Targeted protein degrader has emerged as a transformative therapeutic technology,offering a novel modality to address previously intractable drug targets and enabling innovative approaches to disease treatment1.Unlike...Targeted protein degrader has emerged as a transformative therapeutic technology,offering a novel modality to address previously intractable drug targets and enabling innovative approaches to disease treatment1.Unlike conventional small-molecule drugs that function through occupancy-driven mechanisms,targeted protein degradation(TPD)employs an event-driven pharmacological strategy by harnessing the ubiquitin–proteasome system(UPS)and lysosomal degradation pathways2.展开更多
文摘Targeted protein degrader has emerged as a transformative therapeutic technology,offering a novel modality to address previously intractable drug targets and enabling innovative approaches to disease treatment1.Unlike conventional small-molecule drugs that function through occupancy-driven mechanisms,targeted protein degradation(TPD)employs an event-driven pharmacological strategy by harnessing the ubiquitin–proteasome system(UPS)and lysosomal degradation pathways2.
