This study aims to evaluate the clinical effectiveness of different drug treatment regimens for cervical high-risk human papillomavirus (HR-HPV) infection. Through literature review and randomized group experiment des...This study aims to evaluate the clinical effectiveness of different drug treatment regimens for cervical high-risk human papillomavirus (HR-HPV) infection. Through literature review and randomized group experiment design, the study compares the HPV-DNA clearance rate, TCT results, and colposcopic biopsy findings among the control group, interferon group, and combination treatment group after six months of treatment. The results indicate that recombinant human interferon-2b vaginal effervescent tablets can effectively improve HPV clearance and reduce the risk of lesion progression, although individual responses to treatment vary. Combination therapy may enhance treatment efficacy by boosting immune response. The study also explores the relationship between drug treatment, viral load, cervical lesions, and vaginal microecology, providing scientific support for clinical medication decisions and offering a detailed analysis of the role of pharmacological intervention in the prognosis of HR-HPV infections.展开更多
Objective:This study conducted a systematic review of randomized controlled trials in order to evaluate the efficacy and safety of Baofukang Suppository(保妇康栓)combined with interferon on cervical high-risk human pa...Objective:This study conducted a systematic review of randomized controlled trials in order to evaluate the efficacy and safety of Baofukang Suppository(保妇康栓)combined with interferon on cervical high-risk human papillomavirus(HR-HPV)infection.Methods:Data comes from China National Knowledge Infrastructure(CNKI),Wanfang database,the VIP information database,Chinese Biomedical Literature Database,PubMed,Cochrane Library,Web of Science and Embase.Primary and secondary outcome measures were extracted from 13 included randomized controlled trials:number of HR-HPV turning negative and effective,time of HPV turning negative,duration of abnormal vaginal secretions and adverse events.Results:Baofukang Suppository combined with interferon were better than interferon alone in improving the negative rate of HR-HPV(RR=1.42,95%CI[1.28,1.58],P<0.00001)and the effective rate of HR-HPV RR=1.3,95%CI[1.24,1.37],P<0.00001),time of HR-HPV turning negative(MD=-8.32,95%CI[-9.17,-7.47],P<0.00001),duration of abnormal vaginal secretions(MD=-8.95,95%CI[-11.34,-6.56],P<0.00001).However,there was no statistical difference in improving inflammatory factor(TNF-α:SMD=-0.49,95%CI[-1.02,0.03],Z=1.83,P=0.07;IL-6:SMD=-13.69,95%CI[-41.98,14.6],Z=0.95,P=0.34)and adverse events(RR=-0.73,95%CI[0.48,1.11,P=0.15)between two groups.Conclusion:The results showed that the efficacy of Baofukang Suppository combined with interferon were better than interferon alone in improving the negative and effective rate of HR-HPV,shortening the time of HR-HPV turning negative and duration of abnormal vaginal secretion and reducing adverse events.展开更多
High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child H...High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child Health Hospital of Hubei Province.Each participant accepted hrHPV testing and completed a self^administered questionnaire about basic information and potential risk factors.The univariable and multivariable logistic regression model was used to explore the associations between variants and hrHPV infection.Our results showed that hrHPV prevalence was 16.09% in Hubei Province,among which,hrHPV was more likely to be positive in women aged 51 years or above (OR=1.65,95% CI:1.28-2.14),and in women who had symptoms of bleeding after intercourse (OR=1.32,95% CI:1.17-1.50),had first sexual intercourse at the age of 18 years or below (OR=1.33,95% CI:1.07-1.64),had at least three male sexual partners (OR=2.50,95% CI:2.07-3.03),and who had been diagnosed with sexually transmitted infections (OR=1.50,95% CI:1.12-2.03).Married women (OR=0.66,95% CI:0.55-0.78) and women who frequently used condoms (OR=0.75,95% CI:0.67-0.84) had a relatively lower hrHPV prevalence.This study confirms that hrHPV infection was associated with age,marital status,symptoms of intercourse bleeding,history of sexually transmitted infections,and sex-related behaviors.Above all,this study provides a baseline database prior to obtaining vaccinations for dynamic tracking of the changes in hrHPV prevalence.展开更多
Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the poten...Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the potential to eradicate cervical cancer. In-country evidence of sub-types of HPV associated with cervical cancer is scanty, thus necessitating this study. Methods: A cross-sectional study was performed using a multistage sampling technique. A molecular technique using the Cobas 4800 machine was used for genotyping. Results: 570 participants were recruited for the study. The mean age of the participants was 32.4 ± 5.2 years. The age of sexual debut ranged from 15 - 24 years with a median of 19 years. 194 participants were positive for high-risk HPV giving a prevalence of 34%. 3% (n = 17) were positive for HPV, 16. 4% (23) had a positive result for HPV, 18. 27% (n = 154) had a positive result for other high-risk groups (OHR) other than HPV 16 or 18. Positive status for high-risk HPV is associated with the presence of genital warts (OR = 7.5), a Positive HIV status (OR = 3.48), abnormal vaginal discharge (OR = 2.20), multiple sexual partners (OR = 2.30), and obesity (OR = 2.70). The prevalence of HIV in the study population was 6.84% (n = 39). Conclusion: Another High-risk HPV other than 16 and 18 appears to be the predominant form of HPV infection in Nigerian women. The risk of being positive for high-risk HPV is associated with the presence of genital warts, abnormal vaginal discharge, a positive HIV status, multiple sexual partners and Obesity. It is therefore necessary to disaggregate and study these high-risk sub-types.展开更多
Objective:To study the relationship between the infection of high-risk HPV in cervical precancerous lesion and the expression of oncogene, anti-oncogene.Methods:218 cases ofcervical intraepithelial neoplasia patients ...Objective:To study the relationship between the infection of high-risk HPV in cervical precancerous lesion and the expression of oncogene, anti-oncogene.Methods:218 cases ofcervical intraepithelial neoplasia patients in our hospital during May 2014–May 2016 were chosed and divided into high-risk HPV group (n=107), low-risk HPV group (n=111) according to cervical tissue HPV test;another 100 cases of patients received cervical biopsy and confirmed as benign lesions were enrolled in the control group. RT-PCR method was used to detect the mRNA expression of proto-oncogene and anti-oncogene in three groups, Western-blot method was used to detect the protein expression of Sox-2 and Wnt/β-catenin signal pathway.Results: mRNA expression of oncogene DEK, Bmi-1, c-fos, K-ras, Prdx4 in high-risk HPV group were higher than low-risk HPV group and control group (P<0.05);mRNA expression of anti-oncogene P27, P16, DAPK, PTEN, eIF4E3 in high-risk HPV group were lower than low-risk HPV group and control group (P<0.05);expression of Sox-2 and Wnt/β-catenin signaling pathway protein Sox-2,β-catenin, wnt-1, wnt-3a in high-risk HPV group were higher than low-risk HPV group and control group (P<0.05).Conclusions:High-risk HPV infection can increase the expression of oncogenes and reduce the expression of anti-oncogenes in cervical dysplasia tissues on Sox-2- and Wnt/β-catenin signaling pathway manners.展开更多
Human papillomavirus(HPV) is classified either as high-risk or low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the high-risk kind, is alw...Human papillomavirus(HPV) is classified either as high-risk or low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the high-risk kind, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.展开更多
