This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA f...This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.展开更多
ICE(inducer of CBF expression)基因家族是植物低温信号转导通路中的重要转录调控因子之一,为系统解析白菜型油菜中ICE家族的成员特征及其低温响应表达模式,基于白菜型油菜全基因组数据,通过BLAST与HMM方法鉴定出74个ICE基因家族成员...ICE(inducer of CBF expression)基因家族是植物低温信号转导通路中的重要转录调控因子之一,为系统解析白菜型油菜中ICE家族的成员特征及其低温响应表达模式,基于白菜型油菜全基因组数据,通过BLAST与HMM方法鉴定出74个ICE基因家族成员。染色体定位结果显示,该家族在全部10条染色体上均有分布,其中以第9号染色体上成员数最多。蛋白质特性分析显示,所有成员均定位于细胞核,分子量和等电点差异较大,70个成员蛋白不稳定性指数超过稳定性阈值。基因结构与保守功能模块分析揭示成员间结构组成存在多样性,其中Motif 1和Motif 2在绝大多数成员中高度保守。共线性分析表明,该家族扩展主要受全基因组复制与片段复制事件驱动。启动子区顺式调控元件分析显示大部分基因含有光响应、ABA、MeJA及MYB结合位点等顺式调控元件,其中34个BraICE含有低温响应元件。基于西藏白菜型油菜转录组数据的表达分析发现,BraICE17在低温处理后表达上调幅度最大,BraICE35表达下调幅度最为明显,qRT-PCR实验总体支持转录组数据的可靠性。本研究结果为进一步解析BraICE的分子功能与低温应答机制奠定了理论基础,并提供了潜在的耐寒研究基因资源。展开更多
The electro⁃thermal anti/de-icing systems have high heating efficiency and relatively simple structures,marking them as a key development direction for future icing protection.Existing simulation algorithms for electr...The electro⁃thermal anti/de-icing systems have high heating efficiency and relatively simple structures,marking them as a key development direction for future icing protection.Existing simulation algorithms for electrothermal de-icing seldom delve into comprehensive ice accretion-melting-deicing models that account for ice shedding.Therefore,the detachment behavior of ice layers during the heating process requires in-depth research and discussion.This paper physically models the phenomenon of ice shedding,incorporates the detachment behavior of ice layers during heating,improves the existing mathematical model for electro-thermal de-icing calculations,establishes an ice accretion-melting-deicing model for electro-thermal de-icing systems,and conducts numerical simulation,verification and optimization analysis of electro-thermal de-icing considering ice shedding.Through multi-condition de-icing numerical simulations of a specific wing model,it is found that ambient temperature can serve as a factor for adapting the electro heating anti/de-icing strategy to the environment.An optimization of heating heat flux density and heating/cooling time is conducted for the wing de-icing control law under the calculated conditions.The improved electrothermal de-icing model and algorithm developed in this paper provide solid technical support for the design of electrothermal de-icing systems.展开更多
Objective:To anatomically and phenotypically characterize the insular cortex(IC)-nucleus tractus soli-tari(NTS)neural pathway.Methods:Adult male Sprague-Dawley rats were divided into three experimental cohorts for neu...Objective:To anatomically and phenotypically characterize the insular cortex(IC)-nucleus tractus soli-tari(NTS)neural pathway.Methods:Adult male Sprague-Dawley rats were divided into three experimental cohorts for neural circuit tracing.Anterograde labeling was achieved by injecting anterograde self-complementary adeno-associated viruses(scAAVs)into the IC.Retrograde tracing involved NTS injections of either retrograde scAAVs or FluoroGold(FG),combined with immunofluorescence histochemical staining to identify IC-originating projection neurons.For postsynaptic neurochemical phenotype characterization,IC was injected with AAV2/1-CaMKII-Cre,while a mixture of AAV2/9-Syn-DIO-mCherry and AAV2/9-VGAT1-EGFP was injected into the NTS.The rats were allowed to survive for one week following scAAVs or FG injection or four weeks after recombinase-dependent systems injection.Then the rats were sacrificed,and serial brain sections were prepared for immunofluorescence histochemical staining(brain section containing FG)and subsequent fluorescence/confocal microscopic analysis.Results:(1)Anterograde viral tracing re-vealed dense axonal terminals from the IC projecting to the medial subnucleus of the NTS,while retrograde tracing re-vealed that IC neurons projecting to the NTS were predominantly localized within the dysgranular layer;(2)IC-NTS projection neurons were exclusive glutamatergic(100%,n=3);(3)NTS neurons receiving IC inputs were mainly lo-calized in the medial subnucleus,and were predominantly GABAergic(79.8±3.2%,n=3).Conclusion:The pres-ent results indicate that a descending pathway from excitatory neurons of the IC terminates onto inhibitory neurons of the NTS,which might represent a potential neuromodulatory target for visceral pain disorders.展开更多
