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Petrogenesis and geodynamics of the Dashenshan I-type granite and its implications for the Triassic tectonic evolution of the South China Block
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作者 Zhen Xi Yang Zhang +2 位作者 Zhennan Liu Huan Li Fenliang Liu 《Acta Geochimica》 2025年第4期673-699,共27页
There is significant debate concerning the tectonic characteristics and evolutionary understanding of the South China Block(SCB)during the Early Mesozoic.One of the key points of contention is the tectonic-magmatic ac... There is significant debate concerning the tectonic characteristics and evolutionary understanding of the South China Block(SCB)during the Early Mesozoic.One of the key points of contention is the tectonic-magmatic activity during the Triassic and its dynamic mechanisms.However,research on the detailed chronology and tectonic settings of granite plutons in key regions remains insuffi-cient,limiting the understanding of the tectonic-magmatic dynamic mechanisms in the interior of SCB during the Triassic.In this contribution,we present whole-rock major and trace elemental data,Sr-Nd isotope data,LA-ICP-MS zircon U-Pb age dating,and Lu-Hf isotope data for granites of Dashenshan pluton in the Xiangzhong,northwest part of SCB.The results indicate that the Dashenshan granite has an emplacement age of 208.4-212.5 Ma,characterized by high SiO_(2),Na_(2)O,and K_(2)O contents and low MgO and CaO.The Dashenshan granite is enriched in light rare-earth elements with a significant negative Eu anomaly(averageδEu=0.42).It is also enriched in Rb,K,and Th and shows pronounced depletion in Nb,Ta,and Ti,classifying it as peraluminous calc-alkaline granite,specifically of the I-type.The zircon ε_(Hf(t)) values range from−8.39 to−4.4,with an average of−5.82,and the Sr-Nd isotopes are relatively enriched[ε_(Nd)(t)=−9.31 to−6.8].Combining these geochemical characteristics,it is revealed that the Dashenshan granite was derived from the partial melting of middle to upper crustal metamorphic basement materials under medium-to low-temperature conditions,with possible minor contributions from mantle-derived materials.Furthermore,it underwent fractional crystallization,including plagioclase differentiation.By integrating the geochemical features and spatial distribution of Triassic granites in SCB,this study suggests that the regional tectonic evolution of SCB during the Triassic was primarily controlled by the collision of the SCB with the Indochina Block and the North China Block.In Xiangzhong,the tectonic setting transitioned from syn-collisional compression to post-collisional extension during the Late Triassic.The Dashenshan pluton formed in a post-collisional extensional setting,resulting from the decompression melting of middle-to-upper crustal rocks.The upwelling of the asthenosphere and upward heat transfer likely played a significant role in the formation of the Dashenshan granitic magma. 展开更多
关键词 i-type granite Late Triassic Crustal basement Tectonic evolution Xiangzhong South China Block
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Zircon U-Pb Ages and Sr-Nd-Hf Isotopes Geochemistry of I-Type Granites in the Jiangda-Weixi Region,Eastern Xizang:Implications for the Tectonic Evolution of the Paleo-Tethyan Orogen
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作者 Rui Gao Tao Wu +3 位作者 Andrew C.Kerr Han Liu Long Xiao Wan Huang 《Journal of Earth Science》 2025年第6期2387-2410,共24页
Permian—Triassic granitoids are widely distributed along the Jinshajiang suture belt,eastern Xizang,and are regarded as the result of the tectonic-magmatic activity associated with the evolution of Paleo-Tethys Ocean... Permian—Triassic granitoids are widely distributed along the Jinshajiang suture belt,eastern Xizang,and are regarded as the result of the tectonic-magmatic activity associated with the evolution of Paleo-Tethys Ocean.This paper focuses on the high-K calc-alkaline I-type Rennong(~235 Ma)and Jiaduoling(~232 Ma)granitoid plutons,eastern Xizang,which are enriched in light rare earth elements(LREEs)and large ion lithophile elements(LILEs),but depleted in high field strength elements(HFSEs)with moderate-weak negative Eu anomalies(0.61–0.90).The Rennong granites are characterized by uniform zircon ε_(Hf)(t)values(-7.3 to-3.5)and negative ε_(Nd)(t)values(-7.6 to-5.7),with old two-stage Nd model ages(T_(DM2)=1.51-1.46 Ga)and was likely formed by partial melting of the basement rocks,whereas the Jiaduoling rock samples have variable zircon ε_(Hf)(t)values(-5.7 to+5.5)but negativeεNd(t)values(-7.6 to-7.7)and are proposed to be formed by hybridization of mantle-derived mafic magma,Rennong felsic magma and sediments.Mafic microgranular enclaves(MMEs)in the Jiaduoling granitic rocks,have similar zircon U-Pb ages(~237 Ma)and zircon ε_(Hf)(t)values(-4.4 to+6.3)to the host rocks,indicating that zircons in the MMEs were actually xenocrysts that formed at an early stage in the granitic magma chamber.These results reveal that the break-off of the Jinshajiang oceanic slab beneath Changdu(Qamdo)-Simao Block was in a post-collisional setting,resulted in the upwelling of asthenosphere in the Late Triassic,and then,generated the wide-spread intermediate-felsic magmatism along the Jinshajing belt,including the Rennong and Jiaduoling plutons. 展开更多
关键词 Paleo-Tethys Ocean Jiangda(Jomda)-Weixi Sr-Nd-Hf isotopes i-type granite GEOCHRONOLOGY GEOCHEMISTRY
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Genesis of Highly Fractionated I-Type Granites from Fengshun Complex:Implications to Tectonic Evolutions of South China 被引量:17
