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基于加权基因共表达网络分析识别并鉴定胰腺癌的Hub基因
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作者 彭瑶 张明军 《医学理论与实践》 2026年第1期6-10,共5页
目的:运用加权基因共表达网络分析(WGCNA)结合机器学习算法发掘胰腺癌新的生物标志物。方法:通过对基因表达综合数据库(GEO)中胰腺癌及正常胰腺组织的RNA测序表达数据集进行差异表达基因分析,利用WGCNA识别关键模块和基因,结合Lasso回... 目的:运用加权基因共表达网络分析(WGCNA)结合机器学习算法发掘胰腺癌新的生物标志物。方法:通过对基因表达综合数据库(GEO)中胰腺癌及正常胰腺组织的RNA测序表达数据集进行差异表达基因分析,利用WGCNA识别关键模块和基因,结合Lasso回归分析及生存分析,确定Hub基因并对其诊断效能进行验证。结果:在GSE15471和GSE16515数据集中,鉴定出123个差异表达基因,WGCNA确定了7个共表达模块,其中黄色模块与胰腺癌具有强相关性。在黄色模块中筛选出49个关键基因,并与差异表达基因取交集得到18个交集基因。通过Lasso回归分析和生存分析,最终确定了6个Hub基因(C15orf48、C19orf33、GPRC5A、KRT19、LAMB3和SLC6A14),这些基因在胰腺癌中表达上调,且与患者总生存期相关。ROC曲线分析显示,这6个Hub基因在训练集和验证集中均表现出良好的诊断效能。结论:C15orf48、C19orf33、GPRC5A、KRT19、LAMB3和SLC6A14在胰腺癌的发生发展中可能具有重要生物学意义,为胰腺癌诊断、治疗及预后评估提供生物标志物线索。 展开更多
关键词 胰腺癌 加权基因共表达网络分析 hub基因 生物标志物
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The Automotive Economy of Shiyan,Hubei Province
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作者 Wan Zewei 《China's Foreign Trade》 2025年第4期54-56,共3页
Shiyan,located in the northwestern part of Hubei Province,China,is a city with a population of approximately 3.2 million.As a prefecture-level city,Shiyan is known for its mountainous terrain and rich natural resource... Shiyan,located in the northwestern part of Hubei Province,China,is a city with a population of approximately 3.2 million.As a prefecture-level city,Shiyan is known for its mountainous terrain and rich natural resources.Historically,Shiyan has been a strategic transportation hub connecting Hubei,Shaanxi,and Chongqing. 展开更多
关键词 mountainous terrain prefecture level city strategic location Shiyan automotive economy natural resources hubei province transportation hub
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国际合作项目如何赋能中小微企业国际化——基于深圳市HUA HUB案例的研究
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作者 李小凤 余柔萱 曾志敏 《新经济》 2025年第12期92-107,共16页
跨国采购是中国企业国际化发展的重要方面,当前中国中小微企业在跨国采购领域还存在诸如国际链接程度不足、融入国际市场的能力不够、运营团队不成熟等短板。在此情况下,可持续发展为企业“出海”提供了新的机遇。本文基于资源基础理论... 跨国采购是中国企业国际化发展的重要方面,当前中国中小微企业在跨国采购领域还存在诸如国际链接程度不足、融入国际市场的能力不够、运营团队不成熟等短板。在此情况下,可持续发展为企业“出海”提供了新的机遇。本文基于资源基础理论,以案例分析的方式揭示了深圳市HUA HUB的案例经验,通过研究发现:HUA HUB作为联合国开发计划署(UNDP)在粤港澳大湾区设立的首个可持续发展创新实验室,以国际合作项目为载体,通过“联合国系统-地方政府-企业”三方协同,服务中国企业进入跨国采购市场。具体来说,HUA HUB通过构建国际组织与规则对接机制,提供网络资源供给;通过开展企业赋能培训,强化资源使用能力;通过孵化可持续发展项目,推动资源成果转化。此案例具有区别于传统组织的独特优势,可为中国中小微企业国际化发展提供若干启示。 展开更多
关键词 企业国际化发展 可持续发展 跨国采购 资源基础观 HUA hub
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Mixed parking demand assignment in hub parking lots based on regression modeling 被引量:1
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作者 ZHANG Chu CHEN Kehan +1 位作者 CHEN Jun CHEN Jiayi 《Journal of Southeast University(English Edition)》 2025年第3期270-277,共8页
To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to mi... To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to minimize total time expenditure is constructed.It incorporates parking search time,walking time,and departure time,focusing on short-term parking features.Then,the information dimensions that the parking lot can obtain are evaluated,and three assignment strategies based on three types of regression models-linear regression(LR),extreme gradient boosting(XGBoost),and multilayer perceptron(MLP)-are proposed.A parking process simulation model is built using the traffic simulation package SUMO to facilitate data collection,model training,and case studies.Finally,the performance of the three strategies is com-pared,revealing that the XGBoost-based strategy performs the best in case parking lots,which reduces time expendi-ture by 29.3%and 37.2%,respectively,compared with the MLP-based strategy and LR-based strategy.This method offers diverse options for practical parking manage-ment. 展开更多
关键词 parking areas assignment hub parking lot regression-based modeling extreme gradient boosting(XG-Boost)