The icing characteristics of supercooled large droplet(SLD)impacting carbon fiber-reinforced composites(CFRCs)remain poorly understood,hindering the enhancement of ice protection capabilities and the certification of ...The icing characteristics of supercooled large droplet(SLD)impacting carbon fiber-reinforced composites(CFRCs)remain poorly understood,hindering the enhancement of ice protection capabilities and the certification of ice-accreted composite aircraft.The paper systematically investigates the effects of the supercooling degree,the surface temperature,and the impact velocity on the ice accretion behavior of SLDs impacting carbon fiber-reinforced epoxy composite surfaces.To address the ice-prone nature of CFRCs,nanoparticle-modified anti-icing coatings are developed,and the icing characteristics of SLD-impacted modified carbon fiber-reinforced epoxy composite surfaces are analyzed.Results demonstrate that surface-modified carbon fiber-reinforced epoxy composite exhibits significantly delayed ice formation.Under conditions of droplet temperature(−15℃)and surface temperature(−18℃),the icing time of hydrophobic-modified CFRCs was delayed by over 1100 ms,representing a 5.4-fold improvement compared to the unmodified carbon fiber-reinforced epoxy composite.展开更多
This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(ab...This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(abbreviated as ICs),pharmaceuticals,electric vehicles(abbreviated as EVs),drones(abbreviated as UAVs),and robotics—in response to rising trade tensions and geopolitical conflicts,which have heightened concerns over product origin fraud and information security.While previous literature often focuses on single-industry contexts or isolated technologies,this reviewcomprehensively surveys these sectors and categorizes 116 peer-reviewed studies by application domain,technical architecture,and functional objective.Special attention is given to traceability control mechanisms,data integrity,and the use of forensic technologies to detect origin fraud.The study further evaluates real-world implementations,including blockchain-enabled drug tracking systems,EV battery raw material traceability,and UAV authentication frameworks,demonstrating the practical value of these technologies.By identifying technological challenges and policy implications,this research provides a comprehensive foundation for future academic inquiry,industrial adoption,and regulatory development aimed at enhancing transparency,resilience,and trust in global supply chains.展开更多
This numerical simulation investigates the two⁃phase flow under the condition of supercooled large droplets impinging on the aircraft surface.Based on Eulerian framework,a method for calculating supercooled water drop...This numerical simulation investigates the two⁃phase flow under the condition of supercooled large droplets impinging on the aircraft surface.Based on Eulerian framework,a method for calculating supercooled water droplet impingement characteristics is established.Then,considering the deformation and breaking effects during the movement,this method is extended to calculate the impingement characteristics of supercooled large droplets,as well as the bouncing and splashing effects during impingement.The impingement characteristics of supercooled large droplets is then investigated by this method.The results demonstrate that the deformation and breaking effects of supercooled large droplets have negligible influence on the impingement characteristics under the experimental conditions of this paper.In addition,the results of the impingement range and collection efficiency decrease when considering the bouncing and splashing effects.The bouncing effect mainly affects the mass loss near the impingement limits,while the splashing effect influences the result around the stagnation point.This investigation is beneficial for the analysis of aircraft icing and the design of anti⁃icing system with supercooled large droplet conditions.展开更多
