Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献...背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献,为后续以叉头框转录因子O3为靶点治疗骨疾病的研究提供参考。方法:以“(SU=FoxO3a OR SU=Foxo3 OR SU=Forkhead box O3 OR SU=叉头框转录因子O3)AND SU=骨”为检索句在中国知网进行检索,以“主题:(“FoxO3a”)OR主题:(“Foxo3”)OR主题:(“Forkhead box O3”)OR主题:(“叉头框转录因子O3”)AND主题:(“骨”)”为检索句在万方医学数据库进行检索;以“((FoxO3a)OR(Foxo3)OR(Forkhead box O3))AND((bone)OR(Skeleton))”为检索句在PubMed数据库进行检索,排除陈旧、重复、质量较差以及不相关的文献,最终纳入56篇文献进行综述分析。结果与结论:①叉头框转录因子O3与骨髓间充质干细胞:叉头框转录因子O3能够促进成骨谱系的形成,还可通过激活自噬促进早期成骨分化。同时,叉头框转录因子O3在骨髓间充质干细胞中体现抗氧化特性,保护细胞免受氧化应激诱导的衰老。②叉头框转录因子O3与成骨细胞:叉头框转录因子O3在成骨细胞中能通过干扰Wnt/β-连环蛋白通路抑制成骨,同时能激活抗氧化酶保护成熟成骨细胞。叉头框转录因子O3能促进成骨祖细胞的增殖,并通过激活自噬促进成骨分化。③叉头框转录因子O3与破骨细胞:叉头框转录因子O3表达可抵抗氧化应激和激活自噬抑制破骨细胞生成。④叉头框转录因子O3与骨细胞:叉头框转录因子O3可通过抗氧化作用保护骨细胞,还可通过抑制p16和p53信号通路和抑制衰老相关分泌表型来减少骨流失。⑤叉头框转录因子O3与软骨细胞:叉头框转录因子O3在骨关节炎中对软骨细胞起到保护作用,抑制软骨细胞分解或凋亡,促进软骨细胞外基质合成,可抑制软骨细胞肥大;然而,叉头框转录因子O3与Runt相关转录因子1在软骨细胞中高度共表达却会促进软骨祖细胞的早期软骨形成和终末肥大。⑥叉头框转录因子O3通过参与氧化应激抵抗与调控自噬等过程影响骨代谢,参与多类骨相关疾病的病理进程。展开更多
As a key technology to realize smart services of Internet of Things(Io T),network virtualization technology can support the network diversification and ubiquity,and improve the utilization rate of network resources.Th...As a key technology to realize smart services of Internet of Things(Io T),network virtualization technology can support the network diversification and ubiquity,and improve the utilization rate of network resources.This paper studies the service-oriented network virtualization architecture for Io T services.Firstly the semantic description method for Io T services is proposed,then the resource representation model and resource management model in the environment of network virtualization are presented.Based on the above models,the service-oriented virtual network architecture for Io T is established.Finally,a smart campus system is designed and deployed based on the service-oriented virtual network architecture.Moreover,the proposed architecture and models are verified in experiments.展开更多
Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Betwee...Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Between April 2023 and October 2023,we enrolled patients with breast cancer treated in the Department of Breast Cancer and Oncology at Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangdong Province.The patients were randomly divided into an intervention group(n=118)and a control group(n=119)using block randomization.The intervention group received the VR intervention 3-5 times over 5±2 weeks using natural landscapes with music or relaxation guidance,and the duration of each VR intervention was 15±3 min.The control group received routine nursing care,including disease education and psychological counseling.Patients were assessed using the Type D Scale,Positive and Negative Affect Scale,and Distress Thermometer,and adverse events during the intervention were recorded.Results:Overall,85 patients completed the study(44 in the intervention group and 41 in the control group).Patients with Type D personalities showed more negative emotions[25.0(21.5,27.5)vs.19.0(16.0,24.0),P=0.001]and distressed attitudes[4.0(2.0,5.0)vs.3.0(1.0,4.0),P=0.020]with fewer positive emotions(27.2±5.6 vs.31.0±5.9,P=0.014)than those with non-Type D personalities.Total population analysis revealed no significant differences between the groups.However,in the subgroup analysis,patients with Type D personalities in the intervention group showed greater relief from negative emotions than those in the control group[median difference,-5.0(-9.0,-2.5)vs.-2.0(-4.0,2.0),P=0.046].No significant differences were found between groups of patients with non-Type D personality traits.The proportion of adverse events was not significantly different between groups(P=0.110).Conclusions:Breast cancer patients with Type D personalities suffer more severe negative emotions and distress,and more attention should be paid to them.VR intervention significantly and safely reduced negative emotions in patients with Type D personalities.展开更多
Network Functions Virtualization(NFV) is an attempt to help operators more effectively manage their networks by implementing traditional network functions embedded in specialized hardware platforms in term of virtuali...Network Functions Virtualization(NFV) is an attempt to help operators more effectively manage their networks by implementing traditional network functions embedded in specialized hardware platforms in term of virtualized software instances. But, existing novel network appliances designed for NFV infrastructure are always architected on a general-purpose x86 server, which makes the performance of network functions limited by the hosted single server. To address this challenge, we propose ApplianceB ricks, a novel NFV-enable network appliance architecture that is used to explore the way of consolidating multiple physical network functions into a clustered network appliance, which is able to improve the processing capability of NFV-enabled network appliances.展开更多