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作者 Zuomin Zhou Changqian Ma +3 位作者 Caifu Xie Lianxun Wang Yuanyuan Liu Wei Liu 《Journal of Earth Science》 SCIE CAS CSCD 2016年第3期444-460,共17页
The South China Block is characterized by the large-scale emplacement of felsic magmas and giant ore deposits during the Yanshanian. We present zircon Hf isotopic compositions, whole-rock major and trace element compo... The South China Block is characterized by the large-scale emplacement of felsic magmas and giant ore deposits during the Yanshanian. We present zircon Hf isotopic compositions, whole-rock major and trace element compositions of the Fengshun complex, located in eastern Guangdong Province, South China. The Fengshun complex is a multi-stage magmatic intrusion. It is composed of two main units, i.e., the Mantoushan(MTS) syeno-monzogranites, alkali feldspar granites and the Hulutian(HLT) alkali feldspar granites. LA-ICPMS zircon dating shows that the complex emplaced in 166–161 and 139±2 Ma, respectively. Geochemically, the MTS granites show relatively various geochemical compositions with low REE contents(87.76×10-6–249.71×10-6), Rb/Sr ratios(1.19–58.93), pronounced Eu negative anomaly(0.01–0.37) and low Nb/Ta ratios(2.40–6.82). In contrast, the HLT granites exhibit relatively stable geochemical characteristics with high REE contents(147.35×10-6– 282.17×10-6), Rb/Sr ratios(2.05–10.30) and relatively high Nb/Ta ratios(4.45–13.00). The isotopic data of the MTS granites display relatively enriched values, with ISr varying from 0.708 2 to 0.709 7, εNd(t) from-7.8 to-6.9 and εHf(t) from-7.4 to-3.2, in comparison with those of the HLT which are ISr=0.703 05–0.704 77, εNd(t)=-5–-3.4 and εHf(t)=-0.7–1.8). The two-stage model ages of the MTS granites(T2DM(Nd)=1.51–1.59 Ga and T2DM(Hf)=1.26–1.48 Ga) are also higher than those of the HLT granites(T2DM(Nd)=1.21–1.34 Ga and T2DM(Hf)=0.96–1.10 Ga). Thus the MTS and HLT granites might originate from different sources. The former is more likely derived from partial melting of Meso-Proterozoic basement triggered by upwelling of asthenosphere and/or underplate of the basaltic magma and then extensive fractional crystallisation, similar to the genesis of Early Yanshanian granitoids of the EW-trending tectono-magmatism belt in the Nanling range. In comparison, the latter might have involved with asthenosphere component, similar to the Early Cretaceous granitoids of NE-NNE-trending granitoid-volcanic belt in coastal region, southeastern China. We propose that the MTS granites were mainly formed in Paleo-Tethyan post-orogenic extensional tectonic setting whereas the HLT granites were formed in the back-arc extensional tectonic setting. The period at 139 Ma represents the initial time of roll-back of the paleo-Pacific Plate in SE-trending. 展开更多
关键词 Sr-Nd-Hf isotopes Late Mesozoic magmagtism highly fractionated i-type granite post-orogeny roll-back South China
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Permian–Triassic Highly-Fractionated I-Type Granites from the Southwestern Qaidam Basin(NW China):Implications for the Evolution of the Paleo-Tethys in the Eastern Kunlun Orogenic Belt 被引量:9
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作者 Yinjuan Ju Xiaoli Zhang +1 位作者 Shaocong Lai Jiangfeng Qin 《Journal of Earth Science》 SCIE CAS CSCD 2017年第1期51-62,共12页
Late Paleozoic to Early Mesozoic granites are widespread in the southern Qaidam Basin, northern margin of the eastern Kunlun orogenic belt. Their petrogenesis can provide us insights into the tectonic evolution and cr... Late Paleozoic to Early Mesozoic granites are widespread in the southern Qaidam Basin, northern margin of the eastern Kunlun orogenic belt. Their petrogenesis can provide us insights into the tectonic evolution and crustal growth process in the Qaidam Basin. This paper reports Permian–Triassic granites from the Kunbei area, southwestern Qaidam Basin. Detailed zircon LA-ICP MS U-Pb dating reveals that the granites from the four drilling cores(q404, q406, q1612-8, q1613-8) have identical ages of 251±3, 256±4, 247±2, and 251±6 Ma, respectively, these ages are identical with the Permian–Triassic granites from the eastern Qaidam Basin. Detailed geochemical analyses indicate that these granites display typical affinities of highly-fractionated I-type granites:(1) they have high SiO_2(up to 76.5 wt.%), Na_2O+K_2O(7.91 wt.% to 9.48 wt.%) contents and high FeO^T/MgO values of 4.7 to 9.3, suggesting significant fractional crystallization;(2) their low A/CNK values of 0.54 to 1.03, no normative Al-rich minerals, inconsistent with the per-aluminous S-type granites;(3) their low Ga(14.5 ppm to 20.7 ppm) and 10 000×Ga/Al(2.23 to 3.03, most of them 〈2.6) values are inconsistent with the A-type granites;(4) the high Rb(191 ppm to 406 ppm) contents and Rb/Sr(2.1 to 13.4) ratios, as well as the significant negative Eu anomalies(0.10 to 0.42) also indicate significant fractional crystallization of feldspars;(5) their low P_2O_5 contents(0.02 wt.% to 0.10 wt.%) suggest the limited solubility of phosphorus in primitive metaluminous melts. In combination with the geological background, we propose that the Permian–Triassic highly-fractionated I-type granites resulted from partial melting of intra-crustal mafic rocks, and the primitive I-type granitic melts underwent significant fractional crystallization of feldspars. The occurrence of highly-fractionated I-type granites in the southwestern Qaidam Basin suggests a Permian–Triassic active continental margin in the northern margin of the East Kunlun orogenic belt. 展开更多
关键词 highly-fractionated i-type granites Permain-Triassic Qaidam Basin eastern Kunlunorogenic belt Paleo-Tethys.
