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Hydronephrosis and Ureteral Obstruction in Crohn’s Disease 被引量:1
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作者 Robert Jansen Stanley Zaslau 《Open Journal of Urology》 2013年第5期219-221,共3页
Hydronephrosis and ureteral obstruction are rare sequelae of Crohn’s disease. Chronic obstruction can ultimately lead to dysfunction of the affected kidney, and atypical presenting symptoms create pitfalls in diagnos... Hydronephrosis and ureteral obstruction are rare sequelae of Crohn’s disease. Chronic obstruction can ultimately lead to dysfunction of the affected kidney, and atypical presenting symptoms create pitfalls in diagnosis. Few reviews in the literature focus on this process and are limited to isolated case reports and case reviews. We performed a PubMed search using such terms as “Hydronephrosis” AND “Crohn’s disease” AND/OR “ureteral obstruction.” References from selected papers were reviewed for relevance and used for information-gathering as well. Ureteral obstruction most commonly occurs on the right side, due to ileal involvement. Clinical diagnosis is difficult, as symptoms are notably not genitourinary in origin;rather they are more musculoskeletal in nature. Treatment centers on disease control and temporary drainage of the affected kidney. Though rare, hydronephrosis and ureteral obstruction may develop as a result of inflammatory bowel disease. Due to atypical presenting symptoms, a high clinical suspicion is needed to affirm the diagnosis and ensure proper treatment. 展开更多
关键词 hydronephrosis Ureteral OBSTRUCTION Crohn’s diSEASE
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Migration of varicocele coil leading to ureteral obstruction and hydronephrosis:A case report 被引量:1
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作者 Abdulaziz Alamri 《World Journal of Clinical Cases》 SCIE 2024年第16期2856-2861,共6页
BACKGROUND Varicocele embolization,a minimally invasive treatment for symptomatic varicoceles,carries a rare risk of complications like ureteral obstruction and hydronephrosis.This case report documents such a case to... BACKGROUND Varicocele embolization,a minimally invasive treatment for symptomatic varicoceles,carries a rare risk of complications like ureteral obstruction and hydronephrosis.This case report documents such a case to raise awareness of these potential complications and showcase minimally invasive surgical management as a successful solution.CASE SUMMARY A 35-year-old male presented with flank pain and hematuria following varicocele embolization.Imaging confirmed left ureteral obstruction and hydronephrosis.Laparoscopic ureterolysis successfully removed the embolization coil and repaired the ureter,resolving the patient's symptoms.Follow-up at six months and two years showed sustained improvement.CONCLUSION Minimally invasive surgery offers an effective treatment option for rare complications like ureteral obstruction arising from varicocele embolization. 展开更多
关键词 Varicocele embolization Ureteral obstruction hydronephrosis Iatrogenic ureteral injury Laparoscopic ureterolysis Minimally invasive surgery Case report
