Objective: To determine the hot/cold of South American A?aí(Euterpe oleracea Mart.). Materials and Methods: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay was performed to compare the in...Objective: To determine the hot/cold of South American A?aí(Euterpe oleracea Mart.). Materials and Methods: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay was performed to compare the influence of A?aí and phellodendron bark(Cortex Phellodendri Chinensis) on the growth and proliferation of HepG2 and Hep3 B cell strains. The morphological changes of the two cell strains treated with A?aí and C. Phellodendri were observed using an inverted phase contrast microscope. Trypan blue dye exclusion assay was used to compare and analyze the toxicity effects of A?aí. The content of nicotinamide adenine dinucleotide(NADH) and the ratio of NADH/NAD+ of the treated cells were detected using a spectrophotometer to determine the influence of A?aí to the energy metabolism of the two cell strains. Results: Within the range of measured concentrations, both A?aí and C. Phellodendri displayed separately the stronger inhibitory effects on cell growth, proliferation, and energy metabolism of the two cell strains. By MTT assay, A?aí showed significant(P < 0.05) or highly significant(P < 0.01) inhibitory effects on cell proliferation within the concentration range of 0.25–40 μg/mL, which was similar to the effects of C. Phellodendri. From the results of microscopic examination, the morphological of lower cell density, attenuated granularity, and more outstretched cells in irregular polygonal shape could be observed in the cells treated with A?aí, which was also similar to that of C. Phellodendri. In trypan blue staining assay, all concentrations of A?aí showed negligible toxicity effects, exactly as that of C. Phellodendri. A?aí showed a highly significant effect of decreasing the content of intracellular NADH as well as the ratio of NADH/NAD+(P < 0.05 and P < 0.01, respectively). Conclusion: The effect of A?aí on HepG2 and Hep3 B strains just as C. Phellodendri can reduce energy metabolism and inhibit the growth and proliferation. All performance characteristics of two cell strains treated with A?aí belong to that characteristic of cold property drug. From the study results, we can deduce that the drug property of A?aí is cold.展开更多
Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature&...Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature" herbs, we investigated the antioxidant activities of 40 Tibetan herbs from Qinghai plateau, with 20 herbs in cold-nature and 20 herbs in hot-nature. Antioxidant capacities were evaluated by the following methods: scavenging ABTS?+(2, 2′azinobis-(3-ethylbenz-thiazoline-6-sulfonic acid), scavenging O2?-, and Ferric-reducing antioxidant power(FRAP). The effects on inhibition of mitochondrion lipid peroxidation were determined by measuring the formation of TBARS(Thiobarbituric acid reactive substrates). Total phenolics and flavonoids were estimated by Folin-Ciocalteu and Na NO2-Al(NO3)3-Na OH colorimetric methods. Interestingly, the cold-nature herbs displayed higher antioxidant activities than the hot-nature ones, corresponding to nearly three-fold higher total phenolic contents in the cold-nature herbs. Moreover, the antioxidant activities correlated linearly with the levels of total phenolics for both cold-nature and hot-nature herbs, but only with the levels of total flavonoids for the hot-nature herbs. The results suggested that the phenolic compounds, but not the flavonoids, play the major role in antioxidant capacities of the cold-nature herbs. These findings could shed new lights on the study the theory of Tibetan medicine.展开更多
It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia...It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.展开更多
In order to improve the control ability of synthetic jets in compressible boundary layer,a novel control method based on dual synthetic cold/hot jets coupled control of velocity profile and temperature profile was pro...In order to improve the control ability of synthetic jets in compressible boundary layer,a novel control method based on dual synthetic cold/hot jets coupled control of velocity profile and temperature profile was proposed.As fundamental investigations on the effects of synthetic jet temperature on the jet behavior and flow field characteristics were essentially necessary,preliminary numerical simulations were conducted to study the influence of temperature(200 K and 400 K)on the flow field characteristics of synthetic jets using Large Eddy Simulations(LES)model.Time-averaged flow fields showed that different temperatures led to variable behavior of two