Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ru...Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ruined by industrial civilization.This essay is intended to unveil the destructive force by analyzing the relationship between the husband and wife.展开更多
Neuroscience and neurology research is dominated by experimentation with rodents.Around 75%of neurology disease-associated genes have orthologs in Drosophila mel-anogaster,the fruit fly amenable to complex neurologica...Neuroscience and neurology research is dominated by experimentation with rodents.Around 75%of neurology disease-associated genes have orthologs in Drosophila mel-anogaster,the fruit fly amenable to complex neurological and behavioral investiga-tions.However,non-vertebrate models including Drosophila have so far been unable to significantly replace mice and rats in this field of studies.One reason for this situ-ation is the predominance of gene overexpression(and gene loss-of-function)meth-odologies used when establishing a Drosophila model of a given neurological disease,a strategy that does not recapitulate accurately enough the genetic disease condi-tions.I argue here the need for a systematic humanization approach,whereby the Drosophila orthologs of human disease genes are replaced with the human sequences.This approach will identify the list of diseases and the underlying genes that can be adequately modeled in the fruit fly.I discuss the neurological disease genes to which this systematic humanization approach should be applied and provide an example of such an application,and consider its importance for subsequent disease modeling and drug discovery in Drosophila.I argue that this paradigm will not only advance our un-derstanding of the molecular etiology of a number of neurological disorders,but will also gradually enable researchers to reduce experimentation using rodent models of multiple neurological diseases and eventually replace these models.展开更多
The present article aims to present, by a bibliographic review, the current challenges of the dialog among fundamental issues referring to humanization as for current public policy in Brazilian scenario. The first one...The present article aims to present, by a bibliographic review, the current challenges of the dialog among fundamental issues referring to humanization as for current public policy in Brazilian scenario. The first one concerns with national health humanization policies and ultimately the humanization of the assistance to the woman’s health, especially at delivery and child birth. Using the hermeneutic dialectic as methodology, it’s understood that having these three facets, dialog consists not only of a great challenge but also of a condition on being put into practice, and expected issues become an effective reality.展开更多
This paper investigates a core role of Human Resource Management(HRM)humanization for successful digital transformation in digital economy.The term“humanization”is applied to an iterative method of human relation de...This paper investigates a core role of Human Resource Management(HRM)humanization for successful digital transformation in digital economy.The term“humanization”is applied to an iterative method of human relation development for human resources satisfaction and high results of organizational performance.The author summarized the peculiarities of digitalization in Russian companies in the context of the Russian labor market trends.The paper focuses on factors that determine human potential utilization and development in modern condition.The author grounded linkage between HRM humanization and digital transformation projects effect by three examples of Russian companies.The results let us conclude importance of HRM humanization and define core problems and directions in Russian context.展开更多
In the education and management, people are the objects of the management, and also are the subjects. So in the education of the college students, how can we effectively carry on the management？ In view of this probl...In the education and management, people are the objects of the management, and also are the subjects. So in the education of the college students, how can we effectively carry on the management？ In view of this problem, this paper explains the profound theories with the description of the simple language from three aspects of the basic connotation of the humanization in the educational and management of the college students, the lack of the humanization in the education and management of the college students and its significance, and the thinking of the methods of the humanization in the education and management of the college students, to solve the concept of the humanization in the management, in order to provide the theoretical reference of the humanized management for the educators.展开更多
Jack London was one of the outstanding American writers in the late nineteenth and early twentieth century. The Call of the Wild which was based on the Klondike Gold Rush, was the most famous and popular one in China....Jack London was one of the outstanding American writers in the late nineteenth and early twentieth century. The Call of the Wild which was based on the Klondike Gold Rush, was the most famous and popular one in China. These years, lots of scholars have discussed it from various aspects, such as the contents, the themes, the writing styles and its characters. In this short novel, the protagonist Buck is humanized by the author. He is endowed with lots of human qualities, such as loyalty, brave, self-esteem, intelligence and so on. What are the reasons of humanization of the dog protagonist.？ Finding out the reasons could help us understand this novel better and it may offer some references for the research on Jack London＇ s animal novels.展开更多