Objective:To study the relationship of high-risk human papilloma virus (HPV) infection with mitogen-activated protein kinase/extracellular signal-regulated kinase 3 (MEKK3) and nuclear factorκB (NF-κB) expression in...Objective:To study the relationship of high-risk human papilloma virus (HPV) infection with mitogen-activated protein kinase/extracellular signal-regulated kinase 3 (MEKK3) and nuclear factorκB (NF-κB) expression in cervical intraepithelial neoplasia tissue.Methods:125 cases of cervical biopsy specimens between May 2013 and March 2016 were collected. The cervical inflammation specimens, cervical intraepithelial neoplasia specimens and cervical cancer specimens were included in inflammation group, CIN group and malignant group respectively. HPV-DNA typing detection kits were used to determine HPV typing, immunohistochemical kits were used to determine MEKK3 and NF-κB protein expression, and fluorescent quantitative PCR kits were used to determine the mRNA expression of MEKK3, NF-κB and downstream molecules.Results: MEKK3 and NF-κB protein expression in high-risk HPV-positive cervical tissue were significantly higher than those in high-risk HPV-negative cervical tissue (P<0.05), and MEKK3, NF-κB, Bcl-2, XIAP, Bmi-1, TGF-β and Vimentin mRNA expression in high-risk type HPV-positive cervical tissue were significantly higher than those in high-risk HPV-negative cervical tissue (P<0.05);Bcl-2, XIAP, Bmi-1, TGF-β and Vimentin mRNA expression in tissue with positive MEKK3 and NF-κB expression were significantly higher than those in tissue with negative MEKK3 and NF-κB expression (P<0.05).Conclusions:High-risk HPV infection will increase the expression of proliferation genes Bcl-2, XIAP and Bmi-1 as well as invasion genes TGF-β and Vimentin in cervical intraepithelial neoplasia tissue through MEKK3/NF-κB pathway.展开更多
Background: Cervical cancer is a significant global public health issue, with an effective screening strategy being a key challenge in its prevention. The primary objective of this study was to determine the prevalenc...Background: Cervical cancer is a significant global public health issue, with an effective screening strategy being a key challenge in its prevention. The primary objective of this study was to determine the prevalence of HPV and assess the contribution of molecular screening to primary cervical cancer detection in Dakar. Patients and Method: This cross-sectional study was conducted from January 2016 to December 2020. We compared cervico-vaginal smear results, classified according to the Bethesda 2014 system, with molecular screening results from the Cobas® 4800 HPV test (Roche). Additionally, we conducted a survey of health facilities in the Dakar medical region to evaluate the availability and accessibility (cost) of molecular testing. Results: A total of 106 patient files were analyzed. The mean age of the patients was 43.6 years (range: 22 - 76 years). Smears were normal in 41.5% of cases. Detected lesions included ASCUS (49.1%), LSIL (5.7%), and HSIL (3.8%). The overall prevalence of HPV infection was 30.2%, with non-genotype 16/18 high-risk HPV (HR HPV) infections being the most common (73%). Genotypes 16 and 18 were found in 16% and 11% of cases, respectively. Among normal smears, HPV was present in 11.3% of cases. HPV typing was positive in 40.3% of ASCUS smears and 83.3% of LSILs. HPV testing identified 85% of lesions classified as CIN2 or higher, compared to only 70% detected through cytology. The survey revealed that molecular HPV screening was unavailable in referral hospitals, and the high cost of testing in the private sector posed a significant barrier to access. Conclusion: Cervical cancer remains a serious public health issue in Senegal. The proven effectiveness of preventive measures, such as vaccination against the most oncogenic HPV types and molecular screening for HPV detection, could significantly reduce the incidence of this disease.展开更多
过去数十年,子宫颈癌的防控推动了高危人乳头瘤病毒(high-risk human papilloma virus,HR-HPV)研究的深入,除了女性外,男性也是HPV感染的重要宿主,其感染的流行病学特征及防控措施尚处于研究“洼地”。我国作为HPV感染高负担国家,男性HP...过去数十年,子宫颈癌的防控推动了高危人乳头瘤病毒(high-risk human papilloma virus,HR-HPV)研究的深入,除了女性外,男性也是HPV感染的重要宿主,其感染的流行病学特征及防控措施尚处于研究“洼地”。我国作为HPV感染高负担国家,男性HPV相关疾病(如肛门癌、肛门生殖器疣)的发病率持续攀升。本文将从流行病学、疾病负担、传播风险、检测技术及疫苗防控五个维度,分析男性HPV感染的研究现状与预防,提出男性HPV感染需要关注的问题。展开更多
在体检报告上看到“HPV阳性”的那一刻,很多人会感到惊慌失措,仿佛自己已经被宫颈癌“盯上”。事实上,HPV(人乳头瘤病毒)感染远比我们想象的更普遍,但它并非不可预防、不可战胜。今天,就带大家深入了解HPV,学会科学预防的有效方法。认识...在体检报告上看到“HPV阳性”的那一刻,很多人会感到惊慌失措,仿佛自己已经被宫颈癌“盯上”。事实上,HPV(人乳头瘤病毒)感染远比我们想象的更普遍,但它并非不可预防、不可战胜。今天,就带大家深入了解HPV,学会科学预防的有效方法。认识HPV:并非“洪水猛兽”H P V是一个庞大的病毒“家族”,目前已发现超过200种亚型,根据致癌性可分为低危型和高危型。低危型HPV如6型、11型,主要引起生殖器疣等良性病变。高危型HPV如16型、18型,持续感染可能引发宫颈癌、肛门癌等恶性肿瘤,其中宫颈癌是与HPV感染关系最为密切的癌症。展开更多
