Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a seri...Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.展开更多
Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examinatio...Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition.展开更多
The limited ability of cartilage tissue to repair itself poses a functionally impairing health problem. While many treatment methods are available, full restoration of the tissue to its original state is rare. Often, ...The limited ability of cartilage tissue to repair itself poses a functionally impairing health problem. While many treatment methods are available, full restoration of the tissue to its original state is rare. Often, complete joint replacement surgery is required to obtain long-term relief. Tissue engineering approaches, however, provide new opportunities for cartilage replacement. They seek to provide mechanisms to repair or replace lost tissue or function. A theoretical method is presented here for regenerating hyaline cartilage in vitro using a chondrocyte-seeded three-dimensional biomimetic engineered scaffold with mechanical properties similar to those occurring naturally. The scaffold composition, type II collagen, aggrecan, hyaluronan, hyaluronan binding protein (for link protein), and BMP-7, were chosen to encourage synthesis of hyaline cartilage by providing a more native environment and signaling cue for the seeded chondrocytes. The scaffold components mimic the macrofibrillar collagen network found in articular cartilage. Type II collagen provides tensile strength, and aggrecan, the predominant proteoglycan, provides compressive strength.展开更多
The articular osteochondral injury involves the repair of hyaline cartilage,subchondral bone plate,and cancellous bone.Due to the weak regeneration ability of chondrocytes and the complex structure of the bone-cartila...The articular osteochondral injury involves the repair of hyaline cartilage,subchondral bone plate,and cancellous bone.Due to the weak regeneration ability of chondrocytes and the complex structure of the bone-cartilage junction,there is currently no excellent repair method.The challenge of hyaline cartilage repair is to avoid fibrosis and hypertrophy,which has been solved to some extent after the advent of type II collagen scaffolds;the difficulty of the subchondral bone plate and cancellous bone repair lies in the repair of the complex transition structure of cartilage tidemark,calcified cartilage,subchondral bone plate,and cancellous bone.Inspired by developmental biology,the generation of this complex structure during development depends on endochondral ossification(ECO).ECO depends on some specific proteins,such as IHH,PTHrP,BMP,and WNT,and the receptors of these proteins.Studies have shown that polydopamine coating can promote the production of BMP and WNT proteins.We developed a type II collagen-based double-layer scaffold(Col II&Dopa-Col II)with type II collagen on the upper layer and polydopamine-coated type II collagen on the lower layer.Proteomics and RNA sequencing analysis have found that polydopamine coating can mobilize the proliferation and hy-pertrophy differentiation of chondrocytes,induce intra-chondral vascular nerve invasion,and promote ECO and bone remodeling by upregulating Parathyroid hormone signaling pathway,Hedgehog signaling pathway,VEGF signaling pathway,and Axon guidance.All the results indicate that Col II&Dopa-Col II can achieve hyaline cartilage and vascularized subchondral bone regeneration.展开更多
930603 Ultrastructural study of the thymus inpatients with myasthenia gravis.LI Shixiao(李世校),et al.Henan Med Univ,Zhengzhou,450052.Chin J Intern Med 1993;32(5):310-311.The ultrastructure of the thymus gland fromten...930603 Ultrastructural study of the thymus inpatients with myasthenia gravis.LI Shixiao(李世校),et al.Henan Med Univ,Zhengzhou,450052.Chin J Intern Med 1993;32(5):310-311.The ultrastructure of the thymus gland fromten patients with myasthenia gravis was studiedand compared with that from three normal sub-jects.Thymic tissue in myasthenia gravis showedinflammatory reaction chracterized by presence ofneutrophils and macrophages,plasma cell infil-tration,epithelial reticular cell hyperplasia。展开更多
BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary glands.This neoplasia constitutes less than 1%of minor salivary gland tumors.CASE SUMMARY A 67-year-old female visi...BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary glands.This neoplasia constitutes less than 1%of minor salivary gland tumors.CASE SUMMARY A 67-year-old female visited the maxillofacial surgery department owing to a smooth,slightly yellowish protruding mass on the left side of the floor of the mouth,at the level of the molars;the tumor mass had a soft consistency on palpation and did not adhere to deep planes.The microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline collagen.Normal glandular tissue was absent,periodic acid-Schiff with and without diastase stains,and immunohistochemical reactions were performed to confirm the diagnosis.This is the second case reported in the literature of HCCC arising in the floor of the mouth.CONCLUSION HCCC is a rare salivary gland tumor that has not been studied extensively.Its diagnosis is usually challenging,because clinically,it can be confused with a benign neoplasm.展开更多
Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Re...Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Report: Reported herein is a case of primary tumour of buttock HSCT that had rare FUS-CREB3L1 fusion transcripts, a product of characteristic chromosomal abnormality t (7;16) (q33;p11) of HSCT and LGFMS. The patient was a 48-year-old man who had a large solitary mass in the buttock. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L1 fusion transcripts. In our knowledge is the second case may display a variant FUS/CREB3L1 fusion transcript in international literature. Conclusion: LGFMS and HSCT probably have a wider spectrum of morphologic features than previously thought, the awareness of which will help pathologists to avoid diagnostic pitfalls. Demonstration of the t (7;16) translocation will help to diagnose difficult cases with unusual histologic features.展开更多
Pulmonary hyalinizing granuloma (PHG) is a rare nodular disease of unknown etiology. PHG can present with solitary or bilateral lung nodules and be asymptomatic or present with fever, cough, dyspnea, chest pain and he...Pulmonary hyalinizing granuloma (PHG) is a rare nodular disease of unknown etiology. PHG can present with solitary or bilateral lung nodules and be asymptomatic or present with fever, cough, dyspnea, chest pain and hemoptysis.展开更多
Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with ...Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with variable solid and pseudopapillary areas.The characteristic features of SPN are poorly cohesive epithelial cells forming papillary-like structures on myxoid or hyalinized vascular stalk.展开更多
With the support by the National Natural Science Foundation of China,the research team led by Prof.Jiang Qing(蒋青)at the Joint Rsearch Center for Bone and Joint Disease,Model Animal Research Center,Nanjing University...With the support by the National Natural Science Foundation of China,the research team led by Prof.Jiang Qing(蒋青)at the Joint Rsearch Center for Bone and Joint Disease,Model Animal Research Center,Nanjing University,cooperated with Prof.Gu Zhen’s team from the Joint Department of Biomedical Engineering,展开更多
Fungi have evolved diverse strategies to acquire nutrients as endophytes,saprobes,symbionts,or pathogens.Appressoria have been intensively studied due to their importance in attaching and breaching the host surface.Th...Fungi have evolved diverse strategies to acquire nutrients as endophytes,saprobes,symbionts,or pathogens.Appressoria have been intensively studied due to their importance in attaching and breaching the host surface.These specialized infection structures have evolved into various morpho-types:proto-appressoria,hyaline appressoria,melanized(dark)appressoria,and compound appressoria.In this review,we discuss the differences in the formation,differentiation,and function of appres-soria among fungi with diverse life strategies.Using DNA sequence information,LSU,5.8S,SSU and rpb2 gene fragments,we reconstructed the ancestral states for appressorial types in the main phyla of fungi and fungus-like organisms and found that the hyaline appressoria was the most ancestral form.Our analysis estimated proto-appressoria diversification during the Mesozoic period(92-239 million years ago),however,its origin remains inconclusive.Our data suggest that these hyaline appressoria diversified into melanized or compound appressoria,with evidence of adaptive radiation.展开更多
Polyneuropathy,organomegaly,endocrinopathy,M proteins,and skin changes(POEMS)syndrome is a multisystemic disorder that clinically manifests as paraneoplastic and monoclonal plasma cell dyscrasia.Its acronym is derived...Polyneuropathy,organomegaly,endocrinopathy,M proteins,and skin changes(POEMS)syndrome is a multisystemic disorder that clinically manifests as paraneoplastic and monoclonal plasma cell dyscrasia.Its acronym is derived from its principal characteristics:polyneuropathy,organomegaly,endocrinopathy,M proteins,and skin changes.Here,the authors reported a case of POEMS syndrome that was also associated with Castleman disease.A 53-year-old female patient was admitted to our hospital with limb weakness,numbness,edema,abdominal distention,and fever.Physical examination revealed tetraplegia,paraesthesia,and hyporeflexia in all four limbs,in addition to lymphadenectasis,splenomegaly,skin hyperpigmentation,hypertrichosis,and pitting edema.Laboratory tests and imaging revealed thrombocytosis,hypothyroidism,diabetes,hydropericardium,hydrothorax,splenomegaly,and lymphadenectasis.Electromyography showed the characteristic patterns of both demyelinating disease and axonal degeneration.Serum protein electrophoresis revealed monoclonal immunoglobulin G-lambda paraproteins.Histological examination clearly diagnosed the disease as the hyaline vascular subtype.The final diagnosis in this case was POEMS syndrome in association with Castleman disease.展开更多
