Protecting human rights is a noble ideal enshrined in the Universal Declaration of Human Rights.For an extended period,the United States has positioned itself as a"defender"of this cause,politicizing,weaponi...Protecting human rights is a noble ideal enshrined in the Universal Declaration of Human Rights.For an extended period,the United States has positioned itself as a"defender"of this cause,politicizing,weaponizing,and instrumentalizing human rights issues to criticize and discredit other countries.展开更多
As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four edi...As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four editions demonstrates a clear and distinct logic of progression:human rights education in primary and secondary schools has shifted from fostering students’awareness of human rights to establishing human rights values;human rights education in higher education has transitioned from the construction of single human rights course to the systematic development of human rights disciplines;human rights knowledge training has evolved from disseminating basic human rights knowledge among legal and political workers to cultivating a human rights mindset among public officials;and the popularization of human rights knowledge has moved from enhancing communication effectiveness to strengthening cultural confidence in human rights.These shifts reflect the characteristics of the policy evolution of human rights education,which are unified in their gradual and continuous nature,responsiveness and forward-looking nature,and value-oriented and contemporary nature.Fundamentally,the gap between the current state of human rights education development and policy goals serves as the intrinsic driving force for the evolution of human rights education policies.While the external factors influencing the evolution of policy content mainly include the human rights cause’s contemporary context,historical achievements,and current needs.Looking ahead to the future development of human rights education,it is essential to continuously innovate human rights teaching methods,enrich the content of human rights education,improve relevant institutional guarantee mechanisms,strengthen the construction of multi-stakeholder collaborative human rights education teams,compile and publish high-quality human rights textbooks,and increase the intensity of human rights knowledge training for journalists,in order to create a favorable public opinion atmosphere and cultural environment for the development of China’s human rights cause in the new era.展开更多
BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investi...BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investigate maternal viral load results and infant HIV testing uptake at 6-weeks,and 9-months and 18-months in Rwanda.METHODS Between 2015 and 2022,VLS(<200 copies/mL)was measured among pregnant women living with HIV(WLHIV)from 38-healthcare facilities.Viral loads(VL)were measured at 6-months,12-months and 24-months,respectively.For maternal VL,the unit of analysis was visit-pair,and the pairs were created to define those with VL<200 copies/mL at two consecutive visits as having sustained VLS,persistent viremia(VL≥200 copies/mL at two consecutive visits),viral rebound(VL<200 copies/mL at prior visit only)and newly suppressed(VL<200 copies/mL at subsequent visit only).HEI were considered to have persistent HIV testing if they had all three HIV tests.Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio(aIRR)and 95%CI for factors associated with sustained VLS and persistent HIV testing.RESULTS A total of 1145 mother-infant pairs were analyzed.Infant HIV testing uptake at 6-weeks,9-months and 18-months was 1145(100.0%),1089(95.1%),1006(87.9%)respectively.Nine hundred ninety-nine HEI(87.3%)tested for HIV persistently.At 18-months,the incidence of HIV among HEI was 8(0.7%).Of 1145 mothers,1076(94.0%)had≥2 VL results making a total of 2010 visit-pairs(142-single;934-double visit-pairs).The incidence rate of sustained VLS,persistent viremia,viral rebound and new suppression were 91.0%,1.3%,3.6%and 4.0%respectively.Maternal disclosure of HIV status(aIRR=1.08,95%CI:1.02-1.14)was associated with increased likelihood of sustained VLS.Having peer support(aIRR=1.0595%CI:1.01-1.10)was associated with persistent HIV testing among HEI.CONCLUSION Sustained VLS is high among pregnant WLHIV in Rwanda.The low incidence of HIV among HEI may be attributed to high VLS levels.Targeted interventions,including enhanced HIV disclosure and peer support,are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT.展开更多
In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and d...In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and discourses.Building an independent human rights knowledge system has become a core academic focus in China’s human rights research field.Upholding fundamental principles and breaking new ground are the key methodological principles for the process.China’s human rights research should be rooted in the“cultural lineage”by preserving the essence of fine traditional Chinese culture,guided by the“moral lineage”by adhering to the Marxist view on human rights,and anchored in the“Four-sphere Confidence”by upholding a distinct human rights development path,so as to define the historical coordinates and value stance of China’s independent human rights knowledge system.Meanwhile,it should maintain a high degree of openness in knowledge,theory,and methodology to address emerging rights demands and contribute to building a new global human rights governance order,so as to underscore the mission of China’s independent human rights knowledge system in the contemporary era and China’s responsibility as a major global actor.China’s human rights research should uphold the dialectical unity between the fundamental principles and innovations,and advance the systemic and theoretical interpretation of its independent human rights knowledge.展开更多
Dear Editor,In a recent study,we isolated a protein from human oviductal secretion that could bind to spermatozoa[1].This protein was identified through chromatography and tandem mass spectrometry as human S100A9 and ...Dear Editor,In a recent study,we isolated a protein from human oviductal secretion that could bind to spermatozoa[1].This protein was identified through chromatography and tandem mass spectrometry as human S100A9 and was detected in human tubal epithelium and oviductal secretions.S100A9 belongs to the S100 protein family[2],which has been found in various body fluids and tissues,and plays a role in extracellular functions,such as the enhancement of neutrophil extravasation,induction of proinflammatory cytokine release,antimicrobial properties through divalent ion sequestration,and modulation of cellular proliferation,differentiation,and apoptosis,as well as acting as a chemotactic factor[3–4].Because S100A9 is involved in various pathologies and the physiology of inflammation,research on S100A9 effects continues to grow rapidly.Recently,we have shown the presence of binding sites for S100A9 on human spermatozoa,and also found that S100A9 modulated certain sperm capacitation parameters in vitro,such as the induced acrosome reaction(AR)[1].To continue our studies on sperm function parameters,the current study aimed to express and purify human recombinant S100A9 and to assess its effect on sperm capacitation parameters,specifically the AR.展开更多
BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs...BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs exhibit dynamic secretion patterns during lactation,influenced by maternal genetics and environ-mental factors.Their direct and indirect antimicrobial properties have garnered significant research interest.However,a comprehensive understanding of the secretion dynamics of HMOs and their correlation with antimicrobial efficacy remains underexplored.AIM To synthesize current evidence on the secretion dynamics of HMOs during lactation and evaluate their antimicrobial roles against bacterial,viral,and protozoal pathogens.METHODS A systematic search of PubMed,Scopus,Web of Science,and Cochrane Library focused on studies investigating natural and synthetic HMOs,their secretion dynamics,and antimicrobial properties.Studies involving human,animal,and in vitro models were included.Data on HMO composition,temporal secretion patterns,and mechanisms of antimicrobial action were extracted.Quality assess-ment was performed using validated tools appropriate for study design.RESULTS A total of 44 studies were included,encompassing human,animal,and in vitro research.HMOs exhibited dynamic secretion patterns,with 2′-fucosyllactose(2′-FL)and lacto-N-tetraose peaking in early lactation and declining over time,while 3-fucosyllactose(3-FL)increased during later stages.HMOs demonstrated significant antimicrobial properties through pathogen adhesion inhibition,biofilm disruption,and enzymatic activity impairment.Synthetic HMOs,including bioengineered 2′-FL and 3-FL,were structurally and functionally comparable to natural HMOs,effectively inhibiting pathogens such as Pseudomonas aeruginosa,Escherichia coli,and Campylobacter jejuni.Additionally,HMOs exhibited synergistic effects with antibiotics,enhancing their efficacy against resistant pathogens.CONCLUSION HMOs are vital in antimicrobial defense,supporting infant health by targeting various pathogens.Both natural and synthetic HMOs hold significant potential for therapeutic applications,particularly in infant nutrition and as adjuncts to antibiotics.Further research,including clinical trials,is essential to address gaps in knowledge,validate findings,and explore the broader applicability of HMOs in improving maternal and neonatal health.展开更多
At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the g...At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the global new round of technological revolution and industrial transformation,along with changes in production methods and social structures,as well as the rising awareness of human rights,have led to the emergence of many new rights.At the same time,these developments have also given traditional human rights new digital forms.The constant emergence of new rights concepts poses challenges to the traditional human rights theoretical framework and has sparked numerous debates within the international community regarding human rights theory and practice.On issues like economic equality and social rights,particularly emerging rights topics such as climate and human rights and digital human rights,countries should focus on balancing the relationship between individuals,society,and nature and seek a path for the sustainable existence and development of humanity.The core principle for protecting emerging rights should be“humanity first,”and true multilateralism should be embraced to prevent imbalances in the global governance of emerging rights.Open and fair cooperation should help build consensus and provide solutions for the global protection of emerging rights.展开更多
Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans a...Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans are the most precious”is the most representative expression of human dignity.Ancient Chinese scholars’elaboration on dignity was ethically oriented;they affirmed that humans have the freedom to make moral choices in spirit and required them to assume moral responsibilities towards others and society.Since modern times,with the changes of the times and the introduction of Western liberalism,the traditional view of moral dignity has seen a significant expansion of its scope,incorporating freedom in economic,political,and social life into the category of human dignity and establishing a closer connection with human rights.In contemporary China,under the guidance of Marxism,the view of dignity regards the free,comprehensive,and common development of human beings as the intrinsic requirement and external manifestation of human dignity,takes the rights to subsistence and development as the primary and fundamental human rights,and comprehensively safeguards the dignity of every individual through the coordinated protection of economic,political,social,and cultural rights.展开更多
The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practi...The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practical dimension,and the theoretical dimension,which collectively form a“unified framework of four”of logical construction.The“world”dimension represents the synchronic extension of human rights practices,outwardly touching on the shared values of all humanity guided by relational rationality and the vision of a community with a shared future for humanity.The“historical”dimension reflects the diachronic extension of China’s path of human rights development,encompassing the cultural subjectivity of Chinese civilization and the complex context of modern human rights endeavors.The“practical”dimension serves as the“meta-perspective”of contemporary Chinese perspective on human rights,where the leadership of the Communist Party of China and the people-centered approach constitute the fundamental stance for developing the perspectives of human rights and human rights governance.The“theoretical”dimension focuses on the deconstruction and reconstruction of indigenous human rights notions,emphasizing a set of values that are confident,inclusive,equitable,shared,and forward-looking.The“world”dimension of“taking the world as a method”,provides a reference perspective for“taking China as a method”narrative centered on the“historical-practical-theoretical”framework,while the latter injects a human rights methodology grounded in Chinese wisdom into the former.By integrating these four dimensions,a more profound and comprehensive understanding of the value core and normative paradigm of contemporary Chinese perspective on human rights can be achieved.展开更多
Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic a...Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic analysis of human dental pulp stem cells(HDPSCs)obtained from individuals of various ages.Our findings showed that the expression of NUP62 was decreased in aged HDPSCs.We discovered that NUP62 alleviated senescence-associated phenotypes and enhanced differentiation potential both in vitro and in vivo.Conversely,the knocking down of NUP62 expression aggravated the senescence-associated phenotypes and impaired the proliferation and migration capacity of HDPSCs.Through RNA-sequence and decoding the epigenomic landscapes remodeled induced by NUP62 overexpression,we found that NUP62 helps alleviate senescence in HDPSCs by enhancing the nuclear transport of the transcription factor E2F1.This,in turn,stimulates the transcription of the epigenetic enzyme NSD2.Finally,the overexpression of NUP62 influences the H3K36me2 and H3K36me3 modifications of anti-aging genes(HMGA1,HMGA2,and SIRT6).Our results demonstrated that NUP62 regulates the fate of HDPSCs via NSD2-dependent epigenetic reprogramming.展开更多
Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical disability.Thus,in the search for more effective treatments than those already applied fo...Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical disability.Thus,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord injury.Each of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional recovery.Although the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in humans.This article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were analyzed.Thus,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.Papers regarding components of food especially nutrients and non-nutrient bioactive compounds(with putative health benefits)are welcomed.FSHW aims to unveil the correlations between food science and human health through the dissemination of both fundamental and applied research outcomes worldwide.展开更多
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb...The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.展开更多
Human herpesvirus 6(HHV-6)is a common childhood infection but rarely causes severe complications.In immunocompetent children,conditions such as febrile convulsions and roseola infantum are typical,with occasional seve...Human herpesvirus 6(HHV-6)is a common childhood infection but rarely causes severe complications.In immunocompetent children,conditions such as febrile convulsions and roseola infantum are typical,with occasional severe manifestations like meningoencephalitis and myocarditis.展开更多
During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalis...During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalism,emphasized respect for human beings,highlighting the importance of caring for,respecting,and protecting people,and focusing on“benefiting the people,”“nurturing the people,”“enriching the people,”and“prospering the people.”It reflected an awareness of human rights such as the rights to life,personality,subsistence,development,and environment.This human rights awareness,oriented towards values such as“achieving benevolence,”“valuing goodness,”“revering righteousness,”“cherishing harmony,”and“seeking the public good,”established a cognitive logic that unifies human nature,virtue,and rationality.It featured a human rights spirit that is not dominated by divine authority,based on moral and ethical philosophy,and oriented towards“positive”rights.This awareness delved into the value of being human and the meaning of human existence,demonstrating creativity and innovation,and marking a significant breakthrough in the history of human rights civilization.The ideological wisdom,spiritual strength,and practical pathways contained in this human rights awareness not only laid the foundation for the human rights thought of classical Chinese civilization but are also indispensable for contemporary China’s commitment to the“two combinations”.It holds important practical significance for advancing Chinese modernization and creating a modern human rights civilization for the Chinese nation.展开更多
The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adj...The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adjustments based on audience feedback.To some extent,the current approach has resulted in characteristics such as strong practical implementation but weak discourse,limited theoretical foundation,and insufficient recognition in China’s international human rights communication.Consequently,while China has achieved remarkable progress in its human rights endeavors,human rights issues remain a critical area of stigmatization by some Western countries.An“effect-oriented”mechanism for the international dissemination of China’s human rights discourse,therefore,aims to address this challenge by re-centering the audience as active participants in the communication process.By emphasizing the dual nature of human rights’international communication,this approach leverages the reflexive monitoring of initial transmitters throughout the dissemination process to finally construct a dynamic human rights discourse framework responsive to different time and space contexts.This mechanism directly confronts the diverse backgrounds of global audiences and the resulting varied interpretations of China’s human rights discourse.It advocates for dynamic evaluation of global dissemination outcomes based on audience feedback and the timely adaptation of communication strategies according to context.By doing so,it seeks to effectively advance China’s human rights communication efforts and enhance dissemination efficiency on the global scale.展开更多
