High-grade pancreatic intraepithelial neoplasia is a challenging diagnosis and itdoes not exhibit mass lesions. It is suspected based on changes in the mainpancreatic duct in magnetic resonance cholangiopancreatograph...High-grade pancreatic intraepithelial neoplasia is a challenging diagnosis and itdoes not exhibit mass lesions. It is suspected based on changes in the mainpancreatic duct in magnetic resonance cholangiopancreatography. Sometimesonly an unclear duct shows in magnetic resonance cholangiopancreatographywith no focal strictures and upstream dilatation of the main pancreatic duct. Serialpancreatic juice cytology is valuable in diagnosis of those patients.展开更多
Although with aggressive standards of care like surgical resection,chemotherapy,and radiation,high-grade gliomas(HGGs)and brain metastases(BM)treatment has remained challenging for more than two decades.However,techno...Although with aggressive standards of care like surgical resection,chemotherapy,and radiation,high-grade gliomas(HGGs)and brain metastases(BM)treatment has remained challenging for more than two decades.However,technological advances in this field and immunotherapeutic strategies have revolutionized the treatment of HGGs and BM.Immunotherapies like immune checkpoint inhibitors,CAR-T targeting,oncolytic virus-based therapy,bispecific antibody treatment,and vaccination approaches,etc.,are emerging as promising avenues offering new hope in refining patient’s survival benefits.However,selective trafficking across the blood-brain barrier(BBB),immunosuppressive tumor microenvironment(TME),metabolic alteration,and tumor heterogeneity limit the therapeutic efficacy of immunotherapy for HGGs and BM.Furthermore,to address this concern,the NanoBioTechnology-based bioinspired delivery system has been gaining tremendous attention in recent years.With technological advances such as Trojan horse targeting and infusing/camouflaging nanoparticles surface with biological molecules/cells like immunocytes,erythrocytes,platelets,glioma cell lysate and/or integrating these strategies to get hybrid membrane for homotypic recognition.These biomimetic nanotherapy offers advantages over conventional nanoparticles,focusing on greater target specificity,increased circulation stability,higher active loading capacity,BBB permeability(inherent inflammatory chemotaxis of neutrophils),decreased immunogenicity,efficient metabolism-based combinatorial effects,and prevention of tumor recurrence by induction of immunological memory,etc.provide new age of improved immunotherapies outcomes against HGGs and BM.In this review,we emphasize on neuro-immunotherapy and the versatility of these biomimetic nano-delivery strategies for precise targeting of hard-to-treat andmost lethal HGGs and BM.Moreover,the challenges impeding the clinical translatability of these approaches were addressed to unmet medical needs of brain cancers.展开更多
BACKGROUND Claudin-6(CLDN6),a tight junction protein typically restricted to embryonic tissues,is re-expressed in various cancers.However,its prognostic significance in high-grade endometrial carcinoma(HGEC)remains un...BACKGROUND Claudin-6(CLDN6),a tight junction protein typically restricted to embryonic tissues,is re-expressed in various cancers.However,its prognostic significance in high-grade endometrial carcinoma(HGEC)remains unclear.AIM To investigate the expression pattern of CLDN6 in HGEC and assess its correlation with clinicopathological parameters and patient survival.METHODS Immunohistochemical analysis of CLDN6 expression was performed on formalinfixed,paraffin-embedded tissues from 80 patients diagnosed with HGEC.Associations between CLDN6 expression and histological subtype,the International Federation of Gynecology and Obstetrics(FIGO)stage,depth of myometrial invasion,lymphovascular space invasion,recurrence,and survival outcomes were statistically analysed.Univariate and multivariate Cox regression models were used to identify independent prognostic factors.RESULTS High CLDN6 expression was detected in a subset of HGEC patients and was significantly associated with nonendometrioid histology(P=0.026),advanced FIGO stage(P=0.015),deep myometrial invasion(P=0.038),and recurrence(P=0.002).While Kaplan-Meier analysis did not reveal a statistically significant difference in disease-free survival or overall survival between the high CLDN6 expression group and the low CLDN6 expression group,multivariate Cox regression revealed that CLDN6 overexpression was an independent predictor of shorter disease-free survival[hazard ratio(HR)=68.98,P=0.022]and overall survival(HR=24.023,P=0.038).CONCLUSION CLDN6 overexpression is associated with aggressive tumor features and poor clinical outcomes in HGEC,suggesting its utility as a prognostic biomarker and potential therapeutic target.展开更多
Myofibroblastic sarcoma(MS)is a rare malignant soft tissue tumor characterized by myofibroblasts.It most commonly arises in the head and neck region,especially the tongue,with rare occurrences in the limbs.MS exhibits...Myofibroblastic sarcoma(MS)is a rare malignant soft tissue tumor characterized by myofibroblasts.It most commonly arises in the head and neck region,especially the tongue,with rare occurrences in the limbs.MS exhibits varying histopathology,ranging from low-to high-grade,with diverse subtypes showing different clinical behaviors and prognoses.This article reports the first case of high-grade MS in the hand,adding to the limited documentation of this rare condition.Here,we present the case of a 30-year-old healthy female with a year-long history of progressive shortening,mobility loss,and weakness in the first finger of the left hand.Left-hand imaging revealed a lytic,cottony tumor involving the entire first metacarpal.Following surgical resection,which included metatarsal grafting and joint reconstruction,a diagnosis of high-grade MS was confirmed based on histological manifestations and immunohistochemical staining,which was further classified as grade 2 according to the French Federation of Cancer Centers Sarcoma Group system.Postoperative radiotherapy was administered and the patient experienced a successful recovery without graft osteonecrosis.The patient regained 90%mobility and strength,without shortening,after surgical resection and radiotherapy.Six months post-surgery,the patient reported full hand functionality.MS is a rare tumor that infrequently affects bones and is often misdiagnosed owing to its controversial characteristics.The initial treatment should focus on complete resection with negative margins,followed by reconstructive surgery to preserve function.Further case studies are needed to establish standardized surgical treatment protocols.展开更多