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数字化转型背景下Sci-Hub对学术出版的影响及应对策略 被引量:1
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作者 严延 《图书馆研究与工作》 2025年第6期47-53,共7页
文章从数字化转型背景下科研信息获取的变化以及Sci-Hub的发展历程入手探讨了学术出版的现状,涉及学术出版模式、出版业的版权、开放获取与付费获取三个方面。分析了Sci-Hub对学术出版的直接影响、对研究者利益的间接影响以及对科学传... 文章从数字化转型背景下科研信息获取的变化以及Sci-Hub的发展历程入手探讨了学术出版的现状,涉及学术出版模式、出版业的版权、开放获取与付费获取三个方面。分析了Sci-Hub对学术出版的直接影响、对研究者利益的间接影响以及对科学传播的长远影响。提出了政策引导、学术界自律和技术与服务创新的建议,以期在保障学术出版知识产权的同时推动科研成果的开放共享。 展开更多
关键词 数字化转型 Sci-hub 学术出版
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基于加权基因共表达网络分析筛选动脉粥样硬化铁死亡相关Hub基因
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作者 王苗茜 马明峰 《中西医结合心脑血管病杂志》 2025年第16期2411-2424,共14页
目的:使用生物信息学分析鉴定动脉粥样硬化(AS)中缺氧和铁死亡相关差异基因。方法:对GSE12288、GSE97210和GSE28829进行生物信息学分析。采用“limma”软件包鉴定差异表达基因(DEG)。进行不同种类的富集分析,以找出相关的途径。采用加... 目的:使用生物信息学分析鉴定动脉粥样硬化(AS)中缺氧和铁死亡相关差异基因。方法:对GSE12288、GSE97210和GSE28829进行生物信息学分析。采用“limma”软件包鉴定差异表达基因(DEG)。进行不同种类的富集分析,以找出相关的途径。采用加权基因共表达网络分析(WGCNA)构建共表达网络,以探索标记相关性并识别与AS相关的重要相互作用基因模块。Cytoscape用于可视化铁死亡相关基因和一些非编码RNA相互作用网络。采用CIBROSORT评估免疫细胞的丰度,揭示AS中免疫反应的影响。结果:共获得30个铁死亡相关的差异表达基因,如铁蛋白轻链(FTL)、谷氨酸受体基因3(GRIA3)、Prominin家族成员2(PROM2)、白介素1β(IL1B)等。基因本体(GO)和GSEA分析发现,上皮细胞增殖调控、膜筏和血管内皮生长因子(VEGF)通路等途径在AS中富集,然后进行调节网络和免疫细胞浸润丰度分析,以评估AS的潜在机制。结论:在AS中发现30个与铁死亡相关的DEG,并与疾病的病理进展相关,且是未来潜在的治疗靶点,然而其潜在的发病机制和潜在的分子靶点仍需要更全面深入的研究。 展开更多
关键词 动脉粥样硬化 铁死亡 hub基因 基因共表达 生物信息学分析
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Hydrogen Hub Potential in the Caribbean: Towards a Sustainable Future
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作者 Kahuina Miller Carolyn Graham 《Sustainable Marine Structures》 2025年第1期52-65,共14页
The Caribbean presents a wide range of opportunities with varying potential to contribute to the Gross National Incomes of the countries.However,the tourism industry remains a key source of income but is vulnerable to... The Caribbean presents a wide range of opportunities with varying potential to contribute to the Gross National Incomes of the countries.However,the tourism industry remains a key source of income but is vulnerable to disasters and other upheavals.There are alternatives to sustainable growth such as the blue economy with the potential for hydrogen extraction from the Caribbean Sea,which can make a signi fiicant contribution.The Caribbean Transshipment Triangle boasts signi fiicant port infrastructure that plays a crucial role in transporting goods and has the potential to become hydrogen hubs.The aim of this research is to examine the potential for countries in the region to develop this industry.A quantitative methodology was employed to examine the correlation between renewable energy and economic growth among six major transshipment countries in the Caribbean transshipment triangle,from 2010 to 2020.The study employed the Pearson correlation coef fiicient to analyze the data collected from these countries.The fiindings indicated that the Dominican Republic and Panama had the highest correlation between renewable energy and economic growth.Speci fiically,Jamaica,Panama,and the Dominican Republic demonstrated a moderate to high correlation between Renewable Power Capacity(RPC)and GDP.Consequently,investing in port infrastructure to facilitate hydrogen production,storage,distribution,and export could have positive effects on these economies.These fiindings are of interest to governments,managers,professionals,policymakers,and investors in the power generation sector.The research supports visions of a resilient blue economy and addresses sustainable development concerns in the Caribbean region. 展开更多
关键词 Caribbean Region Green Hydrogen Renewable Energy TRANSSHIPMENT Hydrogen hub Sustainable Growth
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Topology Optimization Design of a Hub Central Component Considering Fatigue Performance