The establishment of a sound science and technology ethics governance system is an inevitable requirement for national modernization.Faced with the development of human gene technology and the chaos in research activi...The establishment of a sound science and technology ethics governance system is an inevitable requirement for national modernization.Faced with the development of human gene technology and the chaos in research activities,the ethical standards and legal positioning of human gene research activities urgently need to be clarified.The human rights ethics view has value inclusiveness and value fundamentality,and includes three levels of connotations:content dimension,relationship dimension,and obligation dimension.It should serve as the ethical standard for human gene research activities.Based on the provisions of China’s Constitution,the human rights ethics view on human gene research,as a constitutional ethics view,can elucidate different levels of rights content,such as human dignity,life and health,and research freedom.It also addresses the weighing of basic rights conflicts and the dual obligation subjects of public and private nature.Relying on the constitutional value embedding of the research ethics view to form ethical consensus,improving ethical review through framework legislation for human rights interests,and implementing ethical responsibility through the human rights-oriented interpretation of ethical legal norms are the three pathways to realizing the human rights ethics view on human gene research.展开更多
Human rights are both a hallmark of progress in human civilization and a shared achievement of all civilizations.Throughout history,civilizations,including the Chinese civilization,have continuously explored fundament...Human rights are both a hallmark of progress in human civilization and a shared achievement of all civilizations.Throughout history,civilizations,including the Chinese civilization,have continuously explored fundamental questions about human life,value,and dignity,collectively shaping the foundation of global human rights civilization.On November 20,2024,the International Academic Conference on the Ideas of Human Rights in Ancient Chinese Classics was held at the Yuelu Academy of Hunan University.Attendants explored the historical origin and creative transformation of China’s human rights civilization from four dimensions,namely comparative studies of human rights civilizations in China and abroad,human rights concepts in Confucian classics and historical records,human rights concepts in Chinese philosophical and miscellaneous works,and human rights concepts in legal texts.The conference examined the historical connection between human rights concepts in ancient Chinese classics and the shared values of humanity,aiming to promote global human rights dialogue and mutual learning through civilizational exchanges.By bridging“ancient and modern,East and West,”it illuminated the civilizational foundations and Chinese wisdom underlying global human rights governance.展开更多
BACKGROUND Chronic diarrhoea in people living with human immunodeficiency virus(PLHIV)/acquired immunodeficiency syndrome presents a diagnostic challenge,often resulting from opportunistic infections(OIs),malignancies...BACKGROUND Chronic diarrhoea in people living with human immunodeficiency virus(PLHIV)/acquired immunodeficiency syndrome presents a diagnostic challenge,often resulting from opportunistic infections(OIs),malignancies,or disease progression itself.We present a case of an advanced human immunodeficiency virus(HIV)patient with chronic diarrhoea,significant weight loss,and antiretroviral therapy(ART)non-compliance,highlighting the diagnostic dilemma between HIV wasting syndrome,OIs,and malignancy.CASE SUMMARY A 36-year-old female,diagnosed with HIV five years ago on family screening,presented with three months of profuse watery diarrhoea,associated with crampy abdominal pain and weight loss(14 kg,30%in 3 months).She was non-compliant with ART.There was no history of recent travel,food contamination,or tuberculosis contact.Fever episodes were mild and transient.Physical examination revealed pallor and bilateral pedal oedema without lymphadenopathy or organomegaly.Genital examination was unremarkable.Routine investigations revealed severe anaemia and confirmed PLHIV status.CD4 count was<36 cells/μL.Empirical treatment with nitazoxanide was initiated for possible cryptosporidiosis.After ruling out OIs,ART was restarted.With treatment,her diarrhoea resolved,and she tolerated oral intake.Nutritional support was provided,and she was discharged in stable condition with ART,prophylactic antibiotics,and followup instructions for further evaluation.CONCLUSION In ART-noncompliant PLHIV with chronic diarrhoea,distinguishing between HIV wasting syndrome,OIs(Cryptosporidium,Mycobacterium avium complex,cytomegalovirus colitis)and malignancies(non-Hodgkin lymphoma and anal carcinoma)are critical.Gradual CD4 decline,systemic inflammation,and malnutrition favour progressive HIV/acquired immunodeficiency syndrome rather than an acute OI or malignancy.Early recognition and management,including ART reinitiation and nutritional support,are crucial for prognosis.展开更多
Research on human motion prediction has made significant progress due to its importance in the development of various artificial intelligence applications.However,effectively capturing spatio-temporal features for smo...Research on human motion prediction has made significant progress due to its importance in the development of various artificial intelligence applications.However,effectively capturing spatio-temporal features for smoother and more precise human motion prediction remains a challenge.To address these issues,a robust human motion prediction method via integration of spatial and temporal cues(RISTC)has been proposed.This method captures sufficient spatio-temporal correlation of the observable sequence of human poses by utilizing the spatio-temporal mixed feature extractor(MFE).In multi-layer MFEs,the channel-graph united attention blocks extract the augmented spatial features of the human poses in the channel and spatial dimension.Additionally,multi-scale temporal blocks have been designed to effectively capture complicated and highly dynamic temporal information.Our experiments on the Human3.6M and Carnegie Mellon University motion capture(CMU Mocap)datasets show that the proposed network yields higher prediction accuracy than the state-of-the-art methods.展开更多
文摘Protecting human rights is a noble ideal enshrined in the Universal Declaration of Human Rights.For an extended period,the United States has positioned itself as a"defender"of this cause,politicizing,weaponizing,and instrumentalizing human rights issues to criticize and discredit other countries.
基金the National Social Science Fund Major Project“Research on the Background of the Formation,Logical Structure,and Value Orientation of the Chinese Human Rights Knowledge System”(Project Approval Number 24&ZD129)the National Social Science Fund Major Project“Research on General Secretary Xi Jinping’s Important Discourses on Respecting and Protecting Human Rights”(Project Approval Number 22&ZD004).
