Lithium-sulfur batteries(LSBs)represent a next-generation energy storage technology,but widespread applications are restricted by the shuttle of lithium polysulfides(LiPSs).The rational design of separators has been d...Lithium-sulfur batteries(LSBs)represent a next-generation energy storage technology,but widespread applications are restricted by the shuttle of lithium polysulfides(LiPSs).The rational design of separators has been demonstrated to be one of the most efficient and cost-effective strategies to curb the shuttle effect,and tremendous research progress has been achieved.The efficiency of a separator depends on its interaction with LiPSs,which is governed by the surface energy and binding strength.Despite several review works that have been reported to advance the separators,most of them primarily focus on active material innovation and construction.The most crucial issues of surface binding energy have not been systematically reviewed,limiting the precise design of efficient separators.In this review,fundamentals related to surface energy and binding interactions with LiPSs are comprehensively analyzed and discussed.With surface binding and energy main lines,the advancements in separator engineering strategies are elaborately summarized and discussed.Moreover,techniques for evaluating affinity to LiPSs are thoroughly analyzed to avoid any ambiguities in measurement.Based on the research context,valuable research directions are suggested to construct efficient separators.This work provides guidelines to regulate the surface binding and energy of separators for high-performance LSBs.展开更多
The von Hippel-Lindau tumor suppressor(VHL)has been extensively used to develop degraders targeting numerous proteins of interest.However,studies on the rational design of VHL-proteolysis-targeting chimeras(PROTACs)re...The von Hippel-Lindau tumor suppressor(VHL)has been extensively used to develop degraders targeting numerous proteins of interest.However,studies on the rational design of VHL-proteolysis-targeting chimeras(PROTACs)remain scarce.This study aimed to develop strategies to investigate VHL-recruiting PROTACs connecting with varying attachment sites on VHL ligands,which could be utilized for KRAS^(G12C) degraders development and expanded to additional targets.We developed a molecular dynamics(MD)-based strategy to explore the stability of ternary complexes induced by KRAS^(G12C) PROTACs with four distinct attachment sites of VH032.We found a potent degrader namely YN14-H,linked to hydroxyl group on VH032 benzene ring,exhibited the most superior ability of inducing ternary complexes,reflected by the lowest dissociation constant(Kd)for ternary complex induction and the highest AlphaScreen(AS)-based interaction.YN14-H inhibited cell growth with low nanomolar half maximal inhibitory concentration(IC_(50))and half maximal degradation concentration(DC_(50))values as well as>98%of maximum degradation(D_(max))in NCI-H358 and MIA PaCa-2 cells harboring KRAS^(G12C)-mutation.Mechanistically,YN14-H significantly induced apoptosis and inhibited the migratory capacity.Notably,YN14-H demonstrated favorable pharmacokinetic properties and excellent antitumor activity in vivo.Furthermore,bromodomain-containing protein 7(BRD7)and Bruton tyrosine kinase(BTK)degraders attached to distinct sites on VH032 further verified the rationality and universality of our MD-based strategies.Our findings demonstrated that YN14-H could serve as a promising candidate for the treatment of tumors with KRAS^(G12C)-mutation and present a strategy for the rational design of VHL-recruiting PROTACs that target additional proteins at distinct attachment sites.展开更多
Daniel Sabbah博士简介Daniel Sabbah现任IBM软件集团Rational总经理,负责领导提升IBM的软件开发实力。作为一名核心开发人员,Daniel积累了近30年的丰富经验。同时,他还是IBM开放源代码政策以及Eclipse的创立者。目前,Daniel正率领Ratio...Daniel Sabbah博士简介Daniel Sabbah现任IBM软件集团Rational总经理,负责领导提升IBM的软件开发实力。作为一名核心开发人员,Daniel积累了近30年的丰富经验。同时,他还是IBM开放源代码政策以及Eclipse的创立者。目前,Daniel正率领Rational软件部门与IBM研究部门协作研发一项技术,以提升软件开发生命周期内的团队协作与治理能力。展开更多
Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rationa...Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.展开更多
如约见到夏然，同事的第一个评价是“年轻”。从之前IBM大中华区软件集团SOA总经理到目前软件部的Rational总经理，夏然给人的印象是温文尔雅却充满活力。在其负责的Rational产品线下，最新发布了Jazz和Rational Team Concert（RTC）两...如约见到夏然，同事的第一个评价是“年轻”。从之前IBM大中华区软件集团SOA总经理到目前软件部的Rational总经理，夏然给人的印象是温文尔雅却充满活力。在其负责的Rational产品线下，最新发布了Jazz和Rational Team Concert（RTC）两个看起来似乎有些另类的产品，与传统上Rational一贯的风格截然不同，展开更多
2009年12月4日，IBM著名的软件开发品牌Rational宣布推出下一代项目及组合管理（Project and Portfolio Management，简称PPM）解决方案，来帮助软件园区及软件企业实现“软件经济学”。PPM是关于将人、资源，和项目与业务目标结合起来...2009年12月4日，IBM著名的软件开发品牌Rational宣布推出下一代项目及组合管理（Project and Portfolio Management，简称PPM）解决方案，来帮助软件园区及软件企业实现“软件经济学”。PPM是关于将人、资源，和项目与业务目标结合起来的内容。展开更多