BACKGROUND Recent advancements in artificial intelligence(AI)have significantly enhanced the capabilities of endoscopic-assisted diagnosis for gastrointestinal diseases.AI has shown great promise in clinical practice,...BACKGROUND Recent advancements in artificial intelligence(AI)have significantly enhanced the capabilities of endoscopic-assisted diagnosis for gastrointestinal diseases.AI has shown great promise in clinical practice,particularly for diagnostic support,offering real-time insights into complex conditions such as esophageal squamous cell carcinoma.CASE SUMMARY In this study,we introduce a multimodal AI system that successfully identified and delineated a small and flat carcinoma during esophagogastroduodenoscopy,highlighting its potential for early detection of malignancies.The lesion was confirmed as high-grade squamous intraepithelial neoplasia,with pathology results supporting the AI system’s accuracy.The multimodal AI system offers an integrated solution that provides real-time,accurate diagnostic information directly within the endoscopic device interface,allowing for single-monitor use without disrupting endoscopist’s workflow.CONCLUSION This work underscores the transformative potential of AI to enhance endoscopic diagnosis by enabling earlier,more accurate interventions.展开更多
The superconducting high gradient magnetic separation(S-HGMS)technology can be used to effectively extract silica from iron ore tailings(IOTs).However,particle agglomeration in strong magnetic fields poses a challenge...The superconducting high gradient magnetic separation(S-HGMS)technology can be used to effectively extract silica from iron ore tailings(IOTs).However,particle agglomeration in strong magnetic fields poses a challenge in achieving optimal performance.In this study,we investigated the agglomeration of IOT particles and the mechanisms for its inhibition through surface analysis,density functional theory(DFT),and extended Derjaguin-Landau-Verwey-Overbeek(EDLVO)theory.Hematite was found to exhibit the highest magnetic moment among the minerals present in IOTs,making it particularly prone to magnetic agglomeration.The addition of the dispersant SDSH into the slurry was essential in promoting the dispersion of IOT particles during the S-HGMS process.This dispersant hydrolyzed to form HPO_(4)^(2-)and RSO_(3)^(-)groups in the solution,which then chemically adsorbed onto the metal ions exposed on the surfaces of non-quartz particles,increasing interparticle electrostatic repulsion.Furthermore,the RSO_(3)^(-)groups physically adsorbed onto the surface of quartz particles,resulting in strong steric repulsion and enhancing the hydrophilicity of the particle surfaces,thereby inhibiting magnetic agglomeration between the particles.Under optimal conditions,the SiO_(2)grade of the obtained high-grade silica powder increased from an initial value of 76.32%in IOTs to 97.42%,achieving a SiO_(2)recovery rate of 54.81%,which meets the requirements for quartz sand used in glass preparation.This study provides valuable insights into the magnetic agglomeration of IOT particles and its inhibition while providing a foundation for regulating S-HGMS processes.展开更多
BACKGROUND High-grade serous ovarian carcinoma(HGSOC)is among the most lethal gynecological malignancies,characterized by late-stage diagnosis,extensive peritoneal dissemination,and limited treatment options,resulting...BACKGROUND High-grade serous ovarian carcinoma(HGSOC)is among the most lethal gynecological malignancies,characterized by late-stage diagnosis,extensive peritoneal dissemination,and limited treatment options,resulting in poor survival outcomes.The tumor microenvironment plays a critical role in disease progression and therapy resistance,with CD4+T cells exhibiting significant plasticity and functional heterogeneity.Regulatory T cells(Tregs)are particularly implicated in immune suppression and tumor evasion.However,the spatial distribution,functional states,and prognostic significance of CD4+T cell subtypes in HGSOC remain poorly understood.AIM To characterize the functional heterogeneity and tissue-specific distributions of CD4+T cell subtypes in HGSOC and identify biomarkers for therapy.METHODS We analyzed single-cell RNA sequencing(scRNA-seq)data from 42 HGSOC patients,examining samples collected from adnexal tissues and ascites.CD4+T cells were identified and classified into subtypes using unsupervised clustering and marker gene analysis.Functional profiling was performed using pathway enrichment,differential expression analysis,and functional signature scoring.Kaplan-Meier survival and Cox proportional hazards modeling were conducted to evaluate the prognostic value of CD4+T cell subtypes.RESULTS Distinct distributions of CD4+T cell subtypes were identified between adnexal tissues and ascites.Naive CD4+T cells were predominant in ascites,while Tregs and CXCL13-expressing CD4+T cells were enriched in adnexal tissues.Tregs were further categorized into four subtypes(Treg1,Treg2,Treg3,and TISG),each exhibiting unique molecular signatures and tissue-specific adaptations.Treg3 cells,enriched in adnexal tissues,were characterized by high levels of activation and exhaustion markers,correlating with poor clinical outcomes in HGSOC patients.CONCLUSION Treg3 cells drive immune suppression and tumor progression in HGSOC,making them a key immunotherapy target.Their adnexal enrichment highlights the need for tissue-specific immune profiling in precision treatment.展开更多
Objective:The expression of programmed death 1(PD-1)on CD8^(+)T cells is associated with their activation and exhaustion,while CD57 serves as a senescence marker.The impact of PD-1^(+)and CD57^(+)CD8^(+)T cells on the...Objective:The expression of programmed death 1(PD-1)on CD8^(+)T cells is associated with their activation and exhaustion,while CD57 serves as a senescence marker.The impact of PD-1^(+)and CD57^(+)CD8^(+)T cells on the prognosis of patients with advanced high-grade serous ovarian cancer(HGSOC)remain unclear.Methods:We assessed the percentages of PD-1^(+)and CD57^(+)CD8^(+)T cells in tumor-infiltrating lymphocytes(TILs,n=85)and tumor ascites lymphocytes(TALs,n=87)using flow cytometry.The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method.Gene expression analysis elucidated the tumor immune microenvironment(TIME,n=36).Results:Patients with higher PD-1^(+)CD8^(+)TILs(>87.8%)exhibited longer platinum-free interval(PFI)and overall survival(OS).In contrast,those with elevated CD57^(+)CD8^(+)TALs(>28.69%)were more likely to experience chemotherapy and had lower complete remission rates,shorter PFI and OS.PD-1^(+)CD8^(+)TILs are primarily displayed an effector memory state with strong proliferative and secretory capabilities.Approximately 50%of CD57^(+)CD8^(+)TALs were terminally differentiated,exhibiting significantly impaired proliferation.Based on the proportions of PD-1^(+)CD8^(+)TILs and CD57^(+)CD8^(+)TALs,patients were categorized into good,median and poor prognosis groups,with median PFI of 47.78,27.29 and 11.96 months,respectively(P<0.0001).Median OS for these groups was not reach,49.23 and 30.92 months,respectively(P<0.0001).Patients with poor prognosis exhibit significantly reduced CD8^(+)T cell proportion and increased M2 macrophage in the TIME,alongside downregulation of multiple T cell activation-related pathways.Conclusions:Lower levels of PD-1^(+)CD8^(+)TILs and higher CD57^(+)CD8^(+)TALs,assessed prior to treatment,correlated with poor prognosis and suppressive TIME in advanced HGSOC.展开更多