In this paper, we propose a trusted mobile payment environment （TMPE） based on trusted computing and virtualization technology. There are a normal operating system （OS） and a trusted OS （TOS） in TMPE. We store t...In this paper, we propose a trusted mobile payment environment （TMPE） based on trusted computing and virtualization technology. There are a normal operating system （OS） and a trusted OS （TOS） in TMPE. We store the image of TOS in a memory card to hinder tampering. The integrity of TOS is protected by means of a trusted platform module （TPM）. TOS can only be updated through a trusted third party. In addition, virtualization technology is applied to isolate TOS from normal OS. Users complete ordinary affairs in normal OS and security-sensitive affairs in TOS. TMPE can offer users a highly protected environment for mobile payment. Moreover, TMPE has good compatibility in different hardware architectures of mobile platforms. As the evaluation shows, TMPE satisfies the requirement of mobile payment well.展开更多
As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impeda...As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impedance ratio(R/X)is high and affects the transient power angle stability of VSG,this paper proposes a VSG transient power angle stability control strategy based on the combination of frequency difference feedback and virtual impedance.To improve the transient power angle stability of the VSG,a virtual impedance is adopted in the voltage loop to adjust the impedance ratio R/X;and the PI control feedback of the VSG frequency difference is introduced in the reactive powervoltage link of theVSGto enhance the damping effect.Thesecond-orderVSGdynamic nonlinearmodel considering the reactive power-voltage loop is established and the influence of different proportional integral(PI)control parameters on the system balance stability is analyzed.Moreover,the impact of the impedance ratio R/X on the transient power angle stability is presented using the equal area criterion.In the simulations,during the voltage dips with the reduction of R/X from 1.6 to 0.8,Δδ_(1)is reduced from 0.194 rad to 0.072 rad,Δf_(1)is reduced from 0.170 to 0.093 Hz,which shows better transient power angle stability.Simulation results verify that compared with traditional VSG,the proposedmethod can effectively improve the transient power angle stability of the system.展开更多
Since virtualization technology enables the abstraction and sharing of resources in a flexible management way, the overall expenses of network deployment can be significantly reduced. Therefore, the technology has bee...Since virtualization technology enables the abstraction and sharing of resources in a flexible management way, the overall expenses of network deployment can be significantly reduced. Therefore, the technology has been widely applied in the core network. With the tremendous growth in mobile traffic and services, it is natural to extend virtualization technology to the cloud computing based radio access networks(CCRANs) for achieving high spectral efficiency with low cost.In this paper, the virtualization technologies in CC-RANs are surveyed, including the system architecture, key enabling techniques, challenges, and open issues. The enabling key technologies for virtualization in CC-RANs mainly including virtual resource allocation, radio access network(RAN) slicing, mobility management, and social-awareness have been comprehensively surveyed to satisfy the isolation, customization and high-efficiency utilization of radio resources. The challenges and open issues mainly focus on virtualization levels for CC-RANs, signaling design for CC-RAN virtualization, performance analysis for CC-RAN virtualization, and network security for virtualized CC-RANs.展开更多
The concept of virtualization machines is not new, but it is increasing vastly and gaining popularity in the IT world. Hypervisors are also popular for security as a means of isolation. The virtualization of informati...The concept of virtualization machines is not new, but it is increasing vastly and gaining popularity in the IT world. Hypervisors are also popular for security as a means of isolation. The virtualization of information technology infrastructure creates the enablement of IT resources to be shared and used on several other devices and applications;this increases the growth of business needs. The environment created by virtualization is not restricted to any configuration physically or execution. The resources of a computer are shared logically. Hypervisors help in virtualization of hardware that is a software interact with the physical system, enabling or providing virtualized hardware environment to support multiple running operating system simultaneously utilizing one physical server. This paper explores the benefits, types and security issues of Virtualization Hypervisor in virtualized hardware environment.展开更多