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Geochronology,Petrogenesis and Tectonic Setting of the Late Jurassic I-type Granites in the North Qinling Orogenic Belt,Central China 被引量:8
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作者 HUANG Yanna LI Dunpeng +1 位作者 XIAO Aifang XU Songming 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2023年第4期1132-1149,共18页
The North Qinling Orogenic Belt(NQOB)is a composite orogenic belt in central China.It started evolving during the Meso-Neoproterozoic period and underwent multiple stages of plate subduction and collision before enter... The North Qinling Orogenic Belt(NQOB)is a composite orogenic belt in central China.It started evolving during the Meso-Neoproterozoic period and underwent multiple stages of plate subduction and collision before entering intra-continental orogeny in the Late Triassic.The Meso-Cenozoic intra-continental orogeny and tectonic evolution had different responses in various terranes of the belt,with the tectonic evolution of the middle part of the belt being particularly controversial.The granites distributed in the Dayu and Kuyu areas in the middle part of the NQOB can provide an important window for revealing the geodynamic mechanisms of the NQOB.The main lithology of Dayu and Kuyu granites is biotite monzogranite,and the zircon U-Pb dating yielded intrusive ages of 151.3±3.4 Ma and 147.7±1.5 Ma,respectively.The dates suggest that the biotite monzogranite were formed at the end of the Late Jurassic.The whole-rock geochemistry analysis shows that the granites in the study areas are characterized by slightly high SiO_(2)(64.50-68.88 wt%)and high Al_(2)O_(3)(15.12-16.24 wt%)and Na_(2)O(3.55-3.80 wt%)contents.They are also enriched in light rare earth elements,large ion lithophile elements(e.g.,Ba,K,La,Pb and Sr),and depleted in high field strength elements(HFSEs)(e.g.,Ta,Nb,P and Ti).Additionally,the granites have weakly negative-slightly positive Eu anomalies(δEu=0.91-1.19).Zircon Lu-Hf isotopic analysis showedε_(Hf)(t)=-6.1--3.8,and the two-stage model age is T_(2DM(crust))=1.5-1.6 Ga.The granites in the study areas are analyzed as weak peraluminous high-K calc-alkaline I-type granites.They formed by partial melting of the thickened ancient lower crust,accompanied by the addition of minor mantle-derived materials.During magma ascent,they experienced fractional crystallization,with residual garnet and amphibole for a certain proportion in the magma source region.Comprehensive the geotectonic data suggest that the end of the Late Jurassic granite magmatism in the Dayu and Kuyu areas represents a compression-extension transition regime.It may have been a response to multiple tectonic mechanisms,such as the late Mesozoic intra-continental southward subduction of the North China Craton and the remote effect of the Paleo-Pacific Plate subduction. 展开更多
关键词 partial melting tectonic transition i-type granite Late Jurassic North Qinling Orogenic Belt
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Early Cretaceous I-type granites in the Tengchong terrane:New constraints on the late Mesozoic tectonic evolution of southwestern China 被引量:3
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作者 Yi Fang Yun-Hui Zhang +3 位作者 Shou-Ting Zhang Hua-Wen Cao Hao Zou Jian-Hui Dong 《Geoscience Frontiers》 SCIE CAS CSCD 2018年第2期459-470,共12页
The Early Cretaceous granitoids that are widespread in the Tengchong terrane of Southwest China play a critical role in understanding the tectonic framework associated with the Tethyan oceans. In this study, we presen... The Early Cretaceous granitoids that are widespread in the Tengchong terrane of Southwest China play a critical role in understanding the tectonic framework associated with the Tethyan oceans. In this study, we present a detailed description of zircon U-Pb ages, whole-rock geochemistry and Hf isotopes for the Laoxiangkeng pluton in the eastern Tengchong terrane and elucidate their petrogenesis and geodynamic implications. Zircon U-Pb dating of the Laoxiangkeng pluton yields ages of 114 ± 1 Ma and 115 ± 1 Ma,which imply an Early Cretaceous magmatic event. The Laoxiangkeng pluton enriched in Si and Na, is calcalkaline and metaluminous, and has the characteristics of highly fractionated I-type granites. Zircons from the pluton have calculated ε_(Hf)(t) values of-12.7 to-3.7 and two-stage model ages of 1327-1974 Ma,respectively, indicating a mixed source of partial melting of Paleo-Neoproterozoic crust-derived compositions with some inputs of mantle-derived magmas. By integrating all available data for the regional tectonic evolution of the eastern Tethys tectonic domain, we conclude that the Early Cretaceous magmatism in the Tengchong terrane was produced by the northeastward subduction of the Meso-Tethyan Bangong-Nujiang Ocean. 展开更多
关键词 Zircon U-Pb dating GEOCHEMISTRY i-type granite Early Cretaceous Tengchong terrane
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Geochronology and Geochemistry of the 890 Ma I-Type Granites in the Southwestern Yangtze Block:Petrogenesis and Crustal Evolution 被引量:4
