Shiyan,located in the northwestern part of Hubei Province,China,is a city with a population of approximately 3.2 million.As a prefecture-level city,Shiyan is known for its mountainous terrain and rich natural resource...Shiyan,located in the northwestern part of Hubei Province,China,is a city with a population of approximately 3.2 million.As a prefecture-level city,Shiyan is known for its mountainous terrain and rich natural resources.Historically,Shiyan has been a strategic transportation hub connecting Hubei,Shaanxi,and Chongqing.展开更多
The Caribbean presents a wide range of opportunities with varying potential to contribute to the Gross National Incomes of the countries.However,the tourism industry remains a key source of income but is vulnerable to...The Caribbean presents a wide range of opportunities with varying potential to contribute to the Gross National Incomes of the countries.However,the tourism industry remains a key source of income but is vulnerable to disasters and other upheavals.There are alternatives to sustainable growth such as the blue economy with the potential for hydrogen extraction from the Caribbean Sea,which can make a signi fiicant contribution.The Caribbean Transshipment Triangle boasts signi fiicant port infrastructure that plays a crucial role in transporting goods and has the potential to become hydrogen hubs.The aim of this research is to examine the potential for countries in the region to develop this industry.A quantitative methodology was employed to examine the correlation between renewable energy and economic growth among six major transshipment countries in the Caribbean transshipment triangle,from 2010 to 2020.The study employed the Pearson correlation coef fiicient to analyze the data collected from these countries.The fiindings indicated that the Dominican Republic and Panama had the highest correlation between renewable energy and economic growth.Speci fiically,Jamaica,Panama,and the Dominican Republic demonstrated a moderate to high correlation between Renewable Power Capacity(RPC)and GDP.Consequently,investing in port infrastructure to facilitate hydrogen production,storage,distribution,and export could have positive effects on these economies.These fiindings are of interest to governments,managers,professionals,policymakers,and investors in the power generation sector.The research supports visions of a resilient blue economy and addresses sustainable development concerns in the Caribbean region.展开更多
The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diff...The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diffraction,transmission electron microscopy,and finite element simulation revealed that continuous dynamic recrystallization(CDRX)and grain boundary bulging occurred simultaneously throughout the spinning process,leading to an increased proportion of DRXed grain areas.The newly formed DRXed grains largely retained the orientations of their deformed parent grains.The spinning process had two stages:initially,deformation was driven by basalslip as the roller contacted the alloy and descended to its lowest point.In the later stage,pyramidal<c+a>slips became predominant as additional force was applied along the spinning direction(SD),forming a final texture with the c-axis tilting±15°towards the SD.This texture development led to discernible anisotropy in tensile properties along the SD and the tangential direction(TD).展开更多
This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar ...This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.展开更多
China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co....China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.展开更多
To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characte...To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characteristics of each floor vibration were obtained through the time domain and frequency domain analyses.Based on the vibration characteristic under multiple-source excitations,the proposed attenuation model was derived.In addition,a vibration comfort evaluation on the Wuhan Railway Station was conducted.The results show that the effect of the number of vibration sources on horizontal acceleration is more significant than that regarding vertical acceleration.When the structure is under the effects two vibration sources with different frequencies,a high-frequency vibration can amplify a low-frequency vibration.The derived attenuation model can precisely predict the vibration attenuation and reduce the subsequent vibration test workload.Based on the annoyance rate model result,the annoyance rate of Wuhan Railway Station is high,which is harmful to the staff of the station.展开更多
Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this sys...Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.展开更多