In order to reduce cost and complexity,fiber-wireless(FiWi)networks emerge,combining the huge amount of available bandwidth of fiber networks and the flexibility,mobility of wireless networks.However,there is still a ...In order to reduce cost and complexity,fiber-wireless(FiWi)networks emerge,combining the huge amount of available bandwidth of fiber networks and the flexibility,mobility of wireless networks.However,there is still a long way to go before taking fiber and wireless systems as fully integrated networks.In this paper,we propose a network visualization based seamless networking scheme for FiWi networks,including hierarchical model,service model,service implementation and dynamic bandwidth assignment(DBA).Then,we evaluate the performance changes after network virtualization is introduced.Throughput for nodes,bandwidth for links and overheads leaded by network virtualization are analyzed.The performance of our proposed networking scheme is evaluated by simulation and real implementations,respectively.The results show that,compared to traditional networking scheme,our scheme has a better performance.展开更多
The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing ...The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the patient.It also reduces burden on nursing staff and counsellors.Larger and more diverse cohort studies will help us understand the wider application of this tool on the patient population.It may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical comorbidities.Also,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for counselling.We will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.展开更多
This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by em...This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by employing the algorithms of chunking image file into blocks, the blockffmger calculation and the block dedup li cation. A File system in Use Space （FUSE） based storage process for VDeskCAS is also introduced which optimizes current direct storage to suit our content addressable storage. An interface level modification makes our system easy to extend. Experiments on virtual desktop image files and normal files verify the effectiveness of our method and above 60% storage volume decrease is a chieved for Red Hat Enterprise Linux image files. Key words： disaster backup; desktop virtualization; storage optimization; content addressable storage展开更多
The evolution of airborne tactical networks(ATNs)is impeded by the network ossification problem.As a solution,network virtualization(NV)can provide a flexible and scalable architecture where virtual network embedding(...The evolution of airborne tactical networks(ATNs)is impeded by the network ossification problem.As a solution,network virtualization(NV)can provide a flexible and scalable architecture where virtual network embedding(VNE)is a key part.However,existing VNE algorithms cannot be optimally adopted in the virtualization of ATN due to the complex interference in aircombat field.In this context,a highly reliable VNE algorithm based on the transmission rate for ATN virtualization(TR-ATVNE)is proposed to adapt well to the specific electromagnetic environment of ATN.Our algorithm coordinates node and link mapping.In the node mapping,transmission-rate resource is firstly defined to effectively evaluate the ranking value of substrate nodes under the interference of both environmental noises and enemy attacks.Meanwhile,a feasible splitting rule is proposed for path splitting in the link mapping,considering the interference between wireless links.Simulation results reveal that our algorithm is able to improve the acceptance ratio of virtual network requests while maintaining a high revenue-to-cost ratio under the complex electromagnetic interference.展开更多
It is absolutely critical that trusted configuration management which significantly affects trust chain establishment, sealing storage and remote attestation, especially in trusted virtualization platform like Xen who...It is absolutely critical that trusted configuration management which significantly affects trust chain establishment, sealing storage and remote attestation, especially in trusted virtualization platform like Xen whose system configuration changes easily. TPM （trusted platform module） context manager is presented to carry out dynamic configuration management for virtual machine. It manages the TPM command requests and VM （virtual machine） configurations. The dynamic configuration representa- tion method based on Merkle hash tree is explicitly proposed against TCG （trusted computing group） static configuration representation. It reflects the true VM status in real time even if the configuration has changed, and it eliminates the invalidation of configuration representation, sealing storage and remote attestation. TPM context manager supports TCG storage protection, remote attestation etc, which greatly enhances the security on trusted virtualization platform.展开更多
