During the last two centuries, there have been many spectacular advances in medical science, the main consequence of which has been the dramatically reduced burden of infectious diseases. While in the 1800s many peopl...During the last two centuries, there have been many spectacular advances in medical science, the main consequence of which has been the dramatically reduced burden of infectious diseases. While in the 1800s many people died before reaching adult- hood, nowadays most people survive. Hence average life ex- pectancy in 1800s was around 30-40, which was barely higher than it had been in Greek and Roman times （Finch, 2010）, but nowadays life expectancy in most modernised economies is around 75 - 80. This demographic shift, which has happened in only 200 years, has created a dramatic change in the causes of mortality. The major killers in the modern world are non- communicable diseases （NCDs）： principally cardiovascular disease, cancer and neurodegenerative disorders such as Alz- heimer＇s disease. A major factor that influences susceptibility to all these diseases is age. As we get older, our risk of developing these NCDs increases enormously. For example, the rate of breast cancer in females at age 15-19 is less than 10 per 100,000 population, but this increases to 100 at age 40-44, 275 at age 55--59 and 450 at age 85 ＋ （http：//www.cancerresearchuk.org/ cancer-info/cancerstats/types/breast/incidence/#age）. Ageing has consequently become a major medical, social and economic burden to many countries.展开更多
Dear Editor,Rhesus macaques are valuable nonhuman animal models for studying the aging process,but the molecular dynamics of aging remain elusive.Although previous studies have examined gene expression changes in huma...Dear Editor,Rhesus macaques are valuable nonhuman animal models for studying the aging process,but the molecular dynamics of aging remain elusive.Although previous studies have examined gene expression changes in human and rodent aging models(Huan et al.,2018;Li et al.,2023;Schaum et al.,2020;Tumasian Iii et al.,2021),a longitudinal analysis of the aging transcriptome in non-human primates,which are evolutionarily close relatives to humans,is scarce.In this study,we conducted a time series analysis by sequencing the transcriptomes of peripheral blood from healthy female rhesus macaques,aged 7 to 29,to explore age-associated changes in gene expression(Detailed in supplementary methods).展开更多
文摘During the last two centuries, there have been many spectacular advances in medical science, the main consequence of which has been the dramatically reduced burden of infectious diseases. While in the 1800s many people died before reaching adult- hood, nowadays most people survive. Hence average life ex- pectancy in 1800s was around 30-40, which was barely higher than it had been in Greek and Roman times （Finch, 2010）, but nowadays life expectancy in most modernised economies is around 75 - 80. This demographic shift, which has happened in only 200 years, has created a dramatic change in the causes of mortality. The major killers in the modern world are non- communicable diseases （NCDs）： principally cardiovascular disease, cancer and neurodegenerative disorders such as Alz- heimer＇s disease. A major factor that influences susceptibility to all these diseases is age. As we get older, our risk of developing these NCDs increases enormously. For example, the rate of breast cancer in females at age 15-19 is less than 10 per 100,000 population, but this increases to 100 at age 40-44, 275 at age 55--59 and 450 at age 85 ＋ （http：//www.cancerresearchuk.org/ cancer-info/cancerstats/types/breast/incidence/#age）. Ageing has consequently become a major medical, social and economic burden to many countries.
基金supported by the National Key Research and Development Program of China(2023YFC3603400,2022YFF0710900)the CAS Project for Young Scientists in Basic Research(YSBR-076)+8 种基金Digitalization,Development,and Application of Biotic Resource Program(202002AA100007)High-level Talent Promotion and Training Project of Kunming(Spring City Plan2020SCP001)Yunnan Revitalization Talent Support Program Yunling Scholar Project(Q.-P.K.)Yunnan Revitalization Talent Support Program Young Talent Project(G.-H.L.)Yunnan Fundamental Research Projects(202101AS070058,202201AS070080)the National Natural Science Foundation of China(82071595)Academician Expert Workstation of Yunnan Kunming(YSZJGZZ2022063)Technology Talent and Platform Plan of Yunnan Province(202305AF150160).
文摘Dear Editor,Rhesus macaques are valuable nonhuman animal models for studying the aging process,but the molecular dynamics of aging remain elusive.Although previous studies have examined gene expression changes in human and rodent aging models(Huan et al.,2018;Li et al.,2023;Schaum et al.,2020;Tumasian Iii et al.,2021),a longitudinal analysis of the aging transcriptome in non-human primates,which are evolutionarily close relatives to humans,is scarce.In this study,we conducted a time series analysis by sequencing the transcriptomes of peripheral blood from healthy female rhesus macaques,aged 7 to 29,to explore age-associated changes in gene expression(Detailed in supplementary methods).