The Triassic Xujiahe Formation in the slope zone of the Sichuan foreland basin is a new field of continental tight gas exploration in recent years.The fourth member of the Xujiahe Formation(Xu4 Member),the major inter...The Triassic Xujiahe Formation in the slope zone of the Sichuan foreland basin is a new field of continental tight gas exploration in recent years.The fourth member of the Xujiahe Formation(Xu4 Member),the major interval in the Jianyang Block of the Tianfu gas field in the basin,is characterized by considerable buried depth,tight reservoirs,and strong heterogeneity.By using cast thin section,X-ray diffraction(XRD),scanning electron microscopy(SEM),fluid inclusion thermometry,and core analysis,the reservoir rock types,dominant diageneses,diagenetic history,and controls on high-graded reservoirs were investigated.It is found that the Xu4 Member in Jianyang mainly consists of lithic feldspar sandstones and feldspar lithic sandstones,followed by lithic quartz sandstones.High-energy hydrodynamic conditions in the microfacies of underwater distributary channels and mouth bars are beneficial to the preservation of primary pores and the occurrence of secondary pores,and there are no significant differences in petrophysical properties between these two microfacies.Compaction and calcareous cementation are the dominant controls on reservoir porosity decrease in the Xujiahe Formation;corrosion is the major contributor to porosity increase by generating secondary dissolved pores,e.g.intragranular dissolved pores and intergranular dissolved pores,as major reservoir space in the study area.Fracture zones around the faults inside the Xujiahe Formation(fourth‒order faults)are favorable for proximal tight gas accumulation,preservation,and production.The research findings have been successfully applied to explore the Xujiahe Formation in the slope zone of the Sichuan foreland basin.They can be referential for other similar tight sandstone gas accumulations.展开更多
With rapid development of economy and emergence of more and more high-grade residences,it had highlighted that high-grade residence was the inevitable tendency of economic development and urban construction.Based on t...With rapid development of economy and emergence of more and more high-grade residences,it had highlighted that high-grade residence was the inevitable tendency of economic development and urban construction.Based on the fact that high-grade residences paid more attention to harmony of human and architecture with nature and required higher for landscaping,the paper emphasized that landscape quality of high-grade residences was the key factor deciding quality of the residence.In view of insufficiencies of plant landscaping planning in high-grade residences at home and abroad,by taking high-grade residences in Hangzhou City for example,analysis had been conducted by selecting typical cases.It pointed out that plants disposition in high-grade residences was unreasonable,architectures and landscapes were isolated,and greening ratio was stressed while design was neglected.And then,corresponding solutions had been proposed.In terms of plants selection,it should reasonably utilize native tree species,and properly select new and high-quality plant species.In terms of harmonious unity between plant landscape and architecture,it should lay stress on unity between sensory design and comfort design.In terms of plant design and disposition,it should stick to the theme of "residential environment",so as to rationalize plant design and disposition,and create more comfortable residential environment.展开更多
AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected...AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was < 4, the rate of missed diagnosis was higher (20/23, 89.96%) than for when there were > 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions increases with the number of biopsies.展开更多
When a distal common bile duct neoplasm is at the stage of carcinoma in situ or high-grade dysplasia,it is difficult for the surgeon to decide whether to perform pancreaticoduodenectomy.Here we describe a patient with...When a distal common bile duct neoplasm is at the stage of carcinoma in situ or high-grade dysplasia,it is difficult for the surgeon to decide whether to perform pancreaticoduodenectomy.Here we describe a patient with a progressive dysplastic lesion in the common bile duct,which developed from moderate-high to highgrade dysplasia in approximately 2 mo.The patient refused major surgery.Therefore,endoscopic-assisted photodynamic therapy was performed.The result at follow-up using a trans-T-tube choledochoscope showed that the lesion was completely necrotic.This report is the first to describe the successful treatment of highgrade dysplasia of the distal bile duct using photodynamic therapy via a choledochoscope.展开更多
AIM： To evaluate endoscopic mucosal resection （EMR） in patients with high-grade dysplasia （HGD） and/or intramucosal cancer （IMC） in Barrett＇s esophagus （BE）. METHODS： Between June 2000 and December 2003, 39...AIM： To evaluate endoscopic mucosal resection （EMR） in patients with high-grade dysplasia （HGD） and/or intramucosal cancer （IMC） in Barrett＇s esophagus （BE）. METHODS： Between June 2000 and December 2003, 39 consecutive patients with HGD （35） and/or IMC （4） underwent EMR. BE 〉30 mm was present in 27 patients. In three patients with short segment BE （25.0%）, HGD was detected in a normal appearing BE. Lesions had a mean diameter of 14.8＋10.3 ram. Mucosal resection was carried out using the cap method. RESULTS： The average size of resections was 19.7± 9.4×14.6＋8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia （LGD） （12.8%）, 27 HGD （69.2%）, 2 IMC （5.1%）, and 5 SMC （-12.8%）. EMR changed the pre-treatment diagnosis in 10 patients （25.6%）. Three patients with SMC underwent surgery. Histology of the surgical specimen revealed 1 TON0 and 2 TIN0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy, occurred in four patients （10.3%）. After a median follow-up of 34.9 mo, all patients remained in remission. CONCLUSION： In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery.展开更多