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作者 Rui Xu Chaogan Gao +2 位作者 Jiale Shi Guorui Yu Quhao Li 《Computer Modeling in Engineering & Sciences》 2025年第10期1-16,共16页
To address the design challenges of helicopter hub central components under high-performance requirements,this paper conducts safe-life topology optimization design research considering fatigue performance for rotor h... To address the design challenges of helicopter hub central components under high-performance requirements,this paper conducts safe-life topology optimization design research considering fatigue performance for rotor hub central components under multi-load conditions,combined with helicopter fatigue strength engineering design theory.For dealing with the issues of derivative calculation difficulties when directly considering fatigue constraints in existing topology optimization methods,this study establishes a mathematical formulation suitable for structural topology optimization of hub central components by combining modified structural safety fatigue limits based on isolife curves.Then the sensitivity analysis of design variables is derived,and an optimization designmodel for typical main rotor hub central components is constructed.By controlling the safe-life equivalent stress of the hub central structure,the goal of managing structural fatigue life is achieved,providing new insights for long-life,high-reliability hub central component design.The paper presents a topology optimization case study of a typical five-armhub central component,completes optimized structure reconstruction and fatigue strength analysis,which validates the effectiveness of the proposed methodology. 展开更多
关键词 hub central component equivalent stress fatigue performance safe-life design topology optimization
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Dynamic recrystallization behavior and spinning texture formation mechanism of magnesium alloy wheel hub
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作者 Bing-chun JIANG Hao-wei ZHAI +3 位作者 Qing-hang WANG Meng LI Tong ZHANG Bin JIANG 《Transactions of Nonferrous Metals Society of China》 2025年第6期1787-1802,共16页
The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diff... The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diffraction,transmission electron microscopy,and finite element simulation revealed that continuous dynamic recrystallization(CDRX)and grain boundary bulging occurred simultaneously throughout the spinning process,leading to an increased proportion of DRXed grain areas.The newly formed DRXed grains largely retained the orientations of their deformed parent grains.The spinning process had two stages:initially,deformation was driven by basalslip as the roller contacted the alloy and descended to its lowest point.In the later stage,pyramidal<c+a>slips became predominant as additional force was applied along the spinning direction(SD),forming a final texture with the c-axis tilting±15°towards the SD.This texture development led to discernible anisotropy in tensile properties along the SD and the tangential direction(TD). 展开更多
关键词 magnesium alloy wheel hub dynamic recrystallization spinning texture dislocation slip mechanical anisotropy
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Immune Dysregulation and Hub Gene Identification in Non-Pulmonary Sepsis-Induced Acute Lung Injury:Insights from Transcriptomic and Experimental Analyses
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作者 Chen Yan Wen Li +6 位作者 Yang-ming Cai Wei-yi Cai Nian-dan Hu Yang-yi-yan Song Wen-qiang Li Zhou Sun Qing Geng 《Current Medical Science》 2025年第4期877-888,共12页