To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to mi...To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to minimize total time expenditure is constructed.It incorporates parking search time,walking time,and departure time,focusing on short-term parking features.Then,the information dimensions that the parking lot can obtain are evaluated,and three assignment strategies based on three types of regression models-linear regression(LR),extreme gradient boosting(XGBoost),and multilayer perceptron(MLP)-are proposed.A parking process simulation model is built using the traffic simulation package SUMO to facilitate data collection,model training,and case studies.Finally,the performance of the three strategies is com-pared,revealing that the XGBoost-based strategy performs the best in case parking lots,which reduces time expendi-ture by 29.3%and 37.2%,respectively,compared with the MLP-based strategy and LR-based strategy.This method offers diverse options for practical parking manage-ment.展开更多
The Chengdu-Chongqing twin city economic circle has become a national strategy.As the westwards gateway of Chongqing central city,the High-tech Zone should further strengthen its traffic integration and interconnectiv...The Chengdu-Chongqing twin city economic circle has become a national strategy.As the westwards gateway of Chongqing central city,the High-tech Zone should further strengthen its traffic integration and interconnectivity with the Chengdu-Chongqing main Corridor.Combining the design concept and functional positioning of Jinfeng Hub,the research should be carried out from the aspects of hub scale control,three-dimensional spatial layout,rail transit connection,road collection and distribution system construction,and integrated development with the city.It is expected to provide a good reference for the planning and design of modern integrated transportation hub.展开更多
BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unkn...BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.展开更多
BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic e...BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic evaluation.AIM To determine PBC-associated hub genes and assess their clinical utility for disease prediction.METHODS PBC expression data were obtained from the Gene Expression Omnibus database.Overlapping genes from differential expression analysis and weighted gene coexpression network analysis(WGCNA)were identified as key genes for PBC.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were performed to explore the potential roles of key genes.Hub genes were identified in protein-protein interaction(PPI)networks using the Degree algorithm in Cytoscape software.The relationship between hub genes and immune cells was investigated.Finally,a Mendelian randomization study was conducted to determine the causal effects of hub genes on PBC.RESULTS We identified 71 overlapping key genes using differential expression analysis and WGCNA.These genes were primarily enriched in pathways related to cytokinecytokine receptor interaction,and Th1,Th2,and Th17 cell differentiation.We utilized Cytoscape software and identified five hub genes(CD247,IL10,CCL5,CCL3,and STAT3)in PPI networks.These hub genes showed a strong correlation with immune cell infiltration in PBC.However,inverse variance weighting analysis did not indicate the causal effects of hub genes on PBC risk.CONCLUSION Hub genes can potentially serve as valuable biomarkers for PBC prediction and treatment,thereby offering significant clinical utility.展开更多
The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of...The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of the vehicle and increases the cruising range of the vehicle.Because of the limited special working environment and performance requirements,the hub motor has a small internal space and a large heat generation,so it puts forward higher requirements for heat dissipation capacity.For the external rotor hub motor,a new type of in-tank watercooled structure of hub motor was proposed to improve its cooling effect and performance.Firstly,the threedimensional finite element model of the motor is established to analyze the characteristics of motor loss and temperature field distribution.Secondly,the cooling performance of different cooling structures in the tank was studied.Finally,the thermal network model and three-dimensional finite element analysis were used to optimize the water-cooled structure in the tank,and the power density of themotor was improved by improving the cooling performance under the condition of volume limitation of the hub motor.The results show that the cooling effect of the proposed water-cooled structure in the tank is significant under the condition of constant power density.Compared to natural ventilation,the maximum temperature was reduced by 33.13°C and the cooling effect was increased by about 27.7%.展开更多
The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection&q...The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.展开更多
This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a su...This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a subgrade splicing scheme of a project.Roadbed splicing involves stepwise excavation and preparative measures like surface cleaning and backfilling.This article serves to provide a valuable reference for road and bridge construction and improve the quality of China’s road and bridge projects,so as to achieve sustainable development of the road and bridge engineering industry.展开更多