Wind turbine blades in cold regions are susceptible to icing due to meteorological conditions,significantly affecting the turbine's energy capture efficiency and operational safety.Precise calculation of droplet c...Wind turbine blades in cold regions are susceptible to icing due to meteorological conditions,significantly affecting the turbine's energy capture efficiency and operational safety.Precise calculation of droplet collection efficiency(DCE)is essential for accurate icing prediction.This study examines existing methods for calculating DCE and identifies limitations during glaze ice formation.An enhanced method based on the Euler Wall Film(EWF)model is introduced to address these limitations,incorporating splashing and rebound phenomena during glaze ice formation on wind turbine blades.The method's reliability is validated using data from the classic symmetric airfoil,NACA0012.Through the control variable method,this research examines DCE variations under different incoming velocities,medium volume droplet diameters(MVDs),and temperatures.The study also analyzes the distinctions between the improved method and the existing Eulerian method.Results indicate that both impact range and maximum DCE increase with higher incoming velocity and MVD,while temperature exhibits minimal influence on DCE.Variations between the calculation methods reveal differences in water droplet splashing intensity,primarily influenced by droplet kinetic energy and liquid film thickness.The splashing phenomenon gradually decreases as incoming velocity and MVD increase.展开更多
This study presents a data-driven approach to predict tailplane aerodynamics in icing conditions,supporting the ice-tolerant design of aircraft horizontal stabilizers.The core of this work is a low-cost predictive mod...This study presents a data-driven approach to predict tailplane aerodynamics in icing conditions,supporting the ice-tolerant design of aircraft horizontal stabilizers.The core of this work is a low-cost predictive model for analyzing icing effects on swept tailplanes.The method relies on a multi-fidelity data gathering campaign,enabling seamless integration into multidisciplinary aircraft design workflows.A dataset of iced airfoil shapes was generated using 2D inviscid methods across various flight conditions.High-fidelity CFD simulations were conducted on both clean and iced geometries,forming a multidimensional aerodynamic database.This 2D database feeds a nonlinear vortex lattice method to estimate 3D aerodynamic characteristics,following a'quasi-3D'approach.The resulting reduced-order model delivers fast aerodynamic performance estimates of iced tailplanes.To demonstrate its effectiveness,optimal ice-tolerant tailplane designs were selected from a range of feasible shapes based on a reference transport aircraft.The analysis validates the model's reliability,accuracy,and limitations concerning 3D ice shapes and aerodynamic characteristics.Most notably,the model offers near-zero computational cost compared to high-fidelity simulations,making it a valuable tool for efficient aircraft design.展开更多
Characteristics and statistics of seismic tremors occurring during April 2015 were investigated by using short-period and broadband seismographs deployed at Syowa Station (SYO), in the Lützow-Holm Bay (LHB), East...Characteristics and statistics of seismic tremors occurring during April 2015 were investigated by using short-period and broadband seismographs deployed at Syowa Station (SYO), in the Lützow-Holm Bay (LHB), East Antarctica. In order to examine a relationship between surface environments in particular cryosphere variation, the MODIS satellite images were utilized for comparison with the detected tremor events. Since a large volume of sea-ice was discharged during the April, together with several large icebergs passed through from the west to the east at northern edge of the fast sea-ice of LHB, it was expected to detect seismic tremors involving cryospehre dynamics. During the month, a total number of 49 tremor events including short duration ice shocks were identified. Majority of the events (N = 39) had their duration times more than 15 minutes, which were divided into both tremors and ice shocks on the basis of experienced definition at SYO. Cryospheric sources recorded by seismic tremors were classified into several origins (collision, calving, crevassing, crashing, etc.): “crevassing events” along the large cracks inside the fast sea-ice in LHB (04 April), “discharge events” of fast sea-ice from the Bay (07 April), “collision events” between iceberg and the edge of fast sea-ice (14 April), “crashing movement” between fragmentation of fast sea-ice and packed sea-ice (18 April), and other origins. In particular, strong amplitude tremors with harmonic overtones were assumed to be occurred independently from whether condition, because these overtone tremors were identified at less stormy days by comparison with infrasound data at SYO.展开更多