5G is a new generation of mobile networking that aims to achieve unparalleled speed and performance. To accomplish this, three technologies, Device-to-Device communication (D2D), multi-access edge computing (MEC) and ...5G is a new generation of mobile networking that aims to achieve unparalleled speed and performance. To accomplish this, three technologies, Device-to-Device communication (D2D), multi-access edge computing (MEC) and network function virtualization (NFV) with ClickOS, have been a significant part of 5G, and this paper mainly discusses them. D2D enables direct communication between devices without the relay of base station. In 5G, a two-tier cellular network composed of traditional cellular network system and D2D is an efficient method for realizing high-speed communication. MEC unloads work from end devices and clouds platforms to widespread nodes, and connects the nodes together with outside devices and third-party providers, in order to diminish the overloading effect on any device caused by enormous applications and improve users’ quality of experience (QoE). There is also a NFV method in order to fulfill the 5G requirements. In this part, an optimized virtual machine for middle-boxes named ClickOS is introduced, and it is evaluated in several aspects. Some middle boxes are being implemented in the ClickOS and proved to have outstanding performances.展开更多
Virtualization has gained great acceptance in the server and cloud computing arena. In recent years, it has also been widely applied to real-time embedded systems with stringent timing constraints. We present a compre...Virtualization has gained great acceptance in the server and cloud computing arena. In recent years, it has also been widely applied to real-time embedded systems with stringent timing constraints. We present a comprehensive survey on real-time issues in virtualization for embedded systems, covering popular virtualization systems including KVM, Xen, L4 and others.展开更多
为探究稻茬小麦深施肥“一基一追”机艺融合技术的增产增效减排机制,2021—2024年在长江下游南通稻茬麦区开展大田试验。试验采用缓释掺混肥料(SRF,N∶P_(2)O_(5)∶K_(2)O=26∶12∶12)和普通尿素(U,46%N),结合自主研发的2BFGK-12(6)260...为探究稻茬小麦深施肥“一基一追”机艺融合技术的增产增效减排机制,2021—2024年在长江下游南通稻茬麦区开展大田试验。试验采用缓释掺混肥料(SRF,N∶P_(2)O_(5)∶K_(2)O=26∶12∶12)和普通尿素(U,46%N),结合自主研发的2BFGK-12(6)260全秸秆茬地洁区旋耕智能施肥播种机和3ZF-4(200)中耕追肥机,设置7种施肥模式(30 cm+15 cm宽窄行种植):以尿素4次分施(N 240 kg hm^(-2),基肥∶分蘖肥∶拔节肥∶孕穗肥=5∶1∶2∶2,窄行基施,追肥全田撒施)为对照(CK);减氮15%(N 204 kg hm^(-2))条件下设置6种处理:M_(1)(100%SRF窄行基施);M_(2)(60%SRF窄行基施+40%U拔节期窄行撒施);M_(3)(60%SRF窄行基施+40%U返青期宽行条施);M_(4)(60%SRF窄行基施+40%SRF返青期窄行撒施);M_(5)(60%SRF窄行基施+40%SRF返青期宽行条施);M_(4+5)(60%SRF窄行基施+20%SRF返青期宽行条施+20%SRF返青期窄行撒施)。研究比较不同施肥模式对小麦产量效益、根系形态生理、氮素利用效率及N_(2)O排放的影响。结果表明,与CK相比,M_(2)~M_(5)处理提高了小麦产量(4.0%~19.0%)和经济效益(13.7%~35.7%),其中M_(4)和M_(5)处理表现最优,分别增产14.1%和19.0%,经济效益提升34.5%和35.7%。这些处理明显改善了根系特性(根干重密度增加9.7%~111.8%,根系活力和氧化力分别提高6.8%~52.0%和4.2%~44.2%),降低N_(2)O累积排放量22.6%~34.5%,提高0~20 cm土层硝态氮含量11.2%~40.0%。在氮素利用方面,M_(2)~M_(5)处理均提高了籽粒氮素积累量、花后氮素积累量及其对籽粒氮素的贡献率,氮肥利用效率指标(包括偏生产力、农学效率和表观利用率)分别显著提升了22.4%~40.0%、29.7%~74.3%和9.41~18.77个百分点。值得注意的是,M_(4)和M_(5)处理表现出最优的综合效益:N_(2)O累积排放量降幅最大(分别达27.0%和34.5%),氮肥表观利用率2季均维持在43.0%以上(均值分别为43.5%和46.8%),同时在生育后期保持较高的根系活性和耕层无机氮含量。相比之下,M_(1)处理虽然实现了最大的N_(2)O减排效果(降幅35.9%),但导致减产10.4%和经济效益下降10.8%,且氮肥利用效率呈现不稳定的年际变化特征。而优化处理M_(4+5)进一步改善了根系形态生理特性,并提高氮肥表观利用率和籽粒氮素积累量。综上,减氮15%条件下(N 204 kg hm^(-2)),缓混肥2次施用处理(M_(4)和M_(5))能实现产量、经济效益、氮肥利用效率和N_(2)O减排的协同提高,并以追肥深施处理(M_(5))效应更强。本研究为稻茬小麦缓释肥减氮优化高效应用提供重要理论依据。展开更多
Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Speci...Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Specifically, it examined whether VR-based OKS could reduce visual dependency more effectively than visual deprivation through eye closure. Methods: Ten healthy adults participated in this study. A balance function meter was used to measure postural stability, including Romberg ratios before and after two conditions: VR-based OKS (VR + OKS) and eye closure (EC). Participants performed a two-minute standing task under each condition in random order, with adequate rest between tasks. In the VR + OKS condition, a smartphone-based VR headset presented a rotational OKS, while in the EC condition, participants stood with their eyes closed. Statistical analyses were conducted using paired t-tests to compare pre- and post-task Romberg ratios. Results: No significant differences were observed in the pre-task Romberg ratios between conditions. After the VR + OKS condition, significant reductions in Romberg A and Romberg V were observed. In contrast, no significant changes were noted in Romberg ratios after the EC condition. Conclusion: VR-based OKS significantly reduced visual dependency, as indicated by decreased Romberg ratios, suggesting its potential to facilitate sensory reweighting during postural control. These findings highlight the utility of low-cost VR devices in balance rehabilitation for conditions involving high visual dependency. Future studies should expand on this preliminary research by including larger sample sizes and diverse populations to confirm its clinical applicability.展开更多
