Bone regeneration for non-load-bearing defects remains a significant clinical challenge requiring advanced biomaterials and cellular strategies.Adiposederived mesenchymal stem cells(AD-MSCs)have garnered significant i...Bone regeneration for non-load-bearing defects remains a significant clinical challenge requiring advanced biomaterials and cellular strategies.Adiposederived mesenchymal stem cells(AD-MSCs)have garnered significant interest in bone tissue engineering(BTE)because of their abundant availability,minimally invasive harvesting procedures,and robust differentiation potential into osteogenic lineages.Unlike bone marrow-derived mesenchymal stem cells,AD-MSCs can be easily obtained in large quantities,making them appealing alternatives for therapeutic applications.This review explores hydrogels containing polymers,such as chitosan,collagen,gelatin,and hyaluronic acid,and their composites,tailored for BTE,and emphasizes the importance of these hydrogels as scaffolds for the delivery of AD-MSCs.Various hydrogel fabrication techniques and biocompatibility assessments are discussed,along with innovative modifications to enhance osteogenesis.This review also briefly outlines AD-MSC isolation methods and advanced embedding techniques for precise cell placement,such as direct encapsulation and three-dimensional bioprinting.We discuss the mechanisms of bone regeneration in the AD-MSC-laden hydrogels,including osteoinduction,vascularization,and extracellular matrix remodeling.We also review the preclinical and clinical applications of AD-MSC-hydrogel systems,emphasizing their success and limitations.In this review,we provide a comprehensive overview of AD-MSC-based hydrogel systems to guide the development of effective therapies for bone regeneration.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a...Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a special porosity property was reported at the first time. Its gelling mechanism was studied by a group of contrast experiments. Results may provide experimental and theoretical supports for how to apply it on tissue engineering scaffold and how to influeuee or control its essential properties.展开更多
In this paper the suitability of a graft polymer nanocomposite hydrogel system for enhanced oil recovery was examined using polyacrylamide graft starch/clay nanocomposite(a laboratory synthesized product) and chromium...In this paper the suitability of a graft polymer nanocomposite hydrogel system for enhanced oil recovery was examined using polyacrylamide graft starch/clay nanocomposite(a laboratory synthesized product) and chromium(III) acetate(crosslinker). X-ray diffraction analysis,Fourier transform infrared spectrometry analysis, field-emission scanning electron microscopy and transmission electron microscopy were carried out to reveal the laboratory synthesized product as a nanocomposite. The effects of various parameters like salt concentration, p H, temperature, polymer concentration and crosslinker concentration on the properties of the developed gel system were systematically evaluated.The thermal stability of the nanocomposite gel and the conventional gel system were also determined by thermogravimetric analysis. The graft polymer nanocomposite gel system exhibited acceptable gel strength, gelation time and gel stability compared with the conventional gel system. The nanocomposite gels prepared using a low crosslinker concentration showed higher gel strength and required longer gelation time than the conventional gel which is more desirable properties for the effective placement of gel during enhanced oil recovery operations. In addition, sand pack flooding experiments show that the graft polymer nanocomposite gels had better plugging capacity than the conventional gel systems under reservoir conditions. Hence, this gel system may be suitable in the water shutoff treatments required for enhanced oil recovery from oilfields.展开更多
Halloysite nanotube-composited thermo-responsive hydrogel system has been successfully developed for controlled drug release by copolymerization of N-isopropylacrylamide （NIPAM） with silane-modified halloysite nanot...Halloysite nanotube-composited thermo-responsive hydrogel system has been successfully developed for controlled drug release by copolymerization of N-isopropylacrylamide （NIPAM） with silane-modified halloysite nanotubes （HNT） through thermally initiated free-radical polymerization. With methylene blue as a model drug, thermo-responsive drug release results demonstrate that the drug release from the nanotubes in the composited hy-drogel can^be well controlled by manipulating the environmental temperature. When the hydrogel network is swol- len at temperature below the lower critical solution temperature （LCST）, drug releases steadily from lumens of the embedded nanotubes, whereas the drug release stops when hydrogel shrinks at temperature above the LCST. The release of model drug from the HNT-composited hydrogel matches well with its thermo-responsive volume phasetransition, and shows characteristics of well controlled release. The design strategy and release results of the pro- posed novel HNT-composited thermo-responsive hydrogel system provide valuable guidance for designing respon- s_i_ve nanocomposites for controlled-release of active agents.展开更多
Background:Cartilage repair remains a considerable challenge in regenerative medicine.Despite extensive research on biomaterials for cartilage repair in recent years,issues such as prolonged repair cycles and suboptim...Background:Cartilage repair remains a considerable challenge in regenerative medicine.Despite extensive research on biomaterials for cartilage repair in recent years,issues such as prolonged repair cycles and suboptimal outcomes persist.Organoids,miniature three-dimensional(3D)tissue structures derived from the directed differentiation of stem or progenitor cells,mimic the structure and function of natural organs.Therefore,the construction of cartilage organoids(COs)holds great promise as a novel strategy for cartilage repair.Methods:This study employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin(DNA-SF)hydrogel sustained-release system(DSRGT)with bone-marrow mesenchymal stem cells(BMSCs)to construct millimeter-scale CO.COs at different developmental stages were characterized,and the COs with the best cartilage phenotype were selected for in vivo cartilage repair in a rat articular cartilage defect model.Results:This study developed a DSRGT by covalently grafting glucosamine(which promotes cartilage matrix synthesis)and TD-198946(which promotes chondrogenic differentiation)onto a hydrogel using acrylic acid-polyethylene glycolN-hydroxysuccinimide(AC-PEG-NHS).In vitro,4-week COs exhibited higher SRY-box transcription factor 9(SOX9),typeⅡcollagen(ColⅡ),and aggrecan(ACAN)expression and lower typeⅠcollagen(ColⅠ)and typeⅩcollagen(ColⅩ)expression,indicating that 4 weeks is the optimal culture duration for hyaline cartilage development.In vivo,the mitogen-activated protein kinase(MAPK)signaling pathway was upregulated in 4-week COs,enabling cartilage repair within 8 weeks.Transcriptomic analysis revealed that cartilage regenerated with 4-week COs presented gene expression profiles resembling those of healthy cartilage.Conclusion:This study employs DSRGT to construct COs,providing an innovative strategy for the regeneration of cartilage defects.展开更多
