Background and objectives:Huo Xue Tong Luo Capsule(HXTL)has been clinically used to treat osteonecrosis of the femoral head,osteoporosis,and other bone and joint diseases with promising effects.Our previous study has ...Background and objectives:Huo Xue Tong Luo Capsule(HXTL)has been clinically used to treat osteonecrosis of the femoral head,osteoporosis,and other bone and joint diseases with promising effects.Our previous study has shown that HXTL can promote osteogenesis in mesenchymal stem cells by inhibiting lncRNA-Miat expression through histone modifications.However,the mechanism by which HXTL treats postmenopausal osteoporosis(PMOP)remains unclear.In this study,we used network pharmacology-based mechanism prediction,molecular docking,and pharmacological validation to investigate the mechanism of HXTL in treating PMOP.Methods:The key candidate targets and relevant signaling pathways of HXTL for PMOP treatment were predicted using network pharmacology and molecular docking analysis.RAW264.7 cells were used for Western blot to validate the predicted mechanistic pathways.The ovaries of mice were surgically removed to simulate PMOP.The effect of HXTL on PMOP was evaluated using tartrate-resistant acid phosphatase staining and immunohistochemical assays in vivo.Results:Network pharmacology analysis suggested that HXTL interacted with 215 key targets linked to PMOP,primarily affecting the PI3K-AKT signaling pathway.Molecular docking showed that the main components of HXTL exhibited strong binding affinity to NFATc1,p-PI3K,and p-AKT1.Furthermore,our in vitro results confirmed that HXTL suppressed the PI3KAKT signaling pathway.In vivo,HE and tartrate-resistant acid phosphatase staining results showed that HXTL inhibited osteoclast formation and protected bone mass.展开更多
Since ancient times,humans have endeavored to maintain their health.These methods are collectively referred to as“Yang Sheng(养生)”or health preservation practices.The concept of Yang Sheng originated and was nurtur...Since ancient times,humans have endeavored to maintain their health.These methods are collectively referred to as“Yang Sheng(养生)”or health preservation practices.The concept of Yang Sheng originated and was nurtured in ancient China.By the Ming dynasty,this practice had transcended the elite scholarly class and began to garner the attention of the general populace.With the development of the publishing industry,a large number of Yang Sheng-related books were created,disseminated,and widely read.Zhu Quan(朱权),a representative literatus of the Ming dynasty and a member of the imperial family,left behind a vast body of writings across multiple fields,including Yang Sheng,medicine,Daoism,history,drama,and phonology.Among these,his works on Yang Sheng and medicine were also transmitted to Korea and Japan,exerting an influence on East Asian Yang Sheng culture.Previous studies have largely lacked a systematic examination of Zhu Quan’s thought on Yang Sheng and have paid little attention to the transmission of this thought in Korea and Japan.This study begins with an analysis of his Yang Sheng-related text Huo Ren Xin(《活人心》Enlivening the Human Heart),and through an exploration of the core ideas in this work as well as its dissemination and reception in Korea and Japan,it attempts to shed light on the modes of transmission and exchange within East Asian Yang Sheng culture.First,the paper investigates the formation of Zhu Quan’s thinking by examining his life and intellectual background.It then analyzes the compilation,content,and conceptual features of Huo Ren Xin,and explores its transmission in Korea and Japan based on extant editions.Finally,through an examination of medical texts and literary works by scholars in Korea and Japan,the study further elucidates the acceptance and transmission of Zhu Quan’s Yang Sheng thought across East Asia.展开更多
Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly ...Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly its efficacy in managing chemotherapy-induced nausea and vomiting (CINV). Methods: A total of 100 patients with gastrointestinal reactions who were hospitalized in the oncology department of Nanning Third People’s Hospital from January to December 2023 were selected as study subjects. They were randomly divided into two groups: the observation group (n = 50) received standard antiemetic treatment in conjunction with Shen-Shi Zhi-Tong plaster and Lei-Huo moxibustion, while the control group (n = 50) received only standard antiemetic treatment and Lei-Huo moxibustion. The occurrence of nausea and vomiting during chemotherapy was recorded using a CINV nursing log, and the incidence rates of acute and delayed vomiting were statistically analyzed. Results: The incidence rate of acute vomiting in the observation group was 42%, significantly lower than the control group’s 64% (P = 0.0300);the incidence rate of delayed vomiting was 36% in the observation group compared to 48% in the control group (P = 0.1900). The mean nausea grade in the observation group was 1.08, significantly lower than 2.02 in the control group (P Conclusion: Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion can effectively reduce the incidence of nausea and vomiting in patients undergoing highly emetogenic chemotherapy and shows good clinical application prospects. This study provides strong support for the adoption of such combined therapies in the prevention and treatment of CINV in the future.展开更多
在海外汉学著作中,文化层面的误读、专有名词的误译现象时有发生。这些未经校正的误读、误译,往往会在回译环节中持续传递,导致“以讹传讹”的问题。本研究以美国汉学家伯儒(Rhea C.Blue)的长文The Argumentation of the Shih-Huo Chih:...在海外汉学著作中,文化层面的误读、专有名词的误译现象时有发生。这些未经校正的误读、误译,往往会在回译环节中持续传递,导致“以讹传讹”的问题。本研究以美国汉学家伯儒(Rhea C.Blue)的长文The Argumentation of the Shih-Huo Chih:Chapters of Han,Wei,Sui Dynastic History为研究对象,聚焦于专有名词的文化回译问题。根据专有名词出现频率和性质特征,可将其分为四类即官位名词、财经名词、著作名词和制度名词,并提出“还原—重构”二元文化回译策略。还原策略通过“完全还原”与“半还原”锚定术语的文化本体性,旨在维护中国古代专有名词的独特性。重构策略则通过“旧词新造”与“深度翻译”搭建跨文化认知桥梁。二者协同运作,还原文化基因,抵制语义殖民,重构跨文明对话的阐释协商机制,激活对话空间,最终既还原被解构的思想谱系,又建构可通约的跨文化阐释路径。展开更多
OBJECTIVE To evaluate the effects of Tong-Qiao-Huo-Xue decoction(TQHXD)on the bloodbrain barrier(BBB)permeability and the expressions of related proteins on the rats;and to analyse the constituents in the cerebrospina...OBJECTIVE To evaluate the effects of Tong-Qiao-Huo-Xue decoction(TQHXD)on the bloodbrain barrier(BBB)permeability and the expressions of related proteins on the rats;and to analyse the constituents in the cerebrospinal fluid on the rats with cerebral ischemic injury.METHODS Cerebral ischemia rats were induced by middle cerebral artery occlusion(MCAO).Adult male sprague-dawley(SD)rats were randomly divided into seven groups:sham-group;model group;nimodipine(NMP)-treated group and nao mai tai(NMT)-treated group were set as positive drug control groups;TQHXD-treated group(3,6 and 12g·kg-1body weight);The neurological function of rats was estimated by neurological defect scoring after the 1,7and 15 dafter administration.Histological structure of the brain in rats were observed by hematoxylin and eosin(H&E)staining.Ultramicrostructural features of hippocampus neurons and the opening of tight junction(TJ)of BBB in rats were observed by transmission electron microscope(TEM).Western blotting was performed to detect the expression of ZO-1,occludin,claudin-5,AQP-4 and MMP-9 in BBB after cerebral ischemia injury.Component analysis experiments:adult male SD rats were randomly divided into four groups:Distilled water was administered intragastrically sham-operated rats;Distilled water was administered intragastrically model rats by MCAO;TQHXD was administered intragatrically to rats in sham-operated group;TQHXD was administered intragestrically to rats in model group by MCAO.GC and HPLC was used to detect three compounds,namely,muscone,ligustilide and hydroxysafflor yellow A,in rats cerebrospinal fluid(CSF)after oral administration of TQHXD.Finally,samples of cerebrospinal fluid of rats in each group were compared with single medicine so as to explicit the three compounds come from which herb.RESULTS TQHXD significantly reduced the neurological defect scores.Histological examination indicated that dense neuropil and largely surviving neurons had been seen in TQHXD-treated rats.TEM observation revealed that TQHXD could significantly inhibit the damage of hippocampal neurons and reduce the opening of TJ.The decreased protein expression levels of claudin-5,occludin,ZO-1 and the increased protein expression levels of AQP-4 and MMP-9in cerebral ischemia tissue were significantly prevented by treatment of TQHXD.Analysis of experimental results showed that muscone,ligustilide and hydroxysafflor yellow A could penetrate the BBB into the CSF,and the content of the model group was lower than that of sham group after intragastric administration of TQHXD.CONCLUSION These results demonstrated that TQHXD may act as a potential neuroprotective agent against BBB damage for cerebral ischemia through protecting of hippocampus neurons,reducing the opening of TJ and decreasing the permeability of BBB by up-regulating ZO-1,occludin,claudin-5 expressions,down-regulating AQP-4 and MMP-9 expressions.The effect of TQHXD on the decrease of the opening of TJ also reduced the content of muscone,ligustilide and hydroxysafflor yellow A in cerebrospinal fluid.展开更多
Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses w...Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.展开更多
Objective:To evaluate the efficacy of Qing Gan Huo Xue Prescription(QGHXP)in the treatment of patients with alcoholic liver cirrhosis(ALC)of damp and heat stasis syndrome.Methods:A total of 69 patients with ALC were r...Objective:To evaluate the efficacy of Qing Gan Huo Xue Prescription(QGHXP)in the treatment of patients with alcoholic liver cirrhosis(ALC)of damp and heat stasis syndrome.Methods:A total of 69 patients with ALC were randomly divided into TCM group(n=35)and control group(n=34).The TCM group was given QGHXP 1 pack TID orally.Control group received polyene phosphatidylcholine capsule 456 mg TID for 24 weeks.The observation measurements are symptom efficacy rate,serum level of liver enzyme,and non-invasive liver cirrhosis evaluation,including liver stiffness measurement(LSM)examininged by FibroTouch,APRI score,FIB-4 index and Maddrey discriminant function.Results:The symptom efficacy rate of the experimental group and the control group was 85.70%and 61.80%(P=0.024).Liver enzyme levels(serum ALP,γ-GT,AST and ALT)of TCM group were lower than those of control group(P<0.05).LSM of TCM group was reduced after treatment,and was significant lower than control group(14.19±1.49)vs.(15.06±1.24)(P<0.05).The APRI scores,FIB-4 index and Maddrey discriminant functions of TCM group were lower than those of control group(P<0.05).Conclusion:QGHXP is an effective alternative for the treatment of damp and heat stasis syndrome of ALC in improving liver function and clinical symptoms.展开更多
Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemi...Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.展开更多
An article entitled "Highly Effective Layout of Water Resources Is the Key Link in Promoting the Sustainable Development of the Regional Economy in Four Provinces (or Autonomous Regions) of the Chinese Northwest,...An article entitled "Highly Effective Layout of Water Resources Is the Key Link in Promoting the Sustainable Development of the Regional Economy in Four Provinces (or Autonomous Regions) of the Chinese Northwest," contributed by Prof.Huo Mingyuan and carried in the Bulletin’s No.4,1995 issue(Chinese edition),makes an incisive argument and proposes a 24-word guideline emphasizing water-saving in a short period of time and water diversion for long-term operation.All of these viewpoints are correct.展开更多
Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang on delayed cerebral vasospasm(DCD) after subarachnoid hemorrhage(SAH).Methods Macaca cynomolgus we...Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang on delayed cerebral vasospasm(DCD) after subarachnoid hemorrhage(SAH).Methods Macaca cynomolgus were divided into two groups and underwent craniectomy,a semipermeable microdialysis catheter was placed adjacent to right middle cerebral artery (MCA).Therapeutic group were exposed to Tong Qiao Huo Xue Tang and control group to placebo via oral .Results The diameter of proximal MCA in therapeutic group changed slightly on 7th day after operation(P >0.05),whereas it decreased prominently(P< 0.05) in control group with severe vasospasm.OxyHb concentration:There’s no significant difference between the two groups on 2nd ～5th day(P >0.05),the concentration of therapeutic group(was zero after 8 days) was lower than that of control group (became zero after 12 days) on 6th ～8th day(P< 0.05).The peak value of therapeutic group (on 5th day) was lower than that of control group (on 7th day)(P< 0.05).Conclusion Tong Qiao Huo Xue Tang can prevent DCV after SAH effectively and decreasing OxyHb concentration around vessels after SAH maybe the mechanism.展开更多
Jaηguaηzaujauze piηyan he sangaη,Geseηfeijaηzai zuguo de dadi saη,Tianje de maisui xiaηwomn zausou,Guηcaηde qidi wei womn huancaη.Womn sηlauduηrenmin de erz,Yηyan bu gufu zuguo de xiwa(?);Womn xia(?) ji ...Jaηguaηzaujauze piηyan he sangaη,Geseηfeijaηzai zuguo de dadi saη,Tianje de maisui xiaηwomn zausou,Guηcaηde qidi wei womn huancaη.Womn sηlauduηrenmin de erz,Yηyan bu gufu zuguo de xiwa(?);Womn xia(?) ji qyn baised gez,Womn jou ji suaηηianqiaed cηbaη.viaru zuguo xyjau womn qydau naali,Womn (?)iu zankai c(?)ba(?) xia(?) naali feixiaη.Qinηaid xiauzaηqinηaid lausη,展开更多
基金the National Natural Science Foundation of China(Grant No.81873326)the Traditional Chinese Medicine Bureau of Guangdong Province(Grant numbers:20223025,20231120).