文摘This study aims to evaluate the clinical effectiveness of different drug treatment regimens for cervical high-risk human papillomavirus (HR-HPV) infection. Through literature review and randomized group experiment design, the study compares the HPV-DNA clearance rate, TCT results, and colposcopic biopsy findings among the control group, interferon group, and combination treatment group after six months of treatment. The results indicate that recombinant human interferon-2b vaginal effervescent tablets can effectively improve HPV clearance and reduce the risk of lesion progression, although individual responses to treatment vary. Combination therapy may enhance treatment efficacy by boosting immune response. The study also explores the relationship between drug treatment, viral load, cervical lesions, and vaginal microecology, providing scientific support for clinical medication decisions and offering a detailed analysis of the role of pharmacological intervention in the prognosis of HR-HPV infections.
基金The National Natural Science Foundation of China(81674011)。
文摘Objective:This study conducted a systematic review of randomized controlled trials in order to evaluate the efficacy and safety of Baofukang Suppository(保妇康栓)combined with interferon on cervical high-risk human papillomavirus(HR-HPV)infection.Methods:Data comes from China National Knowledge Infrastructure(CNKI),Wanfang database,the VIP information database,Chinese Biomedical Literature Database,PubMed,Cochrane Library,Web of Science and Embase.Primary and secondary outcome measures were extracted from 13 included randomized controlled trials:number of HR-HPV turning negative and effective,time of HPV turning negative,duration of abnormal vaginal secretions and adverse events.Results:Baofukang Suppository combined with interferon were better than interferon alone in improving the negative rate of HR-HPV(RR=1.42,95%CI[1.28,1.58],P<0.00001)and the effective rate of HR-HPV RR=1.3,95%CI[1.24,1.37],P<0.00001),time of HR-HPV turning negative(MD=-8.32,95%CI[-9.17,-7.47],P<0.00001),duration of abnormal vaginal secretions(MD=-8.95,95%CI[-11.34,-6.56],P<0.00001).However,there was no statistical difference in improving inflammatory factor(TNF-α:SMD=-0.49,95%CI[-1.02,0.03],Z=1.83,P=0.07;IL-6:SMD=-13.69,95%CI[-41.98,14.6],Z=0.95,P=0.34)and adverse events(RR=-0.73,95%CI[0.48,1.11,P=0.15)between two groups.Conclusion:The results showed that the efficacy of Baofukang Suppository combined with interferon were better than interferon alone in improving the negative and effective rate of HR-HPV,shortening the time of HR-HPV turning negative and duration of abnormal vaginal secretion and reducing adverse events.
基金This work was supported by the Natural Science Foundation of Hubei Province, China (No.2017CKC891).
文摘High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child Health Hospital of Hubei Province.Each participant accepted hrHPV testing and completed a self^administered questionnaire about basic information and potential risk factors.The univariable and multivariable logistic regression model was used to explore the associations between variants and hrHPV infection.Our results showed that hrHPV prevalence was 16.09% in Hubei Province,among which,hrHPV was more likely to be positive in women aged 51 years or above (OR=1.65,95% CI:1.28-2.14),and in women who had symptoms of bleeding after intercourse (OR=1.32,95% CI:1.17-1.50),had first sexual intercourse at the age of 18 years or below (OR=1.33,95% CI:1.07-1.64),had at least three male sexual partners (OR=2.50,95% CI:2.07-3.03),and who had been diagnosed with sexually transmitted infections (OR=1.50,95% CI:1.12-2.03).Married women (OR=0.66,95% CI:0.55-0.78) and women who frequently used condoms (OR=0.75,95% CI:0.67-0.84) had a relatively lower hrHPV prevalence.This study confirms that hrHPV infection was associated with age,marital status,symptoms of intercourse bleeding,history of sexually transmitted infections,and sex-related behaviors.Above all,this study provides a baseline database prior to obtaining vaccinations for dynamic tracking of the changes in hrHPV prevalence.