Multiresponsive hydrogels,capable of responding to more than one external stimulus,have demonstrated great utility in biomedical applications.This study presents a facile method for preparing an injectable,dual redox/...Multiresponsive hydrogels,capable of responding to more than one external stimulus,have demonstrated great utility in biomedical applications.This study presents a facile method for preparing an injectable,dual redox/p H-responsive hydrogel system based on poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)(PEDOT:PSS)for the controlled delivery of pharmacologically active bevacizumab(BEV).The hydrogel system was fabricated via a one-step physical crosslinking process by mixing PEDOT:PSS with BEV,leveraging electrostatic interactions,hydrogen bonding,and ionic crosslinking.The resulting PEDOT@BEV system exhibited a homogeneously porous structure,robust mechanical stability,and good biocompatibility.Under acidic(p H=5)or alkaline(p H=10)conditions,especially when coupled with elevated reactive oxygen species(ROS)levels,the as-prepared PEDOT@BEV achieved rapid BEV release.This may be attributed to PEDOT oxidation and charge repulsion.In contrast,BEV release remained stable under physiological conditions(p H=7.4,0 mmol/L H_(2)O_(2)).In vitro results supported that the resulting PEDOT@BEV demonstrated potent anti-angiogenic efficacy,significantly inhibiting cellular migration and tube formation of human retinal vascular endothelial cells(HRVECs).The vascular endothelial growth factor expression was further reduced.In a mouse model of corneal neovascularization,the PEDOT@BEV system enabled the continuous controlled release of BEV for over 14 days.It exhibited superior anti-angiogenic efficacy compared to free BEV treatment,more effectively reducing neovascularization and corneal inflammation.The designed platform in this work demonstrated versatility by successfully incorporating other therapeutic antibodies(e.g.,rituximab,trastuzumab),highlighting its potential for tailored drug delivery in oncology and neovascular diseases.The outcome of this study offers a promising strategy for spatiotemporally controlled drug release in response to specific microenvironmental cues.展开更多
The impaired function of periodontal ligament stem cells(PDLSCs)impedes restoration of periodontal tissues.The cGAS-cGAMP-STING pathway is an innate immune pathway that sensing cytosolic double-stranded DNA(dsDNA),but...The impaired function of periodontal ligament stem cells(PDLSCs)impedes restoration of periodontal tissues.The cGAS-cGAMP-STING pathway is an innate immune pathway that sensing cytosolic double-stranded DNA(dsDNA),but its role in regulating the function of PDLSCs is still unclear.In this study,we found that mito-chondrial DNA(mtDNA)was released into the cytoplasm through the mitochondrial permeability transition pore(mPTP)in PDLSCs upon inflammation,which binds to cGAS and activated the STING pathway by promoting the production of cGAMP,and ultimately impaired the osteogenic differentiation of PDLSCs.Additionally,it is first found that inflammation can down-regulate the level of the ATP-binding cassette membrane subfamily member C1(ABCC1,a cGAMP exocellular transporter)and ectonucleotide pyrophosphatase/phosphodiesterase 1(ENPP1,a cGAMP hydrolase),which further aggravated the accumulation of intracellular cGAMP,leading to the persistent activation of the cGAS-STING pathway and thus the impaired the differentiation capacity of PDLSCs.Furthermore,we designed a hydrogel system loaded with a mPTP blocker,an ABCC1 agonist and ENPP1 to promote periodontal tissue regeneration by modulating the production,exocytosis,and clearance of cGAMP.In conclusion,our results highlight the profound effects,and specific mechanisms,of the cGAS-STING pathway on the function of stem cells and propose a new strategy to promote periodontal tissue restoration based on the reestablishment of cGAMP homeostasis.展开更多
Smart farming with outdoor monitoring systems is critical to address food shortages and sustainability challenges.These systems facilitate informed decisions that enhance efficiency in broader environmental management...Smart farming with outdoor monitoring systems is critical to address food shortages and sustainability challenges.These systems facilitate informed decisions that enhance efficiency in broader environmental management.Existing outdoor systems equipped with energy harvesters and self-powered sensors often struggle with fluctuating energy sources,low durability under harsh conditions,non-transparent or non-biocompatible materials,and complex structures.Herein,a multifunctional hydrogel is developed,which can fulfill all the above requirements and build selfsustainable outdoor monitoring systems solely by it.It can serve as a stable energy harvester that continuously generates direct current output with an average power density of 1.9 W m^(-3)for nearly 60 days of operation in normal environments(24℃,60%RH),with an energy density of around 1.36×10^(7)J m^(-3).It also shows good self-recoverability in severe environments(45℃,30%RH)in nearly 40 days of continuous operation.Moreover,this hydrogel enables noninvasive and self-powered monitoring of leaf relative water content,providing critical data on evaluating plant health,previously obtainable only through invasive or high-power consumption methods.Its potential extends to acting as other self-powered environmental sensors.This multifunctional hydrogel enables self-sustainable outdoor systems with scalable and low-cost production,paving the way for future agriculture.展开更多
All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating systems.However,the static single thermal management...All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating systems.However,the static single thermal management for cooling or heating fails to self-regulate the temperature in dynamic seasonal temperature condition.Herein,inspired by the dual-temperature regulation function of the fur color changes on the backs and abdomens of penguins,a smart thermal management composite hydrogel(PNA@H-PM Gel)system was subtly created though an"on-demand"dual-layer structure design strategy.The PNA@H-PM Gel system features synchronous solar and thermal radiation modulation as well as tunable phase transition temperatures to meet the variable seasonal thermal requirements and energy-saving demands via self-adaptive radiative cooling and solar heating regulation.Furthermore,this system demonstrates superb modulations of both the solar reflectance(ΔR=0.74)and thermal emissivity(ΔE=0.52)in response to ambient temperature changes,highlighting efficient temperature regulation with average radiative cooling and solar heating effects of 9.6℃in summer and 6.1℃in winter,respectively.Moreover,compared to standard building baselines,the PNA@H-PM Gel presents a more substantial energy-saving cooling/heating potentials for energy-efficient buildings across various regions and climates.This novel solution,inspired by penguins in the real world,will offer a fresh approach for producing intelligent,energy-saving thermal management materials,and serve for temperature regulation under dynamic climate conditions and even throughout all seasons.展开更多