文摘As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four editions demonstrates a clear and distinct logic of progression:human rights education in primary and secondary schools has shifted from fostering students’awareness of human rights to establishing human rights values;human rights education in higher education has transitioned from the construction of single human rights course to the systematic development of human rights disciplines;human rights knowledge training has evolved from disseminating basic human rights knowledge among legal and political workers to cultivating a human rights mindset among public officials;and the popularization of human rights knowledge has moved from enhancing communication effectiveness to strengthening cultural confidence in human rights.These shifts reflect the characteristics of the policy evolution of human rights education,which are unified in their gradual and continuous nature,responsiveness and forward-looking nature,and value-oriented and contemporary nature.Fundamentally,the gap between the current state of human rights education development and policy goals serves as the intrinsic driving force for the evolution of human rights education policies.While the external factors influencing the evolution of policy content mainly include the human rights cause’s contemporary context,historical achievements,and current needs.Looking ahead to the future development of human rights education,it is essential to continuously innovate human rights teaching methods,enrich the content of human rights education,improve relevant institutional guarantee mechanisms,strengthen the construction of multi-stakeholder collaborative human rights education teams,compile and publish high-quality human rights textbooks,and increase the intensity of human rights knowledge training for journalists,in order to create a favorable public opinion atmosphere and cultural environment for the development of China’s human rights cause in the new era.
文摘BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investigate maternal viral load results and infant HIV testing uptake at 6-weeks,and 9-months and 18-months in Rwanda.METHODS Between 2015 and 2022,VLS(<200 copies/mL)was measured among pregnant women living with HIV(WLHIV)from 38-healthcare facilities.Viral loads(VL)were measured at 6-months,12-months and 24-months,respectively.For maternal VL,the unit of analysis was visit-pair,and the pairs were created to define those with VL<200 copies/mL at two consecutive visits as having sustained VLS,persistent viremia(VL≥200 copies/mL at two consecutive visits),viral rebound(VL<200 copies/mL at prior visit only)and newly suppressed(VL<200 copies/mL at subsequent visit only).HEI were considered to have persistent HIV testing if they had all three HIV tests.Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio(aIRR)and 95%CI for factors associated with sustained VLS and persistent HIV testing.RESULTS A total of 1145 mother-infant pairs were analyzed.Infant HIV testing uptake at 6-weeks,9-months and 18-months was 1145(100.0%),1089(95.1%),1006(87.9%)respectively.Nine hundred ninety-nine HEI(87.3%)tested for HIV persistently.At 18-months,the incidence of HIV among HEI was 8(0.7%).Of 1145 mothers,1076(94.0%)had≥2 VL results making a total of 2010 visit-pairs(142-single;934-double visit-pairs).The incidence rate of sustained VLS,persistent viremia,viral rebound and new suppression were 91.0%,1.3%,3.6%and 4.0%respectively.Maternal disclosure of HIV status(aIRR=1.08,95%CI:1.02-1.14)was associated with increased likelihood of sustained VLS.Having peer support(aIRR=1.0595%CI:1.01-1.10)was associated with persistent HIV testing among HEI.CONCLUSION Sustained VLS is high among pregnant WLHIV in Rwanda.The low incidence of HIV among HEI may be attributed to high VLS levels.Targeted interventions,including enhanced HIV disclosure and peer support,are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT.
基金a phased result funded by the Special Funds for Basic Scientific Research Expenses of Universities under the Central Government(24CXTD01).
文摘In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and discourses.Building an independent human rights knowledge system has become a core academic focus in China’s human rights research field.Upholding fundamental principles and breaking new ground are the key methodological principles for the process.China’s human rights research should be rooted in the“cultural lineage”by preserving the essence of fine traditional Chinese culture,guided by the“moral lineage”by adhering to the Marxist view on human rights,and anchored in the“Four-sphere Confidence”by upholding a distinct human rights development path,so as to define the historical coordinates and value stance of China’s independent human rights knowledge system.Meanwhile,it should maintain a high degree of openness in knowledge,theory,and methodology to address emerging rights demands and contribute to building a new global human rights governance order,so as to underscore the mission of China’s independent human rights knowledge system in the contemporary era and China’s responsibility as a major global actor.China’s human rights research should uphold the dialectical unity between the fundamental principles and innovations,and advance the systemic and theoretical interpretation of its independent human rights knowledge.
文摘Dear Editor,In a recent study,we isolated a protein from human oviductal secretion that could bind to spermatozoa[1].This protein was identified through chromatography and tandem mass spectrometry as human S100A9 and was detected in human tubal epithelium and oviductal secretions.S100A9 belongs to the S100 protein family[2],which has been found in various body fluids and tissues,and plays a role in extracellular functions,such as the enhancement of neutrophil extravasation,induction of proinflammatory cytokine release,antimicrobial properties through divalent ion sequestration,and modulation of cellular proliferation,differentiation,and apoptosis,as well as acting as a chemotactic factor[3–4].Because S100A9 is involved in various pathologies and the physiology of inflammation,research on S100A9 effects continues to grow rapidly.Recently,we have shown the presence of binding sites for S100A9 on human spermatozoa,and also found that S100A9 modulated certain sperm capacitation parameters in vitro,such as the induced acrosome reaction(AR)[1].To continue our studies on sperm function parameters,the current study aimed to express and purify human recombinant S100A9 and to assess its effect on sperm capacitation parameters,specifically the AR.