Objective To observe the clinicopathological features of pulmonary parenchymal involvement of multicentric Castleman’s disease(MCD).Methods Retrospective analysis was carried out for 6 patients of MCD with pulmonary ...Objective To observe the clinicopathological features of pulmonary parenchymal involvement of multicentric Castleman’s disease(MCD).Methods Retrospective analysis was carried out for 6 patients of MCD with pulmonary parenchymal involvement who had been admitted to Peking Union Medical College Hospital from July 2008to March 2013.Relevant literatures were reviewed.The diagnosis was established by surgical lung biopsy and展开更多
Objective To investigate clinical and pathological features of idiopathic membranous nephropathy(IMN)accompanied by mesangial dense deposit.Methods Clinical data of 46 patients who were diagnosed as IMN accompanied by...Objective To investigate clinical and pathological features of idiopathic membranous nephropathy(IMN)accompanied by mesangial dense deposit.Methods Clinical data of 46 patients who were diagnosed as IMN accompanied by mesangial dense deposit admitted to Zhejiang Provincial People’s Hospital from January 2013展开更多
Objective To analyze the CT and MRI findings and pathological characteristics of retroperitoneal localized Castleman’s disease and discuss the diagnostic and differential value of CT and MRI.Methods CT,MRI and clinic...Objective To analyze the CT and MRI findings and pathological characteristics of retroperitoneal localized Castleman’s disease and discuss the diagnostic and differential value of CT and MRI.Methods CT,MRI and clinical data of retroperitoneal localized Castleman’s disease,proved by surgery and pathology,13 patients were reviewed.Among them,all the 13 cases received CT,and4 cases received MRI examination.Results Among展开更多
Objective To study the clinicopathologic features,immunophenotype,differential diagnosis and prognosis of renal cell carcinoma(RCC)associated with t(6;11)(p21.2;q13)/MALAT1-TEEB gene fusion.Methods A total of 9 cases ...Objective To study the clinicopathologic features,immunophenotype,differential diagnosis and prognosis of renal cell carcinoma(RCC)associated with t(6;11)(p21.2;q13)/MALAT1-TEEB gene fusion.Methods A total of 9 cases with such rare tumor were selected for clinicopathologic,immunohistochemical and展开更多
Background Hyalinizing trabecular tumor （HTT） is a rare thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma （TPC）. Clinically, it is frequently misdiagnosed as papillary carcin...Background Hyalinizing trabecular tumor （HTT） is a rare thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma （TPC）. Clinically, it is frequently misdiagnosed as papillary carcinoma, even for some experienced pathologists. The aim of this study was to investigate whether HTT is variant of TPC or HTT is an independent entity of thyroid neoplasm.Methods The expression of CK19, galectin-3, HBME-1 and MIB-1 was detected by immunohistochemical staining in 12 cases of hyalinizing trabecular tumor and 20 cases of thyroid papillary carcinoma.Results Two of the 12 HTT samples were positive or focally positive for CK19. Four of the 12 samples of HTT presented positive to galectin-3; 3 were stained strongly and the other one was focally positive. None of the 12 samples of HTT was positive for HBME-1. Five in 12 HTT samples were stained in nucleus for MIB-1. Almost all the 20 cases of thyroid papillary carcinoma were intensely stained for CK19, galectin-3 and HBME-1. Fifteen in 20 cases of thyroid papillary carcinoma showed nuclear staining for MIB-1.Conclusions HTT is an independent thyroid neoplasm, not a variant of TPC. This study could help in the differential diagnosis of HTT from TPC. CK19, galectin-3 and HBME-1 are adequate to identify HTT and TPC, but MIB-1 does not play an important role in discrimination between HTT and TPC.展开更多
文摘Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.
文摘Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition.
文摘The limited ability of cartilage tissue to repair itself poses a functionally impairing health problem. While many treatment methods are available, full restoration of the tissue to its original state is rare. Often, complete joint replacement surgery is required to obtain long-term relief. Tissue engineering approaches, however, provide new opportunities for cartilage replacement. They seek to provide mechanisms to repair or replace lost tissue or function. A theoretical method is presented here for regenerating hyaline cartilage in vitro using a chondrocyte-seeded three-dimensional biomimetic engineered scaffold with mechanical properties similar to those occurring naturally. The scaffold composition, type II collagen, aggrecan, hyaluronan, hyaluronan binding protein (for link protein), and BMP-7, were chosen to encourage synthesis of hyaline cartilage by providing a more native environment and signaling cue for the seeded chondrocytes. The scaffold components mimic the macrofibrillar collagen network found in articular cartilage. Type II collagen provides tensile strength, and aggrecan, the predominant proteoglycan, provides compressive strength.