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Giant Hydronephrosis in Sourou Sanou University Teaching Hospital of Bobo-Dioulasso (Burkina-Faso). Two Cases Reports and Literature Review
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作者 Timothée Kambou Adama Ouattara +4 位作者 Abdoul Karim Paré Drissa S. Barro Clotaire Yaméogo Abdoulaye Kodo Aristide F. Kabore 《Open Journal of Urology》 2018年第1期17-24,共8页
Giant Hydronephrosis (GH) is a rare condition in urology literature and defined as a pelvicalyceal system of kidney containing more of 1000 ml of urine. This condition is not so rare in our setting. We herein, reporte... Giant Hydronephrosis (GH) is a rare condition in urology literature and defined as a pelvicalyceal system of kidney containing more of 1000 ml of urine. This condition is not so rare in our setting. We herein, reported two cases of giant hydronephrosis, seen in two young patients respectively with 5 and 9 years old and their collecting system containing 4000 ml and 5000 ml of urines respectively. Only simple nephrectomy was performed for the two cases with renal function impairment and the post operative course was uneventful. Our purpose through these cases reports is to discuss diagnosis features and management of such condition in our setting, a context of low income countries as Burkina-Faso where diagnosis tool and further investigation are not always available. 展开更多
关键词 GIANT hydronephrosis CHILD Simple NEPHRECTOMY
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DIS创新教具在初中物理实验循证教学中的融合实践——以“测量滑轮组机械效率”改进创新为例
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作者 景明明 曲曙光 潘书朋 《中学物理》 2026年第2期57-60,共4页
聚焦初中物理循证教学,以“测量滑轮组机械效率”为例,深入探讨传感器与数字化工具融合的实践应用,详细阐述了将力传感器与数字化显示及处理设备相结合,不断改进实验装置的过程,包括实验器材的创新设计、实验数据的数字化呈现.通过这项... 聚焦初中物理循证教学,以“测量滑轮组机械效率”为例,深入探讨传感器与数字化工具融合的实践应用,详细阐述了将力传感器与数字化显示及处理设备相结合,不断改进实验装置的过程,包括实验器材的创新设计、实验数据的数字化呈现.通过这项融合实践,不仅提升了实验数据的准确性、实时性与可操作性,还激发了学生对物理实验的兴趣,培养了学生的科学探究与数据处理能力,为初中物理实验循证教学提供了一定的参考与借鉴. 展开更多
关键词 diS创新教具 初中物理实验 循证教学 融合实践
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Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus 被引量:20
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作者 Frederick D Park Jeffrey K Lee +1 位作者 Ganga D Madduri Pradipta Ghosh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第28期3555-3559,共5页
Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus (SLE). Chronic intestinal pseudoobstruction (CIPO) resulting from intestinal smooth muscle dam... Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus (SLE). Chronic intestinal pseudoobstruction (CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation (megacholedochus). While the molecular pathogenesis is largely unknown, observed histopathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis. High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology. We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs. Since the co-manifestation of all 3 is unusual and has been reported only once previously, we have termed this rare clinical syndrome generalized megaviscera of lupus (GML). Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera. This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation. Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of 'burnt out' inflammation with irreversible end-stage fibrosis. Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. 展开更多