文摘BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs exhibit dynamic secretion patterns during lactation,influenced by maternal genetics and environ-mental factors.Their direct and indirect antimicrobial properties have garnered significant research interest.However,a comprehensive understanding of the secretion dynamics of HMOs and their correlation with antimicrobial efficacy remains underexplored.AIM To synthesize current evidence on the secretion dynamics of HMOs during lactation and evaluate their antimicrobial roles against bacterial,viral,and protozoal pathogens.METHODS A systematic search of PubMed,Scopus,Web of Science,and Cochrane Library focused on studies investigating natural and synthetic HMOs,their secretion dynamics,and antimicrobial properties.Studies involving human,animal,and in vitro models were included.Data on HMO composition,temporal secretion patterns,and mechanisms of antimicrobial action were extracted.Quality assess-ment was performed using validated tools appropriate for study design.RESULTS A total of 44 studies were included,encompassing human,animal,and in vitro research.HMOs exhibited dynamic secretion patterns,with 2′-fucosyllactose(2′-FL)and lacto-N-tetraose peaking in early lactation and declining over time,while 3-fucosyllactose(3-FL)increased during later stages.HMOs demonstrated significant antimicrobial properties through pathogen adhesion inhibition,biofilm disruption,and enzymatic activity impairment.Synthetic HMOs,including bioengineered 2′-FL and 3-FL,were structurally and functionally comparable to natural HMOs,effectively inhibiting pathogens such as Pseudomonas aeruginosa,Escherichia coli,and Campylobacter jejuni.Additionally,HMOs exhibited synergistic effects with antibiotics,enhancing their efficacy against resistant pathogens.CONCLUSION HMOs are vital in antimicrobial defense,supporting infant health by targeting various pathogens.Both natural and synthetic HMOs hold significant potential for therapeutic applications,particularly in infant nutrition and as adjuncts to antibiotics.Further research,including clinical trials,is essential to address gaps in knowledge,validate findings,and explore the broader applicability of HMOs in improving maternal and neonatal health.
基金This paper is a phased achievement of the Major Philosophy and Social Sciences Project of the Ministry of Education,titled“Research on General Secretary Xi Jinping’s Important Discourse on Respecting and Protecting Human Rights”(Project Number 22JZD002).
文摘At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the global new round of technological revolution and industrial transformation,along with changes in production methods and social structures,as well as the rising awareness of human rights,have led to the emergence of many new rights.At the same time,these developments have also given traditional human rights new digital forms.The constant emergence of new rights concepts poses challenges to the traditional human rights theoretical framework and has sparked numerous debates within the international community regarding human rights theory and practice.On issues like economic equality and social rights,particularly emerging rights topics such as climate and human rights and digital human rights,countries should focus on balancing the relationship between individuals,society,and nature and seek a path for the sustainable existence and development of humanity.The core principle for protecting emerging rights should be“humanity first,”and true multilateralism should be embraced to prevent imbalances in the global governance of emerging rights.Open and fair cooperation should help build consensus and provide solutions for the global protection of emerging rights.
基金“Research on the Content and Realization Methods of Citizens’Participation Rights,”a major project(Project Number 21JJD820003)funded by the National Human Rights Education and Training Base of the Ministry of Education of China.
文摘Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans are the most precious”is the most representative expression of human dignity.Ancient Chinese scholars’elaboration on dignity was ethically oriented;they affirmed that humans have the freedom to make moral choices in spirit and required them to assume moral responsibilities towards others and society.Since modern times,with the changes of the times and the introduction of Western liberalism,the traditional view of moral dignity has seen a significant expansion of its scope,incorporating freedom in economic,political,and social life into the category of human dignity and establishing a closer connection with human rights.In contemporary China,under the guidance of Marxism,the view of dignity regards the free,comprehensive,and common development of human beings as the intrinsic requirement and external manifestation of human dignity,takes the rights to subsistence and development as the primary and fundamental human rights,and comprehensively safeguards the dignity of every individual through the coordinated protection of economic,political,social,and cultural rights.
基金This paper is a phased achievement of the Major Project of the Key Research Base for Humanities and Social Sciences of the Ministry of Education in 2024,titled“Theoretical Legal Studies in the Field of Human Rights”(Project Approval Number 24JJD820002).
文摘The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practical dimension,and the theoretical dimension,which collectively form a“unified framework of four”of logical construction.The“world”dimension represents the synchronic extension of human rights practices,outwardly touching on the shared values of all humanity guided by relational rationality and the vision of a community with a shared future for humanity.The“historical”dimension reflects the diachronic extension of China’s path of human rights development,encompassing the cultural subjectivity of Chinese civilization and the complex context of modern human rights endeavors.The“practical”dimension serves as the“meta-perspective”of contemporary Chinese perspective on human rights,where the leadership of the Communist Party of China and the people-centered approach constitute the fundamental stance for developing the perspectives of human rights and human rights governance.The“theoretical”dimension focuses on the deconstruction and reconstruction of indigenous human rights notions,emphasizing a set of values that are confident,inclusive,equitable,shared,and forward-looking.The“world”dimension of“taking the world as a method”,provides a reference perspective for“taking China as a method”narrative centered on the“historical-practical-theoretical”framework,while the latter injects a human rights methodology grounded in Chinese wisdom into the former.By integrating these four dimensions,a more profound and comprehensive understanding of the value core and normative paradigm of contemporary Chinese perspective on human rights can be achieved.