文摘Background and objectives:Huo Xue Tong Luo Capsule(HXTL)has been clinically used to treat osteonecrosis of the femoral head,osteoporosis,and other bone and joint diseases with promising effects.Our previous study has shown that HXTL can promote osteogenesis in mesenchymal stem cells by inhibiting lncRNA-Miat expression through histone modifications.However,the mechanism by which HXTL treats postmenopausal osteoporosis(PMOP)remains unclear.In this study,we used network pharmacology-based mechanism prediction,molecular docking,and pharmacological validation to investigate the mechanism of HXTL in treating PMOP.Methods:The key candidate targets and relevant signaling pathways of HXTL for PMOP treatment were predicted using network pharmacology and molecular docking analysis.RAW264.7 cells were used for Western blot to validate the predicted mechanistic pathways.The ovaries of mice were surgically removed to simulate PMOP.The effect of HXTL on PMOP was evaluated using tartrate-resistant acid phosphatase staining and immunohistochemical assays in vivo.Results:Network pharmacology analysis suggested that HXTL interacted with 215 key targets linked to PMOP,primarily affecting the PI3K-AKT signaling pathway.Molecular docking showed that the main components of HXTL exhibited strong binding affinity to NFATc1,p-PI3K,and p-AKT1.Furthermore,our in vitro results confirmed that HXTL suppressed the PI3KAKT signaling pathway.In vivo,HE and tartrate-resistant acid phosphatase staining results showed that HXTL inhibited osteoclast formation and protected bone mass.
基金financed by the grant from JSPS KAKENHI Grant(No.23K12014).
文摘Since ancient times,humans have endeavored to maintain their health.These methods are collectively referred to as“Yang Sheng(养生)”or health preservation practices.The concept of Yang Sheng originated and was nurtured in ancient China.By the Ming dynasty,this practice had transcended the elite scholarly class and began to garner the attention of the general populace.With the development of the publishing industry,a large number of Yang Sheng-related books were created,disseminated,and widely read.Zhu Quan(朱权),a representative literatus of the Ming dynasty and a member of the imperial family,left behind a vast body of writings across multiple fields,including Yang Sheng,medicine,Daoism,history,drama,and phonology.Among these,his works on Yang Sheng and medicine were also transmitted to Korea and Japan,exerting an influence on East Asian Yang Sheng culture.Previous studies have largely lacked a systematic examination of Zhu Quan’s thought on Yang Sheng and have paid little attention to the transmission of this thought in Korea and Japan.This study begins with an analysis of his Yang Sheng-related text Huo Ren Xin(《活人心》Enlivening the Human Heart),and through an exploration of the core ideas in this work as well as its dissemination and reception in Korea and Japan,it attempts to shed light on the modes of transmission and exchange within East Asian Yang Sheng culture.First,the paper investigates the formation of Zhu Quan’s thinking by examining his life and intellectual background.It then analyzes the compilation,content,and conceptual features of Huo Ren Xin,and explores its transmission in Korea and Japan based on extant editions.Finally,through an examination of medical texts and literary works by scholars in Korea and Japan,the study further elucidates the acceptance and transmission of Zhu Quan’s Yang Sheng thought across East Asia.