关键词 Systemic lupus erythematosus Intestinalpseudo-obstruction Biliary tract diseases Hydroureter hydronephrosis Smooth muscle Autoimmune myositis
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Renovascular Morphological Changes in a Rabbit Model of Hydronephrosis 被引量:1
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作者 李万强 董自强 +6 位作者 周小兵 龙兵 张路生 杨简 周晓光 郑壬平 张杰 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2014年第4期575-581,共7页
Obstructive nephropathy ultimately leads to end-stage renal failure. Renovascular lesions are involved in various nephropathies, and most renal diseases have an ischemic component that underlies the resulting renal fi... Obstructive nephropathy ultimately leads to end-stage renal failure. Renovascular lesions are involved in various nephropathies, and most renal diseases have an ischemic component that underlies the resulting renal fibrosis. The aim of this study was to investigate whether morphological changes occur in the renal vasculature in hydronephrosis and the possible mechanisms involved. A model of complete unilateral ureteral obstruction(CUUO) was used. Experimental animals were divided into five groups: a normal control group(N) and groups of animals at 1st week(O1), 2nd week(O2), 4th week(O4) and 8th week(O8) after CUUO. Blood pressure was measured, renal arterial trees and glomeruli were assessed quantitatively, and renovascular three-dimensional reconstruction was performed on all groups. Glomerular ultrastructural changes were examined by transmission electron microscopy. The results showed that the systolic blood pressure was significantly increased in the obstructed groups(O1, O2, O4 and O8). Three-dimensional reconstruction showed sparse arterial trees in the O8 group, and a tortuous and sometimes ruptured glomerular basement membrane was found in the O4 and O8 groups. Furthermore, epithelial media thickness and media/lumen ratio were increased, lumen diameters were decreased, and the cross-sectional area of the media was unaltered in the segmental renal artery, interlobar artery and afferent arterioles, respectively. In conclusion, renal arterial trees and glomeruli were dramatically altered following CUUO and the changes may be partially ascribed to vascular remodeling. Elucidation of the molecular mechanisms of renovascular morphological alterations will enable the development of potential therapeutic approaches for hydronephrosis. 展开更多
关键词 renal artery hydronephrosis ureteral obstruction vascular cast RABBIT
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Postnatal management of antenatally detected hydronephrosis 被引量:1
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作者 Gyanendra Sharma Anshu Sharma 《World Journal of Clinical Urology》 2014年第3期283-294,共12页