This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)syste...This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)system connected to the local grid.The study focuses on Dakhla,Morocco,a region with vast untapped renewable energy potential.By leveraging GIS,we are innovatively analyzing geographical and environmental factors that influence optimal site selection and system design.The incorporation of VR technologies offers an unprecedented level of realism and immersion,allowing stakeholders to virtually experience the project's impact and design in a dynamic,interactive environment.This novel methodology includes extensive data collection,advanced modeling,and simulations,ensuring that the hybrid system is precisely tailored to the unique climatic and environmental conditions of Dakhla.Our analysis reveals that the region possesses a photovoltaic solar potential of approximately2400 k Wh/m^(2) per year,with an average annual wind power density of about 434 W/m^(2) at an 80-meter hub height.Productivity simulations indicate that the 20 MW hybrid system could generate approximately 60 GWh of energy per year and 1369 GWh over its 25-year lifespan.To validate these findings,we employed the System Advisor Model(SAM)software and the Global Solar Photovoltaic Atlas platform.This comprehensive and interdisciplinary approach not only provides a robust assessment of the system's feasibility but also offers valuable insights into its potential socio-economic and environmental impact.展开更多
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
文摘背景:骨代谢紊乱会引起骨相关疾病的发生,而叉头框转录因子O3可以通过调节氧化应激、自噬水平等来影响骨组织细胞增殖、分化与凋亡,调控骨代谢过程。目的:系统性分析叉头框转录因子O3调控骨代谢及其在骨科疾病中作用机制的相关研究文献,为后续以叉头框转录因子O3为靶点治疗骨疾病的研究提供参考。方法:以“(SU=FoxO3a OR SU=Foxo3 OR SU=Forkhead box O3 OR SU=叉头框转录因子O3)AND SU=骨”为检索句在中国知网进行检索,以“主题:(“FoxO3a”)OR主题:(“Foxo3”)OR主题:(“Forkhead box O3”)OR主题:(“叉头框转录因子O3”)AND主题:(“骨”)”为检索句在万方医学数据库进行检索;以“((FoxO3a)OR(Foxo3)OR(Forkhead box O3))AND((bone)OR(Skeleton))”为检索句在PubMed数据库进行检索,排除陈旧、重复、质量较差以及不相关的文献,最终纳入56篇文献进行综述分析。结果与结论:①叉头框转录因子O3与骨髓间充质干细胞:叉头框转录因子O3能够促进成骨谱系的形成,还可通过激活自噬促进早期成骨分化。同时,叉头框转录因子O3在骨髓间充质干细胞中体现抗氧化特性,保护细胞免受氧化应激诱导的衰老。②叉头框转录因子O3与成骨细胞:叉头框转录因子O3在成骨细胞中能通过干扰Wnt/β-连环蛋白通路抑制成骨,同时能激活抗氧化酶保护成熟成骨细胞。叉头框转录因子O3能促进成骨祖细胞的增殖,并通过激活自噬促进成骨分化。③叉头框转录因子O3与破骨细胞:叉头框转录因子O3表达可抵抗氧化应激和激活自噬抑制破骨细胞生成。④叉头框转录因子O3与骨细胞:叉头框转录因子O3可通过抗氧化作用保护骨细胞,还可通过抑制p16和p53信号通路和抑制衰老相关分泌表型来减少骨流失。⑤叉头框转录因子O3与软骨细胞:叉头框转录因子O3在骨关节炎中对软骨细胞起到保护作用,抑制软骨细胞分解或凋亡,促进软骨细胞外基质合成,可抑制软骨细胞肥大;然而,叉头框转录因子O3与Runt相关转录因子1在软骨细胞中高度共表达却会促进软骨祖细胞的早期软骨形成和终末肥大。⑥叉头框转录因子O3通过参与氧化应激抵抗与调控自噬等过程影响骨代谢,参与多类骨相关疾病的病理进程。
基金supported by the national 973 project of China under Grants 2013CB329104the Natural Science Foundation of China under Grants 61372124,61427801,61271237,61271236Jiangsu Collaborative Innovation Center for Technology and Application of Internet of Things under Grants SJ213003
文摘As a key technology to realize smart services of Internet of Things(Io T),network virtualization technology can support the network diversification and ubiquity,and improve the utilization rate of network resources.This paper studies the service-oriented network virtualization architecture for Io T services.Firstly the semantic description method for Io T services is proposed,then the resource representation model and resource management model in the environment of network virtualization are presented.Based on the above models,the service-oriented virtual network architecture for Io T is established.Finally,a smart campus system is designed and deployed based on the service-oriented virtual network architecture.Moreover,the proposed architecture and models are verified in experiments.
基金supported by a project of the National Natural Science Foundation of China:Research on the integration of artificial intelligence and virtual reality technology to promote psychological rehabilitation of breast cancer patients with different personalities(project approval no.82073408).
文摘Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Between April 2023 and October 2023,we enrolled patients with breast cancer treated in the Department of Breast Cancer and Oncology at Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangdong Province.The patients were randomly divided into an intervention group(n=118)and a control group(n=119)using block randomization.The intervention group received the VR intervention 3-5 times over 5±2 weeks using natural landscapes with music or relaxation guidance,and the duration of each VR intervention was 15±3 min.The control group received routine nursing care,including disease education and psychological counseling.Patients were assessed using the Type D Scale,Positive and Negative Affect Scale,and Distress Thermometer,and adverse events during the intervention were recorded.Results:Overall,85 patients completed the study(44 in the intervention group and 41 in the control group).Patients with Type D personalities showed more negative emotions[25.0(21.5,27.5)vs.19.0(16.0,24.0),P=0.001]and distressed attitudes[4.0(2.0,5.0)vs.3.0(1.0,4.0),P=0.020]with fewer positive emotions(27.2±5.6 vs.31.0±5.9,P=0.014)than those with non-Type D personalities.Total population analysis revealed no significant differences between the groups.However,in the subgroup analysis,patients with Type D personalities in the intervention group showed greater relief from negative emotions than those in the control group[median difference,-5.0(-9.0,-2.5)vs.-2.0(-4.0,2.0),P=0.046].No significant differences were found between groups of patients with non-Type D personality traits.The proportion of adverse events was not significantly different between groups(P=0.110).Conclusions:Breast cancer patients with Type D personalities suffer more severe negative emotions and distress,and more attention should be paid to them.VR intervention significantly and safely reduced negative emotions in patients with Type D personalities.