While it is true,quality has always been measured through statistics and percentages,often forgetting the training of the whole person.Now,when we talk about issues such as humanism and education supported by technolo...While it is true,quality has always been measured through statistics and percentages,often forgetting the training of the whole person.Now,when we talk about issues such as humanism and education supported by technology,we can fall into extremes:it is common to label technology as the provider of all the evils of today’s civilization;or the opposite assumption;to argue that incorporating technologies into education would be the panacea for all the problems it faces and finally,to assume that the subject of the humanities is more typical of actions and attitudes of the past than as a current need,giving vitality to any educational process.However,and fortunately for the educational community,today there are global efforts to make the educational task a human action that minimizes inequities and the abysmal differences that exist in countries like ours.Fernando Reimers says:“Equal educational opportunities must be the priority objective of educational policies,the aim of education must be to contribute to creating just societies”.This requires improving the learning environments of the poor,but not only along the paths that have been started over the last decade.This aspect pointed out by Reimers is precisely the central aspect that all educational action must contemplate;the educational policies that are implemented in our country must guarantee,above all,the construction of a just and egalitarian society,strengthening the cultural wealth that we have,with respect to the diversity of people,their past,their present and especially their future.展开更多
With the development of the times, all aspects of life are changing, and concepts are also changing. People have higher and higher requirements for living environment, space and layout, especially in todays low-carbon...With the development of the times, all aspects of life are changing, and concepts are also changing. People have higher and higher requirements for living environment, space and layout, especially in todays low-carbon society. People prefer a healthy, happy and comfortable living environment. With the continuous improvement of peoples living needs, the design concept of "people-oriented" in architectural design also appears. It adopts humanized design to create a warm and pleasant atmosphere. Therefore, in the current residential building design, it is necessary to meet the needs of residents. While living needs, we should also consider the impact of the living environment on all aspects of human beings, so as to create a livable living environment for human beings.展开更多
Purpose:This article explores the literary work of a teacher and activist,Yi O-Deok,as a lens to approach historically and culturally embedded notions of humanization in education in Korea.Anchored in the ethos of“As...Purpose:This article explores the literary work of a teacher and activist,Yi O-Deok,as a lens to approach historically and culturally embedded notions of humanization in education in Korea.Anchored in the ethos of“Asia as Method,”this study offers a unique perspective that exemplifies the importance of the local sociocultural context in Asia in enriching our understanding of universal concepts.Design/Approach/Methods:This study adopts a methodological approach centered around the examination of Yi O-Deok's work and his influence on critical literacy education.Key source materials include Yi's extensive five-volume diary and the various literary pieces he edited from the1950stothe1980s.Findings:Yi O-Deok's philosophy on humanizing education,deeply influenced by local contexts,provides a distinct,non-Western perspective.It offers a critical counterpoint to Western-centric educational paradigms and enriches the broader understanding of humanization in education.Originality/Value:The uniqueness of this study resides in its focus on children's writings,affirming faith in the unfiltered expressions of their pure spirits encapsulated in the raw“languages of the soil,”which have persevered through the sociopolitical upheavals of Korea's modern history.This in turn strengthens the call for a nuanced,non-Western interpretation of the concept of“humanization”in education.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci plinary subjects related to food science and human health Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci plinary subjects related to food science and human health Topics may include but not limited to:nutriology,bio.chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topic...Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to: nutriology, biochemistry, microbiology, immunology and toxicology.展开更多
通知(第一轮)2026年8月15-16日中国安徽合肥主办:北京食品科学研究院中国食品杂志社《食品科学》杂志(EI收录)中国食品杂志社《Food Science and Human Wellness》杂志(SCI收录)中国食品杂志社《Journal of Future Foods》杂志(ESCI收录)。
1.Guidelines for Authors Please read the guidelines below before uploading your manuscript via the journal's submission system at https://www.sciopen.com/journal/2097-0765.Please note that manuscripts not conformi...1.Guidelines for Authors Please read the guidelines below before uploading your manuscript via the journal's submission system at https://www.sciopen.com/journal/2097-0765.Please note that manuscripts not conforming to these guidelines may be returned.You can log in to the submission site at any time to check the status of your manuscript throughout the peer review process.Only manuscripts that fit within the aims and scope of Food Science and Human Wellness and meet the journal's required standards will be reviewed.展开更多