Objective Sepsis-induced acute lung injury(ALI)poses a critical challenge in critical care,yet its immunoregulatory mechanisms remain poorly defined.This study aimed to delineate immune dysregulation networks and iden... Objective Sepsis-induced acute lung injury(ALI)poses a critical challenge in critical care,yet its immunoregulatory mechanisms remain poorly defined.This study aimed to delineate immune dysregulation networks and identify therapeutic targets through multiomics data integration.Methods Transcriptomic datasets(GSE40180 and GSE165226)were analyzed through a multiphase bioinformatics workflow,including gene set enrichment analysis(GSEA),immune cell deconvolution(CIBERSORT),differential gene expression profiling(|log2FC|>1.5,P.adj<0.05),and pathway annotation(GO/KEGG).Protein–protein interaction(PPI)networks were constructed to identify hub genes.Experimental validation was done using a murine cecal ligation and puncture(CLP)model with histopathological lung injury scoring and RT-qPCR-based hub gene verification.Results Integrated analysis revealed 26 consensus biological processes(24 upregulated,2 downregulated)dominated by innate immune activation.CIBERSORT revealed significant infiltration of M1 macrophages,neutrophils,activated dendritic cells(DCs),and activated natural killer(NK)cells in septic lungs,which was concurrent with Th17/naive CD8+T-cell dysregulation.Among the 58 differentially expressed genes(DEG),7 hub genes(Cxcl1,Cxcl2,Ccl3,Cd14,Saa3,Timp1,and Socs3)were significantly correlated with immune cell dynamics.CLP modeling confirmed severe alveolar damage(lung injury score:8.11±1.17 vs.1.97±0.29;P<0.0001)and upregulated hub gene expression(all P<0.01)in septic lungs,with hub gene expression levels strongly correlated with the lung injury score(Pearson’s r>0.85,P<0.001).Conclusion Innate adaptive immune crosstalk,particularly dysregulated immune cell infiltration,drives sepsis-induced ALI pathogenesis.The 7 hub genes mechanistically connect immune dyshomeostasis to tissue injury,suggesting novel targets for precision immunomodulation and biomarker development in critical care. 展开更多
关键词 Acute lung injury Non-pulmonary sepsis Immune dysregulation Immune cell infiltration hub gene
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Global textile technology hub in Istanbul
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《China Textile》 2025年第6期54-54,共1页
The ITM 2026 International Textile Machinery Exhibition is set to take place in Istanbul/Turkey from June 9–13,2026,serving as a vital meeting point for textile technology manufacturers and investors worldwide.Levera... The ITM 2026 International Textile Machinery Exhibition is set to take place in Istanbul/Turkey from June 9–13,2026,serving as a vital meeting point for textile technology manufacturers and investors worldwide.Leveraging Istanbul's strategic location and accessibility,the event aims to bridge gaps in the global textile industry,particularly for professionals from regions facing barriers to attending European trade fairs. 展开更多
关键词 istanbul bridge gaps textile machinery trade fair global textile industry technological hub international textile machinery exhibition INVESTORS
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Security distance analysis of active distribution network considering energy hub demand response
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作者 Rui Ma Qi Zhou +2 位作者 Shengyang Liu Qin Yan Mo Shi 《Global Energy Interconnection》 2025年第1期160-173,共14页
This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar ... This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system. 展开更多
关键词 Active distribution network Energy hub Security distance Base station load Air-conditioning load
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A Strategic Pharmaceutical Hub
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作者 FRANCIS ESSOMBA 《ChinAfrica》 2025年第12期46-47,共2页