基金supported by Program for National Basic Research Program of China (973 Program) "Reconfigurable Network Emulation Testbed for Basic Network Communication"
文摘Network Functions Virtualization(NFV) is an attempt to help operators more effectively manage their networks by implementing traditional network functions embedded in specialized hardware platforms in term of virtualized software instances. But, existing novel network appliances designed for NFV infrastructure are always architected on a general-purpose x86 server, which makes the performance of network functions limited by the hosted single server. To address this challenge, we propose ApplianceB ricks, a novel NFV-enable network appliance architecture that is used to explore the way of consolidating multiple physical network functions into a clustered network appliance, which is able to improve the processing capability of NFV-enabled network appliances.
基金Supported by the National Basic Research Program of China(973 Program)(2014CB340600)the National Natural Science Foundation of China(61173138,61103628,61103220)the Intel Collaborative Research Project
文摘In this paper, we propose a trusted mobile payment environment （TMPE） based on trusted computing and virtualization technology. There are a normal operating system （OS） and a trusted OS （TOS） in TMPE. We store the image of TOS in a memory card to hinder tampering. The integrity of TOS is protected by means of a trusted platform module （TPM）. TOS can only be updated through a trusted third party. In addition, virtualization technology is applied to isolate TOS from normal OS. Users complete ordinary affairs in normal OS and security-sensitive affairs in TOS. TMPE can offer users a highly protected environment for mobile payment. Moreover, TMPE has good compatibility in different hardware architectures of mobile platforms. As the evaluation shows, TMPE satisfies the requirement of mobile payment well.
基金supported by theMajor Science and Technology Projects of China Southern Power Grid(Grant number CGYKJXM20210328).
文摘As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impedance ratio(R/X)is high and affects the transient power angle stability of VSG,this paper proposes a VSG transient power angle stability control strategy based on the combination of frequency difference feedback and virtual impedance.To improve the transient power angle stability of the VSG,a virtual impedance is adopted in the voltage loop to adjust the impedance ratio R/X;and the PI control feedback of the VSG frequency difference is introduced in the reactive powervoltage link of theVSGto enhance the damping effect.Thesecond-orderVSGdynamic nonlinearmodel considering the reactive power-voltage loop is established and the influence of different proportional integral(PI)control parameters on the system balance stability is analyzed.Moreover,the impact of the impedance ratio R/X on the transient power angle stability is presented using the equal area criterion.In the simulations,during the voltage dips with the reduction of R/X from 1.6 to 0.8,Δδ_(1)is reduced from 0.194 rad to 0.072 rad,Δf_(1)is reduced from 0.170 to 0.093 Hz,which shows better transient power angle stability.Simulation results verify that compared with traditional VSG,the proposedmethod can effectively improve the transient power angle stability of the system.
文摘Since virtualization technology enables the abstraction and sharing of resources in a flexible management way, the overall expenses of network deployment can be significantly reduced. Therefore, the technology has been widely applied in the core network. With the tremendous growth in mobile traffic and services, it is natural to extend virtualization technology to the cloud computing based radio access networks(CCRANs) for achieving high spectral efficiency with low cost.In this paper, the virtualization technologies in CC-RANs are surveyed, including the system architecture, key enabling techniques, challenges, and open issues. The enabling key technologies for virtualization in CC-RANs mainly including virtual resource allocation, radio access network(RAN) slicing, mobility management, and social-awareness have been comprehensively surveyed to satisfy the isolation, customization and high-efficiency utilization of radio resources. The challenges and open issues mainly focus on virtualization levels for CC-RANs, signaling design for CC-RAN virtualization, performance analysis for CC-RAN virtualization, and network security for virtualized CC-RANs.
文摘The concept of virtualization machines is not new, but it is increasing vastly and gaining popularity in the IT world. Hypervisors are also popular for security as a means of isolation. The virtualization of information technology infrastructure creates the enablement of IT resources to be shared and used on several other devices and applications;this increases the growth of business needs. The environment created by virtualization is not restricted to any configuration physically or execution. The resources of a computer are shared logically. Hypervisors help in virtualization of hardware that is a software interact with the physical system, enabling or providing virtualized hardware environment to support multiple running operating system simultaneously utilizing one physical server. This paper explores the benefits, types and security issues of Virtualization Hypervisor in virtualized hardware environment.
