治疗效果的肠道菌群特征等内容,并通过梳理相关文献进行了总结。本文研究表明肠道菌群在维持人体健康和疾病进程中扮演着关键角色,肠道菌群的不同组成能够显著影响ICB的治疗效果,通过粪便微生物移植、抗生素的合理使用、益生菌补充等方法调节肠道菌群成为了优化结直肠癌ICB治疗效果的一个重要研究方向。本文能够为临床制定肠道菌群干预结直肠癌ICB治疗提供一定的参考,并为更深入地探讨肠道菌群与ICB治疗之间的相互作用机制提供借鉴。The role of the gut microbiome in immunotherapy for colorectal cancer, particularly with immune checkpoint inhibitors (ICB), is increasingly being recognized. Modulating the gut microbiome has become an important area of research for optimizing the effects of ICB therapy. Currently, there is a lack of comprehensive integration of research findings on the gut microbiome’s impact on colorectal cancer ICB treatment, as well as a lack of unified clinical treatment guidelines. This article systematically and comprehensively explores the influence of the gut microbiome on colorectal cancer ICB treatment, including the mechanisms of therapy, challenges faced, the association between the gut microbiome and ICB treatment outcomes, and the characteristics of the gut microbiome that affect ICB treatment efficacy, summarized through a review of relevant literature. The study indicates that the gut microbiome plays a key role in maintaining human health and the disease process, with different compositions of the gut microbiome significantly impacting the efficacy of ICB treatment. Methods such as fecal microbiota transplantation, rational use of antibiotics, and probiotic supplementation to modulate the gut microbiome have become important research directions for optimizing colorectal cancer ICB treatment outcomes. This article provides references for the clinical development of gut microbiome interventions in colorectal cancer ICB treatment and offers insights for further exploration of the interaction mechanisms between the gut microbiome and ICB therapy.
文摘国际电工委员会于2003年出版低压断路器国际标准IEC60947—2第3版，其中刊出附录L无过电流保护要求的断路器的标准。无过电流保护要求的断路器简称CBI（circuit—breakers not fulfilling requirements for over current protection），是一种在原体断路器基础上省去过电流保护装置的断路器（但可有不可调的瞬时短路脱扣器）。