With the increasing use of ultrasonography,congenital anomalies are often picked in utero.Antenatally detected hydronephrosis is amongst the most commonly detected abnormality.The management of this condition has rais... With the increasing use of ultrasonography,congenital anomalies are often picked in utero.Antenatally detected hydronephrosis is amongst the most commonly detected abnormality.The management of this condition has raised considerable debate amongst clinicians dealing with it.This article is written with an idea to provide comprehensive information regarding the postnatal management of antenatally detected hydronephrosis.A detailed review of the current literature on this topic is provided.Also,guidelines have been given to facilitate the management of this condition. 展开更多
关键词 ANTENATAL hydronephrosis Ultrasonography Pelvi URETERIC junction obstruction MEGAURETER hydronephrosis Multicystic DYSPLASTIC kidney
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罕见抗-Di^(b)合并抗-E抗体的实验室检测与临床输血
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作者 吕红娟 朱海峰 《临床血液学杂志》 2025年第10期792-795,共4页
目的对1例十二指肠腺癌患者鉴定出罕见高频抗体(抗-Di^(b)),实施献血者Di^(b)抗原筛选和自体输血,保证临床输血安全,探讨稀有血型血液保障方案。方法运用血型血清学试验,使用试剂红细胞和稀有血型献血者红细胞检测患者血清,使用试剂抗... 目的对1例十二指肠腺癌患者鉴定出罕见高频抗体(抗-Di^(b)),实施献血者Di^(b)抗原筛选和自体输血,保证临床输血安全,探讨稀有血型血液保障方案。方法运用血型血清学试验,使用试剂红细胞和稀有血型献血者红细胞检测患者血清,使用试剂抗血清检测患者红细胞和献血者红细胞血型抗原;在Microlab STAR全自动样品处理系统编程,以稀有血型单克隆抗-Di^(b)抗体对献血者实施抗原筛选;对患者实施术前自体采血。结果患者为A型,RhD阳性,其稀有血型为Di^(b)阴性,抗-Di^(b)合并抗-E同种抗体引起配血困难;使用抗-Di^(b)单克隆抗体筛选献血者,从1090例献血者中发现1例供者,血量2个单位;术前采集自体血400 mL;术中输入400 mL自体血和2个单位稀有异体血,手术顺利。结论鉴定发现2例Di^(b)阴性稀有血型;采取对献血者实施抗原筛选寻找相合血液联合自体输血策略成功解决患者手术用血问题;建立起了1种自动化抗原筛选模式用于稀有血型库工作。 展开更多
关键词 稀有血型 抗原筛选 自体输血 抗-di^(b) 抗-E
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Psoas Muscle Hydatid Cyst Causing Ureteric Compression and Hydronephrosis
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作者 Riyaz Ahmad Sheikh Rayees Ahmad Dar +4 位作者 Sabiya Hamid Wani Mushtaq Ahmad Gagloo Suhail Farooq Mir Gulzar Ahmad Bhat Irfan Jan Khan 《International Journal of Clinical Medicine》 2012年第4期300-301,共2页
Psoas muscle is a rare location for hydatid disease. Here we present a case of infected hydatid cyst left psoas muscle presenting as left flank pain, fever, local flank tenderness, and raised blood counts. Preoperativ... Psoas muscle is a rare location for hydatid disease. Here we present a case of infected hydatid cyst left psoas muscle presenting as left flank pain, fever, local flank tenderness, and raised blood counts. Preoperative diagnoses was made by Ultrasonography (USG) and Computed Tomography (CT) abdomen, although serology for hydatid disease was negative. 展开更多
关键词 HYDATID CYST PSOAS Muscle hydronephrosis
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Obstructed labour caused by foetal congenital hydronephrosis. Trans-abdominal drainage of the hydronephrosis with resultant delivery per vagina
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作者 Ishaq Funsho Abdul Abiodun S. Adeniran +5 位作者 Enoch U. Okpara Olalekan Ibukun Oyinloye Aisha Oluwatoyin Saka Emmanuel A. Adekanye Muhammed Jimoh Saka Abiodun Abdul G. Jimoh 《Open Journal of Obstetrics and Gynecology》 2013年第1期74-77,共4页
A case of a 25 year old 2 alive Patient, with obstructed labour with fetal death and delivery of the fetus up to the trunk caused by congenital Bilateral Hydronephrosis is presented. Obstetric examination on admission... A case of a 25 year old 2 alive Patient, with obstructed labour with fetal death and delivery of the fetus up to the trunk caused by congenital Bilateral Hydronephrosis is presented. Obstetric examination on admission supported by Abdominal Ultrasound revealed Bilateral Hydronephrosis which was then drained per abdomen using needle and intravenous fluid giving set with eventual relief of the obstruction and vaginal delivery of the stillborn baby. 展开更多