strands of jets.For dual synthetic cold jets,a potential-core arose apparently with its height ranging from 0.01 to 0.03 m,while for dual synthetic hot jets,two strands of jets emerged downstream.The modal decomposition of instantaneous flow fields had been done using both Proper Orthogonal Decomposition(POD)and Dynamic Mode Decomposition(DMD).Various modes showed different characteristics of the flow fields.As the POD method focuses on the energy of flow while the DMD method focuses on the frequency,the first two modes had many similarities,but the third and fourth modes demonstrated completely different vortex structures.The current researches play a role of preliminary investigations for further and comprehensive exploration of novel flow control measures in global velocity field.展开更多
Tomato processing includes a break step, which involves rapid heating of freshly chopped tomatoes to >90°C for hot break, or 60°C to 77°C for cold break. Pectolytic enzyme deactivation is...Tomato processing includes a break step, which involves rapid heating of freshly chopped tomatoes to >90°C for hot break, or 60°C to 77°C for cold break. Pectolytic enzyme deactivation is believed to be the key element in the hot break step;therefore, pectin content of different products should be qualitatively distinct. The objective of this study was to investigate the effect of hot break versus cold break on the cell-wall pectin of tomato. Cell-wall pectin from hot and cold break tomato products was isolated and analyzed for carbohydrate composition, degree of polymerization, and degree of esterification. The results showed no observable differences in the cell-wall pectin isolated from the two products, indicating that there was no significant pectolytic breakdown of the tomato in the cold break product, and the pectin might not, by itself, contribute to the differences in the final product viscosity resulting from the two processing techniques.展开更多
AIM: To compare previously reported randomized controlled studies (RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and advers...AIM: To compare previously reported randomized controlled studies (RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords “cold polypectomy”. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients’ demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size (less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy.展开更多
This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing sma...This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy" needs more rigorous evidence.展开更多
Tension-tension fatigue properties of hot rolled and cold rolled strips with same contents and sizes were measured by using group test method at room temperature in air. The results showed that the fatigue properties ...Tension-tension fatigue properties of hot rolled and cold rolled strips with same contents and sizes were measured by using group test method at room temperature in air. The results showed that the fatigue properties of the hot rolled strips were obviously higher than those of the cold rolled strips. The hot rolled strips with similar or higher tensile strength exhibited superior fatigue property over the cold rolled strips. Fracture morphologies observed using scanning electronic microscope （SEM） showed that the hot rolled strips exhibited larger fracture areas, indicating a slightly lower plasticity, and more even fracture microstructure and stable properties. It is feasible and reliable to replace cold rolled strips with hot rolled strips.展开更多
The oxidation behaviour of 10%, 30%, and 50% cold rolled and unprocessed 9Cr 1Mo ferritic steels in air have been studied under isothermal conditions at a temperature of 900°C in a cyclic manner. Oxidation kineti...The oxidation behaviour of 10%, 30%, and 50% cold rolled and unprocessed 9Cr 1Mo ferritic steels in air have been studied under isothermal conditions at a temperature of 900°C in a cyclic manner. Oxidation kinetics was established for all samples on which experiment was conducted in air at 900°C under cyclic conditions for 50 cycles by thermogravimetric technique. Each cycle consisted of 1 hour heating at 900°C followed by 20 min of cooling in air. 10% cold rolled sample followed parabolic rate of oxidation while 30% cold rolled sample showed accelerated rate of weight gain. X-ray diffraction (XRD) and scanning electron microscopy/energy dispersive X-ray (SEM/EDAX) techniques were used to characterise the oxidized sample and their scales. 10% cold rolled steel was found to be more corrosion resistance than other in air oxidation for 50 cycles.展开更多
