HOX transcription factors and their cofactors,MEINOX,are critical regulators of positional identity and cellular plasticity.While their functions are essential during embryonic development,they also play key roles in ...HOX transcription factors and their cofactors,MEINOX,are critical regulators of positional identity and cellular plasticity.While their functions are essential during embryonic development,they also play key roles in maintaining adult tissue homeostasis.Dysregulation of HOX and MEINOX has been implicated in the pathogenesis of various diseases,including fibrosis and cancer.This review explores the contributions of HOX and MEINOX to dedifferentiation and cellular reprogramming,processes that drive fibrotic disease onset and cancer progression.It also addresses their role in extracellular matrix remodeling in these conditions.Particular attention is given to their involvement in epithelialmesenchymal transition,where altered HOX and MEINOX expression promotes phenotypic plasticity,cancer invasiveness,and fibrotic tissue remodeling.By integrating these perspectives,this review underscores the significance of HOXMEINOX dysregulation and altered positional identity in disease progression.Targeting this dysregulation may offer innovative strategies to modulate epithelial-mesenchymal transition and extracellular matrix dynamics,presenting new therapeutic opportunities for combating fibrosis and cancer.展开更多
While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients,effective treatments are still lacking.Here,we identified homeobox C10(HOXC10)as a lynchpin in pan-KRAS-mutant lun...While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients,effective treatments are still lacking.Here,we identified homeobox C10(HOXC10)as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis.展开更多
文摘HOX transcription factors and their cofactors,MEINOX,are critical regulators of positional identity and cellular plasticity.While their functions are essential during embryonic development,they also play key roles in maintaining adult tissue homeostasis.Dysregulation of HOX and MEINOX has been implicated in the pathogenesis of various diseases,including fibrosis and cancer.This review explores the contributions of HOX and MEINOX to dedifferentiation and cellular reprogramming,processes that drive fibrotic disease onset and cancer progression.It also addresses their role in extracellular matrix remodeling in these conditions.Particular attention is given to their involvement in epithelialmesenchymal transition,where altered HOX and MEINOX expression promotes phenotypic plasticity,cancer invasiveness,and fibrotic tissue remodeling.By integrating these perspectives,this review underscores the significance of HOXMEINOX dysregulation and altered positional identity in disease progression.Targeting this dysregulation may offer innovative strategies to modulate epithelial-mesenchymal transition and extracellular matrix dynamics,presenting new therapeutic opportunities for combating fibrosis and cancer.
基金sponsored by National Natural Science Foundation of China (82303396,82022051,82072972 and 81672883)Science and Technology Commission of Shanghai (22YF1408400)+6 种基金Shanghai Pilot Program for Basic Research (TQ20240208)Natural Science Foundation of Chongqing (CSTB2024NSCQ-JQX0009 and CSTB2024NSCQ-MSX0594)The Postdoctoral Foundation of China (2023T160122)Anti-cancer Association in Shanghai,Joint Foundation from Fudan University Shanghai Cancer Center (YJQN202102)Science&Techenology Department of Sichuan Province (2023NSFSC0705)the Fund of major military joint research project (2019LH 02)Shanghai municipal hospital emerging frontier joint research project (SHDC12024112)。
文摘While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients,effective treatments are still lacking.Here,we identified homeobox C10(HOXC10)as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis.