基金supported by National Natural Science Foundation of China under Grant No.61240040
文摘In order to reduce cost and complexity,fiber-wireless(FiWi)networks emerge,combining the huge amount of available bandwidth of fiber networks and the flexibility,mobility of wireless networks.However,there is still a long way to go before taking fiber and wireless systems as fully integrated networks.In this paper,we propose a network visualization based seamless networking scheme for FiWi networks,including hierarchical model,service model,service implementation and dynamic bandwidth assignment(DBA).Then,we evaluate the performance changes after network virtualization is introduced.Throughput for nodes,bandwidth for links and overheads leaded by network virtualization are analyzed.The performance of our proposed networking scheme is evaluated by simulation and real implementations,respectively.The results show that,compared to traditional networking scheme,our scheme has a better performance.
文摘The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the patient.It also reduces burden on nursing staff and counsellors.Larger and more diverse cohort studies will help us understand the wider application of this tool on the patient population.It may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical comorbidities.Also,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for counselling.We will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.
基金the Hi-tech Research and Development Program of China，the National Natural Science Foundation of China，the Beijing Natural Science Foundation，the Fundamental Research Funds for the Central Universities，the Fund of the State Key Laboratory of Software Development Environment
文摘This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by employing the algorithms of chunking image file into blocks, the blockffmger calculation and the block dedup li cation. A File system in Use Space （FUSE） based storage process for VDeskCAS is also introduced which optimizes current direct storage to suit our content addressable storage. An interface level modification makes our system easy to extend. Experiments on virtual desktop image files and normal files verify the effectiveness of our method and above 60% storage volume decrease is a chieved for Red Hat Enterprise Linux image files. Key words： disaster backup; desktop virtualization; storage optimization; content addressable storage
基金supported by the National Natural Science Foundation of China(61701521)the Shaanxi Provincial Natural Science Foundation(2018JQ6074)。
文摘The evolution of airborne tactical networks(ATNs)is impeded by the network ossification problem.As a solution,network virtualization(NV)can provide a flexible and scalable architecture where virtual network embedding(VNE)is a key part.However,existing VNE algorithms cannot be optimally adopted in the virtualization of ATN due to the complex interference in aircombat field.In this context,a highly reliable VNE algorithm based on the transmission rate for ATN virtualization(TR-ATVNE)is proposed to adapt well to the specific electromagnetic environment of ATN.Our algorithm coordinates node and link mapping.In the node mapping,transmission-rate resource is firstly defined to effectively evaluate the ranking value of substrate nodes under the interference of both environmental noises and enemy attacks.Meanwhile,a feasible splitting rule is proposed for path splitting in the link mapping,considering the interference between wireless links.Simulation results reveal that our algorithm is able to improve the acceptance ratio of virtual network requests while maintaining a high revenue-to-cost ratio under the complex electromagnetic interference.
基金the National High Technology Research and Development Program of China (2007AA01Z412)
文摘It is absolutely critical that trusted configuration management which significantly affects trust chain establishment, sealing storage and remote attestation, especially in trusted virtualization platform like Xen whose system configuration changes easily. TPM （trusted platform module） context manager is presented to carry out dynamic configuration management for virtual machine. It manages the TPM command requests and VM （virtual machine） configurations. The dynamic configuration representa- tion method based on Merkle hash tree is explicitly proposed against TCG （trusted computing group） static configuration representation. It reflects the true VM status in real time even if the configuration has changed, and it eliminates the invalidation of configuration representation, sealing storage and remote attestation. TPM context manager supports TCG storage protection, remote attestation etc, which greatly enhances the security on trusted virtualization platform.
文摘5G is a new generation of mobile networking that aims to achieve unparalleled speed and performance. To accomplish this, three technologies, Device-to-Device communication (D2D), multi-access edge computing (MEC) and network function virtualization (NFV) with ClickOS, have been a significant part of 5G, and this paper mainly discusses them. D2D enables direct communication between devices without the relay of base station. In 5G, a two-tier cellular network composed of traditional cellular network system and D2D is an efficient method for realizing high-speed communication. MEC unloads work from end devices and clouds platforms to widespread nodes, and connects the nodes together with outside devices and third-party providers, in order to diminish the overloading effect on any device caused by enormous applications and improve users’ quality of experience (QoE). There is also a NFV method in order to fulfill the 5G requirements. In this part, an optimized virtual machine for middle-boxes named ClickOS is introduced, and it is evaluated in several aspects. Some middle boxes are being implemented in the ClickOS and proved to have outstanding performances.
文摘Virtualization has gained great acceptance in the server and cloud computing arena. In recent years, it has also been widely applied to real-time embedded systems with stringent timing constraints. We present a comprehensive survey on real-time issues in virtualization for embedded systems, covering popular virtualization systems including KVM, Xen, L4 and others.