The term neurodegeneration emphasizes the destruction of neuronal cells as the primary explanation of many major neurological illnesses, including Alzheimer’s disease. Specialized functioning of cells requires more c...The term neurodegeneration emphasizes the destruction of neuronal cells as the primary explanation of many major neurological illnesses, including Alzheimer’s disease. Specialized functioning of cells requires more cellular energy than is needed for basic cell survival. Cells can acquire energy both from the metabolism of food and from the alternative cellular energy (ACE) pathway. The ACE pathway is an added dynamic (kinetic) quality of the body’s fluids occurring from the absorption of an external force termed KELEA (Kinetic Energy Limiting Electrostatic Attraction). KELEA is attracted to separated electrical charges and is seemingly partially released as the charges become more closely linked. As suggested elsewhere, the fluctuating electrical activity in the brain may attract KELEA from the environment and, thereby, contribute to the body’s ACE pathway. Certain illnesses affecting the brain may impede this proposed antenna function of the brain, leading to a systemic insufficiency of cellular energy (ICE). Furthermore, individual neurons may derive some of the energy for their own activities from the repetitive depolarization of the cell. This may explain why hyper-excitability of neurons can occur in response to cell damage. This adaptive mechanism is unlikely to be sustainable, however, especially if there is a continuing need to synthesize neurotransmitters and membrane ion channels. The energy deficient neurons would then become quiescent and, although remaining viable, would not perform their intended specialized functions. Actual cell death would not necessarily occur till much later in the disease process. The distinction between quiescent and degenerated cells is important since the ACE pathway can be enhanced by several means, including the regular consumption of KELEA activated water. This, in turn, may improve the proposed antenna function of individual neurons, leading to a sustained restoration of specialized function via the ACE pathway. This paper explores this novel concept and provides a rationale for clinical testing of KELEA activated water in patients with neurological and psychiatric illnesses, including Alzheimer’s disease.展开更多
近年来全球极端低温天气频发,严重影响了茶树的产量和品质。ICE(Inducer of CBF expression)基因家族主要参与植物的低温胁迫响应,但在茶树领域中的相关研究还不够全面。本研究从茶树基因组中鉴定出51个茶树CsICEs基因,对其理化性质、...近年来全球极端低温天气频发,严重影响了茶树的产量和品质。ICE(Inducer of CBF expression)基因家族主要参与植物的低温胁迫响应,但在茶树领域中的相关研究还不够全面。本研究从茶树基因组中鉴定出51个茶树CsICEs基因,对其理化性质、基因结构和启动子顺式作用元件展开生物信息学分析。茶树CsICEs基因的启动子区域富含光响应、植物激素、生长发育及非生物胁迫相关顺式作用元件,其可能参与多种逆境胁迫响应。转录组分析和RT-qPCR验证结果发现,低温下CsICE43基因的表达量上升了4.24倍,其可能与茶树低温响应相关。以茶树品种‘保靖黄金茶1号’的cDNA为模板,克隆获得了CsICE43基因,其在不同组织中的表达模式存在差异,在顶芽和嫩叶中特异性高表达。蛋白氨基酸序列和系统进化树分析表明,CsICE43基因包含与ICE家族其他成员一致的S-rich、bHLH、ACT等保守结构域,且与毛花猕猴桃(Actinidiaeriantha)的亲缘关系较近。在STRING在线网站中以拟南芥AtICEs为模型,推测茶树CsICE43蛋白与HOS1、MYB15、DREB1/2存在潜在的互作关系。亚细胞定位试验表明CsICE43定位于细胞核,与跨膜结构分析结果一致。综上所述,本研究发现CsICE43基因可能与茶树低温响应关联,为深入挖掘其基因功能与抗寒分子机理提供了一定的理论基础。展开更多
During years 1980/1981-2012/2013, inter-annual variations in sea ice and snow thickness in Kemi, in the northern coast of the Gulf of Bothnia, Baltic Sea, depended on the air temperature, snow fall, and rain. Inter-an...During years 1980/1981-2012/2013, inter-annual variations in sea ice and snow thickness in Kemi, in the northern coast of the Gulf of Bothnia, Baltic Sea, depended on the air temperature, snow fall, and rain. Inter-annual variations in the November--April mean air temperature, accumulated total precipitation, snow fall, and rain, as well as ice and snow thickness in Kemi and ice concentration in the Gulf of Bothnia correlated with inter-annual variations of the Pacific Decadal Oscillation （PDO）, Arctic Oscillation （AO）, North Atlantic Oscillation （NAO）, Scandinavian Pattern （SCA）, and Polar / Eurasian