Anti-tumor necrosis factor(TNF)therapy for inflammatory bowel disease(IBD)is hampered by issues of nonresponse and resistance,highlighting the urgent need for alternative or complementary treatments.Our study revealed...Anti-tumor necrosis factor(TNF)therapy for inflammatory bowel disease(IBD)is hampered by issues of nonresponse and resistance,highlighting the urgent need for alternative or complementary treatments.Our study revealed significant upregulation of taurine in the intestinal tissues of IBD patients,which was inversely related to the severity of the disease.A key discovery was that TNF directly induced taurine synthesis in intestinal epithelial cells and increased the production of angiogenin,a nuclease that degrades mitochondrial RNA,which is known to amplify inflammatory responses.By degrading mitochondrial RNA,angiogenin inhibits the inflammatory response in macrophages,suggesting a potent immune-modulatory role for taurine.This mechanism implies that taurine could serve as an adjunct to anti-TNF therapies,enhancing their efficacy and providing a novel strategy for the management of IBD and other chronic inflammatory diseases by harnessing the body's innate immune regulatory mechanisms.展开更多
炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先...炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先天性免疫应答及适应性免疫应答,在调节人类健康和疾病中起着至关重要的作用,同样,在IBD的发病过程中,其炎症细胞和细胞因子也发挥了极其重要的调控作用。本文对近年来IBD免疫反应及调控机制方面的研究进展进行综述,以期为IBD的研究及治疗提供新的思路和策略。Inflammatory Bowel Disease (IBD) is a disease involving complex pathological processes such as intestinal immune disorders, inflammatory cell infiltration, intestinal mucosal barrier destruction, intestinal inflammatory cells and cytokine aggregation. In recent years, the incidence rate has increased significantly worldwide and caused a huge burden of disease. Immune response, including congenital immune response and adaptive immune response, plays a vital role in regulating human health and disease. Similarly, in the onset of IBD, its inflammatory cells and cytokines also play an extremely important regulatory role. This article reviews the research progress of IBD immune response and regulatory mechanism in recent years, with a view to providing new ideas and strategies for the research and treatment of IBD.展开更多
Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppres...Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppression in diseased chicks(Muller et al.2012).The pathogenic infectious bursal disease virus(IBDV)is a member of the Avira virus genus in the Birnaviridae family.(Harkness et al.1975;Dobos et al.1979;Müller et al.1979).IBDV is prevalent worldwide,causing serious economic losses to the global poultry industry.Currently,vaccination remains the most cost-effective way to prevent IBDV.展开更多
基金supported by the distinguished Young Scientist Fund of NSFC(82125016)the National Natural Science Foundation of China,and the Key Program(82230061)+6 种基金This research was supported by the National Natural Science Foundation of China,Special Program(82341216)This study was also supported by the National Natural Science Foundation of China(82071046,82100540,82341215,82370531,82300581)the Jiangsu Science and Technology Project(Social Development)(BE2019669)the Natural Science Foundation of Zhejiang Province(LQ24H030005)This project is supported by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.82202019)The project was supported by the China Postdoctoral Science Foundation(Grant No.2022M723664/2023M734007)supported by the 111 Program(D20036).
文摘Anti-tumor necrosis factor(TNF)therapy for inflammatory bowel disease(IBD)is hampered by issues of nonresponse and resistance,highlighting the urgent need for alternative or complementary treatments.Our study revealed significant upregulation of taurine in the intestinal tissues of IBD patients,which was inversely related to the severity of the disease.A key discovery was that TNF directly induced taurine synthesis in intestinal epithelial cells and increased the production of angiogenin,a nuclease that degrades mitochondrial RNA,which is known to amplify inflammatory responses.By degrading mitochondrial RNA,angiogenin inhibits the inflammatory response in macrophages,suggesting a potent immune-modulatory role for taurine.This mechanism implies that taurine could serve as an adjunct to anti-TNF therapies,enhancing their efficacy and providing a novel strategy for the management of IBD and other chronic inflammatory diseases by harnessing the body's innate immune regulatory mechanisms.
文摘炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加,并造成巨大的疾病负担。免疫反应包括先天性免疫应答及适应性免疫应答,在调节人类健康和疾病中起着至关重要的作用,同样,在IBD的发病过程中,其炎症细胞和细胞因子也发挥了极其重要的调控作用。本文对近年来IBD免疫反应及调控机制方面的研究进展进行综述,以期为IBD的研究及治疗提供新的思路和策略。Inflammatory Bowel Disease (IBD) is a disease involving complex pathological processes such as intestinal immune disorders, inflammatory cell infiltration, intestinal mucosal barrier destruction, intestinal inflammatory cells and cytokine aggregation. In recent years, the incidence rate has increased significantly worldwide and caused a huge burden of disease. Immune response, including congenital immune response and adaptive immune response, plays a vital role in regulating human health and disease. Similarly, in the onset of IBD, its inflammatory cells and cytokines also play an extremely important regulatory role. This article reviews the research progress of IBD immune response and regulatory mechanism in recent years, with a view to providing new ideas and strategies for the research and treatment of IBD.
基金supported by grants from the National Key R&D Program of China(2022YFD1801000)the Natural Science Foundation of Shanghai,China(24ZR1479200)。
文摘Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppression in diseased chicks(Muller et al.2012).The pathogenic infectious bursal disease virus(IBDV)is a member of the Avira virus genus in the Birnaviridae family.(Harkness et al.1975;Dobos et al.1979;Müller et al.1979).IBDV is prevalent worldwide,causing serious economic losses to the global poultry industry.Currently,vaccination remains the most cost-effective way to prevent IBDV.
