High-voltage-activated(HVA) Ca^(2+)channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission,...High-voltage-activated(HVA) Ca^(2+)channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote ‘‘bench-to-bedside'' translation.展开更多
基金supported by the National Natural Science Foundation of China (81701092)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Support (20171916)Shanghai Municipal Commission of Health and Family Planning Funding for Key Developing Disciplines (2015ZB0101)
文摘High-voltage-activated(HVA) Ca^(2+)channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote ‘‘bench-to-bedside'' translation.
