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A homeopathic nosode, Hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase Ⅱ activities as also by promoting apoptosis via intrinsic mitochondrial pathway 被引量:6
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作者 Jesmin Mondal Jayeeta Das +1 位作者 Rajesh Shah Anisur Rahman Khuda-Bukhsh 《Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第3期209-218,共10页
OBJECTIVE: Homeopathic nosodes have seldom been scientifically validated for their anticancer effects. This study was conducted to examine if a recently developed hepatitis C nosode has demonstrable anticancer potent... OBJECTIVE: Homeopathic nosodes have seldom been scientifically validated for their anticancer effects. This study was conducted to examine if a recently developed hepatitis C nosode has demonstrable anticancer potential in cancer cells in vitro.METHODS: Anticancer effects of Hepatitis C 30C(Hep C 30), if any, were initially tested on three cancer cell lines, HepG2(liver cancer), MCF-7(breast cancer) and A549(lung cancer) and one normal liver cell line WRL-68 cells and subsequently a more thorough study using further scientific protocols was undertaken on HepG2 cells(against WRL-68 cells as the normal control) as HepG2 cells showed better anticancer response than the other two. Three doses, one at 50% lethal dose(LD50) and the other two below LD50, were used on HepG2 cells subsequently. Protocols like apoptosis induction and its possible signaling mechanism were deployed using immunoblots of relevant signal proteins and confocal microscopy, with particular reference to telomerase and topoisomerase Ⅱ(Top Ⅱ) activities, two strong cancer biomarkers for their direct relationship with divisional activities of cells and DNAs. RESULTS: Hep C 30 induced apoptosis, caused distorted cell morphology typical of apoptotic cells, increased reactive oxygen species generation and produced increased DNA nicks. Further it enhanced pro-apototic signal proteins like Bax, cytochrome c and inhibited anti-apoptotic signal proteins, Bcl-2, cytochrome c and caspase-3, changed mitochondrial membrane potential and caused externalization of phosphatidylserine. The drug also decreased expression of two cancer biomarkers, Top Ⅱ and telomerase, consistent with its anticancer effect. CONCLUSION: Hep C 30 has demonstrable anticancer effects against liver cancer cells in vitro. 展开更多
关键词 formularies homeopathic antineoplastic agents TELOMERASE DNA topoisomerases type membrane potential mitochondrial
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Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017
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作者 Jose Antonio Castilla-Jimena Isabel Ruiz-Perez Jesus Henares-Montiel 《Journal of Integrative Medicine》 SCIE CAS CSCD 2022年第1期52-56,共5页
Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to u... Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic recession.Methods: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were performed.Results: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors associated.Conclusion: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine. 展开更多
关键词 Complementary and alternative medicine homeopathic remedies Natural remedies Economic recession Gender differences
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Evaluation of homeopathic treatments in early lactation in buffalo cows and neonatal mortality in buffalo calf
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作者 Fiorella Sarubbi Rodolfo Baculo +1 位作者 Raffaele Palomba Giuseppe Auriemma 《Open Journal of Animal Sciences》 2012年第3期196-203,共8页
The trial was conducted on thirty buffalo cows subdivided in three groups. In the immediate pre-calving, 2.5 ml of Echinacea purpurea were orally administered to the first group (A) and, after calving, Nux vomica, Che... The trial was conducted on thirty buffalo cows subdivided in three groups. In the immediate pre-calving, 2.5 ml of Echinacea purpurea were orally administered to the first group (A) and, after calving, Nux vomica, Chelidonium and Lycopodium were administered at 7 days intervals. The second group (B) was only subjected to the post-calving treatment, while the third group (C) represented the control group. Immediately after calving two groups of calves were formed. The first group received 5 granules of Pyrogenium in the first days of life and then for 10 days the 0.5 ml of E. purpurea. The second group did not receive any remedy. Before the calving, in conventional farm twenty buffalo cows (D group) were vaccinated. Remedies administration did not affect milk protein content, milk lipid contents and the achievement of the lactation peak. Blood samples showed that total protein, albumin and globulin levels were lower in group A, compared to groups B and C. Cholesterol and urea were lower in the treated groups than in the control. We therefore conclude that the use of homeopathic remedies are a chance to improve animal welfare and their productive characteristics. 展开更多
关键词 BUFFALO COWS BUFFALO CALF homeopathic REMEDY NEONATAL Mortality Milk Production Metabolic Profiles
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A new explanation to homeopathy:analysis of the pharmacological property of homeopathic remedies
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作者 Dipangkar Deb 《TMR Theory and Hypothesis》 2021年第1期445-454,共10页