Only two cases of myofibroblastic sarcoma in the liver have been reported in the literature. Here, we report the case of a male patient with high-grade myofibroblastic sarcoma mimicking echinococcosis in the liver. Th...Only two cases of myofibroblastic sarcoma in the liver have been reported in the literature. Here, we report the case of a male patient with high-grade myofibroblastic sarcoma mimicking echinococcosis in the liver. The 25-year-old male patient complained of right upper quadrant swelling pain for one week and was initially diagnosed with echinococcosis. He was then scheduled for an exploratory laparotomy. During the operation, a huge mass exceeding 16 cm in diameter was found to occupy nearly the entire right trisegment of the liver, with a clear boundary and a round shape, and the mass was resected by right hepatic trisegmentectomy. Immunohistochemical staining revealed that the tumor tissue was positive for desmin, alpha-smooth muscle actin, CD56, and vimentin and negative for ALK-1, myogenin, calponin, beta-catenin, S100, and glypican-3, with a Ki-67 (MIB-1) index of approximately 20%. Based on the histological manifestations and immunohistochemical staining, a diagnosis of myofibroblastic sarcoma was established. The postoperative recovery was uneventful. There was no evidence of recurrence or metastasis through the last follow-up, 6 mo after surgery, despite a lack of postoperative chemotherapy or radiotherapy. To the best of our knowledge, the present case is the first reported case of high-grade myofibroblastic sarcoma in the liver, and it is also the first reported case in a male patient.展开更多
The relationship between micro structure and corrosion behavior of high-grade pipeline steel under low-temperature conditions was comparatively investigated by the potentiodynamic polarization and electrochemical impe...The relationship between micro structure and corrosion behavior of high-grade pipeline steel under low-temperature conditions was comparatively investigated by the potentiodynamic polarization and electrochemical impedance spec-troscopy test combining with optical micrographs,scanning electron microscopy,transmission electron microscopy and electron back-scattered diffraction.The results showed that,compared with room and high temperature,low temperature could influence the corrosion behavior of high-grade pipeline steel,which means that the corrosion potential and current density decreased and the corrosion resistance increased significantly.Moreover,double layer structures of the interface became thicker and more compact.Under low-temperature environment,acicular ferrite had the martensite/austenite constituents with less amount and smaller size,a higher density of low angle grain boundaries and smaller effective grain sizes compared with granular bainite,which demonstrated higher corrosion resistance.展开更多
The influence of basicity on the metallurgical performances and reduction characteristics of fired super high-grade magnetite pellets under the simulated shaft furnace gas conditions was investigated.The fired pellets...The influence of basicity on the metallurgical performances and reduction characteristics of fired super high-grade magnetite pellets under the simulated shaft furnace gas conditions was investigated.The fired pellets in the basicity range of 0.09(natural basicity)to 1.00 show superior reducibility and low-temperature disintegration performance.However,in the basicity range of 0.20–0.80,the abnormal swelling of the fired pellets occurs.Improving basicity from 0.09 to 0.40 promotes the generation of low melting point slag phases and lower porosity of fired pellets,and accelerates the growth and densification of hematite crystals,impeding the reduction of hematite particles and the formation of metallic iron shell.In addition,the slags that distribute between the hematite particles absorb the reduction stresses by increased distances between the particles during the reduction process,which leads to the large reduction swelling of pellets.展开更多
BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most ...BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.展开更多
High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indica...High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic.展开更多
With the completion of the Qinghai-Tibetan Railway,economic development of related areas has been greatly accelerated.This,in return,calls for building or upgrading more roadways,especially high-grade roadways.In cold...With the completion of the Qinghai-Tibetan Railway,economic development of related areas has been greatly accelerated.This,in return,calls for building or upgrading more roadways,especially high-grade roadways.In cold regions,the thawing of permafrost can induce settlement damage of and even failure to railway (or roadway) embankments.Thermosyphons (self-powered refrigera-tion devices that are used to help keep the permafrost cool) have proved effective in mitigating thaw settlement by maintaining the thermal stability of the embankments.However,for high-grade roadway embankments of great width,stabilizing or cooling ef-fects of traditional geotechnological measures may be limited.To enhance the cooling effect of thermosyphons,an L-shaped thermosyphon was designed.A laboratory test was carried out to study the combined cooling effect of the L-shaped thermosyphon and thermal insulation applying to roadbed construction.The angle between the evaporator and condenser sections of the L-shaped thermosyphon is 134 degrees,and the L-shaped thermosyphon was inserted into the soil at an angle of 5 degrees with the road surface.The tested results show that the L-shaped thermosyphon is effective in removing heat from a roadway in winter.When the ambient air temperature is lower than the soil temperature,the thermosyphon is active and extracts the heat in the soil around it.When the ambient air temperature is higher than the soil temperature,the thermosyphon is inactive,and no heat is in-jected into the soil through the L-shaped thermosyphon.Compared to embankments with straight thermosyphons,the inner parts of the embankments with L-shaped thermosyphons were significantly cooled.It is hoped that the present study would be useful to the application of L-shaped thermosyphons in the construction of high-grade roadways in cold regions.展开更多
Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary teams.Improved radiation therapy techniques,new imaging methods,...Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary teams.Improved radiation therapy techniques,new imaging methods,published experience,and a better radiobiological knowledge of brain tissue have positioned re-irradiation(re-RT)as an option for many of these patients.Decisions must be individualized,taking into account the pattern of relapse,previous treatment,and functional status,as well as the patient’s preferences and expected quality of life.Many questions remain unanswered with respect to re-RT:Who is the most appropriate candidate,which dose and fractionation are most effective,how to define the target volume,which imaging technique is best for planning,and what is the optimal timing?This review will focus on describing the most relevant studies that include re-RT as salvage therapy,with the aim of simplifying decision-making and designing the best available therapeutic strategy.展开更多
文摘High-grade pancreatic intraepithelial neoplasia is a challenging diagnosis and itdoes not exhibit mass lesions. It is suspected based on changes in the mainpancreatic duct in magnetic resonance cholangiopancreatography. Sometimesonly an unclear duct shows in magnetic resonance cholangiopancreatographywith no focal strictures and upstream dilatation of the main pancreatic duct. Serialpancreatic juice cytology is valuable in diagnosis of those patients.