In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues ...In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues that the achievements and crises of both fields signify the triumph of rationalism in the context of deepening modernity,while simultaneously harboring an intrinsic impetus and possibility for transitioning from rationalism to emotionalism.This dynamic serves as a quintessential representation of modernity’s crises and their transcendence.Centered on embodied cognitive science,AI and the metaverse—rooted in rationalism—now face challenges in shifting toward emotionalism,revealing their inadequacy in addressing this shift.Humanity must explore new modernity-deepening paradigms grounded in emotionalism to confront and transcend the potential crises posed by the metaverse and AI.展开更多
Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeuti...Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.展开更多
Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria...Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria of DUE of meropenem was established based on drug instructions,related guidelines and experts’opinions.Then,120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study.Results and Conclusion 120 cases of meropenem use involved 8 clinical departments,including 38 cases in the Department of Respiratory Medicine,25 cases in the Department of Tuberculosis,and 20 cases in the Department of Gastroenterology.The detection rate of pathogenic microorganisms before first use was 79.17%,and the clinical treatment effectiveness rate was 81.67%.The irrational use of meropenem included poor grasp of usage indications,excessively high starting points,inappropriate usage and dosage,non-standard treatment courses,and excessive combination medication.Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem,provide timely feedback on relevant situations,and promote rational clinical medication.展开更多
Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to a...Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to antibiotics between August 2021 and August 2023.The types of antibiotics that caused adverse reactions were analyzed,and the symptoms of adverse reactions and measures for rational use of antibiotics were summarized.Results:Among the analyzed cases of adverse reactions to antibiotics,the highest rate was observed in patients aged 61–75 years,accounting for 38.33%,followed by patients aged 51–60 years,accounting for 20.00%.In terms of the types of antibiotics that caused adverse reactions,cephalosporins were the most common,accounting for 40.00%,followed by penicillins,accounting for 18.33%.Analysis of the systems involved in adverse reactions showed that skin and appendage disorders were the most common,accounting for 36.67%,followed by the digestive system,accounting for 28.33%.Conclusion:Irrational use of antibiotics can lead to adverse drug reactions.Therefore,it is necessary to analyze strategies for the rational use of antibiotics to reduce adverse drug reactions and ensure the safety of antibiotic use.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between Marc...Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between March 2023 and December 2023 were selected and randomly divided into two groups.In the experimental group,the pharmacist led the medication management during the perioperative use of antibiotics,while the control group received routine antibiotic management.The management effects were compared between the two groups.Results:The irrational drug use rate,the incidence of adverse drug reactions,the cost of antibiotics,and the incidence of postoperative infection were all lower in the experimental group compared to the control group(P<0.05).Conclusion:Implementing pharmacist-led medication management during the perioperative period of gynecological surgery can prevent irrational drug use,reduce adverse drug reactions,control drug costs,and lower the risk of postoperative infection.展开更多
IBM Rational是IBM在全球系统工程和软件工程所涉及行业中处于领先地位的主打品牌。该品牌通过提供以行业为主导的流程、方法、最佳实践、工具和服务的一整套解决方案．帮助客户实现以高质量、高效率、低成本进行产品研发的业务目标，...IBM Rational是IBM在全球系统工程和软件工程所涉及行业中处于领先地位的主打品牌。该品牌通过提供以行业为主导的流程、方法、最佳实践、工具和服务的一整套解决方案．帮助客户实现以高质量、高效率、低成本进行产品研发的业务目标，立足于市场，并为其创造最大的商业价值，已成功地应用到航空航天、汽车等各大行业。展开更多
Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)a...Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group(n=80,adopting the medical institution prescription review mechanism)and a control group(n=79,without prescription review)based on the random number table method.A comparative analysis was conducted on the work quality of medical personnel,irrational prescription drug use,and prescription drug dispensing situations.Results:The work quality of medical personnel in the observation group was significantly better than that in the control group(P<0.05).The incidence of irrational prescription drug use in the observation group(22.50%)was significantly higher than that in the control group(7.59%)(P<0.05).The observation group had fewer types of prescribed drugs,lower usage rates of injections and antibiotics,and a significantly higher usage rate of national essential drugs compared to the control group(P<0.05).Conclusion:The prescription review mechanism can significantly improve the work quality of medical personnel,increase the detection rate of irrational drug use,reduce the types of prescription drugs and the use of injections and antibiotics,and promote the standardized application of national essential drugs,which has important intervention value.展开更多