Pattern （PEU）. The strong role of PDO is a new finding. In general, the relationships with PDO were approximately equally strong as those with AO, but rain and sea ice concentration were better correlated with PDO. The correlations with PDO were, however, not persistent; for a study period since 1950 the correlations were much lower. During 1980/1981--2012/2013, also the Pacific / North American Pattern （PNA） and E1 Nino-Southern Oscillation （ENSO） had statistical connections with the conditions in the Gulf of Bothnia, revealed by analyzing their effects combined with those of PDO and AO. A reduced autumn sea ice area in the Arctic was related to increased rain and total precipitation in the following winter in Kemi. This correlation was significant for the Pan-Arctic sea ice area in September, October, and November, and for the November sea ice area in the Barents / Kara seas.展开更多
基金funded by the Office of Gas and Electricity Markets(Ofgem)and supported by De Montfort University(DMU)and Nottingham Trent University(NTU),UK.
文摘This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.
基金supported by the National Natural Science Foundation of China(No.52272428)。
文摘The electro⁃thermal anti/de-icing systems have high heating efficiency and relatively simple structures,marking them as a key development direction for future icing protection.Existing simulation algorithms for electrothermal de-icing seldom delve into comprehensive ice accretion-melting-deicing models that account for ice shedding.Therefore,the detachment behavior of ice layers during the heating process requires in-depth research and discussion.This paper physically models the phenomenon of ice shedding,incorporates the detachment behavior of ice layers during heating,improves the existing mathematical model for electro-thermal de-icing calculations,establishes an ice accretion-melting-deicing model for electro-thermal de-icing systems,and conducts numerical simulation,verification and optimization analysis of electro-thermal de-icing considering ice shedding.Through multi-condition de-icing numerical simulations of a specific wing model,it is found that ambient temperature can serve as a factor for adapting the electro heating anti/de-icing strategy to the environment.An optimization of heating heat flux density and heating/cooling time is conducted for the wing de-icing control law under the calculated conditions.The improved electrothermal de-icing model and algorithm developed in this paper provide solid technical support for the design of electrothermal de-icing systems.
文摘Objective:To anatomically and phenotypically characterize the insular cortex(IC)-nucleus tractus soli-tari(NTS)neural pathway.Methods:Adult male Sprague-Dawley rats were divided into three experimental cohorts for neural circuit tracing.Anterograde labeling was achieved by injecting anterograde self-complementary adeno-associated viruses(scAAVs)into the IC.Retrograde tracing involved NTS injections of either retrograde scAAVs or FluoroGold(FG),combined with immunofluorescence histochemical staining to identify IC-originating projection neurons.For postsynaptic neurochemical phenotype characterization,IC was injected with AAV2/1-CaMKII-Cre,while a mixture of AAV2/9-Syn-DIO-mCherry and AAV2/9-VGAT1-EGFP was injected into the NTS.The rats were allowed to survive for one week following scAAVs or FG injection or four weeks after recombinase-dependent systems injection.Then the rats were sacrificed,and serial brain sections were prepared for immunofluorescence histochemical staining(brain section containing FG)and subsequent fluorescence/confocal microscopic analysis.Results:(1)Anterograde viral tracing re-vealed dense axonal terminals from the IC projecting to the medial subnucleus of the NTS,while retrograde tracing re-vealed that IC neurons projecting to the NTS were predominantly localized within the dysgranular layer;(2)IC-NTS projection neurons were exclusive glutamatergic(100%,n=3);(3)NTS neurons receiving IC inputs were mainly lo-calized in the medial subnucleus,and were predominantly GABAergic(79.8±3.2%,n=3).Conclusion:The pres-ent results indicate that a descending pathway from excitatory neurons of the IC terminates onto inhibitory neurons of the NTS,which might represent a potential neuromodulatory target for visceral pain disorders.