China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.... China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape. 展开更多
关键词 pharmaceutical hub pharmaceutical landscape Yicheng pharmaceutical group fabrication co ltd plant sino cameroonian cooperation pharmaceutical cooperation
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Research on vibration response and vibration attenuation model of comprehensive transportation hub under multiple-source excitations
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作者 Wu Qiaoyun Zhang Qingdong +2 位作者 Sun Jubo Chen Xuyong Xie Weiping 《Earthquake Engineering and Engineering Vibration》 2025年第2期527-545,共19页
To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characte... To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characteristics of each floor vibration were obtained through the time domain and frequency domain analyses.Based on the vibration characteristic under multiple-source excitations,the proposed attenuation model was derived.In addition,a vibration comfort evaluation on the Wuhan Railway Station was conducted.The results show that the effect of the number of vibration sources on horizontal acceleration is more significant than that regarding vertical acceleration.When the structure is under the effects two vibration sources with different frequencies,a high-frequency vibration can amplify a low-frequency vibration.The derived attenuation model can precisely predict the vibration attenuation and reduce the subsequent vibration test workload.Based on the annoyance rate model result,the annoyance rate of Wuhan Railway Station is high,which is harmful to the staff of the station. 展开更多
关键词 comprehensive transportation hub multiple-source excitations Wuhan Railway Station vibration measurement vibration attenuation model comfort evaluation
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Flexible train formation strategies for connecting rail transit in integrated transport hubs under high-demand conditions
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作者 ZHANG Renjie YANG Min +2 位作者 CHEN Shantao YE Mao CHENG Long 《Journal of Southeast University(English Edition)》 2025年第4期422-429,F0003,共9页
To address the challenges of supply-demand imbal-ance in rail transit and the complex passenger flow interactions among multiple hub stations under high-passenger-volume scenarios,this study proposes an optimized rail... To address the challenges of supply-demand imbal-ance in rail transit and the complex passenger flow interactions among multiple hub stations under high-passenger-volume scenarios,this study proposes an optimized rail transit scheduling method based on a flexible train formation strat-egy(FTFS).By constructing interaction parameters that characterize the coupling effects of high passenger flow across multiple hubs,a multiobjective optimization model is developed to minimize passenger waiting time at hub sta-tions and operational costs.An improved nondominated sorting genetic algorithm incorporating chaotic mapping and adaptive evolutionary parameters is designed for efficient so-lution optimization.This method overcomes the limitations of fixed train formations by supporting diversified modular unit detachment and reconnection,enabling dynamic capac-ity adjustment and efficient rolling stock circulation.A case study on Nanjing Metro Line 1 demonstrates that the FTFS reduces the average waiting time at hub stations by 47.2%,alleviates train congestion by approximately 18.6%,and re-duces the operational costs under low-demand scenarios by 44.8%.Pareto frontier analysis further reveals the trade-off mechanism between transport capacity elasticity and opera-tional costs.These findings validate the effectiveness of the flexible train formation model in mitigating platform conges-tion and enhancing passenger flow evacuation efficiency at transport hubs,providing multiobjective decision-making support for managing extreme passenger flow during holi-days and peak events. 展开更多