基金General Research Fund (GRF) from the Research Grants Council (RGC) of the Hong Kong Special Administrative Region, China (CUHK11205324)Grant from Karolinska Institutet Ming Wai Lau Center of Reparative Medicine (CityUHK 9231486)Grant from Health@InnoHK: CNRM, Innovation and Technology Commission, Hong Kong SAR.
文摘The articular osteochondral injury involves the repair of hyaline cartilage,subchondral bone plate,and cancellous bone.Due to the weak regeneration ability of chondrocytes and the complex structure of the bone-cartilage junction,there is currently no excellent repair method.The challenge of hyaline cartilage repair is to avoid fibrosis and hypertrophy,which has been solved to some extent after the advent of type II collagen scaffolds;the difficulty of the subchondral bone plate and cancellous bone repair lies in the repair of the complex transition structure of cartilage tidemark,calcified cartilage,subchondral bone plate,and cancellous bone.Inspired by developmental biology,the generation of this complex structure during development depends on endochondral ossification(ECO).ECO depends on some specific proteins,such as IHH,PTHrP,BMP,and WNT,and the receptors of these proteins.Studies have shown that polydopamine coating can promote the production of BMP and WNT proteins.We developed a type II collagen-based double-layer scaffold(Col II&Dopa-Col II)with type II collagen on the upper layer and polydopamine-coated type II collagen on the lower layer.Proteomics and RNA sequencing analysis have found that polydopamine coating can mobilize the proliferation and hy-pertrophy differentiation of chondrocytes,induce intra-chondral vascular nerve invasion,and promote ECO and bone remodeling by upregulating Parathyroid hormone signaling pathway,Hedgehog signaling pathway,VEGF signaling pathway,and Axon guidance.All the results indicate that Col II&Dopa-Col II can achieve hyaline cartilage and vascularized subchondral bone regeneration.
文摘930603 Ultrastructural study of the thymus inpatients with myasthenia gravis.LI Shixiao(李世校),et al.Henan Med Univ,Zhengzhou,450052.Chin J Intern Med 1993;32(5):310-311.The ultrastructure of the thymus gland fromten patients with myasthenia gravis was studiedand compared with that from three normal sub-jects.Thymic tissue in myasthenia gravis showedinflammatory reaction chracterized by presence ofneutrophils and macrophages,plasma cell infil-tration,epithelial reticular cell hyperplasia。
文摘BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary glands.This neoplasia constitutes less than 1%of minor salivary gland tumors.CASE SUMMARY A 67-year-old female visited the maxillofacial surgery department owing to a smooth,slightly yellowish protruding mass on the left side of the floor of the mouth,at the level of the molars;the tumor mass had a soft consistency on palpation and did not adhere to deep planes.The microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline collagen.Normal glandular tissue was absent,periodic acid-Schiff with and without diastase stains,and immunohistochemical reactions were performed to confirm the diagnosis.This is the second case reported in the literature of HCCC arising in the floor of the mouth.CONCLUSION HCCC is a rare salivary gland tumor that has not been studied extensively.Its diagnosis is usually challenging,because clinically,it can be confused with a benign neoplasm.
文摘Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Report: Reported herein is a case of primary tumour of buttock HSCT that had rare FUS-CREB3L1 fusion transcripts, a product of characteristic chromosomal abnormality t (7;16) (q33;p11) of HSCT and LGFMS. The patient was a 48-year-old man who had a large solitary mass in the buttock. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L1 fusion transcripts. In our knowledge is the second case may display a variant FUS/CREB3L1 fusion transcript in international literature. Conclusion: LGFMS and HSCT probably have a wider spectrum of morphologic features than previously thought, the awareness of which will help pathologists to avoid diagnostic pitfalls. Demonstration of the t (7;16) translocation will help to diagnose difficult cases with unusual histologic features.
文摘Pulmonary hyalinizing granuloma (PHG) is a rare nodular disease of unknown etiology. PHG can present with solitary or bilateral lung nodules and be asymptomatic or present with fever, cough, dyspnea, chest pain and hemoptysis.
文摘Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with variable solid and pseudopapillary areas.The characteristic features of SPN are poorly cohesive epithelial cells forming papillary-like structures on myxoid or hyalinized vascular stalk.
