Human endogenous retroviruses(HERVs)comprise approximately 8%of the human genome,integrated into the dynamic regulatory network of cellular potency during early embryonic development.In recent studies,resurgent the tr...Human endogenous retroviruses(HERVs)comprise approximately 8%of the human genome,integrated into the dynamic regulatory network of cellular potency during early embryonic development.In recent studies,resurgent the transcriptional activity of HERVs has been frequently observed in many types of human cancers,suggesting their potential functions in the occurrence and progression of malignancy.However,a dedicated web resource for querying the relationship between the activation of HERVs and cancer development is lacking.Here,we construct a database to explore the sequence information,expression profiles,survival prognosis,and genetic interactions of HERVs in diverse cancer types.Our database currently contains RNA sequencing data of 580 HERVs across 16,246 samples,including that of 6478 tumoral and 634 normal tissues,932 cancer cell lines,as well as 151 early embryonic and 8051 human adult tissues.The primary goal is to provide an easily accessible and user-friendly database for professionals in the fields of bioinformatics,pathology,pharmacology,and related areas,enabling them to efficiently screen the activity of HERVs of interest in normal and cancerous tissues and evaluate the clinical relevance.The ERVcancer database is available at http://kyuanlab.com/ervcancer/.展开更多
基金supported by the National Natural Science Foundation of China(32370821,32170821,and 92153301 to K.Y)National Key Research and Development Program of China(2021YFC2701200)+2 种基金Department of Science&Technology of Hunan Province(2023RC1028,and 2023SK2091 to K.Y)Middle/Young aged Teachers'Research Ability Improvement Project of Guangxi Higher Education(2024KY0111 to X.L)Joint Project on Regional High-lncidence Diseases Research of Guangxi Natural Science Foundation(2023JJB140356 to X.L).
文摘Human endogenous retroviruses(HERVs)comprise approximately 8%of the human genome,integrated into the dynamic regulatory network of cellular potency during early embryonic development.In recent studies,resurgent the transcriptional activity of HERVs has been frequently observed in many types of human cancers,suggesting their potential functions in the occurrence and progression of malignancy.However,a dedicated web resource for querying the relationship between the activation of HERVs and cancer development is lacking.Here,we construct a database to explore the sequence information,expression profiles,survival prognosis,and genetic interactions of HERVs in diverse cancer types.Our database currently contains RNA sequencing data of 580 HERVs across 16,246 samples,including that of 6478 tumoral and 634 normal tissues,932 cancer cell lines,as well as 151 early embryonic and 8051 human adult tissues.The primary goal is to provide an easily accessible and user-friendly database for professionals in the fields of bioinformatics,pathology,pharmacology,and related areas,enabling them to efficiently screen the activity of HERVs of interest in normal and cancerous tissues and evaluate the clinical relevance.The ERVcancer database is available at http://kyuanlab.com/ervcancer/.