The aim of the present study is to assess the efficacy of the methods used in a HACCP system by measuring the Total Viable Count (TVC) and Coliforms, after cleaning and disinfecting the surfaces used and also by monit...The aim of the present study is to assess the efficacy of the methods used in a HACCP system by measuring the Total Viable Count (TVC) and Coliforms, after cleaning and disinfecting the surfaces used and also by monitoring TVC and enterobacteriaceae of hot and cold meals. In order to evaluate the appropriateness of the surfaces used, samples were obtained from kitchens of 37 Greek hotels/resorts, all of which operated a documented HACCP safety management scheme, while the samples of hot and cold meals were selected from the menu of a catering unit and collected from the actual point of hot and cold dishes banquette at the start time (time 0) and after 4 hours. The developed colonies were counted. The results showed that only 13.5% of the hotels presented surfaces without any TVC or coliforms and 86.5% of the hotels had surfaces with TVC or coliforms or both above the limits. However, 75.8% of the total surfaces examined were acceptable for TVC and 81.9% of the surfaces examined were coliforms. Our microbiological monitoring of food showed that the TVC content of hot meal samples after 4 hours of display (above 60℃) was not significantly different from the TVC content of the aforementioned samples at time 0, while in cold meals TVC and enterobacteriaceae content had significantly risen after 4 hours of display (below 5℃).Conclusively, insufficient application of disinfection and ineffective surface and equipment cleaning programs were found. Additionally, cold meals are more vulnerable than hot meals in developing TVC and enterobacteriaceae.展开更多
A new processing method for producing hot dip galvanized steel is designed and tested, in which pickling is skipped. Hot-rolled low carbon steel sheets are roiled with oxide scale in an experimental mill at room tempe...A new processing method for producing hot dip galvanized steel is designed and tested, in which pickling is skipped. Hot-rolled low carbon steel sheets are roiled with oxide scale in an experimental mill at room temperature, prior to annealing under a 20% hydrogen reducing atmosphere and galvanizing on a hot-dip galvanizing simulator. Micro-cracks formed in the oxide scale during cold rolling roughen the steel surface and enlarge the specific surface. Through-thickness cracks provide transport channels for hydrogen, and hence the reduction of oxide scale is en- hanced. When the sheet is dipped in the zinc bath, cracks are submerged by liquated zinc and the defects are not dis- tinct after hot-dip galvanizing. The overlay coating occludes with rough surface of the sheet, whereby a superior coat- ing adherence is realized.展开更多
Starting from the research on and collection of the damaging factors andindex of the cold and hot damages to citrus, this peper systematically studies the apparent properties in temporal and spatial distribution, diff...Starting from the research on and collection of the damaging factors andindex of the cold and hot damages to citrus, this peper systematically studies the apparent properties in temporal and spatial distribution, differences, relationship of the twokinds of disasters and their impact on citrus production in the Three Gorges area inHubei. It also reveals the important faCt that it is warmer in winter and hotter in springsince the 1980s, which is the cause of departing to two poles of the cold and hot damages, and discusses the alleviating effect to the disasters by the Three Gorges Project.Finally some countermeasures are proposed.展开更多
Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing S...Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing Shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism.展开更多
In this paper, the suitability and construction technology of self-insulation walls were studied under the specific climatic conditions and regional resources of Hanzhong and Ankang in the hot summer and cold winter z...In this paper, the suitability and construction technology of self-insulation walls were studied under the specific climatic conditions and regional resources of Hanzhong and Ankang in the hot summer and cold winter zone of Southern Shaanxi. Through the calculation of heat transfer coefficient and thermal inertia index, combined with the specifications of the shale hollow brick and aerated concrete block of Hanzhong and Ankang in southern Shaanxi, the thermal performance and suitable thickness of the external wall using self-insulation materials that meet the Design Standard for Energy Efficiency of Residential Buildings(DBJ61-65-2011) in Shaanxi Province were obtained. The results showed that the self-insulation wall had technical suitability in the hot summer and cold winter zone. The research results provide not only a theoretical basis for the external wall insulation design of urban residential buildings in the hot summer and cold winter zone of southern Shaanxi, but also a reference for designers to carry out energy-saving design of external walls of residential buildings in other similar climate zones.展开更多
