Inflammatory bowel disease(IBD)comprises a heterogeneous group of chronic inflammatory conditions of the intestine.Current therapeutic strategies primarily focus on maintaining remission and mitigating the secondary e...Inflammatory bowel disease(IBD)comprises a heterogeneous group of chronic inflammatory conditions of the intestine.Current therapeutic strategies primarily focus on maintaining remission and mitigating the secondary effects rather than reversing its pathogenic mechanisms(Jeong et al.,2019).The pathogenesis of IBD involves intestinal barrier dysfunction,tissue damage,and dysregulated innate and adaptive immune responses(de Souza et al.,2017).Elevated neutrophil activity has been reported in IBD(Danne et al.,2024),yet the precise roles and mechanisms of neutrophils in disease progression remain to be elucidated.展开更多
炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先...炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先天性免疫应答及适应性免疫应答,在调节人类健康和疾病中起着至关重要的作用,同样,在IBD的发病过程中,其炎症细胞和细胞因子也发挥了极其重要的调控作用。本文对近年来IBD免疫反应及调控机制方面的研究进展进行综述,以期为IBD的研究及治疗提供新的思路和策略。Inflammatory Bowel Disease (IBD) is a disease involving complex pathological processes such as intestinal immune disorders, inflammatory cell infiltration, intestinal mucosal barrier destruction, intestinal inflammatory cells and cytokine aggregation. In recent years, the incidence rate has increased significantly worldwide and caused a huge burden of disease. Immune response, including congenital immune response and adaptive immune response, plays a vital role in regulating human health and disease. Similarly, in the onset of IBD, its inflammatory cells and cytokines also play an extremely important regulatory role. This article reviews the research progress of IBD immune response and regulatory mechanism in recent years, with a view to providing new ideas and strategies for the research and treatment of IBD.展开更多
Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteri...Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteristics of gut microbiota of children and their mothers,and examine the correlation of the microbial composition in mother–child pairs.Methods:We conducted a case-control study including children with PIBD and their mothers as the case group,as well as healthy children and their mothers as the control group.Questionnaires were used to collect information such as family illness history and maternal and early-life events.Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA(rRNA)sequencing to analyze the composition and its potential association with PIBD.Results:A total of 54 pairs of cases and 122 pairs of controls were recruited.A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD,and a higher education level of the father was associated with a decreased risk of PIBD.Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers.Similarities were observed in the gut microbiota of mothers and children in the same groups.Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.Conclusions:PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics.The mother–child gut microbiota is closely related,suggesting the transmission and influence of the gut microbiota between mothers and children.This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.展开更多
基金supported by the National Key R&D Program of China(2023YFA1800100and 2024YFF1206600)the National Natural Science Foundation of China(32100664)the Basic and Applied Basic Research Foundation of Guangdong Province(2024B1515040019 and 2022A1515012042).
文摘Inflammatory bowel disease(IBD)comprises a heterogeneous group of chronic inflammatory conditions of the intestine.Current therapeutic strategies primarily focus on maintaining remission and mitigating the secondary effects rather than reversing its pathogenic mechanisms(Jeong et al.,2019).The pathogenesis of IBD involves intestinal barrier dysfunction,tissue damage,and dysregulated innate and adaptive immune responses(de Souza et al.,2017).Elevated neutrophil activity has been reported in IBD(Danne et al.,2024),yet the precise roles and mechanisms of neutrophils in disease progression remain to be elucidated.
文摘炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先天性免疫应答及适应性免疫应答,在调节人类健康和疾病中起着至关重要的作用,同样,在IBD的发病过程中,其炎症细胞和细胞因子也发挥了极其重要的调控作用。本文对近年来IBD免疫反应及调控机制方面的研究进展进行综述,以期为IBD的研究及治疗提供新的思路和策略。Inflammatory Bowel Disease (IBD) is a disease involving complex pathological processes such as intestinal immune disorders, inflammatory cell infiltration, intestinal mucosal barrier destruction, intestinal inflammatory cells and cytokine aggregation. In recent years, the incidence rate has increased significantly worldwide and caused a huge burden of disease. Immune response, including congenital immune response and adaptive immune response, plays a vital role in regulating human health and disease. Similarly, in the onset of IBD, its inflammatory cells and cytokines also play an extremely important regulatory role. This article reviews the research progress of IBD immune response and regulatory mechanism in recent years, with a view to providing new ideas and strategies for the research and treatment of IBD.
基金supported by the National Key R&D Program of China(Nos.2021YFA1301300,2019YFA0905600,and 2023YFC2706503)the National Natural Science Foundation of China(Nos.82170557 and 82000510).
文摘Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteristics of gut microbiota of children and their mothers,and examine the correlation of the microbial composition in mother–child pairs.Methods:We conducted a case-control study including children with PIBD and their mothers as the case group,as well as healthy children and their mothers as the control group.Questionnaires were used to collect information such as family illness history and maternal and early-life events.Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA(rRNA)sequencing to analyze the composition and its potential association with PIBD.Results:A total of 54 pairs of cases and 122 pairs of controls were recruited.A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD,and a higher education level of the father was associated with a decreased risk of PIBD.Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers.Similarities were observed in the gut microbiota of mothers and children in the same groups.Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.Conclusions:PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics.The mother–child gut microbiota is closely related,suggesting the transmission and influence of the gut microbiota between mothers and children.This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.