Artificial sensory systems,designed to emulate human senses like sight,touch,and hearing,have garnered significant attention for their potential to enhance human capabilities,improve human-machine interactions,and ena...Artificial sensory systems,designed to emulate human senses like sight,touch,and hearing,have garnered significant attention for their potential to enhance human capabilities,improve human-machine interactions,and enable autonomous systems to better perceive their surroundings.Hydrogels,with their biocompatibility,flexibility,and water-rich polymer structure,are increasingly recognized as crucial materials in the development of these systems,especially in applications such as wearable sensors,artificial skin,and neural interfaces.This review explores various hydrogel fabrication techniques,including 3D bioprinting,electro spinning,and photopolymerization,which allow for the precise control of hydrogel properties like mechanical strength,flexibility,and conductivity.By tailoring these properties to mimic natural tissues,hydrogels offer transformative benefits in the creation of advanced,biocompatible,and durable sensory systems.We emphasize the importance of selecting appropriate fabrication methods to meet the specific functional requirements of artificial sensory applications,such as sensitivity to stimuli,durability,and ease of integration.This review further highlights the pivotal role of hydrogels in advancing future artificial sensory technologies and their broad potential in fields ranging from robotics to biomedical devices.展开更多
The rise of wearable electronics and intelligent robotics has created an urgent demand for tactile sensors that are soft,biocompatible,and responsive.Hydrogels,with high water content and mechanical compliance such as...The rise of wearable electronics and intelligent robotics has created an urgent demand for tactile sensors that are soft,biocompatible,and responsive.Hydrogels,with high water content and mechanical compliance such as biological tissues,provide a unique platform for constructing next-generation tactile sensors that mimic human skin’s sensory functions.This paper surveys recent progress in smart hydrogel tactile sensors and systems from fundamental concepts to practical applications.Beyond molecular structural design and material selection,we focus on the discussion and summary of the key sensing mechanisms,including triboelectric,piezoresistive,piezoelectric,piezoionic,and piezocapacitive modes.We also discuss material innovations such as ionic hydrogels,dual-conductive networks,zwitterionic matrices,and nanocomposite reinforcement,highlighting strategies to improve sensitivity,durability,and multifunctionality.Finally,the challenges and possible future directions for smart hydrogel tactile systems are outlined.展开更多
Traditional cancer therapies have limitations like poor efficacy on advanced tumors,healthy tissue damage,side effects,and drug resistance,creating an urgent need for new strategies.Hydrogels have good biocompatibilit...Traditional cancer therapies have limitations like poor efficacy on advanced tumors,healthy tissue damage,side effects,and drug resistance,creating an urgent need for new strategies.Hydrogels have good biocompatibility and controlled release,while extracellular vesicles(EVs)enable targeting and bioactive transport.This review systematically summarizes hydrogels and EVs,focusing on the construction of hydrogel-EV delivery system,key influencing factors,drug delivery mechanisms,and tumor therapy apps,clarifying their synergies.The system overcomes single-carrier flaws,construction methods/key factors affect performance,preclinical studies have confirmed efficacy in multiple therapies,but large-scale production and in vivo stability challenges remain,yet it promises to overcome the limits of traditional therapy for precision oncology.展开更多
Meniscus injuries present significant therapeutic challenges due to their limited self-healing capacity and the diverse biological and mechanical properties across the tissue.Conventional repair strategies do not repl...Meniscus injuries present significant therapeutic challenges due to their limited self-healing capacity and the diverse biological and mechanical properties across the tissue.Conventional repair strategies do not replicate the complex zonal characteristics within the meniscus,resulting in suboptimal outcomes.In this study,we introduce an innovative fetal/adult and stiffness-tunable meniscus decellularized extracellular matrix(DEM)-based hydrogel system designed for precision repair of heterogeneous,zonal-dependent meniscus injuries.By syn-thesizing fetal and adult DEM hydrogels,we identified distinct cellular responses,including that hydrogels with adult meniscus-derived DEM promote more fibrochondrogenic phenotypes.The incorporation of methacrylated hyaluronic acid(MeHA)further refined the mechanical properties and injectability of the DEM-based hydrogels.The combination of fetal and adult DEM with MeHA allowed for precise tuning of stiffness,influencing cell differentiation and closely mimicking native tissue environments.In vivo tests confirmed the biocompatibility of hydrogels and their integration with native meniscus tissues.Furthermore,advanced 3D bioprinting techniques enabled the fabrication of hybrid hydrogels with biomaterial and mechanical gradients,effectively emulating the zonal properties of meniscus tissue and enhancing cell integration.This study represents a significant advance in meniscus tissue engineering,providing a promising platform for customized regenerative therapies across a range of heterogeneous fibrous connective tissues.展开更多
Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short...Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short time remains a major challenge.In this study,a multifunctional mussel-inspired hydrogel was synthesized in only 5 min,with polydopamine(PDA)-polypyrrole(Ppy)-polyaniline(PANi)and poly(vinyl alcohol)(PVA)nanoparticles incorporated into the polyacrylamide(PAM)network.The resulting hydrogel exhibited high transparency(about 90% light transmission in the range of 400-800 nm),high conductivity((95.4±0.4)×10^(-4)S/cm),tensile strength(32.60±1.03 k Pa),strain at break(904.46%±11.50%),and adhesive strength(30-60 k Pa).It also demonstrated rapid self-healing properties(about 48% strength recovery within 1h at 50℃)and water-dependent shape memory behavior.As a wearable strain sensor,the hydrogel successfully detected finger flexion,wrist movements,facial expression changes,and breathing with high sensitivity and stability.The calculated gauge factor(GF)was 7.44±0.31,which is higher than that of many previously reported hydrogels.Compared with previous oyster-inspired or Ppy-based hydrogels,our system showed a much shorter synthesis time,higher transparency,and enhanced multifunctionality.These findings highlight the potential of the proposed hydrogel for next-generation flexible electronics,e-skin,and biomedical monitoring devices.展开更多
We proposed a strategy using high-concentration tannic acid(TA) solutions to form robust and dense supramolecular networks in hydrogels,driven by the high osmotic pressure of the TA solution.The resulting hydrogels ar...We proposed a strategy using high-concentration tannic acid(TA) solutions to form robust and dense supramolecular networks in hydrogels,driven by the high osmotic pressure of the TA solution.The resulting hydrogels are both transparent and tough,with highly compacted networks.The hydrogels exhibit an ultimate tensile strength of approximately 4.55 MPa and a toughness of 160 MJ/m^(3).Additionally,the hydrogels adhere to a wide range of substrates,including metals,ceramics,glass,and even Teflon,with an adhesion strength of up to 42 kPa on Teflon plates.Given the biocompatibility and biodegradability of both PVA and TA,along with the hydrogels' toughness,transparency,and adhesiveness,we anticipated broad applications in the biomedical field,such as in articular cartilage restoration,electronic skin,and wound dressings.Additionally,these hydrogels hold significant potential for applications in wearable technology and optoelectronic devices.展开更多
Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent resea...Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent research has significantly improved the performance of lignin-based hydrogels,suggesting their substantial potential in fields such as biomedicine,environmental science,and agriculture.This paper reviews the process of lignin extraction,systematically introduces synthesis strategies for preparing lignin-based hydrogels,and discusses the current state of research on these hydrogels in biomedical and environmental protection fields.It concludes by identifying the existing challenges in lignin hydrogel research and envisioning future prospects and development trends.展开更多
Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injecti...Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injection of hyaluronic acid(HA)is widely used to alleviate symptoms;however,its lubrication persistence,antioxidant,and anti-inflammatory abilities are limited,and it is difficult to effectively delay the early process of cartilage degeneration.Based on this,hyaluronic acid-g-lipoic acid(HA-LA)was synthesized by esterification reaction,and HA-LA microspheres were prepared by a reversed-phase emulsion method,which was combined with a macromolecular HA-LA solution to form injectable hydrogels.The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres(HA-LA MS)for the treatment of KOA and to verify its injectability,lubricity,reactive oxygen species(ROS)scavenging ability,and anti-inflammatory effects.The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability,and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect.In vitro experiments have shown that the hydrogel can efficiently scavenge ROS,reduce the expression of inflammatory factors,and is non-cytotoxic.The HA-LA MS injectable hydrogel has excellent lubricity,ROS scavenging ability,and anti-inflammatory effects in vivo,which can effectively delay the degeneration of early KOA cartilage,and its efficacy is significantly better than that of traditional hyaluronic acid,making it a promising intra-articular injection preparation.展开更多
This study presents a thorough investigation into the use of single and twin-tailed cationic and anionic surfactant-modified chitosan(SMCS)hydrogel beads as effective adsorbents for the elimination of hazardous polycy...This study presents a thorough investigation into the use of single and twin-tailed cationic and anionic surfactant-modified chitosan(SMCS)hydrogel beads as effective adsorbents for the elimination of hazardous polycyclic aromatic hydrocarbons(PAHs)from aqueous solutions.The Chitosan(CS)hydrogel beads were modified with single/twin-tailed anionic surfactants,sodium dodecyl sulfate(SDS)and sodium bis(2-ethylhexyl)sulfosuccinate(AOT),and cationic surfactants,dodecyltrimethylammonium bromide(DTAB)and didodecyldimethylammonium bromide(DDAB),to enhance their adsorption capacity of PAHs.The CS and SMCS beads were evaluated for their structural,mechanical,and adsorption properties using a range of techniques,including infrared spectroscopy(IR),energy-dispersive X-ray spectroscopy(EDX),rheometry,and field emission scanning electron microscopy(FESEM).Adsorption experiments of naphthalene(Nap),acenaphthene(Ace),and phenanthrene(Phe)on SMCS beads demonstrate that they have significantly higher adsorption capacities than CS beads,due to increase in hydrophobic interactions.Adsorption capacity followed the trend,Phen>Ace>Nap for all the beads revealing that twin-tailed SMCS bead possess much higher adsorption capacities(Qmax)compared to single-tailed SMCS beads.For twin tailed surfactants,the maximum adsorption capacities for Nap,Ace and Phe varied as CS-AOT(CS-DDAB):430.0(323.8)611.60(538.18)633.39(536.99)mg/g respectively,outperforming other reported hydrogel beads.The study highlights the simplicity,eco-friendliness,and enhanced performance of surfactant modification for developing high-efficiency adsorbents,paving the way for cost-effective solutions in water re-mediation.展开更多
Green solvent pretreatment of biomass represents a promising ap-proach for enhancing the econom-ic value of lignocellulosic deriva-tives.In this study,corncob biomass was treated with a diol-based deep eutectic solven...Green solvent pretreatment of biomass represents a promising ap-proach for enhancing the econom-ic value of lignocellulosic deriva-tives.In this study,corncob biomass was treated with a diol-based deep eutectic solvent(DES)under mild conditions,facilitating efficient cellulose separation.The extracted cellulose was subsequently used to fabricate cellulose hydrogels in an aqueous zinc chloride solution.The resulting hydrogel exhibited a“water-in-salt”effect due to the high concentration of ZnCl_(2).Leveraging the antifreeze properties of sorbitol,the system demon-strated outstanding low-temperature electrochemical performance,including a broad operat-ing voltage window and an ionic conductivity of 38.4 mS·cm^(-1)at-20℃.At 20℃,the de-vice achieved an energy density of 206 Wh·kg^(-1)and a power density of 2701.05 W·kg^(-1)at a current density of 1 A·g^(-1).Moreover,the flexible zinc-ion hybrid supercapacitor(ZHSC)maintained 89%of its capacitance and nearly 100%Coulombic efficiency after 5500 cycles at 20℃.This work not only advances the development of zinc-ion energy storage devices but al-so establishes a new paradigm for the green and direct utilization of biomass-derived materi-als.展开更多
文摘Bone regeneration for non-load-bearing defects remains a significant clinical challenge requiring advanced biomaterials and cellular strategies.Adiposederived mesenchymal stem cells(AD-MSCs)have garnered significant interest in bone tissue engineering(BTE)because of their abundant availability,minimally invasive harvesting procedures,and robust differentiation potential into osteogenic lineages.Unlike bone marrow-derived mesenchymal stem cells,AD-MSCs can be easily obtained in large quantities,making them appealing alternatives for therapeutic applications.This review explores hydrogels containing polymers,such as chitosan,collagen,gelatin,and hyaluronic acid,and their composites,tailored for BTE,and emphasizes the importance of these hydrogels as scaffolds for the delivery of AD-MSCs.Various hydrogel fabrication techniques and biocompatibility assessments are discussed,along with innovative modifications to enhance osteogenesis.This review also briefly outlines AD-MSC isolation methods and advanced embedding techniques for precise cell placement,such as direct encapsulation and three-dimensional bioprinting.We discuss the mechanisms of bone regeneration in the AD-MSC-laden hydrogels,including osteoinduction,vascularization,and extracellular matrix remodeling.We also review the preclinical and clinical applications of AD-MSC-hydrogel systems,emphasizing their success and limitations.In this review,we provide a comprehensive overview of AD-MSC-based hydrogel systems to guide the development of effective therapies for bone regeneration.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
文摘Thermo-respansive chitosan hydrogel system （TRCHS） was prepared and its mierostructure was investigated by scaning electron microscope （SEM） and mercury intrusion poremaster （MIP）. Based on analyzing the data, a special porosity property was reported at the first time. Its gelling mechanism was studied by a group of contrast experiments. Results may provide experimental and theoretical supports for how to apply it on tissue engineering scaffold and how to influeuee or control its essential properties.