基金supported by the National Natural Science Foundation of China(32171347)the Foundation of Leading Talents from Shanghai Health Commission(2022XD038)+1 种基金Training Program for Research Physicians in Innovation,the Funda-mental Research Funds for the Central Universities(YG2023QNA23)Transforma-tion from shanghai hospital development center(SHDC2022CRD002).
文摘Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic analysis of human dental pulp stem cells(HDPSCs)obtained from individuals of various ages.Our findings showed that the expression of NUP62 was decreased in aged HDPSCs.We discovered that NUP62 alleviated senescence-associated phenotypes and enhanced differentiation potential both in vitro and in vivo.Conversely,the knocking down of NUP62 expression aggravated the senescence-associated phenotypes and impaired the proliferation and migration capacity of HDPSCs.Through RNA-sequence and decoding the epigenomic landscapes remodeled induced by NUP62 overexpression,we found that NUP62 helps alleviate senescence in HDPSCs by enhancing the nuclear transport of the transcription factor E2F1.This,in turn,stimulates the transcription of the epigenetic enzyme NSD2.Finally,the overexpression of NUP62 influences the H3K36me2 and H3K36me3 modifications of anti-aging genes(HMGA1,HMGA2,and SIRT6).Our results demonstrated that NUP62 regulates the fate of HDPSCs via NSD2-dependent epigenetic reprogramming.
文摘Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical disability.Thus,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord injury.Each of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional recovery.Although the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in humans.This article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were analyzed.Thus,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.Papers regarding components of food especially nutrients and non-nutrient bioactive compounds(with putative health benefits)are welcomed.FSHW aims to unveil the correlations between food science and human health through the dissemination of both fundamental and applied research outcomes worldwide.
基金supported by the Grant PID2021-126715OB-IOO financed by MCIN/AEI/10.13039/501100011033 and"ERDFA way of making Europe"by the Grant PI22CⅢ/00055 funded by Instituto de Salud CarlosⅢ(ISCⅢ)+6 种基金the UFIECPY 398/19(PEJ2018-004965) grant to RGS funded by AEI(Spain)the UFIECPY-396/19(PEJ2018-004961)grant financed by MCIN (Spain)FI23CⅢ/00003 grant funded by ISCⅢ-PFIS Spain) to PMMthe UFIECPY 328/22 (PEJ-2021-TL/BMD-21001) grant to LM financed by CAM (Spain)the grant by CAPES (Coordination for the Improvement of Higher Education Personnel)through the PDSE program (Programa de Doutorado Sanduiche no Exterior)to VSCG financed by MEC (Brazil)
文摘The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.
文摘Human herpesvirus 6(HHV-6)is a common childhood infection but rarely causes severe complications.In immunocompetent children,conditions such as febrile convulsions and roseola infantum are typical,with occasional severe manifestations like meningoencephalitis and myocarditis.
基金the Major Project of the National Social Science Fund of China,entitled“Research on the Generative Context,Construction Logic,and Value Orientation of China’s Human Rights Knowledge System”(Project Approval Number 24&ZD129).
文摘During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalism,emphasized respect for human beings,highlighting the importance of caring for,respecting,and protecting people,and focusing on“benefiting the people,”“nurturing the people,”“enriching the people,”and“prospering the people.”It reflected an awareness of human rights such as the rights to life,personality,subsistence,development,and environment.This human rights awareness,oriented towards values such as“achieving benevolence,”“valuing goodness,”“revering righteousness,”“cherishing harmony,”and“seeking the public good,”established a cognitive logic that unifies human nature,virtue,and rationality.It featured a human rights spirit that is not dominated by divine authority,based on moral and ethical philosophy,and oriented towards“positive”rights.This awareness delved into the value of being human and the meaning of human existence,demonstrating creativity and innovation,and marking a significant breakthrough in the history of human rights civilization.The ideological wisdom,spiritual strength,and practical pathways contained in this human rights awareness not only laid the foundation for the human rights thought of classical Chinese civilization but are also indispensable for contemporary China’s commitment to the“two combinations”.It holds important practical significance for advancing Chinese modernization and creating a modern human rights civilization for the Chinese nation.
基金This paper is a phased outcome of the“Research on the Strategy to Improve the Mechanism for the International Dissemination of China’s Human Rights Discourse”(22JJD820045),a key research project of the National Human Rights Education and Training Base under China’s Ministry of Education.
文摘The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adjustments based on audience feedback.To some extent,the current approach has resulted in characteristics such as strong practical implementation but weak discourse,limited theoretical foundation,and insufficient recognition in China’s international human rights communication.Consequently,while China has achieved remarkable progress in its human rights endeavors,human rights issues remain a critical area of stigmatization by some Western countries.An“effect-oriented”mechanism for the international dissemination of China’s human rights discourse,therefore,aims to address this challenge by re-centering the audience as active participants in the communication process.By emphasizing the dual nature of human rights’international communication,this approach leverages the reflexive monitoring of initial transmitters throughout the dissemination process to finally construct a dynamic human rights discourse framework responsive to different time and space contexts.This mechanism directly confronts the diverse backgrounds of global audiences and the resulting varied interpretations of China’s human rights discourse.It advocates for dynamic evaluation of global dissemination outcomes based on audience feedback and the timely adaptation of communication strategies according to context.By doing so,it seeks to effectively advance China’s human rights communication efforts and enhance dissemination efficiency on the global scale.
