To the Editor Heart failure(HF)is a multifactorial-induced chronic cardiovascular disease characterized by high mortality rates and poor patient prognosis.While current therapeutic interventions may relieve symptoms a...To the Editor Heart failure(HF)is a multifactorial-induced chronic cardiovascular disease characterized by high mortality rates and poor patient prognosis.While current therapeutic interventions may relieve symptoms and enhance survival rates,the 5-year survival rate for patients remains below 50%1.This limitation may stem from the fact that the underlying pathophysiological mechanisms of HF have not yet been fully elucidated.Currently,clinical drug therapy primarily involves polypharmacy(quadruple therapy).展开更多
基金supported by the National Natural Science Foundation of China(22307038)National key R&D Program of China(2021YFA0804904)+7 种基金National Natural Science Foundation of China(32121005)National Natural Science Foundation of China(22107030)National Natural Science Foundation of China(22437002)National Natural Science Foundation of China(22037002)Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-02-E00104,China)Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03e28,China)Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20212702,China)Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204).
文摘To the Editor Heart failure(HF)is a multifactorial-induced chronic cardiovascular disease characterized by high mortality rates and poor patient prognosis.While current therapeutic interventions may relieve symptoms and enhance survival rates,the 5-year survival rate for patients remains below 50%1.This limitation may stem from the fact that the underlying pathophysiological mechanisms of HF have not yet been fully elucidated.Currently,clinical drug therapy primarily involves polypharmacy(quadruple therapy).