基金the Indian Institute of Technology(Indian School of Mines),Dhanbad,India,for providing financial support
文摘In this paper the suitability of a graft polymer nanocomposite hydrogel system for enhanced oil recovery was examined using polyacrylamide graft starch/clay nanocomposite(a laboratory synthesized product) and chromium(III) acetate(crosslinker). X-ray diffraction analysis,Fourier transform infrared spectrometry analysis, field-emission scanning electron microscopy and transmission electron microscopy were carried out to reveal the laboratory synthesized product as a nanocomposite. The effects of various parameters like salt concentration, p H, temperature, polymer concentration and crosslinker concentration on the properties of the developed gel system were systematically evaluated.The thermal stability of the nanocomposite gel and the conventional gel system were also determined by thermogravimetric analysis. The graft polymer nanocomposite gel system exhibited acceptable gel strength, gelation time and gel stability compared with the conventional gel system. The nanocomposite gels prepared using a low crosslinker concentration showed higher gel strength and required longer gelation time than the conventional gel which is more desirable properties for the effective placement of gel during enhanced oil recovery operations. In addition, sand pack flooding experiments show that the graft polymer nanocomposite gels had better plugging capacity than the conventional gel systems under reservoir conditions. Hence, this gel system may be suitable in the water shutoff treatments required for enhanced oil recovery from oilfields.
基金Supported by the National ]qatural Science Foundation of China （20906064）, the National Basic Research Program of China （2009CB623407）, the Program for Changjiang Scholars and Innovative Research Team in University （IRTl163）, and the Foundation for the Author of National Excellent Doctoral Dissertation of China （201163）.
文摘Halloysite nanotube-composited thermo-responsive hydrogel system has been successfully developed for controlled drug release by copolymerization of N-isopropylacrylamide （NIPAM） with silane-modified halloysite nanotubes （HNT） through thermally initiated free-radical polymerization. With methylene blue as a model drug, thermo-responsive drug release results demonstrate that the drug release from the nanotubes in the composited hy-drogel can^be well controlled by manipulating the environmental temperature. When the hydrogel network is swol- len at temperature below the lower critical solution temperature （LCST）, drug releases steadily from lumens of the embedded nanotubes, whereas the drug release stops when hydrogel shrinks at temperature above the LCST. The release of model drug from the HNT-composited hydrogel matches well with its thermo-responsive volume phasetransition, and shows characteristics of well controlled release. The design strategy and release results of the pro- posed novel HNT-composited thermo-responsive hydrogel system provide valuable guidance for designing respon- s_i_ve nanocomposites for controlled-release of active agents.
基金supported by the National Key Research and Development Program of China(2022YFB3804300)the National Natural Science Foundation of China(82230071,32471395,82427809,82472479)+2 种基金the Shanghai Science and Technology Innovation Action Plan(23141900600)the Research Physician Training Program of Shanghai Hospital Development Center(SHDC2023CRT013)the Shanghai Municipal Demonstration Project for Innovative Medical Device Applications(23SHS05700)。
文摘Background:Cartilage repair remains a considerable challenge in regenerative medicine.Despite extensive research on biomaterials for cartilage repair in recent years,issues such as prolonged repair cycles and suboptimal outcomes persist.Organoids,miniature three-dimensional(3D)tissue structures derived from the directed differentiation of stem or progenitor cells,mimic the structure and function of natural organs.Therefore,the construction of cartilage organoids(COs)holds great promise as a novel strategy for cartilage repair.Methods:This study employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin(DNA-SF)hydrogel sustained-release system(DSRGT)with bone-marrow mesenchymal stem cells(BMSCs)to construct millimeter-scale CO.COs at different developmental stages were characterized,and the COs with the best cartilage phenotype were selected for in vivo cartilage repair in a rat articular cartilage defect model.Results:This study developed a DSRGT by covalently grafting glucosamine(which promotes cartilage matrix synthesis)and TD-198946(which promotes chondrogenic differentiation)onto a hydrogel using acrylic acid-polyethylene glycolN-hydroxysuccinimide(AC-PEG-NHS).In vitro,4-week COs exhibited higher SRY-box transcription factor 9(SOX9),typeⅡcollagen(ColⅡ),and aggrecan(ACAN)expression and lower typeⅠcollagen(ColⅠ)and typeⅩcollagen(ColⅩ)expression,indicating that 4 weeks is the optimal culture duration for hyaline cartilage development.In vivo,the mitogen-activated protein kinase(MAPK)signaling pathway was upregulated in 4-week COs,enabling cartilage repair within 8 weeks.Transcriptomic analysis revealed that cartilage regenerated with 4-week COs presented gene expression profiles resembling those of healthy cartilage.Conclusion:This study employs DSRGT to construct COs,providing an innovative strategy for the regeneration of cartilage defects.
基金supported by the National Natural Science Foundation of China(Nos.82502583 and U20A20338)Huadong Medicine Joint Funds of Natural Science Foundation of Zhejiang Province(No.LHDMY23H070004)the Summit Advancement Disciplines of Zhejiang Province(Wenzhou Medical University-Pharmaceutics)。
文摘Multiresponsive hydrogels,capable of responding to more than one external stimulus,have demonstrated great utility in biomedical applications.This study presents a facile method for preparing an injectable,dual redox/p H-responsive hydrogel system based on poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)(PEDOT:PSS)for the controlled delivery of pharmacologically active bevacizumab(BEV).The hydrogel system was fabricated via a one-step physical crosslinking process by mixing PEDOT:PSS with BEV,leveraging electrostatic interactions,hydrogen bonding,and ionic crosslinking.The resulting PEDOT@BEV system exhibited a homogeneously porous structure,robust mechanical stability,and good biocompatibility.Under acidic(p H=5)or alkaline(p H=10)conditions,especially when coupled with elevated reactive oxygen species(ROS)levels,the as-prepared PEDOT@BEV achieved rapid BEV release.This may be attributed to PEDOT oxidation and charge repulsion.In contrast,BEV release remained stable under physiological conditions(p H=7.4,0 mmol/L H_(2)O_(2)).In vitro results supported that the resulting PEDOT@BEV demonstrated potent anti-angiogenic efficacy,significantly inhibiting cellular migration and tube formation of human retinal vascular endothelial cells(HRVECs).The vascular endothelial growth factor expression was further reduced.In a mouse model of corneal neovascularization,the PEDOT@BEV system enabled the continuous controlled release of BEV for over 14 days.It exhibited superior anti-angiogenic efficacy compared to free BEV treatment,more effectively reducing neovascularization and corneal inflammation.The designed platform in this work demonstrated versatility by successfully incorporating other therapeutic antibodies(e.g.,rituximab,trastuzumab),highlighting its potential for tailored drug delivery in oncology and neovascular diseases.The outcome of this study offers a promising strategy for spatiotemporally controlled drug release in response to specific microenvironmental cues.