关键词 integrated transport hub urban rail transit flex-ible train formation MULTIOBJECTIVE nondominated sorting genetic algorithmⅡ
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Comprehensive Index Evaluation of the Cooling System with the Level Loop Thermosyphon System in Different Computing Hub Nodes in China
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作者 Li Ling Danhao Song +2 位作者 Qianlong Hu Zihao Xiang Zeyu Zhang 《Energy Engineering》 2025年第8期3309-3328,共20页
Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this sys... Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores. 展开更多
关键词 Data center rack level loop thermosyphon different Computing hub node different load rates comprehensive indicator analysis
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Research on Key Points of Planning and Design of Modern Integrated Transportation Hub-Taking Jinfeng Hub in Chongqing High-Tech Zone as an Example
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作者 Lijuan Chen Qingsong Fu 《Journal of Architectural Research and Development》 2025年第4期1-9,共9页
The Chengdu-Chongqing twin city economic circle has become a national strategy.As the westwards gateway of Chongqing central city,the High-tech Zone should further strengthen its traffic integration and interconnectiv... The Chengdu-Chongqing twin city economic circle has become a national strategy.As the westwards gateway of Chongqing central city,the High-tech Zone should further strengthen its traffic integration and interconnectivity with the Chengdu-Chongqing main Corridor.Combining the design concept and functional positioning of Jinfeng Hub,the research should be carried out from the aspects of hub scale control,three-dimensional spatial layout,rail transit connection,road collection and distribution system construction,and integrated development with the city.It is expected to provide a good reference for the planning and design of modern integrated transportation hub. 展开更多
关键词 Modern comprehensive transportation hub Transportation collection and distribution Zero-distance transfer
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为何在蛋白质相互作用网络中伪hub没有致命性?(英文)
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作者 董蕴源 王勇献 《生物物理学报》 CAS CSCD 北大核心 2014年第7期509-516,共8页
在系统生物学中,中心性-致命性法则的机制至今仍是一个有争议的问题。但是,在蛋白质-蛋白质相互作用网络中,存在很多伪hub,它们并不具有致命性。为了解释这一现象,作者提出了三个新的度量标准:n-neighbor、n-ip和n-ibep,并从拓扑和功能... 在系统生物学中,中心性-致命性法则的机制至今仍是一个有争议的问题。但是,在蛋白质-蛋白质相互作用网络中,存在很多伪hub,它们并不具有致命性。为了解释这一现象,作者提出了三个新的度量标准:n-neighbor、n-ip和n-ibep,并从拓扑和功能两方面将伪hub与致命性hub进行比较,发现两者所有的区别都具有统计学意义。实验结果显示伪hub具有更高的进化速率,参与了较少的子图且倾向于与非致命性蛋白质发生相互作用。 展开更多
关键词 hub 致命性hub 蛋白质-蛋白质相互作用网络 致命性
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一款集成HUB的USB设备控制器的设计 被引量:2
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作者 杨存永 詹克团 +1 位作者 杨英 袁国顺 《电子技术应用》 北大核心 2005年第11期78-80,共3页
介绍了USB设备控制器的基本功能和原理,提出了一款基于6502MCU的通用的带HUB的全速USB设备控制器的体系结构,并完成了整个芯片的设计,而且通过了FPGA验证。这款芯片可以用来开发带HUB的全速USB设备、全速USB设备或全速USBHUB。
关键词 USB hub SIE 转发器 FPGA USBhub USB设备 设备控制器 设计 集成
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基于产品开发网络Hub节点的工程变更 被引量:16
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作者 宫中伟 莫蓉 +1 位作者 杨海成 张欣 《计算机集成制造系统》 EI CSCD 北大核心 2012年第1期40-46,共7页
为了深入研究工程变更的传播机理,在产品开发网络中扩充了Hub节点的内涵,揭示了Hub节点在变更传播中的重要性;为了识别Hub节点,基于设计结构矩阵和图论的有关知识,对产品开发网络的节点进行聚类;提出了以INI指数作为判定Hub节点"... 为了深入研究工程变更的传播机理,在产品开发网络中扩充了Hub节点的内涵,揭示了Hub节点在变更传播中的重要性;为了识别Hub节点,基于设计结构矩阵和图论的有关知识,对产品开发网络的节点进行聚类;提出了以INI指数作为判定Hub节点"重要性"的量化指标;分析了确定Hub节点个数的方法;在此基础上,阐述了从Hub节点出发的工程变更控制策略。以某型号摩托车发动机为例,验证了所提方法的合理性。 展开更多
关键词 工程变更 变更传播 产品开发网络 hub节点 图论
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