基金supported by the National Key Laboratory of Advanced Composite Materials(No.KZ42191814)。
文摘The icing characteristics of supercooled large droplet(SLD)impacting carbon fiber-reinforced composites(CFRCs)remain poorly understood,hindering the enhancement of ice protection capabilities and the certification of ice-accreted composite aircraft.The paper systematically investigates the effects of the supercooling degree,the surface temperature,and the impact velocity on the ice accretion behavior of SLDs impacting carbon fiber-reinforced epoxy composite surfaces.To address the ice-prone nature of CFRCs,nanoparticle-modified anti-icing coatings are developed,and the icing characteristics of SLD-impacted modified carbon fiber-reinforced epoxy composite surfaces are analyzed.Results demonstrate that surface-modified carbon fiber-reinforced epoxy composite exhibits significantly delayed ice formation.Under conditions of droplet temperature(−15℃)and surface temperature(−18℃),the icing time of hydrophobic-modified CFRCs was delayed by over 1100 ms,representing a 5.4-fold improvement compared to the unmodified carbon fiber-reinforced epoxy composite.
文摘This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(abbreviated as ICs),pharmaceuticals,electric vehicles(abbreviated as EVs),drones(abbreviated as UAVs),and robotics—in response to rising trade tensions and geopolitical conflicts,which have heightened concerns over product origin fraud and information security.While previous literature often focuses on single-industry contexts or isolated technologies,this reviewcomprehensively surveys these sectors and categorizes 116 peer-reviewed studies by application domain,technical architecture,and functional objective.Special attention is given to traceability control mechanisms,data integrity,and the use of forensic technologies to detect origin fraud.The study further evaluates real-world implementations,including blockchain-enabled drug tracking systems,EV battery raw material traceability,and UAV authentication frameworks,demonstrating the practical value of these technologies.By identifying technological challenges and policy implications,this research provides a comprehensive foundation for future academic inquiry,industrial adoption,and regulatory development aimed at enhancing transparency,resilience,and trust in global supply chains.
基金supported in part by the National Natural Science Foundation of China(No.51806008)the Open Fund of Key Laboratory of Rotor Aerodynamics Key Laboratory(No.RAL202104-2)。
文摘This numerical simulation investigates the two⁃phase flow under the condition of supercooled large droplets impinging on the aircraft surface.Based on Eulerian framework,a method for calculating supercooled water droplet impingement characteristics is established.Then,considering the deformation and breaking effects during the movement,this method is extended to calculate the impingement characteristics of supercooled large droplets,as well as the bouncing and splashing effects during impingement.The impingement characteristics of supercooled large droplets is then investigated by this method.The results demonstrate that the deformation and breaking effects of supercooled large droplets have negligible influence on the impingement characteristics under the experimental conditions of this paper.In addition,the results of the impingement range and collection efficiency decrease when considering the bouncing and splashing effects.The bouncing effect mainly affects the mass loss near the impingement limits,while the splashing effect influences the result around the stagnation point.This investigation is beneficial for the analysis of aircraft icing and the design of anti⁃icing system with supercooled large droplet conditions.