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb...The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.展开更多
Aims and scope GeoSus encourages wider analysis and innovative thinking about global and regional sustainability by bridging and synthesising natural and human sciences.GeoSus welcomes original,high-quality research a...Aims and scope GeoSus encourages wider analysis and innovative thinking about global and regional sustainability by bridging and synthesising natural and human sciences.GeoSus welcomes original,high-quality research articles,review articles,short communications,technical comments,perspective articles and editorials on the following themes.展开更多
With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State I...With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing.展开更多
The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and...The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and single-cell transcriptomics of human medial ganglionic eminence(hMGE),a pivotal source of cortical and subpallial INs,and built the trajectories of hMGE-derived cells during brain development.We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct IN types.展开更多
Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and geneti...Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).展开更多
In a world growing ever more cruel and violent as nihilism becomes generalized,a world in which the disintegration of the human assumes dimensions that threaten its very cohesion,the demand for the humanization of the...In a world growing ever more cruel and violent as nihilism becomes generalized,a world in which the disintegration of the human assumes dimensions that threaten its very cohesion,the demand for the humanization of the Western individual asserts itself as an urgent historical task.Among the institutions implicated in this process,education assumes a central role,as it is within it that wonder and critical thinking are gradually eliminated,together with the demand for shared deliberation,coherent meaning,and the tragic dimension of human existence,while an education of cruelty comes to permeate it from end to end.In order to prevent the full entrenchment of evil in the social world,from which only destruction can be expected,a decisive role could be played by caring thinking that would be coordinated with corresponding action and would come to deeply characterize the educational institution.Such a form of thinking was proposed in the second half of the twentieth century and took flesh and bones within the framework of the Philosophy for Children movement.Its contemporary application within educational practice could reactivate phronesis(practical wisdom)and contribute to enabling the Western human being to re-create themselves as a democratic human being-one who desires the creation of a world of freedom,equality,and justice,and who acts accordingly to bring it about:the creation of a compassionate and prudent world,the preservation of which would be the responsibility of all.展开更多
文摘Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ruined by industrial civilization.This essay is intended to unveil the destructive force by analyzing the relationship between the husband and wife.
基金This work was supported by Swiss National Science Foundation,grant#31003A_175658 to VLK.
文摘Neuroscience and neurology research is dominated by experimentation with rodents.Around 75%of neurology disease-associated genes have orthologs in Drosophila mel-anogaster,the fruit fly amenable to complex neurological and behavioral investiga-tions.However,non-vertebrate models including Drosophila have so far been unable to significantly replace mice and rats in this field of studies.One reason for this situ-ation is the predominance of gene overexpression(and gene loss-of-function)meth-odologies used when establishing a Drosophila model of a given neurological disease,a strategy that does not recapitulate accurately enough the genetic disease condi-tions.I argue here the need for a systematic humanization approach,whereby the Drosophila orthologs of human disease genes are replaced with the human sequences.This approach will identify the list of diseases and the underlying genes that can be adequately modeled in the fruit fly.I discuss the neurological disease genes to which this systematic humanization approach should be applied and provide an example of such an application,and consider its importance for subsequent disease modeling and drug discovery in Drosophila.I argue that this paradigm will not only advance our un-derstanding of the molecular etiology of a number of neurological disorders,but will also gradually enable researchers to reduce experimentation using rodent models of multiple neurological diseases and eventually replace these models.
文摘The present article aims to present, by a bibliographic review, the current challenges of the dialog among fundamental issues referring to humanization as for current public policy in Brazilian scenario. The first one concerns with national health humanization policies and ultimately the humanization of the assistance to the woman’s health, especially at delivery and child birth. Using the hermeneutic dialectic as methodology, it’s understood that having these three facets, dialog consists not only of a great challenge but also of a condition on being put into practice, and expected issues become an effective reality.