The energy efficiency design of the exterior wall in the buildings of the hot summer and cold winter zone of China should consider the heat prevention in summer and the heat insulation in winter. The self-insulation o...The energy efficiency design of the exterior wall in the buildings of the hot summer and cold winter zone of China should consider the heat prevention in summer and the heat insulation in winter. The self-insulation of the exterior?wall is a more feasible design to satisfy the energy efficiency of buildings in the?zone. However, the systematic research is urgently needed for the self-insulation of the exterior wall in the hot summer and cold winter zone of China. The paper tested the thermal performance of the common non-clay materials such as shale sintered hollow brick, sand autoclaved aerated concrete block, etc. by means of indoor experiments. The energy efficiency effect of the common materials was verified using dynamic calculation soft PKPM and several constitutions of exterior wall with different main bricks and insulation materials on the heat bridge were simulated, too. Besides, the tests of the thermal performance of exterior wall in real constructions were carried out to testify the practical effect of the recommended constitutions of exterior wall with different main bricks and insulation materials on the heat bridge. The conclusions are: the physical and thermal properties of the six non-clay wall material are better than the clay porous brick;the thermal performance of the non-clay brick can be improved obviously through the rational arrangement of the holes;shale sintered hollow brick after increasing the holes and rationalizing the hole arrangement and sand autoclaved aerated concrete block are recommended for buildings in the hot summer and cold winter area of China. The dynamic calculation results show that the thermal performances?of the non-clay materials are all satisfied with the energy efficiency;The heat transfer coefficient of the exterior wall with composition?③,?in which?the main wall was sand autoclaved aerated concrete block and the material on the heat bridge was sand autoclaved aerated concrete plate, is the smallest among the three recommended compositions.展开更多
In China, rural residential environment under the poor construction measures has not been satisfactory due to the backward infrastructure of countryside and the lacking of professional planning, which will result in c...In China, rural residential environment under the poor construction measures has not been satisfactory due to the backward infrastructure of countryside and the lacking of professional planning, which will result in considerable amount of energy consumption in the future. The economy of rural residences in the hot summer and cold winter region of China is relative developed, but the indoor thermal environmental quality is not so good. In this paper, the design strategies directed by passive design ideas for a small experimental rural residential building located in Hangzhou city was introduced and researched in response to hot summer and cold winter climate. Through modeling solution undertaken by Ecotect software, the building performance was simulated and analyzed for the optimization of design factors, such as shape, roof angle, insulation system, shading devices, as well as day-lighting system. Based on the above study, a set of appropriate energy-saving technologies were provided for improving the new rural residences construction in Hangzhou, which should also be recommended to other projects constructed in the same climate region.展开更多
Hot crack is one of common defects in castings, which often results in failure of castings. This work studies the formation of hot crack during cold crucible continuous casting by means of experiments and theoretical ...Hot crack is one of common defects in castings, which often results in failure of castings. This work studies the formation of hot crack during cold crucible continuous casting by means of experiments and theoretical analysis. The results show that hot crack occurs on the surface and in the circumference of ingots, where the solidified shell and the solidification front meet each other. The tendency of hot cracking decreases with the increase of withdrawal velocities in some extent. The hot crack is caused mainly by the friction force between the shell and the crucible inner wall, and it takes place when the stress resulting from friction exceeds the tensile strength of the shell. The factors of μ_m, η_t, η_s and η_m, affecting hot cracks are analyzed and verified. In order to decrease the tendency of hot cracks, technical parameters should be optimized by decreasing μ_m, η_t, η_s and η_m.展开更多