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作者 Jibiao Zhang Xiaozhong Ding +3 位作者 Yanxue Liu Heng Zhang Chenglong Shi Yu Zou 《Journal of Earth Science》 SCIE CAS CSCD 2020年第6期1216-1228,共13页
The tectonic evolution of the southwestern Yangtze Block during the Early Neoproterozoic period is still controversial because of the limited quantities of 1000–860 Ma magmatic rocks.In this study,our new LA-ICP-MS z... The tectonic evolution of the southwestern Yangtze Block during the Early Neoproterozoic period is still controversial because of the limited quantities of 1000–860 Ma magmatic rocks.In this study,our new LA-ICP-MS zircon U-Pb dating results demonstrate that the Yanbian granodiorites in the southwest Yangtze Block were emplaced at 894.6±7.4 Ma,representing the product of an 894 Ma magmatism.The Yanbian granodiorites are metaluminous to weak peraluminous with A/CNK values of 0.8–1.1,resembling Itype granitoids.They are characterized by right-inclined REE patterns with moderate to insignificant negative Eu anomalies(δEu=0.6–0.9).Their primitive mantle-normalized trace element patterns are characterized by depletion of Nb,Ta and Ti and weakly enrichment of Th.Considering the positive whole-rockεNd(t)(+5.8 to+6.8),we propose that these granodiorites originated from the partial melting of juvenile mafic lower crust.The Yanbian I-type granitoids have low Y and Nb contents similar to volcanic arc igneous rocks in the Y-Nb plot for tectonic discrimination.In conclusion,Early Neoproterozoic Yanbian granodiorites have generated in a compression setting in an active continental margin.Together with previous studies from the southwestern Yangtze Block,we suggest that the 894 Ma subduction-related Yanbian granodiorites represent the early stage of subduction at the southwestern margin of the Yangtze Block. 展开更多
关键词 i-type granites zircon U-Pb dating Early Neoproterozoic SUBDUCTION southwestern Yangtze Block
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The Late Triassic I-Type Granites from the Longmu Co-Shuanghu Suture Zone in the interior of Tibetan Plateau, China: Petrogenesis and Implication for Slab Break-Off 被引量:2
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作者 ZHAO Zhen WU Zhenhan +2 位作者 LU Lu YU Junqiu WU Yanjun 《Acta Geologica Sinica(English Edition)》 CAS CSCD 2018年第3期935-951,共17页
The Jiangaidarina granitic mass(JM) is an important part of the magmatic belt in Longmu CoShuanghu Suture Zone(LSSZ) in the central Tibetan Plateau. An integrated research involving wholerock geochemistry, zircon LA-I... The Jiangaidarina granitic mass(JM) is an important part of the magmatic belt in Longmu CoShuanghu Suture Zone(LSSZ) in the central Tibetan Plateau. An integrated research involving wholerock geochemistry, zircon LA-ICP-MS U-Pb ages and Hf isotopic compositions was carried out to define the timing, genesis and tectonic setting of the JM. Zircon LA-ICP-MS U-Pb ages have been obtained ranging from 210 to 215 Ma, rather than the Early Jurassic as previously thought. Fifteen granite samples contain hornblendes and show a negative correlation between POand SiO, indicating that the JM is an I-type granite. All the granites are enriched in LREE relative to HREE, with negative Eu anomalies(Eu/Eu*=0.56-0.81), and have similar trace elements patterns, with depletion of Ba, Nb, Sr and P. These suggest that the JM was fractionated, and this is also proved by the characteristic of negative correlations between oxide elements(TiO, MgO, FeOt, MnO, CaO) and SiO. Almost all ε(t) values of the granites are between-10.3 and-5.8, implying that the JM has a crustal source intimately related with the South Qiangtang Block(SQB), except for one(+10.2), showing a minor contribution from mantle source.Moreover, relatively low NaO/KO ratios(0.42-0.93) and high A/CNK values(0.91-1.50) reflect that the JM was predominately derived from the medium-high potassium basaltic crust, interacted with greywacke. Our new geochemical data and geochronological results imply that the Late Triassic magmas were generated in a post-collisional tectonic setting, probably caused by slab break-off of the Longmu Co-Shuanghu Tethyan Ocean(LSTO). This mechanism caused the asthenosphere upwelling, formed extension setting, offered an enormous amount of heat, and provided favorable conditions for emplacement of voluminous felsic magmas. Furthermore, the LSTO could be completely closed during the Middle Triassic, succeed by continental collision and later the slab broke off in the Late Triassic. 展开更多
关键词 the Late Triassic i-type granite slab break-off Longmu Co-Shuanghu Suture Tibetan Plateau China
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Petrogenesis of an Early Cretaceous Xiabie Co I-type Granite in Southern Qiangtang,Tibet:Evidence from Geochemistry,Geochronology,Rb-Sr,Sm-Nd,Lu-Hf and Pb isotopes 被引量:2