文摘Although with aggressive standards of care like surgical resection,chemotherapy,and radiation,high-grade gliomas(HGGs)and brain metastases(BM)treatment has remained challenging for more than two decades.However,technological advances in this field and immunotherapeutic strategies have revolutionized the treatment of HGGs and BM.Immunotherapies like immune checkpoint inhibitors,CAR-T targeting,oncolytic virus-based therapy,bispecific antibody treatment,and vaccination approaches,etc.,are emerging as promising avenues offering new hope in refining patient’s survival benefits.However,selective trafficking across the blood-brain barrier(BBB),immunosuppressive tumor microenvironment(TME),metabolic alteration,and tumor heterogeneity limit the therapeutic efficacy of immunotherapy for HGGs and BM.Furthermore,to address this concern,the NanoBioTechnology-based bioinspired delivery system has been gaining tremendous attention in recent years.With technological advances such as Trojan horse targeting and infusing/camouflaging nanoparticles surface with biological molecules/cells like immunocytes,erythrocytes,platelets,glioma cell lysate and/or integrating these strategies to get hybrid membrane for homotypic recognition.These biomimetic nanotherapy offers advantages over conventional nanoparticles,focusing on greater target specificity,increased circulation stability,higher active loading capacity,BBB permeability(inherent inflammatory chemotaxis of neutrophils),decreased immunogenicity,efficient metabolism-based combinatorial effects,and prevention of tumor recurrence by induction of immunological memory,etc.provide new age of improved immunotherapies outcomes against HGGs and BM.In this review,we emphasize on neuro-immunotherapy and the versatility of these biomimetic nano-delivery strategies for precise targeting of hard-to-treat andmost lethal HGGs and BM.Moreover,the challenges impeding the clinical translatability of these approaches were addressed to unmet medical needs of brain cancers.
文摘BACKGROUND Claudin-6(CLDN6),a tight junction protein typically restricted to embryonic tissues,is re-expressed in various cancers.However,its prognostic significance in high-grade endometrial carcinoma(HGEC)remains unclear.AIM To investigate the expression pattern of CLDN6 in HGEC and assess its correlation with clinicopathological parameters and patient survival.METHODS Immunohistochemical analysis of CLDN6 expression was performed on formalinfixed,paraffin-embedded tissues from 80 patients diagnosed with HGEC.Associations between CLDN6 expression and histological subtype,the International Federation of Gynecology and Obstetrics(FIGO)stage,depth of myometrial invasion,lymphovascular space invasion,recurrence,and survival outcomes were statistically analysed.Univariate and multivariate Cox regression models were used to identify independent prognostic factors.RESULTS High CLDN6 expression was detected in a subset of HGEC patients and was significantly associated with nonendometrioid histology(P=0.026),advanced FIGO stage(P=0.015),deep myometrial invasion(P=0.038),and recurrence(P=0.002).While Kaplan-Meier analysis did not reveal a statistically significant difference in disease-free survival or overall survival between the high CLDN6 expression group and the low CLDN6 expression group,multivariate Cox regression revealed that CLDN6 overexpression was an independent predictor of shorter disease-free survival[hazard ratio(HR)=68.98,P=0.022]and overall survival(HR=24.023,P=0.038).CONCLUSION CLDN6 overexpression is associated with aggressive tumor features and poor clinical outcomes in HGEC,suggesting its utility as a prognostic biomarker and potential therapeutic target.
文摘Myofibroblastic sarcoma(MS)is a rare malignant soft tissue tumor characterized by myofibroblasts.It most commonly arises in the head and neck region,especially the tongue,with rare occurrences in the limbs.MS exhibits varying histopathology,ranging from low-to high-grade,with diverse subtypes showing different clinical behaviors and prognoses.This article reports the first case of high-grade MS in the hand,adding to the limited documentation of this rare condition.Here,we present the case of a 30-year-old healthy female with a year-long history of progressive shortening,mobility loss,and weakness in the first finger of the left hand.Left-hand imaging revealed a lytic,cottony tumor involving the entire first metacarpal.Following surgical resection,which included metatarsal grafting and joint reconstruction,a diagnosis of high-grade MS was confirmed based on histological manifestations and immunohistochemical staining,which was further classified as grade 2 according to the French Federation of Cancer Centers Sarcoma Group system.Postoperative radiotherapy was administered and the patient experienced a successful recovery without graft osteonecrosis.The patient regained 90%mobility and strength,without shortening,after surgical resection and radiotherapy.Six months post-surgery,the patient reported full hand functionality.MS is a rare tumor that infrequently affects bones and is often misdiagnosed owing to its controversial characteristics.The initial treatment should focus on complete resection with negative margins,followed by reconstructive surgery to preserve function.Further case studies are needed to establish standardized surgical treatment protocols.