文摘Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly its efficacy in managing chemotherapy-induced nausea and vomiting (CINV). Methods: A total of 100 patients with gastrointestinal reactions who were hospitalized in the oncology department of Nanning Third People’s Hospital from January to December 2023 were selected as study subjects. They were randomly divided into two groups: the observation group (n = 50) received standard antiemetic treatment in conjunction with Shen-Shi Zhi-Tong plaster and Lei-Huo moxibustion, while the control group (n = 50) received only standard antiemetic treatment and Lei-Huo moxibustion. The occurrence of nausea and vomiting during chemotherapy was recorded using a CINV nursing log, and the incidence rates of acute and delayed vomiting were statistically analyzed. Results: The incidence rate of acute vomiting in the observation group was 42%, significantly lower than the control group’s 64% (P = 0.0300);the incidence rate of delayed vomiting was 36% in the observation group compared to 48% in the control group (P = 0.1900). The mean nausea grade in the observation group was 1.08, significantly lower than 2.02 in the control group (P Conclusion: Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion can effectively reduce the incidence of nausea and vomiting in patients undergoing highly emetogenic chemotherapy and shows good clinical application prospects. This study provides strong support for the adoption of such combined therapies in the prevention and treatment of CINV in the future.
文摘在海外汉学著作中,文化层面的误读、专有名词的误译现象时有发生。这些未经校正的误读、误译,往往会在回译环节中持续传递,导致“以讹传讹”的问题。本研究以美国汉学家伯儒(Rhea C.Blue)的长文The Argumentation of the Shih-Huo Chih:Chapters of Han,Wei,Sui Dynastic History为研究对象,聚焦于专有名词的文化回译问题。根据专有名词出现频率和性质特征,可将其分为四类即官位名词、财经名词、著作名词和制度名词,并提出“还原—重构”二元文化回译策略。还原策略通过“完全还原”与“半还原”锚定术语的文化本体性,旨在维护中国古代专有名词的独特性。重构策略则通过“旧词新造”与“深度翻译”搭建跨文化认知桥梁。二者协同运作,还原文化基因,抵制语义殖民,重构跨文明对话的阐释协商机制,激活对话空间,最终既还原被解构的思想谱系,又建构可通约的跨文化阐释路径。
基金The project supported by National Natural Science Foundation of China(81374005)″Twelfth Five Year″National Science and Technology Support Program(2012BAI26B03)
文摘OBJECTIVE To evaluate the effects of Tong-Qiao-Huo-Xue decoction(TQHXD)on the bloodbrain barrier(BBB)permeability and the expressions of related proteins on the rats;and to analyse the constituents in the cerebrospinal fluid on the rats with cerebral ischemic injury.METHODS Cerebral ischemia rats were induced by middle cerebral artery occlusion(MCAO).Adult male sprague-dawley(SD)rats were randomly divided into seven groups:sham-group;model group;nimodipine(NMP)-treated group and nao mai tai(NMT)-treated group were set as positive drug control groups;TQHXD-treated group(3,6 and 12g·kg-1body weight);The neurological function of rats was estimated by neurological defect scoring after the 1,7and 15 dafter administration.Histological structure of the brain in rats were observed by hematoxylin and eosin(H&E)staining.Ultramicrostructural features of hippocampus neurons and the opening of tight junction(TJ)of BBB in rats were observed by transmission electron microscope(TEM).Western blotting was performed to detect the expression of ZO-1,occludin,claudin-5,AQP-4 and MMP-9 in BBB after cerebral ischemia injury.Component analysis experiments:adult male SD rats were randomly divided into four groups:Distilled water was administered intragastrically sham-operated rats;Distilled water was administered intragastrically model rats by MCAO;TQHXD was administered intragatrically to rats in sham-operated group;TQHXD was administered intragestrically to rats in model group by MCAO.GC and HPLC was used to detect three compounds,namely,muscone,ligustilide and hydroxysafflor yellow A,in rats cerebrospinal fluid(CSF)after oral administration of TQHXD.Finally,samples of cerebrospinal fluid of rats in each group were compared with single medicine so as to explicit the three compounds come from which herb.RESULTS TQHXD significantly reduced the neurological defect scores.Histological examination indicated that dense neuropil and largely surviving neurons had been seen in TQHXD-treated rats.TEM observation revealed that TQHXD could significantly inhibit the damage of hippocampal neurons and reduce the opening of TJ.The decreased protein expression levels of claudin-5,occludin,ZO-1 and the increased protein expression levels of AQP-4 and MMP-9in cerebral ischemia tissue were significantly prevented by treatment of TQHXD.Analysis of experimental results showed that muscone,ligustilide and hydroxysafflor yellow A could penetrate the BBB into the CSF,and the content of the model group was lower than that of sham group after intragastric administration of TQHXD.CONCLUSION These results demonstrated that TQHXD may act as a potential neuroprotective agent against BBB damage for cerebral ischemia through protecting of hippocampus neurons,reducing the opening of TJ and decreasing the permeability of BBB by up-regulating ZO-1,occludin,claudin-5 expressions,down-regulating AQP-4 and MMP-9 expressions.The effect of TQHXD on the decrease of the opening of TJ also reduced the content of muscone,ligustilide and hydroxysafflor yellow A in cerebrospinal fluid.