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作者 LIU Hong LI Youguo +6 位作者 LI Wenchang LI Guangming HUANG Hanxiao MA Dongfang HUANG Yong ZHOU Qing FU Jiangang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第3期919-937,共19页
Cretaceous magmatism is widely distributed on both sides of the Bangong-Nujiang suture zone(BNSZ).These rocks record the subduction to closure history of the Bangong-Nujiang Tethys Ocean(BNO)and the collisional histor... Cretaceous magmatism is widely distributed on both sides of the Bangong-Nujiang suture zone(BNSZ).These rocks record the subduction to closure history of the Bangong-Nujiang Tethys Ocean(BNO)and the collisional history between the Lhasa(LS)and Qiangtang(QT)terranes.The Xiabie Co granite in Nyima County,which located on the southern margin of the QT terrane,Tibet.In this study,whole-rock geochemistry;Rb-Sr,Sm-Nd,and Pb isotopes;and laser ablation inductively coupled mass spectrometry(LA-ICP-MS)zircon U-Pb ages and Lu-Hf isotopes of the Xiabie Co granite in the Nyima area have been studied to constrain its petrogenesis and tectonic setting.Our study can help explain the tectonic evolution of the BNSZ and crust-mantle interaction.Zircon U-Pb dating indicates that the granite was emplaced at ca.120 Ma.The granite contains a small amount of hornblende and has high silicon(SiO2=73.97-78.03 wt%),potassium(K_(2)O=4.75-6.53 wt%),and total alkali(K_(2)O+Na_(2)O=7.98-8.98 wt%)contents;low calcium content(CaO=2.33-4.11 wt%);and variable A/CNK(1.00-1.18)and A/NK(1.09-1.22)values.The P_(2)O_(5)content of the granite negatively correlated with the SiO_(2)content.Thus,the Xiabie Co granite is a weakly peraluminous I-type granite belonging to the high-K calcalkaline to Shoshone series.It is enriched in light rare earth elements(LREEs)and relatively depleted in heavy rare earth elements(HREEs),with LREE/HREE ratios of 8.03-16.40 and La_(N)/Yb_(N)ratios of 10.2-27.1.Samples show right-leaning chondrite-normalized rare earth element patterns with pronounced negative Eu anomalies(Eu/Eu*=0.67-0.76).The primitive-mantle-normalized trace element spider diagrams of the samples are right-leaning zigzag curves,showing relative enrichment in large-ion lithophile elements(LILEs,e.g.,Rb,Th,U,and K)and depletion in high-field-strength elements(HFSEs,e.g.,Nb,P,Ti,and Yb)and displaying striking Sr and Ba negative anomalies.The graniteεHf(t)values were positive(2.9-9.9),whereas the whole-rockεNd(t)values were negative(−2.841 to−2.33).The calculated(^(87)Sr/^(86)Sr)t,(^(206)Pb/^(204)Pb)t,(^(207)Pb/^(204)Pb)t,and(^(208)Pb/^(204)Pb)t values are 0.7014-0.7057(0.7044 on average),18.422-18.851(18.670 on average),15.625-15.642(15.633 on average),and 38.332-38.681(39.571 on average),respectively.On the basis of the aforementioned data,we propose that the Xiabie Co granite was derived from a primitive magma that originated from partial melting of juvenile lower crust with the addition of mantle materials.In addition,strong fractional crystallization occurred during the rock-forming process.Given the geodynamic setting,our new data,together with previously reported achievements,imply that the Xiabie Co granite was formed during the LS-QT collision. 展开更多
关键词 i-type granite Lhasa-Qiangtang collision Bangong-Nujiang Tibet(Xizang)
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Petrogenesis of I-type granites from Yuqikapa granite pluton of the western Kunlun orogen: Deformation-driven filter-pressing differentiation 被引量:1
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作者 WEI Xiaopeng WANG He +4 位作者 DONG Rui LI Pei Zhang Xiaoyu QIU Zengwang YAN Qinghe 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第S1期98-99,共2页
1 Introduction The western Kunlun orogen,located in the northwest Tibet Plateau,and is a conjunction between the Pan-Asian and the Tethys tectonic domains.From north to south,the Western Kunlun orogen includes four
关键词 In Petrogenesis of i-type granites from Yuqikapa granite pluton of the western Kunlun orogen ICPMS type
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Robotic natural orifice specimen extraction surgery I-type F method vs conventional robotic resection for lower rectal cancer 被引量:2
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作者 Fang Tao Dong-Ning Liu +4 位作者 Peng-Hui He Xin Luo Chi-Ying Xu Tai-Yuan Li Jin-Yuan Duan 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第10期2142-2153,共12页
