Knee osteoarthritis(KOA)represents one of the most common causes of chronic pain.The high prevalence and disability rates of KOA impose a severe burden on both individuals and society.In contrast to cutaneous pain,KOA...Knee osteoarthritis(KOA)represents one of the most common causes of chronic pain.The high prevalence and disability rates of KOA impose a severe burden on both individuals and society.In contrast to cutaneous pain,KOA-induced joint pain is characterized as a deep tissue pain that potentially involves distinct subgroups of peripheral sensory neurons and central processing mechanisms.Furthermore,KOA pain is closely related to locomotion activity.Impaired sensorimotor integration and pain mutually reinforce each other in KOA,forming a vicious cycle that exacerbates disease progression.In this review,we highlight the key differences between KOA pain and cutaneous pain,and the latter has been extensively studied in the pain field.We hope to offer new insights into the central mechanisms and development of new treatment strategies for KOA based on the interactions between impaired sensorimotor integration and chronic joint pain.展开更多
[目的/意义]学术话语权是国家文化软实力的重要体现,研究学者学术话语权,丰富和完善学者学术话语权评价理论和指标体系,有助于国家学术话语权提升。[方法/过程]本文融合传统文献指标与Altmetrics指标,构建学者学术话语权综合评价体系。...[目的/意义]学术话语权是国家文化软实力的重要体现,研究学者学术话语权,丰富和完善学者学术话语权评价理论和指标体系,有助于国家学术话语权提升。[方法/过程]本文融合传统文献指标与Altmetrics指标,构建学者学术话语权综合评价体系。以Web of Science基因编辑领域数据为例,从学者学术话语影响力和社交话语引导力两维度出发,采用集成因子分析、熵权法、TOPSIS及二维评价法等方法进行实证分析。[结果/结论]研究表明,融合Altmetrics指标的综合评价体系具有一定的可信性,其中“篇均被引”和“Patent Mentions”是影响学者学术话语权的关键指标,且社交媒体和百度百科等传播平台能有效提高学者学术话语权。展开更多
Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that c...Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.展开更多
Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sen...Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.展开更多
In this paper,we present a broadband,high-extinction-ratio,nonvolatile 2×2 Mach-Zehnder interfer⁃ometer(MZI)optical switch based on the phase change material Sb_(2)Se_(3).The insertion loss(IL)is 0.84 dB and the ...In this paper,we present a broadband,high-extinction-ratio,nonvolatile 2×2 Mach-Zehnder interfer⁃ometer(MZI)optical switch based on the phase change material Sb_(2)Se_(3).The insertion loss(IL)is 0.84 dB and the extinction ratio(ER)reaches 28.8 dB at the wavelength of 1550 nm.The 3 dB bandwidth is greater than 150 nm.Within the 3 dB bandwidth,the ER is greater than 20.3 dB and 16.3 dB at bar and cross states,respectively.The power consumption for crystallization and amorphization of Sb_(2)Se_(3) is 105.86 nJ and 49 nJ,respectively.The switch holds significant promise for optical interconnects and optical computing applications.展开更多
The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′...The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.展开更多
Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、...Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。展开更多
This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requireme...This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requirements,and integration capabilities.By implementing a sub-wavelength grating structure,we achieve a Po⁃larization Extinction Ratio(PER)exceeding 29 dB.Furthermore,our electrode design facilitates a voltage-length product(V_(π)L)below 2 V·cm,while a double-tapered coupling structure significantly reduces insertion loss.This advancement provides a pivotal direction for the miniaturization and integration of optical gyroscopes,marking a substantial contribution to the field.展开更多
Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial t...Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial to build a faculty team with knowledge in industry application fields and experience in domestic software development.This paper first analyzes the new requirements for the faculty imposed by the cultivation of specialized software talents and the existing problems in the current faculty.Then,in response to these issues,it introduces the reforms and explorations carried out by the School of Software Engineering at Beijing Jiaotong University in the construction of the faculty for cultivating specialized software talents.The aim is to build a high-caliber and diversified faculty that boasts strong political qualities,interdisciplinary integration,complementary advantages between full-time and part-time faculty,and in-depth integration of industry and education.展开更多
In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)a...In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.展开更多
基金supported by the Natural Science Foundation of Beijing Municipality(No.F252065)the National Natural Science Foundation of China(No.32271190,32571323)the STI 2030 Major Project(No.2021ZD0203202)。
文摘Knee osteoarthritis(KOA)represents one of the most common causes of chronic pain.The high prevalence and disability rates of KOA impose a severe burden on both individuals and society.In contrast to cutaneous pain,KOA-induced joint pain is characterized as a deep tissue pain that potentially involves distinct subgroups of peripheral sensory neurons and central processing mechanisms.Furthermore,KOA pain is closely related to locomotion activity.Impaired sensorimotor integration and pain mutually reinforce each other in KOA,forming a vicious cycle that exacerbates disease progression.In this review,we highlight the key differences between KOA pain and cutaneous pain,and the latter has been extensively studied in the pain field.We hope to offer new insights into the central mechanisms and development of new treatment strategies for KOA based on the interactions between impaired sensorimotor integration and chronic joint pain.