文摘为探究稻茬小麦深施肥“一基一追”机艺融合技术的增产增效减排机制,2021—2024年在长江下游南通稻茬麦区开展大田试验。试验采用缓释掺混肥料(SRF,N∶P_(2)O_(5)∶K_(2)O=26∶12∶12)和普通尿素(U,46%N),结合自主研发的2BFGK-12(6)260全秸秆茬地洁区旋耕智能施肥播种机和3ZF-4(200)中耕追肥机,设置7种施肥模式(30 cm+15 cm宽窄行种植):以尿素4次分施(N 240 kg hm^(-2),基肥∶分蘖肥∶拔节肥∶孕穗肥=5∶1∶2∶2,窄行基施,追肥全田撒施)为对照(CK);减氮15%(N 204 kg hm^(-2))条件下设置6种处理:M_(1)(100%SRF窄行基施);M_(2)(60%SRF窄行基施+40%U拔节期窄行撒施);M_(3)(60%SRF窄行基施+40%U返青期宽行条施);M_(4)(60%SRF窄行基施+40%SRF返青期窄行撒施);M_(5)(60%SRF窄行基施+40%SRF返青期宽行条施);M_(4+5)(60%SRF窄行基施+20%SRF返青期宽行条施+20%SRF返青期窄行撒施)。研究比较不同施肥模式对小麦产量效益、根系形态生理、氮素利用效率及N_(2)O排放的影响。结果表明,与CK相比,M_(2)~M_(5)处理提高了小麦产量(4.0%~19.0%)和经济效益(13.7%~35.7%),其中M_(4)和M_(5)处理表现最优,分别增产14.1%和19.0%,经济效益提升34.5%和35.7%。这些处理明显改善了根系特性(根干重密度增加9.7%~111.8%,根系活力和氧化力分别提高6.8%~52.0%和4.2%~44.2%),降低N_(2)O累积排放量22.6%~34.5%,提高0~20 cm土层硝态氮含量11.2%~40.0%。在氮素利用方面,M_(2)~M_(5)处理均提高了籽粒氮素积累量、花后氮素积累量及其对籽粒氮素的贡献率,氮肥利用效率指标(包括偏生产力、农学效率和表观利用率)分别显著提升了22.4%~40.0%、29.7%~74.3%和9.41~18.77个百分点。值得注意的是,M_(4)和M_(5)处理表现出最优的综合效益:N_(2)O累积排放量降幅最大(分别达27.0%和34.5%),氮肥表观利用率2季均维持在43.0%以上(均值分别为43.5%和46.8%),同时在生育后期保持较高的根系活性和耕层无机氮含量。相比之下,M_(1)处理虽然实现了最大的N_(2)O减排效果(降幅35.9%),但导致减产10.4%和经济效益下降10.8%,且氮肥利用效率呈现不稳定的年际变化特征。而优化处理M_(4+5)进一步改善了根系形态生理特性,并提高氮肥表观利用率和籽粒氮素积累量。综上,减氮15%条件下(N 204 kg hm^(-2)),缓混肥2次施用处理(M_(4)和M_(5))能实现产量、经济效益、氮肥利用效率和N_(2)O减排的协同提高,并以追肥深施处理(M_(5))效应更强。本研究为稻茬小麦缓释肥减氮优化高效应用提供重要理论依据。
文摘Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Specifically, it examined whether VR-based OKS could reduce visual dependency more effectively than visual deprivation through eye closure. Methods: Ten healthy adults participated in this study. A balance function meter was used to measure postural stability, including Romberg ratios before and after two conditions: VR-based OKS (VR + OKS) and eye closure (EC). Participants performed a two-minute standing task under each condition in random order, with adequate rest between tasks. In the VR + OKS condition, a smartphone-based VR headset presented a rotational OKS, while in the EC condition, participants stood with their eyes closed. Statistical analyses were conducted using paired t-tests to compare pre- and post-task Romberg ratios. Results: No significant differences were observed in the pre-task Romberg ratios between conditions. After the VR + OKS condition, significant reductions in Romberg A and Romberg V were observed. In contrast, no significant changes were noted in Romberg ratios after the EC condition. Conclusion: VR-based OKS significantly reduced visual dependency, as indicated by decreased Romberg ratios, suggesting its potential to facilitate sensory reweighting during postural control. These findings highlight the utility of low-cost VR devices in balance rehabilitation for conditions involving high visual dependency. Future studies should expand on this preliminary research by including larger sample sizes and diverse populations to confirm its clinical applicability.
文摘This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)system connected to the local grid.The study focuses on Dakhla,Morocco,a region with vast untapped renewable energy potential.By leveraging GIS,we are innovatively analyzing geographical and environmental factors that influence optimal site selection and system design.The incorporation of VR technologies offers an unprecedented level of realism and immersion,allowing stakeholders to virtually experience the project's impact and design in a dynamic,interactive environment.This novel methodology includes extensive data collection,advanced modeling,and simulations,ensuring that the hybrid system is precisely tailored to the unique climatic and environmental conditions of Dakhla.Our analysis reveals that the region possesses a photovoltaic solar potential of approximately2400 k Wh/m^(2) per year,with an average annual wind power density of about 434 W/m^(2) at an 80-meter hub height.Productivity simulations indicate that the 20 MW hybrid system could generate approximately 60 GWh of energy per year and 1369 GWh over its 25-year lifespan.To validate these findings,we employed the System Advisor Model(SAM)software and the Global Solar Photovoltaic Atlas platform.This comprehensive and interdisciplinary approach not only provides a robust assessment of the system's feasibility but also offers valuable insights into its potential socio-economic and environmental impact.