基金supported by the National Natural Science Foundation of China(Grant No.51879125)。
文摘Wind turbine blades in cold regions are susceptible to icing due to meteorological conditions,significantly affecting the turbine's energy capture efficiency and operational safety.Precise calculation of droplet collection efficiency(DCE)is essential for accurate icing prediction.This study examines existing methods for calculating DCE and identifies limitations during glaze ice formation.An enhanced method based on the Euler Wall Film(EWF)model is introduced to address these limitations,incorporating splashing and rebound phenomena during glaze ice formation on wind turbine blades.The method's reliability is validated using data from the classic symmetric airfoil,NACA0012.Through the control variable method,this research examines DCE variations under different incoming velocities,medium volume droplet diameters(MVDs),and temperatures.The study also analyzes the distinctions between the improved method and the existing Eulerian method.Results indicate that both impact range and maximum DCE increase with higher incoming velocity and MVD,while temperature exhibits minimal influence on DCE.Variations between the calculation methods reveal differences in water droplet splashing intensity,primarily influenced by droplet kinetic energy and liquid film thickness.The splashing phenomenon gradually decreases as incoming velocity and MVD increase.
基金funding from the Department of Industrial Engineering,University of Naples FedericoⅡ,Italy。
文摘This study presents a data-driven approach to predict tailplane aerodynamics in icing conditions,supporting the ice-tolerant design of aircraft horizontal stabilizers.The core of this work is a low-cost predictive model for analyzing icing effects on swept tailplanes.The method relies on a multi-fidelity data gathering campaign,enabling seamless integration into multidisciplinary aircraft design workflows.A dataset of iced airfoil shapes was generated using 2D inviscid methods across various flight conditions.High-fidelity CFD simulations were conducted on both clean and iced geometries,forming a multidimensional aerodynamic database.This 2D database feeds a nonlinear vortex lattice method to estimate 3D aerodynamic characteristics,following a'quasi-3D'approach.The resulting reduced-order model delivers fast aerodynamic performance estimates of iced tailplanes.To demonstrate its effectiveness,optimal ice-tolerant tailplane designs were selected from a range of feasible shapes based on a reference transport aircraft.The analysis validates the model's reliability,accuracy,and limitations concerning 3D ice shapes and aerodynamic characteristics.Most notably,the model offers near-zero computational cost compared to high-fidelity simulations,making it a valuable tool for efficient aircraft design.
文摘Characteristics and statistics of seismic tremors occurring during April 2015 were investigated by using short-period and broadband seismographs deployed at Syowa Station (SYO), in the Lützow-Holm Bay (LHB), East Antarctica. In order to examine a relationship between surface environments in particular cryosphere variation, the MODIS satellite images were utilized for comparison with the detected tremor events. Since a large volume of sea-ice was discharged during the April, together with several large icebergs passed through from the west to the east at northern edge of the fast sea-ice of LHB, it was expected to detect seismic tremors involving cryospehre dynamics. During the month, a total number of 49 tremor events including short duration ice shocks were identified. Majority of the events (N = 39) had their duration times more than 15 minutes, which were divided into both tremors and ice shocks on the basis of experienced definition at SYO. Cryospheric sources recorded by seismic tremors were classified into several origins (collision, calving, crevassing, crashing, etc.): “crevassing events” along the large cracks inside the fast sea-ice in LHB (04 April), “discharge events” of fast sea-ice from the Bay (07 April), “collision events” between iceberg and the edge of fast sea-ice (14 April), “crashing movement” between fragmentation of fast sea-ice and packed sea-ice (18 April), and other origins. In particular, strong amplitude tremors with harmonic overtones were assumed to be occurred independently from whether condition, because these overtone tremors were identified at less stormy days by comparison with infrasound data at SYO.