文摘[目的/意义]学术话语权是国家文化软实力的重要体现,研究学者学术话语权,丰富和完善学者学术话语权评价理论和指标体系,有助于国家学术话语权提升。[方法/过程]本文融合传统文献指标与Altmetrics指标,构建学者学术话语权综合评价体系。以Web of Science基因编辑领域数据为例,从学者学术话语影响力和社交话语引导力两维度出发,采用集成因子分析、熵权法、TOPSIS及二维评价法等方法进行实证分析。[结果/结论]研究表明,融合Altmetrics指标的综合评价体系具有一定的可信性,其中“篇均被引”和“Patent Mentions”是影响学者学术话语权的关键指标,且社交媒体和百度百科等传播平台能有效提高学者学术话语权。
基金supported by the Financial Special Fund,grant number XZ202401JD0027National Barley Industry Technology System(CARS-05-01A-08)+3 种基金the Xizang Agri-Tech Innovation Project(XZNKY-2025-CXGC-T01)the Joint Funds of the National Natural Science Foundation of China(No.U20A2026)the Financial Special Fund,grant number(32401784,2017CZZX001/2,XZNKY-2018-C-021 and NYSTC202401)the China Agriculture Research System of Barley(CARS-05).
文摘Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.
基金supported by the National Natural Science Foundation of China(52272177,12204010)the Foundation for the Introduction of High-Level Talents of Anhui University(S020118002/097)+1 种基金the University Synergy Innovation Program of Anhui Province(GXXT-2023-066)the Scientific Research Project of Anhui Provincial Higher Education Institution(2023AH040008)。
文摘Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.
基金Supported by the National Natural Science Foundation of China(62204250)Autonomous deployment project of State Key Laboratory of Materials for Integrated Circuits(SKLJC-Z2024-A05).
文摘In this paper,we present a broadband,high-extinction-ratio,nonvolatile 2×2 Mach-Zehnder interfer⁃ometer(MZI)optical switch based on the phase change material Sb_(2)Se_(3).The insertion loss(IL)is 0.84 dB and the extinction ratio(ER)reaches 28.8 dB at the wavelength of 1550 nm.The 3 dB bandwidth is greater than 150 nm.Within the 3 dB bandwidth,the ER is greater than 20.3 dB and 16.3 dB at bar and cross states,respectively.The power consumption for crystallization and amorphization of Sb_(2)Se_(3) is 105.86 nJ and 49 nJ,respectively.The switch holds significant promise for optical interconnects and optical computing applications.
基金Supported by Natural Science Foundation of China(12461021)。
文摘The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.
文摘Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。
基金Supported by the Beijing Municipal Natural Science Foundation(424206)the Youth Innovation Promotion Association,CAS(2021108).
文摘This paper introduces an innovative Multifunction Integrated Optic Circuit(MIOC)design utilizing thin-film lithium niobate,surpassing traditional bulk waveguide-based MIOCs in terms of size,half-wave voltage requirements,and integration capabilities.By implementing a sub-wavelength grating structure,we achieve a Po⁃larization Extinction Ratio(PER)exceeding 29 dB.Furthermore,our electrode design facilitates a voltage-length product(V_(π)L)below 2 V·cm,while a double-tapered coupling structure significantly reduces insertion loss.This advancement provides a pivotal direction for the miniaturization and integration of optical gyroscopes,marking a substantial contribution to the field.
文摘Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial to build a faculty team with knowledge in industry application fields and experience in domestic software development.This paper first analyzes the new requirements for the faculty imposed by the cultivation of specialized software talents and the existing problems in the current faculty.Then,in response to these issues,it introduces the reforms and explorations carried out by the School of Software Engineering at Beijing Jiaotong University in the construction of the faculty for cultivating specialized software talents.The aim is to build a high-caliber and diversified faculty that boasts strong political qualities,interdisciplinary integration,complementary advantages between full-time and part-time faculty,and in-depth integration of industry and education.
文摘In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.