BACKGROUND Robotic resection using the natural orifice specimen extraction surgery I-type F method(R-NOSES I-F)is a novel minimally invasive surgical strategy for the treatment of lower rectal cancer.However,the curre... BACKGROUND Robotic resection using the natural orifice specimen extraction surgery I-type F method(R-NOSES I-F)is a novel minimally invasive surgical strategy for the treatment of lower rectal cancer.However,the current literature on this method is limited to case reports,and further investigation into its safety and feasibility is warranted.AIM To evaluate the safety and feasibility of R-NOSES I-F for the treatment of low rectal cancer.METHODS From September 2018 to February 2022,206 patients diagnosed with low rectal cancer at First Affiliated Hospital of Nanchang University were included in this retrospective analysis.Of these patients,22 underwent R-NOSES I-F surgery(RNOSES I-F group)and 76 underwent conventional robotic-assisted low rectal cancer resection(RLRC group).Clinicopathological data of all patients were collected and analyzed.Postoperative outcomes and prognoses were compared between the two groups.Statistical analysis was performed using SPSS software.RESULTS Patients in the R-NOSES I-F group had a significantly lower visual analog score for pain on postoperative day 1(1.7±0.7 vs 2.2±0.6,P=0.003)and shorter postoperative anal venting time(2.7±0.6 vs 3.5±0.7,P<0.001)than those in the RLRC group.There were no significant differences between the two groups in terms of sex,age,body mass index,tumor size,TNM stage,operative time,intrao-perative bleeding,postoperative complications,or inflammatory response(P>0.05).Postoperative anal and urinary functions,as assessed by Wexner,low anterior resection syndrome,and International Prostate Symptom Scale scores,were similar in both groups(P>0.05).Long-term follow-up revealed no significant differences in the rates of local recurrence and distant metastasis between the two groups(P>0.05).CONCLUSION R-NOSES I-F is a safe and effective minimally invasive procedure for the treatment of lower rectal cancer.It improves pain relief,promotes gastrointestinal function recovery,and helps avoid incision-related complications. 展开更多
关键词 Robotic surgery Natural orifice specimen extraction surgery Lower rectal cancer Robotic resection using the natural orifice specimen extraction surgery i-type F method
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Neoproterozoic I-type granites in the Central Tianshan Block (NW China):geochronology,geochemistry,and tectonic implications
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作者 SONG Yujia LIU Xijun +7 位作者 XIAO Wenjiao ZHANG Zhiguo LIU Pengde XIAO Yao LI Rui WANG Baohua LIU Lei HU Rongguo 《Journal of Arid Land》 SCIE CSCD 2022年第1期82-101,共20页
The Central Tianshan Block is one of numerous microcontinental blocks within the Central Asian Orogenic Belt(CAOB)that overlies Precambrian basement rocks.Constraining the evolution of these ancient basement rocks is ... The Central Tianshan Block is one of numerous microcontinental blocks within the Central Asian Orogenic Belt(CAOB)that overlies Precambrian basement rocks.Constraining the evolution of these ancient basement rocks is central to understanding the accretionary and collisional tectonics of the CAOB,and their place within the Rodinia supercontinent.However,to date,the timing and tectonic settings in which the basement rocks in the Central Tianshan Block formed are poorly constrained,with only sparse geochemical and geochronological data from granitic rocks within the northern segment of the block.Here,we present a systematic study combining U-Pb geochronology,whole-rock geochemistry,and the Sr-Nd isotopic compositions of newly-identified granitic gneisses from the Bingdaban area of Central Tianshan Block.The analyzed samples yield a weighted mean Neoproterozoic 206Pb/238U ages of 975-911 Ma.These weakly-peraluminous granitic rocks show a common geochemical I-type granite affinity.The granitic gneisses are calc-alkaline and enriched in large ion lithophile elements(LILEs)and light rare earth elements(LREEs),but they are depleted in high field strength elements(HFSEs);these characteristics are similar to those of typical subduction-related magmatism.All samples show initial(^(87)Sr/^(86)Sr)(t)ratios between 0.705136 and 0.706745.Values forεNd(t)in the granitic gneisses are in the range from-5.7 to-1.2,which correspond to Nd model ages of 2.0-1.7 Ga,indicating a role for Mesoproterozoic to Paleoproterozoic rocks in the generation of the granitic protoliths.The documented geochemical features indicate that the protoliths for the gneisses have a similar petrogenesis and magmatic source,which may reflect partial melting of thickened crust with the addition of small amounts of mantle-derived material.The Central Tianshan Block probably constitute part of an exterior orogen that developed along the margin of the Rodinian supercontinent during the Early Neoproterozoic and underwent a transition from subduction to syn-collision compression at 975-911 Ma. 展开更多
关键词 Neoproterozoic i-type granites GEOCHRONOLOGY Central Tianshan Block Rodinian supercontinent Central Asian Orogenic Belt(CAOB)
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Petrogenesis of highly fractionated I-type granites in the Zayu area of eastern Gangdese, Tibet: Constraints from zircon U-Pb geochronology, geochemistry and Sr-Nd-Hf isotopes 被引量:120
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作者 ZHU DiCheng MO XuanXue +4 位作者 WANG LiQuan ZHAO ZhiDan NIU Yaoling ZHOU ChangYong YANG YueHeng 《Science China Earth Sciences》 SCIE EI CAS 2009年第9期1223-1239,共17页