为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州...为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州组合、雅江-兰州组合枯水遭遇概率以每10 a 1.46%~1.57%的速率显著上升,而大通-花园口组合以每10 a 1.04%的速率显著下降;大金站与雅江站的热点区域主要位于长江中上游与长三角地区,冷点区域位于黄河“几字弯”及长江两湖地区;兰州站与花园口站的热点区域位于黄河中游黄土高原以南,冷点区域集中于长江中下游;未来各站点组合枯水遭遇概率的多模式平均值均超过20%,其中大金-兰州组合与大通-花园口组合呈先减小后增大的趋势,雅江-兰州组合呈线性增大趋势,黄家港-花园口组合呈先减小后缓升趋势。展开更多
基金supported by grants from the Science and Technology Plan Project of Guangdong Province(Grant No.2014A070713031,2015A020209134)Science and Technology Plan Project of Guangzhou(Grant No.201604020171)
文摘Objective: To determine the hot/cold of South American A?aí(Euterpe oleracea Mart.). Materials and Methods: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay was performed to compare the influence of A?aí and phellodendron bark(Cortex Phellodendri Chinensis) on the growth and proliferation of HepG2 and Hep3 B cell strains. The morphological changes of the two cell strains treated with A?aí and C. Phellodendri were observed using an inverted phase contrast microscope. Trypan blue dye exclusion assay was used to compare and analyze the toxicity effects of A?aí. The content of nicotinamide adenine dinucleotide(NADH) and the ratio of NADH/NAD+ of the treated cells were detected using a spectrophotometer to determine the influence of A?aí to the energy metabolism of the two cell strains. Results: Within the range of measured concentrations, both A?aí and C. Phellodendri displayed separately the stronger inhibitory effects on cell growth, proliferation, and energy metabolism of the two cell strains. By MTT assay, A?aí showed significant(P < 0.05) or highly significant(P < 0.01) inhibitory effects on cell proliferation within the concentration range of 0.25–40 μg/mL, which was similar to the effects of C. Phellodendri. From the results of microscopic examination, the morphological of lower cell density, attenuated granularity, and more outstretched cells in irregular polygonal shape could be observed in the cells treated with A?aí, which was also similar to that of C. Phellodendri. In trypan blue staining assay, all concentrations of A?aí showed negligible toxicity effects, exactly as that of C. Phellodendri. A?aí showed a highly significant effect of decreasing the content of intracellular NADH as well as the ratio of NADH/NAD+(P < 0.05 and P < 0.01, respectively). Conclusion: The effect of A?aí on HepG2 and Hep3 B strains just as C. Phellodendri can reduce energy metabolism and inhibit the growth and proliferation. All performance characteristics of two cell strains treated with A?aí belong to that characteristic of cold property drug. From the study results, we can deduce that the drug property of A?aí is cold.
基金supported by Gansu Provincial Natural Science Foundation(No.1208RJYA014)Chinese Postdoctoral Science Foundation(No.2009-0460744)+1 种基金Fundamental Research Funds for the Central Universities(No.lzujbky-2014-151)the Natural Science Foundation of China(No.21302079)
文摘Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature" herbs, we investigated the antioxidant activities of 40 Tibetan herbs from Qinghai plateau, with 20 herbs in cold-nature and 20 herbs in hot-nature. Antioxidant capacities were evaluated by the following methods: scavenging ABTS?+(2, 2′azinobis-(3-ethylbenz-thiazoline-6-sulfonic acid), scavenging O2?-, and Ferric-reducing antioxidant power(FRAP). The effects on inhibition of mitochondrion lipid peroxidation were determined by measuring the formation of TBARS(Thiobarbituric acid reactive substrates). Total phenolics and flavonoids were estimated by Folin-Ciocalteu and Na NO2-Al(NO3)3-Na OH colorimetric methods. Interestingly, the cold-nature herbs displayed higher antioxidant activities than the hot-nature ones, corresponding to nearly three-fold higher total phenolic contents in the cold-nature herbs. Moreover, the antioxidant activities correlated linearly with the levels of total phenolics for both cold-nature and hot-nature herbs, but only with the levels of total flavonoids for the hot-nature herbs. The results suggested that the phenolic compounds, but not the flavonoids, play the major role in antioxidant capacities of the cold-nature herbs. These findings could shed new lights on the study the theory of Tibetan medicine.
