Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method. The results showed that some of the compound had higher antitumor activity than irite...Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method. The results showed that some of the compound had higher antitumor activity than iritecan.展开更多
Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor...Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor activity than topotecan.展开更多
以2,8-二氧-3-乙基-6,6-亚乙二氧基-2,3,5,6,7,8-六氢-3-羟基吡喃(5,4-c)中氮茚为起始原料,经五步反应得到高喜树碱,羟甲基化后与一系列酸成酯合成了6个10-酯基高喜树碱,并利用1HNMR,MS及元素分析对其结构进行了表征.采用经典的噻唑兰(T...以2,8-二氧-3-乙基-6,6-亚乙二氧基-2,3,5,6,7,8-六氢-3-羟基吡喃(5,4-c)中氮茚为起始原料,经五步反应得到高喜树碱,羟甲基化后与一系列酸成酯合成了6个10-酯基高喜树碱,并利用1HNMR,MS及元素分析对其结构进行了表征.采用经典的噻唑兰(Thiazoly blue tetrazolium bromide,MTT)法测定了其体外抗肿瘤活性,活性测试结果表明3个化合物具有比阳性对照药拓扑替康增强的活性.展开更多
基金the National Natural Science Foundation of China (No.30371689)Shanghai Major Program Science and Technology Foundation (No.064319009)Shanghai Leading Academic Discipline Project (No.B906).
文摘Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method. The results showed that some of the compound had higher antitumor activity than iritecan.
基金This research was supported by the National Natural Science Foundation of China （No.30371689）.
文摘Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor activity than topotecan.
文摘以2,8-二氧-3-乙基-6,6-亚乙二氧基-2,3,5,6,7,8-六氢-3-羟基吡喃(5,4-c)中氮茚为起始原料,经五步反应得到高喜树碱,羟甲基化后与一系列酸成酯合成了6个10-酯基高喜树碱,并利用1HNMR,MS及元素分析对其结构进行了表征.采用经典的噻唑兰(Thiazoly blue tetrazolium bromide,MTT)法测定了其体外抗肿瘤活性,活性测试结果表明3个化合物具有比阳性对照药拓扑替康增强的活性.