基金This paper is an interim result of“Constitutional Boundaries of the Application of Human Gene Editing Technology,”a Youth Project of the National Social Science Fund of China(Project Approval Number 23CFX040)supported by the“National Funded Programs for Postdoctoral Researchers”(GZC20230937).
文摘The establishment of a sound science and technology ethics governance system is an inevitable requirement for national modernization.Faced with the development of human gene technology and the chaos in research activities,the ethical standards and legal positioning of human gene research activities urgently need to be clarified.The human rights ethics view has value inclusiveness and value fundamentality,and includes three levels of connotations:content dimension,relationship dimension,and obligation dimension.It should serve as the ethical standard for human gene research activities.Based on the provisions of China’s Constitution,the human rights ethics view on human gene research,as a constitutional ethics view,can elucidate different levels of rights content,such as human dignity,life and health,and research freedom.It also addresses the weighing of basic rights conflicts and the dual obligation subjects of public and private nature.Relying on the constitutional value embedding of the research ethics view to form ethical consensus,improving ethical review through framework legislation for human rights interests,and implementing ethical responsibility through the human rights-oriented interpretation of ethical legal norms are the three pathways to realizing the human rights ethics view on human gene research.
文摘Human rights are both a hallmark of progress in human civilization and a shared achievement of all civilizations.Throughout history,civilizations,including the Chinese civilization,have continuously explored fundamental questions about human life,value,and dignity,collectively shaping the foundation of global human rights civilization.On November 20,2024,the International Academic Conference on the Ideas of Human Rights in Ancient Chinese Classics was held at the Yuelu Academy of Hunan University.Attendants explored the historical origin and creative transformation of China’s human rights civilization from four dimensions,namely comparative studies of human rights civilizations in China and abroad,human rights concepts in Confucian classics and historical records,human rights concepts in Chinese philosophical and miscellaneous works,and human rights concepts in legal texts.The conference examined the historical connection between human rights concepts in ancient Chinese classics and the shared values of humanity,aiming to promote global human rights dialogue and mutual learning through civilizational exchanges.By bridging“ancient and modern,East and West,”it illuminated the civilizational foundations and Chinese wisdom underlying global human rights governance.
文摘BACKGROUND Chronic diarrhoea in people living with human immunodeficiency virus(PLHIV)/acquired immunodeficiency syndrome presents a diagnostic challenge,often resulting from opportunistic infections(OIs),malignancies,or disease progression itself.We present a case of an advanced human immunodeficiency virus(HIV)patient with chronic diarrhoea,significant weight loss,and antiretroviral therapy(ART)non-compliance,highlighting the diagnostic dilemma between HIV wasting syndrome,OIs,and malignancy.CASE SUMMARY A 36-year-old female,diagnosed with HIV five years ago on family screening,presented with three months of profuse watery diarrhoea,associated with crampy abdominal pain and weight loss(14 kg,30%in 3 months).She was non-compliant with ART.There was no history of recent travel,food contamination,or tuberculosis contact.Fever episodes were mild and transient.Physical examination revealed pallor and bilateral pedal oedema without lymphadenopathy or organomegaly.Genital examination was unremarkable.Routine investigations revealed severe anaemia and confirmed PLHIV status.CD4 count was<36 cells/μL.Empirical treatment with nitazoxanide was initiated for possible cryptosporidiosis.After ruling out OIs,ART was restarted.With treatment,her diarrhoea resolved,and she tolerated oral intake.Nutritional support was provided,and she was discharged in stable condition with ART,prophylactic antibiotics,and followup instructions for further evaluation.CONCLUSION In ART-noncompliant PLHIV with chronic diarrhoea,distinguishing between HIV wasting syndrome,OIs(Cryptosporidium,Mycobacterium avium complex,cytomegalovirus colitis)and malignancies(non-Hodgkin lymphoma and anal carcinoma)are critical.Gradual CD4 decline,systemic inflammation,and malnutrition favour progressive HIV/acquired immunodeficiency syndrome rather than an acute OI or malignancy.Early recognition and management,including ART reinitiation and nutritional support,are crucial for prognosis.
基金supported by the National Key R&D Program of China(No.2018YFB1305200)the Natural Science Foundation of Zhejiang Province(No.LGG21F030011)。
文摘Research on human motion prediction has made significant progress due to its importance in the development of various artificial intelligence applications.However,effectively capturing spatio-temporal features for smoother and more precise human motion prediction remains a challenge.To address these issues,a robust human motion prediction method via integration of spatial and temporal cues(RISTC)has been proposed.This method captures sufficient spatio-temporal correlation of the observable sequence of human poses by utilizing the spatio-temporal mixed feature extractor(MFE).In multi-layer MFEs,the channel-graph united attention blocks extract the augmented spatial features of the human poses in the channel and spatial dimension.Additionally,multi-scale temporal blocks have been designed to effectively capture complicated and highly dynamic temporal information.Our experiments on the Human3.6M and Carnegie Mellon University motion capture(CMU Mocap)datasets show that the proposed network yields higher prediction accuracy than the state-of-the-art methods.