Background:Cold exposure is linked to numerous diseases,yet the changes in key genes and pathways in mice under cold exposure remain unexplored.Understanding these alterations could offer insights into the mechanisms ...Background:Cold exposure is linked to numerous diseases,yet the changes in key genes and pathways in mice under cold exposure remain unexplored.Understanding these alterations could offer insights into the mechanisms of cold resistance and contribute valuable ideas for treating cold-related diseases.Methods:The dataset GSE148361 was obtained from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)were identified using the"limma"package in R software.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were performed on DEGs.The STRING(Search Tool for the Retrieval of Interacting Genes)database was used to construct a protein-protein interaction(PPI)network.Additionally,gene set enrichment analysis(GSEA)was conducted to identify pathways associated with key genes.miRNAs and upstream transcription factors(TFs)were predicted using the miRNet database.Results:A total of 208 DEGs were identified,with 137 upregulated and 71 downregulated.In biological processes,DEGs were enriched in nucleotide and purine-containing compound metabolism.For cellular components,DEGs were involved in condensed chromosomes and mitochondrial protein complexes.In molecular functions,proton transmembrane transporter activity was enriched.KEGG pathway analysis showed significant enrichment in biosynthesis of unsaturated fatty acids,fatty acids,and pyruvate metabolism.From the PPI network,12 hub genes were identified using MCODE.Four hub genes(Col3a1,Ifi203,Rtp4,Vcan)demonstrated similar trends in a validation set(GSE110420)and were significantly differentially expressed.GSEA analysis indicated that these four genes were enriched in pathways such as ECM-receptor interaction and cytokine-cytokine receptor interaction.The hub gene network included 93 miRNAs and one TF.Conclusion:This study identified four hub genes as potential diagnostic biomarkers for cold exposure,providing insights for further research on the effects of cold on gene expression and disease.展开更多
文摘Shiyan,located in the northwestern part of Hubei Province,China,is a city with a population of approximately 3.2 million.As a prefecture-level city,Shiyan is known for its mountainous terrain and rich natural resources.Historically,Shiyan has been a strategic transportation hub connecting Hubei,Shaanxi,and Chongqing.
文摘The Caribbean presents a wide range of opportunities with varying potential to contribute to the Gross National Incomes of the countries.However,the tourism industry remains a key source of income but is vulnerable to disasters and other upheavals.There are alternatives to sustainable growth such as the blue economy with the potential for hydrogen extraction from the Caribbean Sea,which can make a signi fiicant contribution.The Caribbean Transshipment Triangle boasts signi fiicant port infrastructure that plays a crucial role in transporting goods and has the potential to become hydrogen hubs.The aim of this research is to examine the potential for countries in the region to develop this industry.A quantitative methodology was employed to examine the correlation between renewable energy and economic growth among six major transshipment countries in the Caribbean transshipment triangle,from 2010 to 2020.The study employed the Pearson correlation coef fiicient to analyze the data collected from these countries.The fiindings indicated that the Dominican Republic and Panama had the highest correlation between renewable energy and economic growth.Speci fiically,Jamaica,Panama,and the Dominican Republic demonstrated a moderate to high correlation between Renewable Power Capacity(RPC)and GDP.Consequently,investing in port infrastructure to facilitate hydrogen production,storage,distribution,and export could have positive effects on these economies.These fiindings are of interest to governments,managers,professionals,policymakers,and investors in the power generation sector.The research supports visions of a resilient blue economy and addresses sustainable development concerns in the Caribbean region.
基金funded by the National Natural Science Foundation of China(No.52204407)the Natural Science Foundation of Jiangsu Province,China(No.BK20220595)the China Postdoctoral Science Foundation(No.2022M723689)。
文摘The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diffraction,transmission electron microscopy,and finite element simulation revealed that continuous dynamic recrystallization(CDRX)and grain boundary bulging occurred simultaneously throughout the spinning process,leading to an increased proportion of DRXed grain areas.The newly formed DRXed grains largely retained the orientations of their deformed parent grains.The spinning process had two stages:initially,deformation was driven by basalslip as the roller contacted the alloy and descended to its lowest point.In the later stage,pyramidal<c+a>slips became predominant as additional force was applied along the spinning direction(SD),forming a final texture with the c-axis tilting±15°towards the SD.This texture development led to discernible anisotropy in tensile properties along the SD and the tangential direction(TD).
基金supported in part by the National Nat-ural Science Foundation of China(No.51977012,No.52307080).
文摘This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.
文摘China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.