The Cretaceous granitoids in the middle and northern Gangdese, Tibet are generally interpreted as the products of anatexis of thickened deep crust genetically associated with the Lhasa-Qiangtang collision. This paper ... The Cretaceous granitoids in the middle and northern Gangdese, Tibet are generally interpreted as the products of anatexis of thickened deep crust genetically associated with the Lhasa-Qiangtang collision. This paper reports bulk-rock major element, trace element and Sr-Nd isotopic data, zircon U-Pb age data, and zircon Hf isotopic data on the Zayu pluton in eastern Gangdese, Tibet. These data shed new light on the petrogenesis of the pluton. Our SHRIMP zircon U-Pb age dates, along with LA-ICPMS zircon U-Pb age dates recently reported in the literature, indicate that the Zayu pluton was emplaced at about 130 Ma, coeval with Early Cretaceous magmatic rocks in other areas of eastern Gangdese (e.g., Rawu, Baxoi areas) and the Middle Gangdese. The Zayu pluton samples lack amphibole and muscovite, and are compositionally characterized by high SiO2 (69.9%–76.8%), K2O (4.4%–5.7%), and low P2O5 (0.05%–0.12%). These samples also have A/CNK values of 1.00–1.05, and are enriched in Rb, Th, U, and Pb, and depleted in Ba, Nb, Ta, Sr, P, Ti, and Eu. These geochemical features suggest that the Zayu pluton samples are metaluminous to slightly peraluminous and are of highly fractionated I-type granite. The Zayu pluton samples have high ? Nd(t) values (?10.9–?7.6) and low initial 87Sr/86Sr ratios (0.7120–0.7179) relative to melts derived from mature continental crust in the Gangdese (e.g., Ningzhong Early Jurassic strongly peraluminous granite). The Zayu pluton samples are heterogeneous in zircon ? Hf(t) values (?12.8–?2.9), yielding ancient zircon Hf crustal model ages of 1.4–2.0 Ga. The data obtained in this study together with the data in the recent literature suggest that the Early Cretaceous granitoids in eastern Gangdese represent the eastward extension of the Early Cretaceous magmatism in the middle Gangdese, and that the Lhasa micro-continent block with ancient basement may extend for ~2000 km from east to west. Zircon Hf isotopic data and bulk-rock zircon saturation temperature (789–821 °C) indicate that mantle-derived materials likely played a role in the generation of the Zayu pluton. We propose that the Zayu pluton was most likely generated in a setting associated with southward subduction of the Bangong-Nujiang ocean floor, where mantle wedge-derived magmas may have provided the heat and material for the anatexis of ancient crust of the Lhasa micro-continent, resulted in hybrid melts (i.e., mantle-derived basaltic magmas + crust-derived felsic magmas). Such hybrid melts with subsequent fractional crystallization are responsible for the highly evolved Zayu pluton (crust thickening is not a prerequisite). 展开更多
关键词 zircon U-Pb dating Sr-Nd-Hf isotope HIGHLY fractionated i-type granite Zayu PLUTON EASTERN GANGDESE TIBET
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1例Stanford A型主动脉夹层术后患者的心肺康复护理
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作者 刘静 胡晓红 +3 位作者 胡佳惠 韩梅 张童 惠佩佩 《中西医结合护理》 2026年第1期25-30,共6页
总结1例Stanford A型主动脉夹层术后患者Ⅰ期心肺康复的个体化护理策略及临床效果。回顾1例接受“孙氏手术”联合冠脉搭桥术的Stanford A型主动脉夹层患者的临床资料。患者术后24 h内完成多维度风险评估,组建跨学科康复团队,实施分阶段... 总结1例Stanford A型主动脉夹层术后患者Ⅰ期心肺康复的个体化护理策略及临床效果。回顾1例接受“孙氏手术”联合冠脉搭桥术的Stanford A型主动脉夹层患者的临床资料。患者术后24 h内完成多维度风险评估,组建跨学科康复团队,实施分阶段康复方案,涵盖呼吸训练、运动康复、心理干预及健康教育等模块。经过14 d的系统化康复护理,患者在心肺功能、活动能力及心理状态方面均得以改善,且住院期间未发生肺部感染、深静脉血栓、伤口感染等并发症。基于多学科协作的分阶段个体化Ⅰ期心肺康复方案可改善Stanford A型主动脉夹层术后患者功能及心理状态,促进患者康复。 展开更多
关键词 Stanford A型主动脉夹层 Ⅰ期心肺康复 多学科协作 术后护理
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大麻素受体Ⅰ对人根尖牙乳头干细胞神经向分化的影响
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作者 刘紫薇 尼加提·吐尔逊 +2 位作者 殷瑞 李淑慧 周晶 《中国组织工程研究》 北大核心 2026年第1期93-100,共8页
背景:研究证实大麻素受体Ⅰ能够促进神经干细胞和间充质干细胞的增殖及神经向分化,也可以调节人根尖牙乳头干细胞的增殖和矿化能力。然而,关于大麻素受体Ⅰ过表达对人根尖牙乳头干细胞神经分化的影响,目前国内外相关研究较少。目的:探... 背景:研究证实大麻素受体Ⅰ能够促进神经干细胞和间充质干细胞的增殖及神经向分化,也可以调节人根尖牙乳头干细胞的增殖和矿化能力。然而,关于大麻素受体Ⅰ过表达对人根尖牙乳头干细胞神经分化的影响,目前国内外相关研究较少。目的:探讨大麻素受体Ⅰ在体外环境下对人根尖牙乳头干细胞神经向分化能力的影响。方法:收集因正畸治疗需要拔除的根尖尚未完全发育成熟的健康第三磨牙,采用组织块法和酶消化法进行原代人根尖牙乳头干细胞的分离培养。通过慢病毒介导的转染技术,将大麻素受体Ⅰ基因引入人根尖牙乳头干细胞中,设置空白对照组、阴性对照组和过表达大麻素受体Ⅰ组,通过Western blot验证过表达大麻素受体Ⅰ慢病毒转染效果;设置对照组、阴性对照组、过表达大麻素受体Ⅰ组和过表达大麻素受体Ⅰ+AM251(大麻素受体Ⅰ拮抗剂)组,分别在成神经诱导第1,5,10天采用CCK-8法检测细胞增殖能力,成神经诱导第10天采用qRT-PCR检测TH、NeuroD-1、NCAM1基因表达水平以及免疫荧光检测Nestin、TUBB3蛋白表达。结果与结论:①与空白对照组和阴性对照组相比,过表达大麻素受体Ⅰ组大麻素受体Ⅰ蛋白表达量明显升高,差异有显著性意义(P<0.05);②与空白对照组和阴性对照组相比,成神经诱导第5,10天时,过表达大麻素受体Ⅰ组人根尖牙乳头干细胞的增殖能力最强(P<0.05);③与空白对照组和阴性对照组相比,过表达大麻素受体Ⅰ组人根尖牙乳头干细胞中NeuroD-1、NCAM1、TH mRNA表达量显著增加,Nestin和TUBB3荧光强度显著增强(P<0.05);④与过表达大麻素受体Ⅰ组相比,过表达大麻素受体Ⅰ+AM251组人根尖牙乳头干细胞增殖能力显著下降,NeuroD-1、NCAM1、TH mRNA表达量以及Nestin、TUBB3荧光强度显著降低(P<0.05)。结果表明:过表达大麻素受体Ⅰ能促进人根尖牙乳头干细胞的增殖及神经向分化。 展开更多
关键词 人根尖牙乳头干细胞 牙乳头 大麻素受体Ⅰ 神经分化 增殖 慢病毒 AM251 神经损伤
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纳米晶胶原基骨联合补肾壮筋汤修复骨质疏松大鼠骨缺损
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作者 周世博 俞兴 +1 位作者 陈海龙 熊洋 《中国组织工程研究》 北大核心 2026年第2期354-361,共8页