基金supported by the Science and Technology Innovation Team of Shanxi Province(No.2013131015)Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi(OIT)
文摘It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.
基金supported by the National Natural Science Foundation of China(Nos.11602299,11502295,11572349,11872374 and 51809271).
文摘In order to improve the control ability of synthetic jets in compressible boundary layer,a novel control method based on dual synthetic cold/hot jets coupled control of velocity profile and temperature profile was proposed.As fundamental investigations on the effects of synthetic jet temperature on the jet behavior and flow field characteristics were essentially necessary,preliminary numerical simulations were conducted to study the influence of temperature(200 K and 400 K)on the flow field characteristics of synthetic jets using Large Eddy Simulations(LES)model.Time-averaged flow fields showed that different temperatures led to variable behavior of two strands of jets.For dual synthetic cold jets,a potential-core arose apparently with its height ranging from 0.01 to 0.03 m,while for dual synthetic hot jets,two strands of jets emerged downstream.The modal decomposition of instantaneous flow fields had been done using both Proper Orthogonal Decomposition(POD)and Dynamic Mode Decomposition(DMD).Various modes showed different characteristics of the flow fields.As the POD method focuses on the energy of flow while the DMD method focuses on the frequency,the first two modes had many similarities,but the third and fourth modes demonstrated completely different vortex structures.The current researches play a role of preliminary investigations for further and comprehensive exploration of novel flow control measures in global velocity field.
文摘Tomato processing includes a break step, which involves rapid heating of freshly chopped tomatoes to >90°C for hot break, or 60°C to 77°C for cold break. Pectolytic enzyme deactivation is believed to be the key element in the hot break step;therefore, pectin content of different products should be qualitatively distinct. The objective of this study was to investigate the effect of hot break versus cold break on the cell-wall pectin of tomato. Cell-wall pectin from hot and cold break tomato products was isolated and analyzed for carbohydrate composition, degree of polymerization, and degree of esterification. The results showed no observable differences in the cell-wall pectin isolated from the two products, indicating that there was no significant pectolytic breakdown of the tomato in the cold break product, and the pectin might not, by itself, contribute to the differences in the final product viscosity resulting from the two processing techniques.
文摘AIM: To compare previously reported randomized controlled studies (RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords “cold polypectomy”. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients’ demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size (less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy.
文摘This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy" needs more rigorous evidence.
基金Item Sponsored by National Natural Science Foundation of China(51074210)
文摘Tension-tension fatigue properties of hot rolled and cold rolled strips with same contents and sizes were measured by using group test method at room temperature in air. The results showed that the fatigue properties of the hot rolled strips were obviously higher than those of the cold rolled strips. The hot rolled strips with similar or higher tensile strength exhibited superior fatigue property over the cold rolled strips. Fracture morphologies observed using scanning electronic microscope （SEM） showed that the hot rolled strips exhibited larger fracture areas, indicating a slightly lower plasticity, and more even fracture microstructure and stable properties. It is feasible and reliable to replace cold rolled strips with hot rolled strips.
文摘The oxidation behaviour of 10%, 30%, and 50% cold rolled and unprocessed 9Cr 1Mo ferritic steels in air have been studied under isothermal conditions at a temperature of 900°C in a cyclic manner. Oxidation kinetics was established for all samples on which experiment was conducted in air at 900°C under cyclic conditions for 50 cycles by thermogravimetric technique. Each cycle consisted of 1 hour heating at 900°C followed by 20 min of cooling in air. 10% cold rolled sample followed parabolic rate of oxidation while 30% cold rolled sample showed accelerated rate of weight gain. X-ray diffraction (XRD) and scanning electron microscopy/energy dispersive X-ray (SEM/EDAX) techniques were used to characterise the oxidized sample and their scales. 10% cold rolled steel was found to be more corrosion resistance than other in air oxidation for 50 cycles.