基金the National Natural Science Founda-tion of China(82220108019 to P.Ji and 82201059 to Q.M.Zhai)the Chongqing Postdoctoral Science Special Foundation(2021XM1031 to Q.M.Zhai)+1 种基金China Postdoctoral Science Foundation(2022M720599 to Q.M.Zhai)Haobo medical technology(Shanghai)limited company helped us synthesize the PEGA materials.
文摘The impaired function of periodontal ligament stem cells(PDLSCs)impedes restoration of periodontal tissues.The cGAS-cGAMP-STING pathway is an innate immune pathway that sensing cytosolic double-stranded DNA(dsDNA),but its role in regulating the function of PDLSCs is still unclear.In this study,we found that mito-chondrial DNA(mtDNA)was released into the cytoplasm through the mitochondrial permeability transition pore(mPTP)in PDLSCs upon inflammation,which binds to cGAS and activated the STING pathway by promoting the production of cGAMP,and ultimately impaired the osteogenic differentiation of PDLSCs.Additionally,it is first found that inflammation can down-regulate the level of the ATP-binding cassette membrane subfamily member C1(ABCC1,a cGAMP exocellular transporter)and ectonucleotide pyrophosphatase/phosphodiesterase 1(ENPP1,a cGAMP hydrolase),which further aggravated the accumulation of intracellular cGAMP,leading to the persistent activation of the cGAS-STING pathway and thus the impaired the differentiation capacity of PDLSCs.Furthermore,we designed a hydrogel system loaded with a mPTP blocker,an ABCC1 agonist and ENPP1 to promote periodontal tissue regeneration by modulating the production,exocytosis,and clearance of cGAMP.In conclusion,our results highlight the profound effects,and specific mechanisms,of the cGAS-STING pathway on the function of stem cells and propose a new strategy to promote periodontal tissue restoration based on the reestablishment of cGAMP homeostasis.
基金supported by the Research Platform for biomedical and Health Technology, NUS (Suzhou) Research Institute (RP-BHT-Prof. LEE Chengkuo)RIE Advanced Manufacturing and Engineering (AME) Programmatic Grant (Grant A18A4b0055)+1 种基金RIE 2025-Industry Alignment Fund – Industry Collaboration Projects (IAF-ICP) (Grant I2301E0027)Reimagine Research Scheme projects, National University of Singapore, A-0009037-03-00 and A-0009454-01-00 and Reimagine Research Scheme projects, National University of Singapore, A-0004772-00-00 and A-0004772-01-00。
文摘Smart farming with outdoor monitoring systems is critical to address food shortages and sustainability challenges.These systems facilitate informed decisions that enhance efficiency in broader environmental management.Existing outdoor systems equipped with energy harvesters and self-powered sensors often struggle with fluctuating energy sources,low durability under harsh conditions,non-transparent or non-biocompatible materials,and complex structures.Herein,a multifunctional hydrogel is developed,which can fulfill all the above requirements and build selfsustainable outdoor monitoring systems solely by it.It can serve as a stable energy harvester that continuously generates direct current output with an average power density of 1.9 W m^(-3)for nearly 60 days of operation in normal environments(24℃,60%RH),with an energy density of around 1.36×10^(7)J m^(-3).It also shows good self-recoverability in severe environments(45℃,30%RH)in nearly 40 days of continuous operation.Moreover,this hydrogel enables noninvasive and self-powered monitoring of leaf relative water content,providing critical data on evaluating plant health,previously obtainable only through invasive or high-power consumption methods.Its potential extends to acting as other self-powered environmental sensors.This multifunctional hydrogel enables self-sustainable outdoor systems with scalable and low-cost production,paving the way for future agriculture.
基金the funding and generous support of the National Natural Science Foundation of China(52103263,52271249)the Key Project of International Science&Technology Cooperation of Shaanxi Province(2023-GHZD-09)+5 种基金the Key Project of Science Foundation of Education Department of Shaanxi Province(22JY011)the Key Project of Scientific Research and Development of Shaanxi Province(2023GXLH-070)the Qinchuangyuan"Scientist+Engineer"Team of Shaanxi Province(2023KXJ-069)the Key Research and Development Program of Shaanxi(2023-YBGY-488)the Sci-tech Innovation Team of Shaanxi Province(2024RS-CXTD-46)the Key Research and Development Program of Shaanxi Province(2020ZDLGY13-11).
文摘All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating systems.However,the static single thermal management for cooling or heating fails to self-regulate the temperature in dynamic seasonal temperature condition.Herein,inspired by the dual-temperature regulation function of the fur color changes on the backs and abdomens of penguins,a smart thermal management composite hydrogel(PNA@H-PM Gel)system was subtly created though an"on-demand"dual-layer structure design strategy.The PNA@H-PM Gel system features synchronous solar and thermal radiation modulation as well as tunable phase transition temperatures to meet the variable seasonal thermal requirements and energy-saving demands via self-adaptive radiative cooling and solar heating regulation.Furthermore,this system demonstrates superb modulations of both the solar reflectance(ΔR=0.74)and thermal emissivity(ΔE=0.52)in response to ambient temperature changes,highlighting efficient temperature regulation with average radiative cooling and solar heating effects of 9.6℃in summer and 6.1℃in winter,respectively.Moreover,compared to standard building baselines,the PNA@H-PM Gel presents a more substantial energy-saving cooling/heating potentials for energy-efficient buildings across various regions and climates.This novel solution,inspired by penguins in the real world,will offer a fresh approach for producing intelligent,energy-saving thermal management materials,and serve for temperature regulation under dynamic climate conditions and even throughout all seasons.