关键词 OBSTRUCTED Labour Congenital hydronephrosis Trans-Abdominal Drainage Vaginal Delivery Developing Countries
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Laparoscopic correction of hydronephrosis caused by left paraduodenal hernia in a child with cryptorchism:A case report
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作者 Xin Wang Yong Wu Yong Guan 《World Journal of Clinical Cases》 SCIE 2022年第27期9814-9820,共7页
BACKGROUND Paraduodenal hernia(PDH)is a mesenteric-parietal hernia with retroperitoneal and retrocolic herniation of the small bowel into a sac,which is formed by a peritoneal fold located near the fourth portion of t... BACKGROUND Paraduodenal hernia(PDH)is a mesenteric-parietal hernia with retroperitoneal and retrocolic herniation of the small bowel into a sac,which is formed by a peritoneal fold located near the fourth portion of the duodenum.The present case revealed that PDH was a possible reason for hydronephrosis,and that the carful laparoscopic exploration surgery was necessary to find infrequent causes of hydronephrosis to avoid invalid Anderson–Hynes pyeloplasty surgery and its injury.CASE SUMMARY An 8-year-old boy presented to the pediatric department with a chief complaint of cryptorchidism.Afterwards,laparoscopy confirmed hydronephrosis secondary to left PDH with cryptorchid.Then,he received laparoscopic surgery,fixed operation for left PDH,release of the ureteropelvic junction obstruction,and treatment for hydronephrosis.It is necessary to perform secondary surgery for cryptorchidism and long-term follow-up.CONCLUSION The case revealed an extremely rare cause of hydronephrosis in children,suggesting a potential correlation between PDH and hydronephrosis. 展开更多
关键词 Paraduodenal hernia hydronephrosis CRYPTORCHIdiSM Laparoscopic surgery Case report
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pMDI桉木胶合板工艺因子对其力学性能影响的研究 被引量:2
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作者 潘礼成 黄强 +3 位作者 李骜 罗晓西 任一萍 覃琼林 《林产工业》 北大核心 2025年第4期18-26,共9页
通过正交试验研究pMDI胶黏剂施胶量、单板含水率、热压温度及时间等关键工艺因子对桉木胶合板物理力学性能的影响,并优化热压工艺,最终得到符合高效连续平压胶合板生产线需求的工艺参数。结果表明:当热压压力为0.9 MPa时,胶合板的最佳... 通过正交试验研究pMDI胶黏剂施胶量、单板含水率、热压温度及时间等关键工艺因子对桉木胶合板物理力学性能的影响,并优化热压工艺,最终得到符合高效连续平压胶合板生产线需求的工艺参数。结果表明:当热压压力为0.9 MPa时,胶合板的最佳工艺方案为施胶量50 g/m^(2),热压温度190℃,热压时间40 s/mm,单板含水率16%。为提高生产效率并降低成本,进一步优化工艺,提出并验证了符合连续平压胶合板生产线的优化方案。优化后的生产工艺方案为施胶量40 g/m^(2),热压温度190℃,热压时间25 s/mm,单板含水率16%。采用该工艺生产的胶合板产品的Ⅰ类胶合强度可达1.43 MPa。研究结果可为pMDI胶合板自动化生产提供理论基础和数据支撑。 展开更多
关键词 桉木 胶合板 聚合4 4’-二苯基甲烷二异氰酸酯(pMdi) 工艺因子 力学性能
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青枯菌GMI 1000菌株c-di-GMP代谢酶调控基因vsrD功能研究
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作者 杨晓欣 许景升 +3 位作者 徐进 韩文超 李志明 冯洁 《植物保护》 北大核心 2025年第3期102-112,共11页