基金Supported by the 135 High-end Talent Project of West China Hospital,Sichuan University,No.ZYDG23029.
文摘BACKGROUND Recent advancements in artificial intelligence(AI)have significantly enhanced the capabilities of endoscopic-assisted diagnosis for gastrointestinal diseases.AI has shown great promise in clinical practice,particularly for diagnostic support,offering real-time insights into complex conditions such as esophageal squamous cell carcinoma.CASE SUMMARY In this study,we introduce a multimodal AI system that successfully identified and delineated a small and flat carcinoma during esophagogastroduodenoscopy,highlighting its potential for early detection of malignancies.The lesion was confirmed as high-grade squamous intraepithelial neoplasia,with pathology results supporting the AI system’s accuracy.The multimodal AI system offers an integrated solution that provides real-time,accurate diagnostic information directly within the endoscopic device interface,allowing for single-monitor use without disrupting endoscopist’s workflow.CONCLUSION This work underscores the transformative potential of AI to enhance endoscopic diagnosis by enabling earlier,more accurate interventions.
基金supported by USTB Institute for International People-to-People Exchange in Mining,Metallurgy and Metals Industries(No.FRF-IPPE-2404)Scientific Research Platform Construction Fund for the Introduction of High-Level Talents at Kunming University of Science and Technology(No.CA25073M246A).
文摘The superconducting high gradient magnetic separation(S-HGMS)technology can be used to effectively extract silica from iron ore tailings(IOTs).However,particle agglomeration in strong magnetic fields poses a challenge in achieving optimal performance.In this study,we investigated the agglomeration of IOT particles and the mechanisms for its inhibition through surface analysis,density functional theory(DFT),and extended Derjaguin-Landau-Verwey-Overbeek(EDLVO)theory.Hematite was found to exhibit the highest magnetic moment among the minerals present in IOTs,making it particularly prone to magnetic agglomeration.The addition of the dispersant SDSH into the slurry was essential in promoting the dispersion of IOT particles during the S-HGMS process.This dispersant hydrolyzed to form HPO_(4)^(2-)and RSO_(3)^(-)groups in the solution,which then chemically adsorbed onto the metal ions exposed on the surfaces of non-quartz particles,increasing interparticle electrostatic repulsion.Furthermore,the RSO_(3)^(-)groups physically adsorbed onto the surface of quartz particles,resulting in strong steric repulsion and enhancing the hydrophilicity of the particle surfaces,thereby inhibiting magnetic agglomeration between the particles.Under optimal conditions,the SiO_(2)grade of the obtained high-grade silica powder increased from an initial value of 76.32%in IOTs to 97.42%,achieving a SiO_(2)recovery rate of 54.81%,which meets the requirements for quartz sand used in glass preparation.This study provides valuable insights into the magnetic agglomeration of IOT particles and its inhibition while providing a foundation for regulating S-HGMS processes.
基金Supported by The Natural Science Foundation of Hunan Province,China,No.2022JJ30329.
文摘BACKGROUND High-grade serous ovarian carcinoma(HGSOC)is among the most lethal gynecological malignancies,characterized by late-stage diagnosis,extensive peritoneal dissemination,and limited treatment options,resulting in poor survival outcomes.The tumor microenvironment plays a critical role in disease progression and therapy resistance,with CD4+T cells exhibiting significant plasticity and functional heterogeneity.Regulatory T cells(Tregs)are particularly implicated in immune suppression and tumor evasion.However,the spatial distribution,functional states,and prognostic significance of CD4+T cell subtypes in HGSOC remain poorly understood.AIM To characterize the functional heterogeneity and tissue-specific distributions of CD4+T cell subtypes in HGSOC and identify biomarkers for therapy.METHODS We analyzed single-cell RNA sequencing(scRNA-seq)data from 42 HGSOC patients,examining samples collected from adnexal tissues and ascites.CD4+T cells were identified and classified into subtypes using unsupervised clustering and marker gene analysis.Functional profiling was performed using pathway enrichment,differential expression analysis,and functional signature scoring.Kaplan-Meier survival and Cox proportional hazards modeling were conducted to evaluate the prognostic value of CD4+T cell subtypes.RESULTS Distinct distributions of CD4+T cell subtypes were identified between adnexal tissues and ascites.Naive CD4+T cells were predominant in ascites,while Tregs and CXCL13-expressing CD4+T cells were enriched in adnexal tissues.Tregs were further categorized into four subtypes(Treg1,Treg2,Treg3,and TISG),each exhibiting unique molecular signatures and tissue-specific adaptations.Treg3 cells,enriched in adnexal tissues,were characterized by high levels of activation and exhaustion markers,correlating with poor clinical outcomes in HGSOC patients.CONCLUSION Treg3 cells drive immune suppression and tumor progression in HGSOC,making them a key immunotherapy target.Their adnexal enrichment highlights the need for tissue-specific immune profiling in precision treatment.
基金supported by National Natural Science Foundation of China(No.82372888)National Key Research and Development Program of China(No.2022YFC2704000)+6 种基金National Natural Science Foundation of China(No.82273383)the Capital’s Funds for Health Improvement and Research(No.2020-2-4098)Youth program of Beijing Municipal Natural Science Foundation(No.7204328)Clinical Medicine Plus X-Young Scholars Project,Peking University(No.PKU2022LCXQ020)Key Clinical Project of Peking University Third Hospital(No.BYSY2022050)Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2021006)Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2019034).