This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the noti...This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the notion of“inner cultivation”(xin xing xiulian)into the analytical framework,we introduce the concept of the“cultivating economic agent,”aiming to explore how rationality is generated,evolved,and transcended throughout the spiritual journey.The study argues that,in the context of Eastern culture,rationality is not merely an innate or static faculty but one that can be cultivated and transformed.Through textual analysis of the behavioral trajectories of Sun Wukong,Zhu Bajie,and Tang Sanzang,we uncover a structured behavioral logic of“goal orientation–institutional discipline–purification of the mind.”The findings suggest that although cultivation behaviors are not utilitarian decisions per se,they exhibit rational characteristics such as goal stability,autonomous will,and embedded incentives.展开更多
基金supported by the National Natural Science Foundation of China (52172228)the Natural Science Foundation of Fujian Province (2024J01475 and 2023J05127)
文摘Lithium-sulfur batteries(LSBs)represent a next-generation energy storage technology,but widespread applications are restricted by the shuttle of lithium polysulfides(LiPSs).The rational design of separators has been demonstrated to be one of the most efficient and cost-effective strategies to curb the shuttle effect,and tremendous research progress has been achieved.The efficiency of a separator depends on its interaction with LiPSs,which is governed by the surface energy and binding strength.Despite several review works that have been reported to advance the separators,most of them primarily focus on active material innovation and construction.The most crucial issues of surface binding energy have not been systematically reviewed,limiting the precise design of efficient separators.In this review,fundamentals related to surface energy and binding interactions with LiPSs are comprehensively analyzed and discussed.With surface binding and energy main lines,the advancements in separator engineering strategies are elaborately summarized and discussed.Moreover,techniques for evaluating affinity to LiPSs are thoroughly analyzed to avoid any ambiguities in measurement.Based on the research context,valuable research directions are suggested to construct efficient separators.This work provides guidelines to regulate the surface binding and energy of separators for high-performance LSBs.
基金supported by National Natural Science Foundation of China(No.82404417)State Key Laboratory of National Security Specially Needed Medicines Program(No.LTMC2022Zz006).
文摘The von Hippel-Lindau tumor suppressor(VHL)has been extensively used to develop degraders targeting numerous proteins of interest.However,studies on the rational design of VHL-proteolysis-targeting chimeras(PROTACs)remain scarce.This study aimed to develop strategies to investigate VHL-recruiting PROTACs connecting with varying attachment sites on VHL ligands,which could be utilized for KRAS^(G12C) degraders development and expanded to additional targets.We developed a molecular dynamics(MD)-based strategy to explore the stability of ternary complexes induced by KRAS^(G12C) PROTACs with four distinct attachment sites of VH032.We found a potent degrader namely YN14-H,linked to hydroxyl group on VH032 benzene ring,exhibited the most superior ability of inducing ternary complexes,reflected by the lowest dissociation constant(Kd)for ternary complex induction and the highest AlphaScreen(AS)-based interaction.YN14-H inhibited cell growth with low nanomolar half maximal inhibitory concentration(IC_(50))and half maximal degradation concentration(DC_(50))values as well as>98%of maximum degradation(D_(max))in NCI-H358 and MIA PaCa-2 cells harboring KRAS^(G12C)-mutation.Mechanistically,YN14-H significantly induced apoptosis and inhibited the migratory capacity.Notably,YN14-H demonstrated favorable pharmacokinetic properties and excellent antitumor activity in vivo.Furthermore,bromodomain-containing protein 7(BRD7)and Bruton tyrosine kinase(BTK)degraders attached to distinct sites on VH032 further verified the rationality and universality of our MD-based strategies.Our findings demonstrated that YN14-H could serve as a promising candidate for the treatment of tumors with KRAS^(G12C)-mutation and present a strategy for the rational design of VHL-recruiting PROTACs that target additional proteins at distinct attachment sites.
文摘Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.
文摘如约见到夏然，同事的第一个评价是“年轻”。从之前IBM大中华区软件集团SOA总经理到目前软件部的Rational总经理，夏然给人的印象是温文尔雅却充满活力。在其负责的Rational产品线下，最新发布了Jazz和Rational Team Concert（RTC）两个看起来似乎有些另类的产品，与传统上Rational一贯的风格截然不同，
基金supported by the China Metaverse and Digital Talent Development Initiative and the general project of the National Social Science Foundation of China titled“Theoretical Interpretation of Advertising Messaging and the Development of a Typical Case Database”(19BXW085).
