To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiova...To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiovascular events.As an indicator of pro-inflammatory nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)–interleukin(IL)-1β–IL-6 pathway activation,high-sensitivity C-reactive protein(hsCRP)has demonstrated significant value as a predictor of major adverse cardiovascular and cerebrovascular events(MACCEs).Due to the ethnic differences,East Asian populations exhibited lower hsCRP levels.It was confirmed by our previous single-center study,in which the median of hsCRP was 1 mg/L at 1-month follow-up,and the 1-month hsCRP>1 mg/L showed a better prediction of the risk of MACCE.展开更多
It was reported that the urotensin Ⅱ(U-Ⅱ) level in inflammatory bowel disease(IBD) patients are significantly higher than in controls. To provide future guidance for the management of cardiovascular risk factors in ...It was reported that the urotensin Ⅱ(U-Ⅱ) level in inflammatory bowel disease(IBD) patients are significantly higher than in controls. To provide future guidance for the management of cardiovascular risk factors in IBD patients, the sample size of the current study appears to be limited, and more clinical samples to compare U-Ⅱ levels in IBD patients and controls are needed. This will clarify the possible roles of inflammation factors and related signaling pathways(like EPK1/2, NF-κB and Rho/ROCK) in the pathophysiology of IBD. Therefore, large multicenter studies should be done to confirm the findings and underlying mechanisms in the future.展开更多
Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of h...Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of high-sensitivity C reactive protein(hsCRP).Methods This cross-sectional study included 2390 individuals who underwent health examinations at our centre from June 2019 to August 2023.Participants received physical examinations,laboratory tests and magnetic resonance angiography evaluations.MetS was defined by the modified acknowledged criteria and quantified by Metsss.Logistic regression,interaction analysis and mediation analysis were employed.Results Among the 2390 participants,135(5.65%)had aICAS,and 726(30.40%)had MetS.After adjusting for confounders,MetS was significantly associated with aICAS(OR:1.68,95%CI:1.16 to 2.43,p=0.006).The prevalence of aICAS increased significantly from 3.6%to 8.6%as the number of MetS components increased.Higher quartiles of Metsss also significantly increased aICAS risk(P for trend<0.001).After multivariable adjustment,MetS(p=0.001)and elevated Metsss(p<0.001)were only associated with posterior circulation aICAS(vs anterior).Furthermore,participants with both MetS and elevated hsCRP levels had a greater risk for aICAS(OR:2.32,95%CI:1.36 to 3.96,p=0.002).hsCRP mediated the association between MetS and alCAS in participants≤65 years old.Conclusions MetS and Metsss were independently associated with the risk of aICAS.The mediating effect of hsCRP on the relationship between MetS and aICAS appears to be age-dependent.These findings offer valuable insights into clinical decision making of aICAS and further improve the primary stroke prevention.展开更多
基金supported by grants from the Noncommunicable Chronic Diseases—National Science and Technology Major Project(No.2025ZD0548400)the National Key Research and Development Program(No.2022YFC2503501)+3 种基金Chinese Society of Cardiology’s Foundation(No.CSCF2023A04)Hubei Technology Innovation Project(No.2024BCB046)Key Research and Development Program of Wuhan(No.2024020702030092)to Xiang ChengThe National Heart,Lung,and Blood Institute(Nos.1R01HL134892 and 1R01HL163099-01),the RRM Charitable Fund,and the Simard Fund to Peter Libby.
文摘To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiovascular events.As an indicator of pro-inflammatory nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)–interleukin(IL)-1β–IL-6 pathway activation,high-sensitivity C-reactive protein(hsCRP)has demonstrated significant value as a predictor of major adverse cardiovascular and cerebrovascular events(MACCEs).Due to the ethnic differences,East Asian populations exhibited lower hsCRP levels.It was confirmed by our previous single-center study,in which the median of hsCRP was 1 mg/L at 1-month follow-up,and the 1-month hsCRP>1 mg/L showed a better prediction of the risk of MACCE.
文摘It was reported that the urotensin Ⅱ(U-Ⅱ) level in inflammatory bowel disease(IBD) patients are significantly higher than in controls. To provide future guidance for the management of cardiovascular risk factors in IBD patients, the sample size of the current study appears to be limited, and more clinical samples to compare U-Ⅱ levels in IBD patients and controls are needed. This will clarify the possible roles of inflammation factors and related signaling pathways(like EPK1/2, NF-κB and Rho/ROCK) in the pathophysiology of IBD. Therefore, large multicenter studies should be done to confirm the findings and underlying mechanisms in the future.
基金supported by National Key Research and Development Program of China(2018YFC1311203).
文摘Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of high-sensitivity C reactive protein(hsCRP).Methods This cross-sectional study included 2390 individuals who underwent health examinations at our centre from June 2019 to August 2023.Participants received physical examinations,laboratory tests and magnetic resonance angiography evaluations.MetS was defined by the modified acknowledged criteria and quantified by Metsss.Logistic regression,interaction analysis and mediation analysis were employed.Results Among the 2390 participants,135(5.65%)had aICAS,and 726(30.40%)had MetS.After adjusting for confounders,MetS was significantly associated with aICAS(OR:1.68,95%CI:1.16 to 2.43,p=0.006).The prevalence of aICAS increased significantly from 3.6%to 8.6%as the number of MetS components increased.Higher quartiles of Metsss also significantly increased aICAS risk(P for trend<0.001).After multivariable adjustment,MetS(p=0.001)and elevated Metsss(p<0.001)were only associated with posterior circulation aICAS(vs anterior).Furthermore,participants with both MetS and elevated hsCRP levels had a greater risk for aICAS(OR:2.32,95%CI:1.36 to 3.96,p=0.002).hsCRP mediated the association between MetS and alCAS in participants≤65 years old.Conclusions MetS and Metsss were independently associated with the risk of aICAS.The mediating effect of hsCRP on the relationship between MetS and aICAS appears to be age-dependent.These findings offer valuable insights into clinical decision making of aICAS and further improve the primary stroke prevention.