文摘Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the potential to eradicate cervical cancer. In-country evidence of sub-types of HPV associated with cervical cancer is scanty, thus necessitating this study. Methods: A cross-sectional study was performed using a multistage sampling technique. A molecular technique using the Cobas 4800 machine was used for genotyping. Results: 570 participants were recruited for the study. The mean age of the participants was 32.4 ± 5.2 years. The age of sexual debut ranged from 15 - 24 years with a median of 19 years. 194 participants were positive for high-risk HPV giving a prevalence of 34%. 3% (n = 17) were positive for HPV, 16. 4% (23) had a positive result for HPV, 18. 27% (n = 154) had a positive result for other high-risk groups (OHR) other than HPV 16 or 18. Positive status for high-risk HPV is associated with the presence of genital warts (OR = 7.5), a Positive HIV status (OR = 3.48), abnormal vaginal discharge (OR = 2.20), multiple sexual partners (OR = 2.30), and obesity (OR = 2.70). The prevalence of HIV in the study population was 6.84% (n = 39). Conclusion: Another High-risk HPV other than 16 and 18 appears to be the predominant form of HPV infection in Nigerian women. The risk of being positive for high-risk HPV is associated with the presence of genital warts, abnormal vaginal discharge, a positive HIV status, multiple sexual partners and Obesity. It is therefore necessary to disaggregate and study these high-risk sub-types.
文摘Objective:To study the relationship between the infection of high-risk HPV in cervical precancerous lesion and the expression of oncogene, anti-oncogene.Methods:218 cases ofcervical intraepithelial neoplasia patients in our hospital during May 2014–May 2016 were chosed and divided into high-risk HPV group (n=107), low-risk HPV group (n=111) according to cervical tissue HPV test;another 100 cases of patients received cervical biopsy and confirmed as benign lesions were enrolled in the control group. RT-PCR method was used to detect the mRNA expression of proto-oncogene and anti-oncogene in three groups, Western-blot method was used to detect the protein expression of Sox-2 and Wnt/β-catenin signal pathway.Results: mRNA expression of oncogene DEK, Bmi-1, c-fos, K-ras, Prdx4 in high-risk HPV group were higher than low-risk HPV group and control group (P<0.05);mRNA expression of anti-oncogene P27, P16, DAPK, PTEN, eIF4E3 in high-risk HPV group were lower than low-risk HPV group and control group (P<0.05);expression of Sox-2 and Wnt/β-catenin signaling pathway protein Sox-2,β-catenin, wnt-1, wnt-3a in high-risk HPV group were higher than low-risk HPV group and control group (P<0.05).Conclusions:High-risk HPV infection can increase the expression of oncogenes and reduce the expression of anti-oncogenes in cervical dysplasia tissues on Sox-2- and Wnt/β-catenin signaling pathway manners.
文摘Human papillomavirus(HPV) is classified either as high-risk or low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the high-risk kind, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.