基金supported by the National Research Foundation of Korea(NRF)Grants funded by the Korea government(MSIT)(Nos.RS-2023-00213047 and RS-2024-00405818)。
文摘Artificial sensory systems,designed to emulate human senses like sight,touch,and hearing,have garnered significant attention for their potential to enhance human capabilities,improve human-machine interactions,and enable autonomous systems to better perceive their surroundings.Hydrogels,with their biocompatibility,flexibility,and water-rich polymer structure,are increasingly recognized as crucial materials in the development of these systems,especially in applications such as wearable sensors,artificial skin,and neural interfaces.This review explores various hydrogel fabrication techniques,including 3D bioprinting,electro spinning,and photopolymerization,which allow for the precise control of hydrogel properties like mechanical strength,flexibility,and conductivity.By tailoring these properties to mimic natural tissues,hydrogels offer transformative benefits in the creation of advanced,biocompatible,and durable sensory systems.We emphasize the importance of selecting appropriate fabrication methods to meet the specific functional requirements of artificial sensory applications,such as sensitivity to stimuli,durability,and ease of integration.This review further highlights the pivotal role of hydrogels in advancing future artificial sensory technologies and their broad potential in fields ranging from robotics to biomedical devices.
基金supported by the National Key R&D Program from the Ministry of Science and Technology of China(Grant No.2024YFB3211902)the National Natural Science Foundation of China(Grant No.52173274).
文摘The rise of wearable electronics and intelligent robotics has created an urgent demand for tactile sensors that are soft,biocompatible,and responsive.Hydrogels,with high water content and mechanical compliance such as biological tissues,provide a unique platform for constructing next-generation tactile sensors that mimic human skin’s sensory functions.This paper surveys recent progress in smart hydrogel tactile sensors and systems from fundamental concepts to practical applications.Beyond molecular structural design and material selection,we focus on the discussion and summary of the key sensing mechanisms,including triboelectric,piezoresistive,piezoelectric,piezoionic,and piezocapacitive modes.We also discuss material innovations such as ionic hydrogels,dual-conductive networks,zwitterionic matrices,and nanocomposite reinforcement,highlighting strategies to improve sensitivity,durability,and multifunctionality.Finally,the challenges and possible future directions for smart hydrogel tactile systems are outlined.
基金funded by the National Natural Science Foundation of China(grant No.82260596)the Natural Science Foundation of Jiangxi Province(grant No.20242BAB25506)+4 种基金the Science and Technology Program of Jiangxi Provincial Health and Family Planning Commission(grant No.202410246)the China Postdoctoral Science Foundation(grant No.2023M741523)he Science and Technology Program of Jiangxi Provincial Administration of Traditional Chinese Medicine(grant No.2024A0028)the Outstanding Youth Fund Program of Jiangxi Province(grant No.20252BAC220050)the Nanchang University Internal Funding Program Fund(grant No.2023efyB05).
文摘Traditional cancer therapies have limitations like poor efficacy on advanced tumors,healthy tissue damage,side effects,and drug resistance,creating an urgent need for new strategies.Hydrogels have good biocompatibility and controlled release,while extracellular vesicles(EVs)enable targeting and bioactive transport.This review systematically summarizes hydrogels and EVs,focusing on the construction of hydrogel-EV delivery system,key influencing factors,drug delivery mechanisms,and tumor therapy apps,clarifying their synergies.The system overcomes single-carrier flaws,construction methods/key factors affect performance,preclinical studies have confirmed efficacy in multiple therapies,but large-scale production and in vivo stability challenges remain,yet it promises to overcome the limits of traditional therapy for precision oncology.
基金supported by the National Institutes of Health(K01 AR07787,R21 R077700,P30 AR069619,R01 AR056624,R01 HL163168)National Science Foundation(CMMI 1548571)+2 种基金Department of Veterans Affairs(CReATE Motion Center,I50 RX004845)in the United Statessupported by the Korea Health Technology R&D Project through the Korea Health Industry Develop-ment Institute(KHIDI)funded by the Ministry of Health and Welfare(HI19C1095)National R&D Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2024-00405574)in the Republic of Korea.
文摘Meniscus injuries present significant therapeutic challenges due to their limited self-healing capacity and the diverse biological and mechanical properties across the tissue.Conventional repair strategies do not replicate the complex zonal characteristics within the meniscus,resulting in suboptimal outcomes.In this study,we introduce an innovative fetal/adult and stiffness-tunable meniscus decellularized extracellular matrix(DEM)-based hydrogel system designed for precision repair of heterogeneous,zonal-dependent meniscus injuries.By syn-thesizing fetal and adult DEM hydrogels,we identified distinct cellular responses,including that hydrogels with adult meniscus-derived DEM promote more fibrochondrogenic phenotypes.The incorporation of methacrylated hyaluronic acid(MeHA)further refined the mechanical properties and injectability of the DEM-based hydrogels.The combination of fetal and adult DEM with MeHA allowed for precise tuning of stiffness,influencing cell differentiation and closely mimicking native tissue environments.In vivo tests confirmed the biocompatibility of hydrogels and their integration with native meniscus tissues.Furthermore,advanced 3D bioprinting techniques enabled the fabrication of hybrid hydrogels with biomaterial and mechanical gradients,effectively emulating the zonal properties of meniscus tissue and enhancing cell integration.This study represents a significant advance in meniscus tissue engineering,providing a promising platform for customized regenerative therapies across a range of heterogeneous fibrous connective tissues.
文摘Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short time remains a major challenge.In this study,a multifunctional mussel-inspired hydrogel was synthesized in only 5 min,with polydopamine(PDA)-polypyrrole(Ppy)-polyaniline(PANi)and poly(vinyl alcohol)(PVA)nanoparticles incorporated into the polyacrylamide(PAM)network.The resulting hydrogel exhibited high transparency(about 90% light transmission in the range of 400-800 nm),high conductivity((95.4±0.4)×10^(-4)S/cm),tensile strength(32.60±1.03 k Pa),strain at break(904.46%±11.50%),and adhesive strength(30-60 k Pa).It also demonstrated rapid self-healing properties(about 48% strength recovery within 1h at 50℃)and water-dependent shape memory behavior.As a wearable strain sensor,the hydrogel successfully detected finger flexion,wrist movements,facial expression changes,and breathing with high sensitivity and stability.The calculated gauge factor(GF)was 7.44±0.31,which is higher than that of many previously reported hydrogels.Compared with previous oyster-inspired or Ppy-based hydrogels,our system showed a much shorter synthesis time,higher transparency,and enhanced multifunctionality.These findings highlight the potential of the proposed hydrogel for next-generation flexible electronics,e-skin,and biomedical monitoring devices.