文摘The aim of the present study is to assess the efficacy of the methods used in a HACCP system by measuring the Total Viable Count (TVC) and Coliforms, after cleaning and disinfecting the surfaces used and also by monitoring TVC and enterobacteriaceae of hot and cold meals. In order to evaluate the appropriateness of the surfaces used, samples were obtained from kitchens of 37 Greek hotels/resorts, all of which operated a documented HACCP safety management scheme, while the samples of hot and cold meals were selected from the menu of a catering unit and collected from the actual point of hot and cold dishes banquette at the start time (time 0) and after 4 hours. The developed colonies were counted. The results showed that only 13.5% of the hotels presented surfaces without any TVC or coliforms and 86.5% of the hotels had surfaces with TVC or coliforms or both above the limits. However, 75.8% of the total surfaces examined were acceptable for TVC and 81.9% of the surfaces examined were coliforms. Our microbiological monitoring of food showed that the TVC content of hot meal samples after 4 hours of display (above 60℃) was not significantly different from the TVC content of the aforementioned samples at time 0, while in cold meals TVC and enterobacteriaceae content had significantly risen after 4 hours of display (below 5℃).Conclusively, insufficient application of disinfection and ineffective surface and equipment cleaning programs were found. Additionally, cold meals are more vulnerable than hot meals in developing TVC and enterobacteriaceae.
基金Item Sponsored by National Science and Technology Pillar Program of China(2011BAE13B04)
文摘A new processing method for producing hot dip galvanized steel is designed and tested, in which pickling is skipped. Hot-rolled low carbon steel sheets are roiled with oxide scale in an experimental mill at room temperature, prior to annealing under a 20% hydrogen reducing atmosphere and galvanizing on a hot-dip galvanizing simulator. Micro-cracks formed in the oxide scale during cold rolling roughen the steel surface and enlarge the specific surface. Through-thickness cracks provide transport channels for hydrogen, and hence the reduction of oxide scale is en- hanced. When the sheet is dipped in the zinc bath, cracks are submerged by liquated zinc and the defects are not dis- tinct after hot-dip galvanizing. The overlay coating occludes with rough surface of the sheet, whereby a superior coat- ing adherence is realized.
文摘Starting from the research on and collection of the damaging factors andindex of the cold and hot damages to citrus, this peper systematically studies the apparent properties in temporal and spatial distribution, differences, relationship of the twokinds of disasters and their impact on citrus production in the Three Gorges area inHubei. It also reveals the important faCt that it is warmer in winter and hotter in springsince the 1980s, which is the cause of departing to two poles of the cold and hot damages, and discusses the alleviating effect to the disasters by the Three Gorges Project.Finally some countermeasures are proposed.
基金National Basic Research Program of China ("973" Program) (2007CB5126072006CB504703)National Science Fund for Distinguished Young Scholars (30625042)
文摘Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing Shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism.
文摘In this paper, the suitability and construction technology of self-insulation walls were studied under the specific climatic conditions and regional resources of Hanzhong and Ankang in the hot summer and cold winter zone of Southern Shaanxi. Through the calculation of heat transfer coefficient and thermal inertia index, combined with the specifications of the shale hollow brick and aerated concrete block of Hanzhong and Ankang in southern Shaanxi, the thermal performance and suitable thickness of the external wall using self-insulation materials that meet the Design Standard for Energy Efficiency of Residential Buildings(DBJ61-65-2011) in Shaanxi Province were obtained. The results showed that the self-insulation wall had technical suitability in the hot summer and cold winter zone. The research results provide not only a theoretical basis for the external wall insulation design of urban residential buildings in the hot summer and cold winter zone of southern Shaanxi, but also a reference for designers to carry out energy-saving design of external walls of residential buildings in other similar climate zones.