文摘In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues that the achievements and crises of both fields signify the triumph of rationalism in the context of deepening modernity,while simultaneously harboring an intrinsic impetus and possibility for transitioning from rationalism to emotionalism.This dynamic serves as a quintessential representation of modernity’s crises and their transcendence.Centered on embodied cognitive science,AI and the metaverse—rooted in rationalism—now face challenges in shifting toward emotionalism,revealing their inadequacy in addressing this shift.Humanity must explore new modernity-deepening paradigms grounded in emotionalism to confront and transcend the potential crises posed by the metaverse and AI.
基金supported by the Natural Science Foundation of Jiangsu Province(BE2021623,BK20220155)Natural Science Foundation of Jiangsu Province(BE2021623)+4 种基金National Natural Science Foundation of China(32001665,U1903205,32021005)the National Key Research and Development Program of China(2017YF0400303)the Key Scientific and Technological Research Projects in the Key Areas of the Xinjiang Production and Construction Corps(2018AB010)the Key Research and Development 303 Program of Ningxia(2020BFG02012)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.
文摘Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria of DUE of meropenem was established based on drug instructions,related guidelines and experts’opinions.Then,120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study.Results and Conclusion 120 cases of meropenem use involved 8 clinical departments,including 38 cases in the Department of Respiratory Medicine,25 cases in the Department of Tuberculosis,and 20 cases in the Department of Gastroenterology.The detection rate of pathogenic microorganisms before first use was 79.17%,and the clinical treatment effectiveness rate was 81.67%.The irrational use of meropenem included poor grasp of usage indications,excessively high starting points,inappropriate usage and dosage,non-standard treatment courses,and excessive combination medication.Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem,provide timely feedback on relevant situations,and promote rational clinical medication.
文摘Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to antibiotics between August 2021 and August 2023.The types of antibiotics that caused adverse reactions were analyzed,and the symptoms of adverse reactions and measures for rational use of antibiotics were summarized.Results:Among the analyzed cases of adverse reactions to antibiotics,the highest rate was observed in patients aged 61–75 years,accounting for 38.33%,followed by patients aged 51–60 years,accounting for 20.00%.In terms of the types of antibiotics that caused adverse reactions,cephalosporins were the most common,accounting for 40.00%,followed by penicillins,accounting for 18.33%.Analysis of the systems involved in adverse reactions showed that skin and appendage disorders were the most common,accounting for 36.67%,followed by the digestive system,accounting for 28.33%.Conclusion:Irrational use of antibiotics can lead to adverse drug reactions.Therefore,it is necessary to analyze strategies for the rational use of antibiotics to reduce adverse drug reactions and ensure the safety of antibiotic use.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
文摘Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between March 2023 and December 2023 were selected and randomly divided into two groups.In the experimental group,the pharmacist led the medication management during the perioperative use of antibiotics,while the control group received routine antibiotic management.The management effects were compared between the two groups.Results:The irrational drug use rate,the incidence of adverse drug reactions,the cost of antibiotics,and the incidence of postoperative infection were all lower in the experimental group compared to the control group(P<0.05).Conclusion:Implementing pharmacist-led medication management during the perioperative period of gynecological surgery can prevent irrational drug use,reduce adverse drug reactions,control drug costs,and lower the risk of postoperative infection.
文摘Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group(n=80,adopting the medical institution prescription review mechanism)and a control group(n=79,without prescription review)based on the random number table method.A comparative analysis was conducted on the work quality of medical personnel,irrational prescription drug use,and prescription drug dispensing situations.Results:The work quality of medical personnel in the observation group was significantly better than that in the control group(P<0.05).The incidence of irrational prescription drug use in the observation group(22.50%)was significantly higher than that in the control group(7.59%)(P<0.05).The observation group had fewer types of prescribed drugs,lower usage rates of injections and antibiotics,and a significantly higher usage rate of national essential drugs compared to the control group(P<0.05).Conclusion:The prescription review mechanism can significantly improve the work quality of medical personnel,increase the detection rate of irrational drug use,reduce the types of prescription drugs and the use of injections and antibiotics,and promote the standardized application of national essential drugs,which has important intervention value.
文摘This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the notion of“inner cultivation”(xin xing xiulian)into the analytical framework,we introduce the concept of the“cultivating economic agent,”aiming to explore how rationality is generated,evolved,and transcended throughout the spiritual journey.The study argues that,in the context of Eastern culture,rationality is not merely an innate or static faculty but one that can be cultivated and transformed.Through textual analysis of the behavioral trajectories of Sun Wukong,Zhu Bajie,and Tang Sanzang,we uncover a structured behavioral logic of“goal orientation–institutional discipline–purification of the mind.”The findings suggest that although cultivation behaviors are not utilitarian decisions per se,they exhibit rational characteristics such as goal stability,autonomous will,and embedded incentives.