基金Science Fund for Distinguished Young Scholars of Hubei Province under Grant No.2023AFA103National Natural Science Foundation of China under Grant No.52078395+1 种基金Open Projects Foundation of State Key Laboratory for Health and Safety of Bridge Structures under Grant No.BHSKL19-07-GFYoung Top-Notch Talent Cultivation Program of Hubei Province。
文摘To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characteristics of each floor vibration were obtained through the time domain and frequency domain analyses.Based on the vibration characteristic under multiple-source excitations,the proposed attenuation model was derived.In addition,a vibration comfort evaluation on the Wuhan Railway Station was conducted.The results show that the effect of the number of vibration sources on horizontal acceleration is more significant than that regarding vertical acceleration.When the structure is under the effects two vibration sources with different frequencies,a high-frequency vibration can amplify a low-frequency vibration.The derived attenuation model can precisely predict the vibration attenuation and reduce the subsequent vibration test workload.Based on the annoyance rate model result,the annoyance rate of Wuhan Railway Station is high,which is harmful to the staff of the station.
基金supported by the Natural Science Foundation of Hunan Province,China(Grant Nos.2023JJ50178 and 2023JJ50194)the Excellent Youth Project of Hunan Provincial Department of Education(Grant No.23B0542).
文摘Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.
基金The National Natural Science Foundation of China(No.52302388)the Natural Science Foundation of Jiangsu Province(No.BK20230853).
文摘To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to minimize total time expenditure is constructed.It incorporates parking search time,walking time,and departure time,focusing on short-term parking features.Then,the information dimensions that the parking lot can obtain are evaluated,and three assignment strategies based on three types of regression models-linear regression(LR),extreme gradient boosting(XGBoost),and multilayer perceptron(MLP)-are proposed.A parking process simulation model is built using the traffic simulation package SUMO to facilitate data collection,model training,and case studies.Finally,the performance of the three strategies is com-pared,revealing that the XGBoost-based strategy performs the best in case parking lots,which reduces time expendi-ture by 29.3%and 37.2%,respectively,compared with the MLP-based strategy and LR-based strategy.This method offers diverse options for practical parking manage-ment.
基金The 2024 Chongqing Municipal Education Commission Science and Technology Research Project,“Research on the Planning and Design of Modern Comprehensive Transportation Hubs under the Background of the Construction of the Chengdu-Chongqing Twin-City Economic Circle:A Case Study of Jinfeng Hub in Chongqing High-tech Zone”(Project No.:KJQN202405604).
文摘The Chengdu-Chongqing twin city economic circle has become a national strategy.As the westwards gateway of Chongqing central city,the High-tech Zone should further strengthen its traffic integration and interconnectivity with the Chengdu-Chongqing main Corridor.Combining the design concept and functional positioning of Jinfeng Hub,the research should be carried out from the aspects of hub scale control,three-dimensional spatial layout,rail transit connection,road collection and distribution system construction,and integrated development with the city.It is expected to provide a good reference for the planning and design of modern integrated transportation hub.
基金Supported by National Natural Science Foundation of China,No.82100594.
文摘BACKGROUND Helicobacter pylori(H.pylori)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting H.pylori infection and T2DM remain unknown.AIM To explore potential molecular connections between H.pylori infection and T2DM.METHODS We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with H.pylori infection and T2DM were identified.Hub genes were validated using human gastric biopsy samples.Correlations between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further analyzed.RESULTS A total of 67 DEGs were commonly presented in patients with H.pylori infection and T2DM.Five significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell infiltration.The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links.TF-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub genes.CONCLUSION We identified five hub genes that may have molecular connections between H.pylori infection and T2DM.This study provides new insights into the pathogenesis of H.pylori-induced onset of T2DM.