背景:课题组前期研究证实,补肾壮筋汤可以调节骨代谢并发挥抗骨质疏松作用,纳米晶胶原基骨可以辅助四肢骨缺损的修复。目的:探索纳米晶胶原基骨联合补肾壮筋汤对骨质疏松骨缺损的修复作用。方法:将84只雌性SD大鼠随机分为假手术组(n=6,... 背景:课题组前期研究证实,补肾壮筋汤可以调节骨代谢并发挥抗骨质疏松作用,纳米晶胶原基骨可以辅助四肢骨缺损的修复。目的:探索纳米晶胶原基骨联合补肾壮筋汤对骨质疏松骨缺损的修复作用。方法:将84只雌性SD大鼠随机分为假手术组(n=6,不造模)和双侧卵巢切除组(n=78),双侧卵巢切除12周后选取假手术组(n=6)、双侧卵巢切除组(n=6)进行骨质疏松造模验证。将双侧卵巢切除组剩余的72只大鼠随机分6组干预,每组12只:A-E组双侧卵巢切除12周后建立股骨缺损(直径3.5 mm,深度4 mm)模型,A组术后给予双蒸水灌胃(1次/d),B组术后给予补肾壮筋汤灌胃(1次/d),C组骨缺损部位填充纳米晶胶原基骨后给予双蒸水灌胃(1次/d),D组骨缺损部位填充纳米晶胶原基骨后给予阿仑膦酸钠灌胃(1次/周),E组骨缺损部位填充纳米晶胶原基骨后给予补肾壮筋汤灌胃(1次/d);F组双侧卵巢切除同时建立股骨缺损模型,骨缺损部位填充纳米晶胶原基骨后给予补肾壮筋汤灌胃(1次/d),均连续给药12周。末次给药12 h后,检测血清Ⅰ型前胶原氨基端原肽、Ⅰ型胶原交联C-末端肽、雌二醇水平,Micro-CT检测骨缺损区域骨体积,免疫组化染色检测骨缺损区域Ⅰ型胶原及血管内皮生长因子表达。结果与结论:①与A组相比,D、E组血清Ⅰ型前胶原氨基端原肽水平降低(P<0.05);与A、C组相比,D、E、F组血清雌二醇水平升高(P<0.05);A-F组缺损区域内骨体积比较差异无显著性意义(P>0.05);②免疫组化染色显示,与A组相比,B、D、E组Ⅰ型胶原与血管内皮生长因子表达均增加(P<0.05);与C组相比,B、D、E、F组Ⅰ型胶原表达增加(P<0.05),D、E、F组血管内皮生长因子表达增加(P<0.05);③结果表明,纳米晶胶原基骨联合补肾壮筋汤可能具备修复去卵巢骨质疏松大鼠骨缺损的潜在作用。 展开更多
关键词 补肾壮筋汤 骨质疏松骨缺损 纳米晶胶原基骨 Ⅰ型胶原 血管内皮细胞生长因子 工程化骨材料
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基于Kano模型的养生壶设计研究
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作者 杨宗霖 左洪亮 席乐 《工业设计》 2026年第2期47-51,共5页
当前,养生理念逐渐成为社会关注的焦点,养生壶设计也亟须深入挖掘用户需求,实现精准定位。为有效探究产品造型与功能要素,研究引入了Kano模型和数量化一类理论,旨在设计开发过程中更精准地回应用户关切点。首先,通过收集样本对养生壶的... 当前,养生理念逐渐成为社会关注的焦点,养生壶设计也亟须深入挖掘用户需求,实现精准定位。为有效探究产品造型与功能要素,研究引入了Kano模型和数量化一类理论,旨在设计开发过程中更精准地回应用户关切点。首先,通过收集样本对养生壶的结构与功能进行细致分类,设计并发放Kano问卷,以广泛收集用户反馈,进而明确用户需求的优先级;其次,运用数量化一类理论对收集到的需求进行深入分析,最终归纳出适用于养生壶的设计策略。实例验证表明,基于此理论设计的产品能够更好地契合用户需求和偏好,不仅验证了该设计思路的可行性,而且为养生产品的需求挖掘与分析提供了新的参考方向。 展开更多
关键词 工业设计 KANO模型 数量化一类 养生壶设计
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小兴安岭北部地区晚石炭世花岗岩年代学、地球化学特征及其对嫩江洋闭合模式的新启示
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作者 赵立东 马天宇 +3 位作者 齐红伟 李旭东 于献章 李博 《地质与勘探》 北大核心 2026年第1期92-110,共19页
小兴安岭北部地区大地构造上位于松嫩地块,九水山-小兴安侵入岩弧。该区侵入岩对研究嫩江洋的俯冲过程及机制有重要的约束意义。本文通过对小兴安岭北部地区碱长花岗岩和二长花岗岩开展锆石U-Pb年代学及岩石地球化学研究,确定了侵入岩... 小兴安岭北部地区大地构造上位于松嫩地块,九水山-小兴安侵入岩弧。该区侵入岩对研究嫩江洋的俯冲过程及机制有重要的约束意义。本文通过对小兴安岭北部地区碱长花岗岩和二长花岗岩开展锆石U-Pb年代学及岩石地球化学研究,确定了侵入岩的形成时代,探讨了岩石成因及大地构造背景。测年结果显示,研究区的碱长花岗岩和二长花岗岩均显示为309~298 Ma的晚石炭世岩浆演化事件。地球化学分析结果表明,研究区晚石炭世碱长花岗岩、二长花岗岩均具有高分异的特点。综合研究表明,研究区的碱长花岗岩(位于贺根山-黑河缝合带东南侧)为A型花岗岩,二长花岗岩为高分异I型花岗岩,与龙江、嫩江、塔西一带晚石炭世造山后伸展背景下的I型和A型花岗岩类型一致。这说明嫩江洋在小兴安岭北部一带于晚石炭世闭合完毕,进入伸展阶段,同时显示出嫩江洋也存在向东南方向松嫩地块的俯冲作用。这一发现为嫩江洋闭合的双向俯冲模式提供了有力证据。 展开更多
关键词 锆石U-PB年代学 A型花岗岩 I型花岗岩 双向俯冲 嫩江洋 晚石炭世 小兴安岭北部
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多发性骨髓瘤患者血清MuC1、PINP、sFLC与临床分期、免疫分型的关系及对预后的预测价值
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作者 黄建霞 张国梁 +5 位作者 张菊山 王燕 吴庆 吴彬章 杜明虎 王玉霞 《实用医学杂志》 北大核心 2026年第3期504-510,共7页
目的探讨多发性骨髓瘤患者血清黏蛋白1(MuC1)、Ⅰ型前胶原氨基端延长肽(PINP)、游离轻链(sFLC)与临床分期、免疫分型的关系及对预后的预测价值。方法选取2020年7月至2024年5月武威市人民医院收治的220例多发性骨髓瘤患者作为病例组,均... 目的探讨多发性骨髓瘤患者血清黏蛋白1(MuC1)、Ⅰ型前胶原氨基端延长肽(PINP)、游离轻链(sFLC)与临床分期、免疫分型的关系及对预后的预测价值。方法选取2020年7月至2024年5月武威市人民医院收治的220例多发性骨髓瘤患者作为病例组,均根据国际分期系统(ISS)明确分为Ⅰ期26例、Ⅱ期82例和Ⅲ期112例;根据免疫分型明确分为免疫球蛋白(Ig)A型52例、IgG型96例、轻链型47例和非分泌型25例,同时根据治疗随访12个月内患者预后情况分为预后不良组(55例)和预后良好组(165例)。另按照1∶1比例选取同期健康体检者220名作为对照组。比较病例组、对照组临床资料及血清MuC1、PINP、s FLC(包括κ轻链sFLC-κ和λ轻链sFLC-λ),比较不同临床分期及不同免疫分型、不同预后患者血清MuC1、PINP、sFLC水平,并采用受试者工作特征(ROC)曲线分析血清MuC1、PINP、sFLC水平对多发性骨髓瘤患者预后的预测价值。结果病例组血清MuC1、sFLC-κ、sFLC-λ水平均高于对照组,血清PINP水平低于对照组(P<0.05)。Ⅲ期患者血清MuC1、sFLC-κ、sFLC-λ水平高于Ⅰ期、Ⅱ期患者,Ⅱ期患者高于Ⅰ期患者;Ⅲ期患者血清PINP水平低于Ⅰ期、Ⅱ期患者,Ⅱ期患者低于Ⅰ期患者(P<0.05)。IgG型患者血清MuC1、sFLC-κ、sFLC-λ水平均高于IgA型、轻链型、非分泌型患者,血清PINP水平均低于IgA型、轻链型、非分泌型患者(P<0.05)。预后不良组血清MuC1、sFLC-κ、sFLC-λ水平高于预后良好组,血清PINP水平低于预后良好组(P<0.05)。将预后不良纳入阳性,预后良好纳入阴性,血清MuC1、PINP、sFLC-κ、sFLC-λ及联合检测预测多发性骨髓瘤患者预后的曲线下面积(AUC)分别为0.765、0.665、0.753、0.710、0.914,诊断敏感度分别为72.73%、69.09%、72.73%、65.45%、87.27%,特异度分别为69.70%、62.42%、72.12%、73.33%、85.45%,其中联合检测的AUC最高(P<0.05)。结论血清MuC1、PINP、sFLC表达与多发性骨髓瘤的发生、发展及免疫分型有关,且对患者预后预测价值较高,而四者联合检测的预测价值最高。 展开更多
关键词 多发性骨髓瘤 黏蛋白1 Ⅰ型前胶原氨基端延长肽 游离轻链 临床分期 免疫分型 预后 预测价值
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血清sST2、PICP与心血管疾病患者心肌纤维化的关系研究
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作者 李前进 何浪 +1 位作者 王审 邱金海 《心电与循环》 2026年第1期56-60,67,共6页
目的探讨血清可溶性生长刺激表达基因2蛋白(sST2)、Ⅰ型前胶原羧基端原肽(PICP)水平与心血管疾病患者心肌纤维化的关系。方法回顾性选取2023年8月至2024年12月在浙江绿城心血管病医院接受钆延迟增强心脏磁共振检查的32例心血管疾病患者... 目的探讨血清可溶性生长刺激表达基因2蛋白(sST2)、Ⅰ型前胶原羧基端原肽(PICP)水平与心血管疾病患者心肌纤维化的关系。方法回顾性选取2023年8月至2024年12月在浙江绿城心血管病医院接受钆延迟增强心脏磁共振检查的32例心血管疾病患者为观察组,同期本院32名既往无心血管疾病且超声心动图检查显示正常的健康体检者为对照组,比较两组对象血清sST2和PICP水平,采用Spearman秩相关分析sST2、PICP与心脏标志物[包括心肌肌钙蛋白I(cTnI)、氨基末端脑钠肽前体(NT-proBNP)]、心肌纤维化半定量评分百分比、心脏结构功能参数[包括左心房内径、左心室横径、右心房内径、右心室横径、室间隔厚度、左心室射血分数(LVEF)、每搏输出量和心输出量]的相关性。绘制ROC曲线分析血清sST2对心肌纤维化的诊断效能。结果观察组血清sST2和PICP水平均明显高于对照组(均P<0.05)。观察组血清sST2水平与cTnI水平呈正相关(rs=0.484,P=0.012),与NT-proBNP水平未见相关性(P=0.182);血清PICP水平与cTnI、NT-proBNP、sST2水平均未见相关性(均P>0.05)。血清sST2、PICP水平与左心房内径、左心室横径、右心房内径、右心室横径、室间隔厚度、LVEF、每搏输出量、心输出量均未见相关性(均P>0.05)。LGE-CMR检查显示,观察组有23例(71.8%)患者存在心肌纤维化,心肌纤维化半定量评分百分比为14.5%(0,40.0%);血清sST2水平与心肌纤维化半定量评分百分比呈正相关(rs=0.550,P=0.002),血清PICP水平与心肌纤维化半定量评分百分比未见相关性(P=0.865)。存在心肌纤维化患者血清sST2水平明显高于无心肌纤维化患者(P=0.028),但PICP水平两组比较差异无统计学意义(P=0.212)。ROC曲线分析显示,血清sST2诊断心肌纤维化的AUC为0.757(95%CI:0.566~0.894,P=0.004),最佳截断值为22.2 ng/mL,灵敏度、特异度分别为0.667、0.889。结论心血管疾病患者血清sST2水平与心肌纤维化密切相关,有望成为评估心肌纤维化的潜在生物标志物。 展开更多
关键词 可溶性生长刺激表达基因2蛋白 Ⅰ型前胶原羧基端原肽 纤维化 心血管疾病
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