基金Funded by the Guangdong Major Project of Basic and Applied Basic Research(No.2021B0301030001)the National Key Research and Development Program of China(No. 2021YFB3802300)the National Natural Science Foundation of China(Nos. 52403153 and 52203169)。
文摘We proposed a strategy using high-concentration tannic acid(TA) solutions to form robust and dense supramolecular networks in hydrogels,driven by the high osmotic pressure of the TA solution.The resulting hydrogels are both transparent and tough,with highly compacted networks.The hydrogels exhibit an ultimate tensile strength of approximately 4.55 MPa and a toughness of 160 MJ/m^(3).Additionally,the hydrogels adhere to a wide range of substrates,including metals,ceramics,glass,and even Teflon,with an adhesion strength of up to 42 kPa on Teflon plates.Given the biocompatibility and biodegradability of both PVA and TA,along with the hydrogels' toughness,transparency,and adhesiveness,we anticipated broad applications in the biomedical field,such as in articular cartilage restoration,electronic skin,and wound dressings.Additionally,these hydrogels hold significant potential for applications in wearable technology and optoelectronic devices.
基金supported by the National Natural Science Foundation of China(21706052,22278114)Natural Science Foundation of Henan Province(242300421575).
文摘Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent research has significantly improved the performance of lignin-based hydrogels,suggesting their substantial potential in fields such as biomedicine,environmental science,and agriculture.This paper reviews the process of lignin extraction,systematically introduces synthesis strategies for preparing lignin-based hydrogels,and discusses the current state of research on these hydrogels in biomedical and environmental protection fields.It concludes by identifying the existing challenges in lignin hydrogel research and envisioning future prospects and development trends.
基金financially supported by the National Natural Science Foundation of China(Nos.82272472 and 52373146)。
文摘Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injection of hyaluronic acid(HA)is widely used to alleviate symptoms;however,its lubrication persistence,antioxidant,and anti-inflammatory abilities are limited,and it is difficult to effectively delay the early process of cartilage degeneration.Based on this,hyaluronic acid-g-lipoic acid(HA-LA)was synthesized by esterification reaction,and HA-LA microspheres were prepared by a reversed-phase emulsion method,which was combined with a macromolecular HA-LA solution to form injectable hydrogels.The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres(HA-LA MS)for the treatment of KOA and to verify its injectability,lubricity,reactive oxygen species(ROS)scavenging ability,and anti-inflammatory effects.The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability,and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect.In vitro experiments have shown that the hydrogel can efficiently scavenge ROS,reduce the expression of inflammatory factors,and is non-cytotoxic.The HA-LA MS injectable hydrogel has excellent lubricity,ROS scavenging ability,and anti-inflammatory effects in vivo,which can effectively delay the degeneration of early KOA cartilage,and its efficacy is significantly better than that of traditional hyaluronic acid,making it a promising intra-articular injection preparation.
基金the Department of Science and Technology(DST),Govt.of India for providing funds under the FIST program and PURSE grant vide No.SR/PURSE/2020/31 to the department of Chemistry,University of Kashmir.
文摘This study presents a thorough investigation into the use of single and twin-tailed cationic and anionic surfactant-modified chitosan(SMCS)hydrogel beads as effective adsorbents for the elimination of hazardous polycyclic aromatic hydrocarbons(PAHs)from aqueous solutions.The Chitosan(CS)hydrogel beads were modified with single/twin-tailed anionic surfactants,sodium dodecyl sulfate(SDS)and sodium bis(2-ethylhexyl)sulfosuccinate(AOT),and cationic surfactants,dodecyltrimethylammonium bromide(DTAB)and didodecyldimethylammonium bromide(DDAB),to enhance their adsorption capacity of PAHs.The CS and SMCS beads were evaluated for their structural,mechanical,and adsorption properties using a range of techniques,including infrared spectroscopy(IR),energy-dispersive X-ray spectroscopy(EDX),rheometry,and field emission scanning electron microscopy(FESEM).Adsorption experiments of naphthalene(Nap),acenaphthene(Ace),and phenanthrene(Phe)on SMCS beads demonstrate that they have significantly higher adsorption capacities than CS beads,due to increase in hydrophobic interactions.Adsorption capacity followed the trend,Phen>Ace>Nap for all the beads revealing that twin-tailed SMCS bead possess much higher adsorption capacities(Qmax)compared to single-tailed SMCS beads.For twin tailed surfactants,the maximum adsorption capacities for Nap,Ace and Phe varied as CS-AOT(CS-DDAB):430.0(323.8)611.60(538.18)633.39(536.99)mg/g respectively,outperforming other reported hydrogel beads.The study highlights the simplicity,eco-friendliness,and enhanced performance of surfactant modification for developing high-efficiency adsorbents,paving the way for cost-effective solutions in water re-mediation.
基金supported by the National Key R&D Program of China(No.2023YFA1507500)the Nation-al Natural Science Foundation of China(No.52373159)。
文摘Green solvent pretreatment of biomass represents a promising ap-proach for enhancing the econom-ic value of lignocellulosic deriva-tives.In this study,corncob biomass was treated with a diol-based deep eutectic solvent(DES)under mild conditions,facilitating efficient cellulose separation.The extracted cellulose was subsequently used to fabricate cellulose hydrogels in an aqueous zinc chloride solution.The resulting hydrogel exhibited a“water-in-salt”effect due to the high concentration of ZnCl_(2).Leveraging the antifreeze properties of sorbitol,the system demon-strated outstanding low-temperature electrochemical performance,including a broad operat-ing voltage window and an ionic conductivity of 38.4 mS·cm^(-1)at-20℃.At 20℃,the de-vice achieved an energy density of 206 Wh·kg^(-1)and a power density of 2701.05 W·kg^(-1)at a current density of 1 A·g^(-1).Moreover,the flexible zinc-ion hybrid supercapacitor(ZHSC)maintained 89%of its capacitance and nearly 100%Coulombic efficiency after 5500 cycles at 20℃.This work not only advances the development of zinc-ion energy storage devices but al-so establishes a new paradigm for the green and direct utilization of biomass-derived materi-als.