青枯菌Ralstonia solanacearum是全球作物生产中的一种重要病原细菌。由青枯菌引起的植物细菌性枯萎病(简称青枯病)危害数百种经济作物并造成严重经济损失。环二鸟苷酸(cyclic diguanylate,c-di-GMP)是一种广泛存在于细菌中的第二信使分... 青枯菌Ralstonia solanacearum是全球作物生产中的一种重要病原细菌。由青枯菌引起的植物细菌性枯萎病(简称青枯病)危害数百种经济作物并造成严重经济损失。环二鸟苷酸(cyclic diguanylate,c-di-GMP)是一种广泛存在于细菌中的第二信使分子,通过调控生物膜形成、运动性等影响病原菌致病力。但在青枯菌中,c-di-GMP的调控网络并不清楚。本试验以青枯菌GMI 1000中的c-di-GMP降解酶基因gedrG缺失突变体菌株(ΔgedrG-GMI)为研究对象,将pMiniHimarI RB1质粒通过双亲共结合法导入ΔgedrG-GMI突变体,筛选运动性表型恢复的转座子插入突变体(transposon mutagenesis),共鉴定了13272株转座子插入突变体。其中,转座子插入vsrD基因时,ΔgedrG-GMI运动性恢复为野生型水平。分析表明vsrD基因缺失后,突变株运动性极显著增强,胞内c-di-GMP水平降低,致病力丧失,vsrD基因互补菌株运动性恢复至缺失前水平。以上结果表明,vsrD参与了青枯菌GMI 1000中c-di-GMP调控通路,影响GMI 1000运动性,且与致病性密切相关。 展开更多
关键词 青枯菌 C-di-GMP 致病力 运动性 调控
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About 4 Cases Report of Giant Hydronephrosis Inurology Department of the National University Healthcare, CNHU HKM of Cotonou
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作者 Dodji Magloire Ines Yevi Christian Henry Renaud Hounnasso +5 位作者 Gilles Natchagande Dejennin Georges Josue Avakoudjo Michel Michael Agounkpe Jean Sossa Fred Hodonou Prince-Pascal Hounnasso 《Open Journal of Urology》 2018年第4期118-124,共7页
The authors report 4 different cases of giant hydronephrosis in the urology department of the national university healthcare, CNHU HKM of Cotonou. The frequency of the items, the etiologies and the different treatment... The authors report 4 different cases of giant hydronephrosis in the urology department of the national university healthcare, CNHU HKM of Cotonou. The frequency of the items, the etiologies and the different treatments carried out were elucidated. The patients were all females. The hydronephrosis affected the left kidney. The most frequent etiology was pyelouretral junction syndrome seconded by obstructive nephrolithiasis in the upper urinary tract. One of the last etiologies was lower pole vascular plexus. Three nephrectomies and one K?SS-HEYNES-ANDERSON pyeloplasty were carried out. Conclusion: Giant hydronephrosis is a rare condition. The etiologies were organic-based and malformed. The therapeutic attitude adopted shows the interest of an antenatal diagnosis for early care. 展开更多
关键词 Giant hydronephrosis PUJ Syndrome Pyéloplasty NEPHRECTOMY
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The Effect and Value of Nursing Intervention in the Prevention of Postoperative Complications in Children with Hydronephrosis
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作者 LI Linlin 《外文科技期刊数据库(文摘版)医药卫生》 2021年第9期478-479,共4页
Objective: to study and explore the clinical effect of nursing intervention in the prevention of postoperative complications in children with hydronephrosis, and to analyze its application value. Methods: 30 cases of ... Objective: to study and explore the clinical effect of nursing intervention in the prevention of postoperative complications in children with hydronephrosis, and to analyze its application value. Methods: 30 cases of pediatric hydronephrosis patients admitted to our hospital last year were selected to carry out this study, which were divided into two groups, respectively, with different nursing intervention mode for nursing, after the end of nursing, its application effect and application value were analyzed. Results: in this study, the incidence of complications was significantly lower and the prevention effect was better after the end of nursing. In the comparison of this data, there was a statistically significant difference (P <0.05). Conclusion: according to the results of the study, it can be concluded that nursing intervention can promote the incidence of postoperative complications in children. This is a relatively effective way of nursing intervention, which can quickly promote the recovery of patients, and has won unanimous praise from the children and their families, and is worthy of promotion in clinical practice. 展开更多