文摘This paper investigates a core role of Human Resource Management(HRM)humanization for successful digital transformation in digital economy.The term“humanization”is applied to an iterative method of human relation development for human resources satisfaction and high results of organizational performance.The author summarized the peculiarities of digitalization in Russian companies in the context of the Russian labor market trends.The paper focuses on factors that determine human potential utilization and development in modern condition.The author grounded linkage between HRM humanization and digital transformation projects effect by three examples of Russian companies.The results let us conclude importance of HRM humanization and define core problems and directions in Russian context.
文摘In the education and management, people are the objects of the management, and also are the subjects. So in the education of the college students, how can we effectively carry on the management？ In view of this problem, this paper explains the profound theories with the description of the simple language from three aspects of the basic connotation of the humanization in the educational and management of the college students, the lack of the humanization in the education and management of the college students and its significance, and the thinking of the methods of the humanization in the education and management of the college students, to solve the concept of the humanization in the management, in order to provide the theoretical reference of the humanized management for the educators.
文摘Jack London was one of the outstanding American writers in the late nineteenth and early twentieth century. The Call of the Wild which was based on the Klondike Gold Rush, was the most famous and popular one in China. These years, lots of scholars have discussed it from various aspects, such as the contents, the themes, the writing styles and its characters. In this short novel, the protagonist Buck is humanized by the author. He is endowed with lots of human qualities, such as loyalty, brave, self-esteem, intelligence and so on. What are the reasons of humanization of the dog protagonist.？ Finding out the reasons could help us understand this novel better and it may offer some references for the research on Jack London＇ s animal novels.
文摘While it is true,quality has always been measured through statistics and percentages,often forgetting the training of the whole person.Now,when we talk about issues such as humanism and education supported by technology,we can fall into extremes:it is common to label technology as the provider of all the evils of today’s civilization;or the opposite assumption;to argue that incorporating technologies into education would be the panacea for all the problems it faces and finally,to assume that the subject of the humanities is more typical of actions and attitudes of the past than as a current need,giving vitality to any educational process.However,and fortunately for the educational community,today there are global efforts to make the educational task a human action that minimizes inequities and the abysmal differences that exist in countries like ours.Fernando Reimers says:“Equal educational opportunities must be the priority objective of educational policies,the aim of education must be to contribute to creating just societies”.This requires improving the learning environments of the poor,but not only along the paths that have been started over the last decade.This aspect pointed out by Reimers is precisely the central aspect that all educational action must contemplate;the educational policies that are implemented in our country must guarantee,above all,the construction of a just and egalitarian society,strengthening the cultural wealth that we have,with respect to the diversity of people,their past,their present and especially their future.
文摘With the development of the times, all aspects of life are changing, and concepts are also changing. People have higher and higher requirements for living environment, space and layout, especially in todays low-carbon society. People prefer a healthy, happy and comfortable living environment. With the continuous improvement of peoples living needs, the design concept of "people-oriented" in architectural design also appears. It adopts humanized design to create a warm and pleasant atmosphere. Therefore, in the current residential building design, it is necessary to meet the needs of residents. While living needs, we should also consider the impact of the living environment on all aspects of human beings, so as to create a livable living environment for human beings.
文摘Purpose:This article explores the literary work of a teacher and activist,Yi O-Deok,as a lens to approach historically and culturally embedded notions of humanization in education in Korea.Anchored in the ethos of“Asia as Method,”this study offers a unique perspective that exemplifies the importance of the local sociocultural context in Asia in enriching our understanding of universal concepts.Design/Approach/Methods:This study adopts a methodological approach centered around the examination of Yi O-Deok's work and his influence on critical literacy education.Key source materials include Yi's extensive five-volume diary and the various literary pieces he edited from the1950stothe1980s.Findings:Yi O-Deok's philosophy on humanizing education,deeply influenced by local contexts,provides a distinct,non-Western perspective.It offers a critical counterpoint to Western-centric educational paradigms and enriches the broader understanding of humanization in education.Originality/Value:The uniqueness of this study resides in its focus on children's writings,affirming faith in the unfiltered expressions of their pure spirits encapsulated in the raw“languages of the soil,”which have persevered through the sociopolitical upheavals of Korea's modern history.This in turn strengthens the call for a nuanced,non-Western interpretation of the concept of“humanization”in education.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci plinary subjects related to food science and human health Topics may include but not limited to:nutriology,bio.chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to: nutriology, biochemistry, microbiology, immunology and toxicology.