文摘The term neurodegeneration emphasizes the destruction of neuronal cells as the primary explanation of many major neurological illnesses, including Alzheimer’s disease. Specialized functioning of cells requires more cellular energy than is needed for basic cell survival. Cells can acquire energy both from the metabolism of food and from the alternative cellular energy (ACE) pathway. The ACE pathway is an added dynamic (kinetic) quality of the body’s fluids occurring from the absorption of an external force termed KELEA (Kinetic Energy Limiting Electrostatic Attraction). KELEA is attracted to separated electrical charges and is seemingly partially released as the charges become more closely linked. As suggested elsewhere, the fluctuating electrical activity in the brain may attract KELEA from the environment and, thereby, contribute to the body’s ACE pathway. Certain illnesses affecting the brain may impede this proposed antenna function of the brain, leading to a systemic insufficiency of cellular energy (ICE). Furthermore, individual neurons may derive some of the energy for their own activities from the repetitive depolarization of the cell. This may explain why hyper-excitability of neurons can occur in response to cell damage. This adaptive mechanism is unlikely to be sustainable, however, especially if there is a continuing need to synthesize neurotransmitters and membrane ion channels. The energy deficient neurons would then become quiescent and, although remaining viable, would not perform their intended specialized functions. Actual cell death would not necessarily occur till much later in the disease process. The distinction between quiescent and degenerated cells is important since the ACE pathway can be enhanced by several means, including the regular consumption of KELEA activated water. This, in turn, may improve the proposed antenna function of individual neurons, leading to a sustained restoration of specialized function via the ACE pathway. This paper explores this novel concept and provides a rationale for clinical testing of KELEA activated water in patients with neurological and psychiatric illnesses, including Alzheimer’s disease.
文摘近年来全球极端低温天气频发,严重影响了茶树的产量和品质。ICE(Inducer of CBF expression)基因家族主要参与植物的低温胁迫响应,但在茶树领域中的相关研究还不够全面。本研究从茶树基因组中鉴定出51个茶树CsICEs基因,对其理化性质、基因结构和启动子顺式作用元件展开生物信息学分析。茶树CsICEs基因的启动子区域富含光响应、植物激素、生长发育及非生物胁迫相关顺式作用元件,其可能参与多种逆境胁迫响应。转录组分析和RT-qPCR验证结果发现,低温下CsICE43基因的表达量上升了4.24倍,其可能与茶树低温响应相关。以茶树品种‘保靖黄金茶1号’的cDNA为模板,克隆获得了CsICE43基因,其在不同组织中的表达模式存在差异,在顶芽和嫩叶中特异性高表达。蛋白氨基酸序列和系统进化树分析表明,CsICE43基因包含与ICE家族其他成员一致的S-rich、bHLH、ACT等保守结构域,且与毛花猕猴桃(Actinidiaeriantha)的亲缘关系较近。在STRING在线网站中以拟南芥AtICEs为模型,推测茶树CsICE43蛋白与HOS1、MYB15、DREB1/2存在潜在的互作关系。亚细胞定位试验表明CsICE43定位于细胞核,与跨膜结构分析结果一致。综上所述,本研究发现CsICE43基因可能与茶树低温响应关联,为深入挖掘其基因功能与抗寒分子机理提供了一定的理论基础。
基金supported by the Academy of Finland (Grant no.259537)The Young Scientists Fund of National Natural Science Foundation of China (Grant no.41206186) is acknowledged
文摘During years 1980/1981-2012/2013, inter-annual variations in sea ice and snow thickness in Kemi, in the northern coast of the Gulf of Bothnia, Baltic Sea, depended on the air temperature, snow fall, and rain. Inter-annual variations in the November--April mean air temperature, accumulated total precipitation, snow fall, and rain, as well as ice and snow thickness in Kemi and ice concentration in the Gulf of Bothnia correlated with inter-annual variations of the Pacific Decadal Oscillation （PDO）, Arctic Oscillation （AO）, North Atlantic Oscillation （NAO）, Scandinavian Pattern （SCA）, and Polar / Eurasian Pattern （PEU）. The strong role of PDO is a new finding. In general, the relationships with PDO were approximately equally strong as those with AO, but rain and sea ice concentration were better correlated with PDO. The correlations with PDO were, however, not persistent; for a study period since 1950 the correlations were much lower. During 1980/1981--2012/2013, also the Pacific / North American Pattern （PNA） and E1 Nino-Southern Oscillation （ENSO） had statistical connections with the conditions in the Gulf of Bothnia, revealed by analyzing their effects combined with those of PDO and AO. A reduced autumn sea ice area in the Arctic was related to increased rain and total precipitation in the following winter in Kemi. This correlation was significant for the Pan-Arctic sea ice area in September, October, and November, and for the November sea ice area in the Barents / Kara seas.