关键词 nursing intervention hydronephrosis in children postoperative complications value analysis appli
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巧用DIS无系统误差验证牛顿第二定律 被引量:1
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作者 赵登峰 《中学理科园地》 2025年第1期77-80,共4页
通过巧妙设计实验装置并且用DIS实验辅助实验过程中物理量的测量消除了实验中系统误差,有力地验证了牛顿第二定律。
关键词 实验 diS 系统误差 牛顿第二定律
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用DISLab和Tracker软件研究“绳碰钉”问题
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作者 王思尧 张敏 +1 位作者 方伟 黄声达 《物理通报》 2025年第10期131-134,共4页
“绳碰钉”问题是圆周运动中一个比较典型的瞬时变化问题,因其复杂性和抽象性,对高中生来说较难理解.实验利用简单改制后的DIS机械能守恒实验器和视频分析软件Tracker研究“绳碰钉”问题中的变量和不变量,帮助学生更清晰直观地理解这类... “绳碰钉”问题是圆周运动中一个比较典型的瞬时变化问题,因其复杂性和抽象性,对高中生来说较难理解.实验利用简单改制后的DIS机械能守恒实验器和视频分析软件Tracker研究“绳碰钉”问题中的变量和不变量,帮助学生更清晰直观地理解这类问题.同时基于实验进行题目创新,打破传统出题思路,深入考查学生对这类问题的理解. 展开更多
关键词 diS 圆周运动 绳碰钉 Tracker软件
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c-di-AMP为佐剂的重组卡介苗免疫对小鼠白色脂肪的调节作用
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作者 董梦娟 常宇骁 +8 位作者 宁唤唤 路延之 康健 徐铭泽 代婷 李嘉玲 郝乐冉 张琳娜 柏银兰 《中国人兽共患病学报》 北大核心 2025年第4期370-375,共6页
目的研究c-di-AMP为佐剂的重组卡介苗(rBCG)调节小鼠附睾白色脂肪(eWAT)代谢及免疫的作用和机制。方法SPF级雄性C57BL/6小鼠经静脉免疫卡介苗(BCG)和重组卡介苗(rBCG),监测小鼠体重变化。分离并称重小鼠eWAT重量,血球仪计血管基质成分(S... 目的研究c-di-AMP为佐剂的重组卡介苗(rBCG)调节小鼠附睾白色脂肪(eWAT)代谢及免疫的作用和机制。方法SPF级雄性C57BL/6小鼠经静脉免疫卡介苗(BCG)和重组卡介苗(rBCG),监测小鼠体重变化。分离并称重小鼠eWAT重量,血球仪计血管基质成分(SVFs)数量。制备小鼠脂肪组织切片,HE染色后显微镜下观察和比较各组小鼠eWAT脂肪细胞大小、数量和形态以及冠状结构(CLS)形成等变化。qRT-PCR检测各组小鼠脂肪代谢相关因子、细胞因子和衰老相关基因的转录水平。结果BCG和rBCG免疫小鼠体重随时间逐渐增加,rBCG免疫诱导eWAT比重增加,SVFs数量降低。HE染色结果显示,BCG免疫促进eWAT脂肪细胞增生和rBCG免疫促进脂肪细胞肥大,BCG和rBCG免疫均可诱导eWAT中CLS形成。qRT-PCR检测结果显示,rBCG免疫可抑制eWAT脂肪分解和能量消耗相关基因表达。BCG免疫对细胞因子转录作用影响不大,而rBCG可诱导IFN-γ和IL-1Ra显著表达,抑制IL-15和IL-2的转录,但不诱导衰老相关基因的表达。结论rBCG免疫可诱导eWAT脂肪细胞肥大,其机制与抑制eWAT脂肪分解及调节细胞因子表达有关。 展开更多
关键词 卡介苗 重组卡介苗 环二腺苷酸 白色脂肪 脂肪代谢 细胞因子
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变力作用下的动量定理DIS实验教学改进
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作者 许菖 林方婷 刘爱云 《物理通报》 2025年第3期114-117,共4页
在传统DIS实验中,研究变力作用下的动量定理基本上以专用软件为主,实验步骤过于简单,容易限制学生的思维.利用通用软件,引导学生自主设计实验方案和数据表格,对实验误差进行分析,提出改进方案加以验证.改进后的实验教学方式对于发展学... 在传统DIS实验中,研究变力作用下的动量定理基本上以专用软件为主,实验步骤过于简单,容易限制学生的思维.利用通用软件,引导学生自主设计实验方案和数据表格,对实验误差进行分析,提出改进方案加以验证.改进后的实验教学方式对于发展学生的物理核心素养具有显著优势. 展开更多
关键词 diS实验 通用软件 变力 动量定理 误差分析
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基于物理学科核心素养的高中物理DIS实验教学实践探究 被引量:1
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作者 蓝树明 《国家通用语言文字教学与研究》 2025年第3期49-51,共3页
高中物理作为科学教育的重要组成部分,其实验教学在培养学生物理核心素养方面有着独特的作用。传统实验教学在一定程度上受到仪器精度、数据采集与处理效率等因素的限制。而DIS实验教学通过数字化信息系统,实现了实验数据的实时采集、... 高中物理作为科学教育的重要组成部分,其实验教学在培养学生物理核心素养方面有着独特的作用。传统实验教学在一定程度上受到仪器精度、数据采集与处理效率等因素的限制。而DIS实验教学通过数字化信息系统,实现了实验数据的实时采集、处理和分析,能够更加准确地呈现物理现象和规律,有效提高了实验的精确度和效率,为高中物理实验教学带来了新的思路。对此,本文通过分析DIS实验的特点,研究基于物理学科核心素养的高中物理DIS实验教学的优势,在此基础上探讨基于物理学科核心素养的高中物理DIS实验教学实践策略。 展开更多
关键词 学科核心素养 高中物理 diS实验教学
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