文摘Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.
基金Traditional Chinese Medicine Scientific Research Project of Shanghai Municiple Health Commission(No.2018LP033)Specialized and General Program of Medical Talent Garden of Shanghai Health Commission,Shanghai Medical and Health Development Foundation(SH,Health Personnel No.[2020]087)。
文摘Objective:To evaluate the efficacy of Qing Gan Huo Xue Prescription(QGHXP)in the treatment of patients with alcoholic liver cirrhosis(ALC)of damp and heat stasis syndrome.Methods:A total of 69 patients with ALC were randomly divided into TCM group(n=35)and control group(n=34).The TCM group was given QGHXP 1 pack TID orally.Control group received polyene phosphatidylcholine capsule 456 mg TID for 24 weeks.The observation measurements are symptom efficacy rate,serum level of liver enzyme,and non-invasive liver cirrhosis evaluation,including liver stiffness measurement(LSM)examininged by FibroTouch,APRI score,FIB-4 index and Maddrey discriminant function.Results:The symptom efficacy rate of the experimental group and the control group was 85.70%and 61.80%(P=0.024).Liver enzyme levels(serum ALP,γ-GT,AST and ALT)of TCM group were lower than those of control group(P<0.05).LSM of TCM group was reduced after treatment,and was significant lower than control group(14.19±1.49)vs.(15.06±1.24)(P<0.05).The APRI scores,FIB-4 index and Maddrey discriminant functions of TCM group were lower than those of control group(P<0.05).Conclusion:QGHXP is an effective alternative for the treatment of damp and heat stasis syndrome of ALC in improving liver function and clinical symptoms.
基金the 2022 Chongqing Natural Science Foundation(Postdoctoral Project)(CSTB2022NSCQ-BHX0690)the 2022 Chongqing Postdoctoral Innovation Talent Support Plan(CQBX202212)the 2023 Chongqing Science and Health Joint Medical Research Project(2023QNXM002).
文摘Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.
文摘An article entitled "Highly Effective Layout of Water Resources Is the Key Link in Promoting the Sustainable Development of the Regional Economy in Four Provinces (or Autonomous Regions) of the Chinese Northwest," contributed by Prof.Huo Mingyuan and carried in the Bulletin’s No.4,1995 issue(Chinese edition),makes an incisive argument and proposes a 24-word guideline emphasizing water-saving in a short period of time and water diversion for long-term operation.All of these viewpoints are correct.
文摘Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang on delayed cerebral vasospasm(DCD) after subarachnoid hemorrhage(SAH).Methods Macaca cynomolgus were divided into two groups and underwent craniectomy,a semipermeable microdialysis catheter was placed adjacent to right middle cerebral artery (MCA).Therapeutic group were exposed to Tong Qiao Huo Xue Tang and control group to placebo via oral .Results The diameter of proximal MCA in therapeutic group changed slightly on 7th day after operation(P >0.05),whereas it decreased prominently(P< 0.05) in control group with severe vasospasm.OxyHb concentration:There’s no significant difference between the two groups on 2nd ～5th day(P >0.05),the concentration of therapeutic group(was zero after 8 days) was lower than that of control group (became zero after 12 days) on 6th ～8th day(P< 0.05).The peak value of therapeutic group (on 5th day) was lower than that of control group (on 7th day)(P< 0.05).Conclusion Tong Qiao Huo Xue Tang can prevent DCV after SAH effectively and decreasing OxyHb concentration around vessels after SAH maybe the mechanism.