文摘Objective:To study the relationship of high-risk human papilloma virus (HPV) infection with mitogen-activated protein kinase/extracellular signal-regulated kinase 3 (MEKK3) and nuclear factorκB (NF-κB) expression in cervical intraepithelial neoplasia tissue.Methods:125 cases of cervical biopsy specimens between May 2013 and March 2016 were collected. The cervical inflammation specimens, cervical intraepithelial neoplasia specimens and cervical cancer specimens were included in inflammation group, CIN group and malignant group respectively. HPV-DNA typing detection kits were used to determine HPV typing, immunohistochemical kits were used to determine MEKK3 and NF-κB protein expression, and fluorescent quantitative PCR kits were used to determine the mRNA expression of MEKK3, NF-κB and downstream molecules.Results: MEKK3 and NF-κB protein expression in high-risk HPV-positive cervical tissue were significantly higher than those in high-risk HPV-negative cervical tissue (P<0.05), and MEKK3, NF-κB, Bcl-2, XIAP, Bmi-1, TGF-β and Vimentin mRNA expression in high-risk type HPV-positive cervical tissue were significantly higher than those in high-risk HPV-negative cervical tissue (P<0.05);Bcl-2, XIAP, Bmi-1, TGF-β and Vimentin mRNA expression in tissue with positive MEKK3 and NF-κB expression were significantly higher than those in tissue with negative MEKK3 and NF-κB expression (P<0.05).Conclusions:High-risk HPV infection will increase the expression of proliferation genes Bcl-2, XIAP and Bmi-1 as well as invasion genes TGF-β and Vimentin in cervical intraepithelial neoplasia tissue through MEKK3/NF-κB pathway.
文摘Background: Cervical cancer is a significant global public health issue, with an effective screening strategy being a key challenge in its prevention. The primary objective of this study was to determine the prevalence of HPV and assess the contribution of molecular screening to primary cervical cancer detection in Dakar. Patients and Method: This cross-sectional study was conducted from January 2016 to December 2020. We compared cervico-vaginal smear results, classified according to the Bethesda 2014 system, with molecular screening results from the Cobas® 4800 HPV test (Roche). Additionally, we conducted a survey of health facilities in the Dakar medical region to evaluate the availability and accessibility (cost) of molecular testing. Results: A total of 106 patient files were analyzed. The mean age of the patients was 43.6 years (range: 22 - 76 years). Smears were normal in 41.5% of cases. Detected lesions included ASCUS (49.1%), LSIL (5.7%), and HSIL (3.8%). The overall prevalence of HPV infection was 30.2%, with non-genotype 16/18 high-risk HPV (HR HPV) infections being the most common (73%). Genotypes 16 and 18 were found in 16% and 11% of cases, respectively. Among normal smears, HPV was present in 11.3% of cases. HPV typing was positive in 40.3% of ASCUS smears and 83.3% of LSILs. HPV testing identified 85% of lesions classified as CIN2 or higher, compared to only 70% detected through cytology. The survey revealed that molecular HPV screening was unavailable in referral hospitals, and the high cost of testing in the private sector posed a significant barrier to access. Conclusion: Cervical cancer remains a serious public health issue in Senegal. The proven effectiveness of preventive measures, such as vaccination against the most oncogenic HPV types and molecular screening for HPV detection, could significantly reduce the incidence of this disease.
文摘过去数十年,子宫颈癌的防控推动了高危人乳头瘤病毒(high-risk human papilloma virus,HR-HPV)研究的深入,除了女性外,男性也是HPV感染的重要宿主,其感染的流行病学特征及防控措施尚处于研究“洼地”。我国作为HPV感染高负担国家,男性HPV相关疾病(如肛门癌、肛门生殖器疣)的发病率持续攀升。本文将从流行病学、疾病负担、传播风险、检测技术及疫苗防控五个维度,分析男性HPV感染的研究现状与预防,提出男性HPV感染需要关注的问题。
文摘在体检报告上看到“HPV阳性”的那一刻,很多人会感到惊慌失措,仿佛自己已经被宫颈癌“盯上”。事实上,HPV(人乳头瘤病毒)感染远比我们想象的更普遍,但它并非不可预防、不可战胜。今天,就带大家深入了解HPV,学会科学预防的有效方法。认识HPV:并非“洪水猛兽”H P V是一个庞大的病毒“家族”,目前已发现超过200种亚型,根据致癌性可分为低危型和高危型。低危型HPV如6型、11型,主要引起生殖器疣等良性病变。高危型HPV如16型、18型,持续感染可能引发宫颈癌、肛门癌等恶性肿瘤,其中宫颈癌是与HPV感染关系最为密切的癌症。