文摘通知(第一轮)2026年8月15-16日中国安徽合肥主办:北京食品科学研究院中国食品杂志社《食品科学》杂志(EI收录)中国食品杂志社《Food Science and Human Wellness》杂志(SCI收录)中国食品杂志社《Journal of Future Foods》杂志(ESCI收录)。
文摘1.Guidelines for Authors Please read the guidelines below before uploading your manuscript via the journal's submission system at https://www.sciopen.com/journal/2097-0765.Please note that manuscripts not conforming to these guidelines may be returned.You can log in to the submission site at any time to check the status of your manuscript throughout the peer review process.Only manuscripts that fit within the aims and scope of Food Science and Human Wellness and meet the journal's required standards will be reviewed.
基金supported by the Grant PID2021-126715OB-IOO financed by MCIN/AEI/10.13039/501100011033 and"ERDFA way of making Europe"by the Grant PI22CⅢ/00055 funded by Instituto de Salud CarlosⅢ(ISCⅢ)+6 种基金the UFIECPY 398/19(PEJ2018-004965) grant to RGS funded by AEI(Spain)the UFIECPY-396/19(PEJ2018-004961)grant financed by MCIN (Spain)FI23CⅢ/00003 grant funded by ISCⅢ-PFIS Spain) to PMMthe UFIECPY 328/22 (PEJ-2021-TL/BMD-21001) grant to LM financed by CAM (Spain)the grant by CAPES (Coordination for the Improvement of Higher Education Personnel)through the PDSE program (Programa de Doutorado Sanduiche no Exterior)to VSCG financed by MEC (Brazil)
文摘The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.
文摘Aims and scope GeoSus encourages wider analysis and innovative thinking about global and regional sustainability by bridging and synthesising natural and human sciences.GeoSus welcomes original,high-quality research articles,review articles,short communications,technical comments,perspective articles and editorials on the following themes.
基金supported by National Natural Science Foundation of China(NSFC)under grant U23A20310.
文摘With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing.
文摘The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and single-cell transcriptomics of human medial ganglionic eminence(hMGE),a pivotal source of cortical and subpallial INs,and built the trajectories of hMGE-derived cells during brain development.We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct IN types.
基金supported by the Belle Carnell Regenerative Neurorehabilitation Fundthe National Institutes of Health(R01NS113935 to CKF)。
文摘Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).
文摘In a world growing ever more cruel and violent as nihilism becomes generalized,a world in which the disintegration of the human assumes dimensions that threaten its very cohesion,the demand for the humanization of the Western individual asserts itself as an urgent historical task.Among the institutions implicated in this process,education assumes a central role,as it is within it that wonder and critical thinking are gradually eliminated,together with the demand for shared deliberation,coherent meaning,and the tragic dimension of human existence,while an education of cruelty comes to permeate it from end to end.In order to prevent the full entrenchment of evil in the social world,from which only destruction can be expected,a decisive role could be played by caring thinking that would be coordinated with corresponding action and would come to deeply characterize the educational institution.Such a form of thinking was proposed in the second half of the twentieth century and took flesh and bones within the framework of the Philosophy for Children movement.Its contemporary application within educational practice could reactivate phronesis(practical wisdom)and contribute to enabling the Western human being to re-create themselves as a democratic human being-one who desires the creation of a world of freedom,equality,and justice,and who acts accordingly to bring it about:the creation of a compassionate and prudent world,the preservation of which would be the responsibility of all.