文摘Objective:The expression of programmed death 1(PD-1)on CD8^(+)T cells is associated with their activation and exhaustion,while CD57 serves as a senescence marker.The impact of PD-1^(+)and CD57^(+)CD8^(+)T cells on the prognosis of patients with advanced high-grade serous ovarian cancer(HGSOC)remain unclear.Methods:We assessed the percentages of PD-1^(+)and CD57^(+)CD8^(+)T cells in tumor-infiltrating lymphocytes(TILs,n=85)and tumor ascites lymphocytes(TALs,n=87)using flow cytometry.The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method.Gene expression analysis elucidated the tumor immune microenvironment(TIME,n=36).Results:Patients with higher PD-1^(+)CD8^(+)TILs(>87.8%)exhibited longer platinum-free interval(PFI)and overall survival(OS).In contrast,those with elevated CD57^(+)CD8^(+)TALs(>28.69%)were more likely to experience chemotherapy and had lower complete remission rates,shorter PFI and OS.PD-1^(+)CD8^(+)TILs are primarily displayed an effector memory state with strong proliferative and secretory capabilities.Approximately 50%of CD57^(+)CD8^(+)TALs were terminally differentiated,exhibiting significantly impaired proliferation.Based on the proportions of PD-1^(+)CD8^(+)TILs and CD57^(+)CD8^(+)TALs,patients were categorized into good,median and poor prognosis groups,with median PFI of 47.78,27.29 and 11.96 months,respectively(P<0.0001).Median OS for these groups was not reach,49.23 and 30.92 months,respectively(P<0.0001).Patients with poor prognosis exhibit significantly reduced CD8^(+)T cell proportion and increased M2 macrophage in the TIME,alongside downregulation of multiple T cell activation-related pathways.Conclusions:Lower levels of PD-1^(+)CD8^(+)TILs and higher CD57^(+)CD8^(+)TALs,assessed prior to treatment,correlated with poor prognosis and suppressive TIME in advanced HGSOC.
基金supported by the China National Petroleum Corporation Science and Technology Project(Study on genesis mechanism and distribution law of high quality reservoir of the fourth Member of Xujiahe Formation in middle and west Sichuan area,20230301-23)。
文摘The Triassic Xujiahe Formation in the slope zone of the Sichuan foreland basin is a new field of continental tight gas exploration in recent years.The fourth member of the Xujiahe Formation(Xu4 Member),the major interval in the Jianyang Block of the Tianfu gas field in the basin,is characterized by considerable buried depth,tight reservoirs,and strong heterogeneity.By using cast thin section,X-ray diffraction(XRD),scanning electron microscopy(SEM),fluid inclusion thermometry,and core analysis,the reservoir rock types,dominant diageneses,diagenetic history,and controls on high-graded reservoirs were investigated.It is found that the Xu4 Member in Jianyang mainly consists of lithic feldspar sandstones and feldspar lithic sandstones,followed by lithic quartz sandstones.High-energy hydrodynamic conditions in the microfacies of underwater distributary channels and mouth bars are beneficial to the preservation of primary pores and the occurrence of secondary pores,and there are no significant differences in petrophysical properties between these two microfacies.Compaction and calcareous cementation are the dominant controls on reservoir porosity decrease in the Xujiahe Formation;corrosion is the major contributor to porosity increase by generating secondary dissolved pores,e.g.intragranular dissolved pores and intergranular dissolved pores,as major reservoir space in the study area.Fracture zones around the faults inside the Xujiahe Formation(fourth‒order faults)are favorable for proximal tight gas accumulation,preservation,and production.The research findings have been successfully applied to explore the Xujiahe Formation in the slope zone of the Sichuan foreland basin.They can be referential for other similar tight sandstone gas accumulations.
文摘With rapid development of economy and emergence of more and more high-grade residences,it had highlighted that high-grade residence was the inevitable tendency of economic development and urban construction.Based on the fact that high-grade residences paid more attention to harmony of human and architecture with nature and required higher for landscaping,the paper emphasized that landscape quality of high-grade residences was the key factor deciding quality of the residence.In view of insufficiencies of plant landscaping planning in high-grade residences at home and abroad,by taking high-grade residences in Hangzhou City for example,analysis had been conducted by selecting typical cases.It pointed out that plants disposition in high-grade residences was unreasonable,architectures and landscapes were isolated,and greening ratio was stressed while design was neglected.And then,corresponding solutions had been proposed.In terms of plants selection,it should reasonably utilize native tree species,and properly select new and high-quality plant species.In terms of harmonious unity between plant landscape and architecture,it should lay stress on unity between sensory design and comfort design.In terms of plant design and disposition,it should stick to the theme of "residential environment",so as to rationalize plant design and disposition,and create more comfortable residential environment.
文摘AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was < 4, the rate of missed diagnosis was higher (20/23, 89.96%) than for when there were > 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions increases with the number of biopsies.
文摘When a distal common bile duct neoplasm is at the stage of carcinoma in situ or high-grade dysplasia,it is difficult for the surgeon to decide whether to perform pancreaticoduodenectomy.Here we describe a patient with a progressive dysplastic lesion in the common bile duct,which developed from moderate-high to highgrade dysplasia in approximately 2 mo.The patient refused major surgery.Therefore,endoscopic-assisted photodynamic therapy was performed.The result at follow-up using a trans-T-tube choledochoscope showed that the lesion was completely necrotic.This report is the first to describe the successful treatment of highgrade dysplasia of the distal bile duct using photodynamic therapy via a choledochoscope.
文摘AIM： To evaluate endoscopic mucosal resection （EMR） in patients with high-grade dysplasia （HGD） and/or intramucosal cancer （IMC） in Barrett＇s esophagus （BE）. METHODS： Between June 2000 and December 2003, 39 consecutive patients with HGD （35） and/or IMC （4） underwent EMR. BE 〉30 mm was present in 27 patients. In three patients with short segment BE （25.0%）, HGD was detected in a normal appearing BE. Lesions had a mean diameter of 14.8＋10.3 ram. Mucosal resection was carried out using the cap method. RESULTS： The average size of resections was 19.7± 9.4×14.6＋8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia （LGD） （12.8%）, 27 HGD （69.2%）, 2 IMC （5.1%）, and 5 SMC （-12.8%）. EMR changed the pre-treatment diagnosis in 10 patients （25.6%）. Three patients with SMC underwent surgery. Histology of the surgical specimen revealed 1 TON0 and 2 TIN0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy, occurred in four patients （10.3%）. After a median follow-up of 34.9 mo, all patients remained in remission. CONCLUSION： In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery.