基金Supported by School-Level Key Projects at Bengbu Medical College,No.2021byzd109。
文摘BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic evaluation.AIM To determine PBC-associated hub genes and assess their clinical utility for disease prediction.METHODS PBC expression data were obtained from the Gene Expression Omnibus database.Overlapping genes from differential expression analysis and weighted gene coexpression network analysis(WGCNA)were identified as key genes for PBC.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were performed to explore the potential roles of key genes.Hub genes were identified in protein-protein interaction(PPI)networks using the Degree algorithm in Cytoscape software.The relationship between hub genes and immune cells was investigated.Finally,a Mendelian randomization study was conducted to determine the causal effects of hub genes on PBC.RESULTS We identified 71 overlapping key genes using differential expression analysis and WGCNA.These genes were primarily enriched in pathways related to cytokinecytokine receptor interaction,and Th1,Th2,and Th17 cell differentiation.We utilized Cytoscape software and identified five hub genes(CD247,IL10,CCL5,CCL3,and STAT3)in PPI networks.These hub genes showed a strong correlation with immune cell infiltration in PBC.However,inverse variance weighting analysis did not indicate the causal effects of hub genes on PBC risk.CONCLUSION Hub genes can potentially serve as valuable biomarkers for PBC prediction and treatment,thereby offering significant clinical utility.
基金supported by National Science Foundation of China(Grant No.51705306).
文摘The external rotor hub motor adopts direct drive mode,no deceleration drive device,and has a compact structure.Its axial size is smaller than that of a deceleration-driven hub motor,which greatly reduces the weight of the vehicle and increases the cruising range of the vehicle.Because of the limited special working environment and performance requirements,the hub motor has a small internal space and a large heat generation,so it puts forward higher requirements for heat dissipation capacity.For the external rotor hub motor,a new type of in-tank watercooled structure of hub motor was proposed to improve its cooling effect and performance.Firstly,the threedimensional finite element model of the motor is established to analyze the characteristics of motor loss and temperature field distribution.Secondly,the cooling performance of different cooling structures in the tank was studied.Finally,the thermal network model and three-dimensional finite element analysis were used to optimize the water-cooled structure in the tank,and the power density of themotor was improved by improving the cooling performance under the condition of volume limitation of the hub motor.The results show that the cooling effect of the proposed water-cooled structure in the tank is significant under the condition of constant power density.Compared to natural ventilation,the maximum temperature was reduced by 33.13°C and the cooling effect was increased by about 27.7%.
文摘The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.
文摘This article discusses the roadbed splicing for hub interchanges.The article starts with a description of the characteristics of junction roadbed splicing.The application of splicing technology is explained using a subgrade splicing scheme of a project.Roadbed splicing involves stepwise excavation and preparative measures like surface cleaning and backfilling.This article serves to provide a valuable reference for road and bridge construction and improve the quality of China’s road and bridge projects,so as to achieve sustainable development of the road and bridge engineering industry.
文摘Background:Cold exposure is linked to numerous diseases,yet the changes in key genes and pathways in mice under cold exposure remain unexplored.Understanding these alterations could offer insights into the mechanisms of cold resistance and contribute valuable ideas for treating cold-related diseases.Methods:The dataset GSE148361 was obtained from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)were identified using the"limma"package in R software.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were performed on DEGs.The STRING(Search Tool for the Retrieval of Interacting Genes)database was used to construct a protein-protein interaction(PPI)network.Additionally,gene set enrichment analysis(GSEA)was conducted to identify pathways associated with key genes.miRNAs and upstream transcription factors(TFs)were predicted using the miRNet database.Results:A total of 208 DEGs were identified,with 137 upregulated and 71 downregulated.In biological processes,DEGs were enriched in nucleotide and purine-containing compound metabolism.For cellular components,DEGs were involved in condensed chromosomes and mitochondrial protein complexes.In molecular functions,proton transmembrane transporter activity was enriched.KEGG pathway analysis showed significant enrichment in biosynthesis of unsaturated fatty acids,fatty acids,and pyruvate metabolism.From the PPI network,12 hub genes were identified using MCODE.Four hub genes(Col3a1,Ifi203,Rtp4,Vcan)demonstrated similar trends in a validation set(GSE110420)and were significantly differentially expressed.GSEA analysis indicated that these four genes were enriched in pathways such as ECM-receptor interaction and cytokine-cytokine receptor interaction.The hub gene network included 93 miRNAs and one TF.Conclusion:This study identified four hub genes as potential diagnostic biomarkers for cold exposure,providing insights for further research on the effects of cold on gene expression and disease.