文摘With the support by the National Natural Science Foundation of China,the research team led by Prof.Jiang Qing(蒋青)at the Joint Rsearch Center for Bone and Joint Disease,Model Animal Research Center,Nanjing University,cooperated with Prof.Gu Zhen’s team from the Joint Department of Biomedical Engineering,
文摘Fungi have evolved diverse strategies to acquire nutrients as endophytes,saprobes,symbionts,or pathogens.Appressoria have been intensively studied due to their importance in attaching and breaching the host surface.These specialized infection structures have evolved into various morpho-types:proto-appressoria,hyaline appressoria,melanized(dark)appressoria,and compound appressoria.In this review,we discuss the differences in the formation,differentiation,and function of appres-soria among fungi with diverse life strategies.Using DNA sequence information,LSU,5.8S,SSU and rpb2 gene fragments,we reconstructed the ancestral states for appressorial types in the main phyla of fungi and fungus-like organisms and found that the hyaline appressoria was the most ancestral form.Our analysis estimated proto-appressoria diversification during the Mesozoic period(92-239 million years ago),however,its origin remains inconclusive.Our data suggest that these hyaline appressoria diversified into melanized or compound appressoria,with evidence of adaptive radiation.
文摘Polyneuropathy,organomegaly,endocrinopathy,M proteins,and skin changes(POEMS)syndrome is a multisystemic disorder that clinically manifests as paraneoplastic and monoclonal plasma cell dyscrasia.Its acronym is derived from its principal characteristics:polyneuropathy,organomegaly,endocrinopathy,M proteins,and skin changes.Here,the authors reported a case of POEMS syndrome that was also associated with Castleman disease.A 53-year-old female patient was admitted to our hospital with limb weakness,numbness,edema,abdominal distention,and fever.Physical examination revealed tetraplegia,paraesthesia,and hyporeflexia in all four limbs,in addition to lymphadenectasis,splenomegaly,skin hyperpigmentation,hypertrichosis,and pitting edema.Laboratory tests and imaging revealed thrombocytosis,hypothyroidism,diabetes,hydropericardium,hydrothorax,splenomegaly,and lymphadenectasis.Electromyography showed the characteristic patterns of both demyelinating disease and axonal degeneration.Serum protein electrophoresis revealed monoclonal immunoglobulin G-lambda paraproteins.Histological examination clearly diagnosed the disease as the hyaline vascular subtype.The final diagnosis in this case was POEMS syndrome in association with Castleman disease.
文摘Objective To observe the clinicopathological features of pulmonary parenchymal involvement of multicentric Castleman’s disease(MCD).Methods Retrospective analysis was carried out for 6 patients of MCD with pulmonary parenchymal involvement who had been admitted to Peking Union Medical College Hospital from July 2008to March 2013.Relevant literatures were reviewed.The diagnosis was established by surgical lung biopsy and
文摘Objective To investigate clinical and pathological features of idiopathic membranous nephropathy(IMN)accompanied by mesangial dense deposit.Methods Clinical data of 46 patients who were diagnosed as IMN accompanied by mesangial dense deposit admitted to Zhejiang Provincial People’s Hospital from January 2013
文摘Objective To analyze the CT and MRI findings and pathological characteristics of retroperitoneal localized Castleman’s disease and discuss the diagnostic and differential value of CT and MRI.Methods CT,MRI and clinical data of retroperitoneal localized Castleman’s disease,proved by surgery and pathology,13 patients were reviewed.Among them,all the 13 cases received CT,and4 cases received MRI examination.Results Among
文摘Objective To study the clinicopathologic features,immunophenotype,differential diagnosis and prognosis of renal cell carcinoma(RCC)associated with t(6;11)(p21.2;q13)/MALAT1-TEEB gene fusion.Methods A total of 9 cases with such rare tumor were selected for clinicopathologic,immunohistochemical and
文摘Background Hyalinizing trabecular tumor （HTT） is a rare thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma （TPC）. Clinically, it is frequently misdiagnosed as papillary carcinoma, even for some experienced pathologists. The aim of this study was to investigate whether HTT is variant of TPC or HTT is an independent entity of thyroid neoplasm.Methods The expression of CK19, galectin-3, HBME-1 and MIB-1 was detected by immunohistochemical staining in 12 cases of hyalinizing trabecular tumor and 20 cases of thyroid papillary carcinoma.Results Two of the 12 HTT samples were positive or focally positive for CK19. Four of the 12 samples of HTT presented positive to galectin-3; 3 were stained strongly and the other one was focally positive. None of the 12 samples of HTT was positive for HBME-1. Five in 12 HTT samples were stained in nucleus for MIB-1. Almost all the 20 cases of thyroid papillary carcinoma were intensely stained for CK19, galectin-3 and HBME-1. Fifteen in 20 cases of thyroid papillary carcinoma showed nuclear staining for MIB-1.Conclusions HTT is an independent thyroid neoplasm, not a variant of TPC. This study could help in the differential diagnosis of HTT from TPC. CK19, galectin-3 and HBME-1 are adequate to identify HTT and TPC, but MIB-1 does not play an important role in discrimination between HTT and TPC.