文摘Only two cases of myofibroblastic sarcoma in the liver have been reported in the literature. Here, we report the case of a male patient with high-grade myofibroblastic sarcoma mimicking echinococcosis in the liver. The 25-year-old male patient complained of right upper quadrant swelling pain for one week and was initially diagnosed with echinococcosis. He was then scheduled for an exploratory laparotomy. During the operation, a huge mass exceeding 16 cm in diameter was found to occupy nearly the entire right trisegment of the liver, with a clear boundary and a round shape, and the mass was resected by right hepatic trisegmentectomy. Immunohistochemical staining revealed that the tumor tissue was positive for desmin, alpha-smooth muscle actin, CD56, and vimentin and negative for ALK-1, myogenin, calponin, beta-catenin, S100, and glypican-3, with a Ki-67 (MIB-1) index of approximately 20%. Based on the histological manifestations and immunohistochemical staining, a diagnosis of myofibroblastic sarcoma was established. The postoperative recovery was uneventful. There was no evidence of recurrence or metastasis through the last follow-up, 6 mo after surgery, despite a lack of postoperative chemotherapy or radiotherapy. To the best of our knowledge, the present case is the first reported case of high-grade myofibroblastic sarcoma in the liver, and it is also the first reported case in a male patient.
基金supported by the National Key Research and Development Program of China(Grant No.2017YFB0304900)the National Natural Science Foundation of China(Grant No.51911530129).
文摘The relationship between micro structure and corrosion behavior of high-grade pipeline steel under low-temperature conditions was comparatively investigated by the potentiodynamic polarization and electrochemical impedance spec-troscopy test combining with optical micrographs,scanning electron microscopy,transmission electron microscopy and electron back-scattered diffraction.The results showed that,compared with room and high temperature,low temperature could influence the corrosion behavior of high-grade pipeline steel,which means that the corrosion potential and current density decreased and the corrosion resistance increased significantly.Moreover,double layer structures of the interface became thicker and more compact.Under low-temperature environment,acicular ferrite had the martensite/austenite constituents with less amount and smaller size,a higher density of low angle grain boundaries and smaller effective grain sizes compared with granular bainite,which demonstrated higher corrosion resistance.
基金The authors want to express their gratitude for the financial support from the National Natural Science Foundation of China(No.52004075)Science and Technology Planning Projects of Guizhou Province(No.ZK[2021]262)+1 种基金Program Foundation for Talents of Guizhou University(No.(2020)15)the Hunan Provincial Co-innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources.
文摘The influence of basicity on the metallurgical performances and reduction characteristics of fired super high-grade magnetite pellets under the simulated shaft furnace gas conditions was investigated.The fired pellets in the basicity range of 0.09(natural basicity)to 1.00 show superior reducibility and low-temperature disintegration performance.However,in the basicity range of 0.20–0.80,the abnormal swelling of the fired pellets occurs.Improving basicity from 0.09 to 0.40 promotes the generation of low melting point slag phases and lower porosity of fired pellets,and accelerates the growth and densification of hematite crystals,impeding the reduction of hematite particles and the formation of metallic iron shell.In addition,the slags that distribute between the hematite particles absorb the reduction stresses by increased distances between the particles during the reduction process,which leads to the large reduction swelling of pellets.
文摘BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.
文摘High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic.
基金supported by National Natural Science Foundation of China (Grant No.40730736 and No.40601023)the National Hi-Tech Research and Development Plan (2008AA11Z103)the Western Project Program of the Chinese Academy of Sciences (No.KZCX2-XB2-10)
文摘With the completion of the Qinghai-Tibetan Railway,economic development of related areas has been greatly accelerated.This,in return,calls for building or upgrading more roadways,especially high-grade roadways.In cold regions,the thawing of permafrost can induce settlement damage of and even failure to railway (or roadway) embankments.Thermosyphons (self-powered refrigera-tion devices that are used to help keep the permafrost cool) have proved effective in mitigating thaw settlement by maintaining the thermal stability of the embankments.However,for high-grade roadway embankments of great width,stabilizing or cooling ef-fects of traditional geotechnological measures may be limited.To enhance the cooling effect of thermosyphons,an L-shaped thermosyphon was designed.A laboratory test was carried out to study the combined cooling effect of the L-shaped thermosyphon and thermal insulation applying to roadbed construction.The angle between the evaporator and condenser sections of the L-shaped thermosyphon is 134 degrees,and the L-shaped thermosyphon was inserted into the soil at an angle of 5 degrees with the road surface.The tested results show that the L-shaped thermosyphon is effective in removing heat from a roadway in winter.When the ambient air temperature is lower than the soil temperature,the thermosyphon is active and extracts the heat in the soil around it.When the ambient air temperature is higher than the soil temperature,the thermosyphon is inactive,and no heat is in-jected into the soil through the L-shaped thermosyphon.Compared to embankments with straight thermosyphons,the inner parts of the embankments with L-shaped thermosyphons were significantly cooled.It is hoped that the present study would be useful to the application of L-shaped thermosyphons in the construction of high-grade roadways in cold regions.
文摘Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary teams.Improved radiation therapy techniques,new imaging methods,published experience,and a better radiobiological knowledge of brain tissue have positioned re-irradiation(re-RT)as an option for many of these patients.Decisions must be individualized,taking into account the pattern of relapse,previous treatment,and functional status,as well as the patient’s preferences and expected quality of life.Many questions remain unanswered with respect to re-RT:Who is the most appropriate candidate,which dose and fractionation are most effective,how to define the target volume,which imaging technique is best for planning,and what is the optimal timing?This review will focus on describing the most relevant studies that include re-RT as salvage therapy,with the aim of simplifying decision-making and designing the best available therapeutic strategy.
