Acne is a dermatological condition with significant psychosocial consequences.This study evaluated the efficacy of an unmedicated acne-concealing hydrogel patch for improving acne appearance and acne-related quality o...Acne is a dermatological condition with significant psychosocial consequences.This study evaluated the efficacy of an unmedicated acne-concealing hydrogel patch for improving acne appearance and acne-related quality of life(AQoL).A randomized,open-label,home-use 10-day clinical trial was conducted with 37 volunteers,each presenting at least one active pustule.Twenty-three acne lesions were treated with Pimple Patches,and 23 served as untreated controls.Lesion size,severity,erythema,and post-inflammatory hyperpigmentation(PIH)were assessed by an expert grader at baseline,Day 2,and Day 10.AQoL scores were measured at the start and end of the study.The hydrogel patch treatment resulted in a 35%reduction in lesion size and a 44%improvement in lesion severity by Day 2 compared to the control group.By Day 10,the treated group exhibited greater reductions in lesion size,severity,and erythema.PIH worsened significantly in the untreated group compared to the treated group by Day 10.AQoL scores indicated a 57%improvement in the treated group,higher than the untreated group(p<0.05).Our exploratory findings suggest that the unmedicated acneconcealing patches are a safe and practical treatment for reducing acne lesion size and severity,calming erythema,inhibiting PIH onset,and improving AQoL.展开更多
To address postoperative melanoma issues of high recurrence and poor wound healing,we developed a nanocomposite hydrogel wound patch(M_(xNd/yCe)@M SAC)for cascade sequential therapy.Methotrexate(MTX)loaded Nd/Ce-doped...To address postoperative melanoma issues of high recurrence and poor wound healing,we developed a nanocomposite hydrogel wound patch(M_(xNd/yCe)@M SAC)for cascade sequential therapy.Methotrexate(MTX)loaded Nd/Ce-doped mesoporous bioactive glass was encapsulated in a sulfobetaine-polyacrylamide-carboxymethyl chitosan hydrogel via thermal polymerization.Under the acidic microenvironment of the residual tumor,the amide bonds in M_(xNd/yCe)@M SAC are broken,releasing M_(xNd/yCe)@M.M_(xNd/yCe)@M targets tumor cells,and the combined therapy of mild photothermal treatment and chemotherapy ablates tumor cells.Subsequently,the continuously released MTX downregulates the expression of pro-inflammatory factors and reshapes the immune microenvironment.Finally,M_(xNd/yCe)@M disintegrates,releasing Si^(4+),Ca^(2+),P^(5+)and Ce^(3+)ions,which can effectively promote angiogenesis and tissue repair.In the postoperative melanoma model,this method effectively cleared the residual tumors after surgery,shortened the inflammatory period,and promoted tissue regeneration.In conclusion,the nanocomposite hydrogel wound patch for cascade sequential treatment prepared in this study has excellent anti-tumor,immune regulation and tissue repair properties,providing prospective insights for the postoperative treatment of malignant melanoma.展开更多
文摘Acne is a dermatological condition with significant psychosocial consequences.This study evaluated the efficacy of an unmedicated acne-concealing hydrogel patch for improving acne appearance and acne-related quality of life(AQoL).A randomized,open-label,home-use 10-day clinical trial was conducted with 37 volunteers,each presenting at least one active pustule.Twenty-three acne lesions were treated with Pimple Patches,and 23 served as untreated controls.Lesion size,severity,erythema,and post-inflammatory hyperpigmentation(PIH)were assessed by an expert grader at baseline,Day 2,and Day 10.AQoL scores were measured at the start and end of the study.The hydrogel patch treatment resulted in a 35%reduction in lesion size and a 44%improvement in lesion severity by Day 2 compared to the control group.By Day 10,the treated group exhibited greater reductions in lesion size,severity,and erythema.PIH worsened significantly in the untreated group compared to the treated group by Day 10.AQoL scores indicated a 57%improvement in the treated group,higher than the untreated group(p<0.05).Our exploratory findings suggest that the unmedicated acneconcealing patches are a safe and practical treatment for reducing acne lesion size and severity,calming erythema,inhibiting PIH onset,and improving AQoL.
基金supported by the National Key Research and Development Program of China(No.2022YFC2106100)the National Natural Science Foundation of China(No.22078265).
文摘To address postoperative melanoma issues of high recurrence and poor wound healing,we developed a nanocomposite hydrogel wound patch(M_(xNd/yCe)@M SAC)for cascade sequential therapy.Methotrexate(MTX)loaded Nd/Ce-doped mesoporous bioactive glass was encapsulated in a sulfobetaine-polyacrylamide-carboxymethyl chitosan hydrogel via thermal polymerization.Under the acidic microenvironment of the residual tumor,the amide bonds in M_(xNd/yCe)@M SAC are broken,releasing M_(xNd/yCe)@M.M_(xNd/yCe)@M targets tumor cells,and the combined therapy of mild photothermal treatment and chemotherapy ablates tumor cells.Subsequently,the continuously released MTX downregulates the expression of pro-inflammatory factors and reshapes the immune microenvironment.Finally,M_(xNd/yCe)@M disintegrates,releasing Si^(4+),Ca^(2+),P^(5+)and Ce^(3+)ions,which can effectively promote angiogenesis and tissue repair.In the postoperative melanoma model,this method effectively cleared the residual tumors after surgery,shortened the inflammatory period,and promoted tissue regeneration.In conclusion,the nanocomposite hydrogel wound patch for cascade sequential treatment prepared in this study has excellent anti-tumor,immune regulation and tissue repair properties,providing prospective insights for the postoperative treatment of malignant melanoma.