文摘The energy efficiency design of the exterior wall in the buildings of the hot summer and cold winter zone of China should consider the heat prevention in summer and the heat insulation in winter. The self-insulation of the exterior?wall is a more feasible design to satisfy the energy efficiency of buildings in the?zone. However, the systematic research is urgently needed for the self-insulation of the exterior wall in the hot summer and cold winter zone of China. The paper tested the thermal performance of the common non-clay materials such as shale sintered hollow brick, sand autoclaved aerated concrete block, etc. by means of indoor experiments. The energy efficiency effect of the common materials was verified using dynamic calculation soft PKPM and several constitutions of exterior wall with different main bricks and insulation materials on the heat bridge were simulated, too. Besides, the tests of the thermal performance of exterior wall in real constructions were carried out to testify the practical effect of the recommended constitutions of exterior wall with different main bricks and insulation materials on the heat bridge. The conclusions are: the physical and thermal properties of the six non-clay wall material are better than the clay porous brick;the thermal performance of the non-clay brick can be improved obviously through the rational arrangement of the holes;shale sintered hollow brick after increasing the holes and rationalizing the hole arrangement and sand autoclaved aerated concrete block are recommended for buildings in the hot summer and cold winter area of China. The dynamic calculation results show that the thermal performances?of the non-clay materials are all satisfied with the energy efficiency;The heat transfer coefficient of the exterior wall with composition?③,?in which?the main wall was sand autoclaved aerated concrete block and the material on the heat bridge was sand autoclaved aerated concrete plate, is the smallest among the three recommended compositions.
文摘In China, rural residential environment under the poor construction measures has not been satisfactory due to the backward infrastructure of countryside and the lacking of professional planning, which will result in considerable amount of energy consumption in the future. The economy of rural residences in the hot summer and cold winter region of China is relative developed, but the indoor thermal environmental quality is not so good. In this paper, the design strategies directed by passive design ideas for a small experimental rural residential building located in Hangzhou city was introduced and researched in response to hot summer and cold winter climate. Through modeling solution undertaken by Ecotect software, the building performance was simulated and analyzed for the optimization of design factors, such as shape, roof angle, insulation system, shading devices, as well as day-lighting system. Based on the above study, a set of appropriate energy-saving technologies were provided for improving the new rural residences construction in Hangzhou, which should also be recommended to other projects constructed in the same climate region.
文摘Hot crack is one of common defects in castings, which often results in failure of castings. This work studies the formation of hot crack during cold crucible continuous casting by means of experiments and theoretical analysis. The results show that hot crack occurs on the surface and in the circumference of ingots, where the solidified shell and the solidification front meet each other. The tendency of hot cracking decreases with the increase of withdrawal velocities in some extent. The hot crack is caused mainly by the friction force between the shell and the crucible inner wall, and it takes place when the stress resulting from friction exceeds the tensile strength of the shell. The factors of μ_m, η_t, η_s and η_m, affecting hot cracks are analyzed and verified. In order to decrease the tendency of hot cracks, technical parameters should be optimized by decreasing μ_m, η_t, η_s and η_m.
文摘为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州组合、雅江-兰州组合枯水遭遇概率以每10 a 1.46%~1.57%的速率显著上升,而大通-花园口组合以每10 a 1.04%的速率显著下降;大金站与雅江站的热点区域主要位于长江中上游与长三角地区,冷点区域位于黄河“几字弯”及长江两湖地区;兰州站与花园口站的热点区域位于黄河中游黄土高原以南,冷点区域集中于长江中下游;未来各站点组合枯水遭遇概率的多模式平均值均超过20%,其中大金-兰州组合与大通-花园口组合呈先减小后增大的趋势,雅江-兰州组合呈线性增大趋势,黄家港-花园口组合呈先减小后缓升趋势。