Although the biological system is a combination of different chemical processes,many of the mechanisms can not be explained by general chemical processes.Therefore,as a driving force of biological system,a distinct en... Although the biological system is a combination of different chemical processes,many of the mechanisms can not be explained by general chemical processes.Therefore,as a driving force of biological system,a distinct entity called'vital force'can be imagined.But this is not essential to explain homeopathy.From the analysis of different phenomena it apparent that biological system has a tendency to maintain a balanced state.Such a good example is catch-up growth.A stimulus is required to disrupt the balance.This stimulus must enter the body from outside or in case of disease it must arise from within inside.This is the primary stimulus.Infection,chronic poisoning,etc.help the expression of the internal stimulus.These are secondary stimulus.The active dose of similar drug acts on the terminal site of the disease process.This causes the actual reversal of the disease process.Allopathic dissimilar drugs act on different stages of the disease process and alter the course of the disease process.The effect of allopathic drugs does not destroy the effect of disease and compete with the effect of the disease.Potentized homeopathic remedies neutralize the effect of disease but do not alter the course of the disease.As a result,either symptoms of the disease are neutralized or the disease process is accelerated.Different other phenomena support that the property of the potentized remedy is not similar to the original substance.It is a new property which is negative pharmacological property. 展开更多
关键词 HOMEOPATHY Biological system Pharmacological property homeopathic remedies
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Homeopathy--A Regulation Therapy Healing Hypo- or Hyper-functions of Pathological Pathways by Magnetic Photons according to the Resonance Principle
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作者 Lenger Karin 《Journal of Life Sciences》 2017年第2期53-64,共12页
Since Lenger's detection of magnetic photons in homeopathic remedies by magnetic resonance the mystery of homeopathy comes to a solution. Homeopathy is a regulation therapy curing hypo- and hyper-functions of patholo... Since Lenger's detection of magnetic photons in homeopathic remedies by magnetic resonance the mystery of homeopathy comes to a solution. Homeopathy is a regulation therapy curing hypo- and hyper-functions of pathological pathways. It reacts according to the principle of resonance. The fundamental principles of homeopathy as proving, symptom picture, curing according to the Law of Similars and the production of homeopathic remedies over the Avogadro number by repeated dilution and succussion are explained to have the same frequencies so that the resonance principle can work. Pathological pathways are cured by using their highly potentized substrates, inhibitors and enzymes, given daily or each second day. This is in contradiction to the normal applied homeopathy. The efficacy of homeopathy now has a scientific base and is completely explained by applying biochemical and biophysical laws. 展开更多
关键词 Magnetic photons resonance principle magnetic frequencies homeopathic remedies homeopathic healing.
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Surrounding Plants as Reliable Immune Boosters
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作者 Sevinj Maharramova Mahbuba Veliyeva +5 位作者 Mahira Amirova Ulviyya Azizova Ulker Majidova Huseyn Abıyev Gulnara Dashdamirova Farah Mammadova 《Health》 CAS 2022年第11期1105-1113,共9页
Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of... Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of the medical preparations development, for changing chemicals to naturally produced ones based on herbal natural remedies. Since homeopathy is a branch of medicine that includes not only herbal preparations, but also chemical ingredients, our newly developed patent—although it belongs to the field of homeopathy—is its offshoot aimed solely at maintaining the body’s strength without harming it, increasing the survival of the body in a polluted environment removing toxins from the body by strengthening adaptive immune mechanisms. Thus, thyme, cumin, oregano, licorice, and other natural resources of the earth, which are the basis of our patent, successfully fight cold and diseases of the upper respiratory tract. The article presents a methodology for the development of a new herbal preparation, its dosage, and use as the main ingredient in a treatment course in infectious diseases. 展开更多
关键词 Herbal Composition homeopathic Medicine Immune Booster PATENT
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A new explanation to homeopathy: observation of some phenomena and the nature of disease
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作者 Dipangkar Deb 《TMR Theory and Hypothesis》 2020年第4期386-392,共7页
Homeopathic potentized remedies work in different ways.In some cases,a single dose cures the disease.In some cases,new symptoms appear.In some skin diseases,it does not stop the arising of eruptions but heals rapidly.... Homeopathic potentized remedies work in different ways.In some cases,a single dose cures the disease.In some cases,new symptoms appear.In some skin diseases,it does not stop the arising of eruptions but heals rapidly.The eruptions come out for a limited period of time.In another skin disease,one homeopathic remedy heals the lesion while another somewhat aggravates the symptoms.On the other hand,it is thought that the cause of infectious diseases is different types of pathogens.But it has been observed that even after the proper invasion of microorganisms symptoms are not produced.Researchers call it asymptomatic infection.Many infectious diseases are cured spontaneously after a certain period of time.Except for this many other chronic diseases are cured spontaneously.From the analysis of observed phenomena,it can be decided that symptomatic disease is caused by an internal stimulus.It has a limited lifespan.It is expressed for a limited period of time.Potentized homeopathic remedies neutralize the effect of the stimulus.As a result,symptoms are neutralized or disease process is accelerated. 展开更多
关键词 homeopathic LIMITED LIFESPAN Neutralize
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