High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-co...High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-corrected transmission electron microscopy constrain resolution.A machine learning algorithm is developed to determine the aberration parameters with higher precision from small,lattice-periodic crystal images.The proposed algorithm is then validated with simulated HRTEM images of graphene and applied to the experimental images of a molybdenum disulfide(MoS_(2))monolayer with 25 variables(14 aberrations)resolved in wide ranges.Using these measured parameters,the phases of the exit-wave functions are reconstructed for each image in a focal series of MoS_(2)monolayers.The images were acquired due to the unexpected movement of the specimen holder.Four-dimensional data extraction reveals time-varying atomic structures and ripple.In particular,the atomic evolution of the sulfur-vacancy point and line defects,as well as the edge structure near the amorphous,is visualized as the resolution has been improved from about 1.75?to 0.9 A.This method can help salvage important transmission electron microscope images and is beneficial for the images obtained from electron microscopes with average stability.展开更多
Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-...Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.展开更多
Scale variation is amajor challenge inmulti-person pose estimation.In scenes where persons are present at various distances,models tend to perform better on larger-scale persons,while the performance for smaller-scale...Scale variation is amajor challenge inmulti-person pose estimation.In scenes where persons are present at various distances,models tend to perform better on larger-scale persons,while the performance for smaller-scale persons often falls short of expectations.Therefore,effectively balancing the persons of different scales poses a significant challenge.So this paper proposes a newmulti-person pose estimation model called FSANet to improve themodel’s performance in complex scenes.Our model utilizes High-Resolution Network(HRNet)as the backbone and feeds the outputs of the last stage’s four branches into the DCB module.The dilated convolution-based(DCB)module employs a parallel structure that incorporates dilated convolutions with different rates to expand the receptive field of each branch.Subsequently,the attention operation-based(AOB)module performs attention operations at both branch and channel levels to enhance high-frequency features and reduce the influence of noise.Finally,predictions are made using the heatmap representation.The model can recognize images with diverse scales and more complex semantic information.Experimental results demonstrate that FSA Net achieves competitive results on the MSCOCO and MPII datasets,validating the effectiveness of our proposed approach.展开更多
The integration of Unmanned Aerial Vehicles(UAVs)into Intelligent Transportation Systems(ITS)holds trans-formative potential for real-time traffic monitoring,a critical component of emerging smart city infrastructure....The integration of Unmanned Aerial Vehicles(UAVs)into Intelligent Transportation Systems(ITS)holds trans-formative potential for real-time traffic monitoring,a critical component of emerging smart city infrastructure.UAVs offer unique advantages over stationary traffic cameras,including greater flexibility in monitoring large and dynamic urban areas.However,detecting small,densely packed vehicles in UAV imagery remains a significant challenge due to occlusion,variations in lighting,and the complexity of urban landscapes.Conventional models often struggle with these issues,leading to inaccurate detections and reduced performance in practical applications.To address these challenges,this paper introduces CFEMNet,an advanced deep learning model specifically designed for high-precision vehicle detection in complex urban environments.CFEMNet is built on the High-Resolution Network(HRNet)architecture and integrates a Context-aware Feature Extraction Module(CFEM),which combines multi-scale feature learning with a novel Self-Attention and Convolution layer setup within a Multi-scale Feature Block(MFB).This combination allows CFEMNet to accurately capture fine-grained details across varying scales,crucial for detecting small or partially occluded vehicles.Furthermore,the model incorporates an Equivalent Feed-Forward Network(EFFN)Block to ensure robust extraction of both spatial and semantic features,enhancing its ability to distinguish vehicles from similar objects.To optimize computational efficiency,CFEMNet employs a local window adaptation of Multi-head Self-Attention(MSA),which reduces memory overhead without sacrificing detection accuracy.Extensive experimental evaluations on the UAVDT and VisDrone-DET2018 datasets confirm CFEMNet’s superior performance in vehicle detection compared to existing models.This new architecture establishes CFEMNet as a benchmark for UAV-enabled traffic management,offering enhanced precision,reduced computational demands,and scalability for deployment in smart city applications.The advancements presented in CFEMNet contribute significantly to the evolution of smart city technologies,providing a foundation for intelligent and responsive traffic management systems that can adapt to the dynamic demands of urban environments.展开更多
Sanduao is an important sea-breeding bay in Fujian,South China and holds a high economic status in aquaculture.Quickly and accurately obtaining information including the distribution area,quantity,and aquaculture area...Sanduao is an important sea-breeding bay in Fujian,South China and holds a high economic status in aquaculture.Quickly and accurately obtaining information including the distribution area,quantity,and aquaculture area is important for breeding area planning,production value estimation,ecological survey,and storm surge prevention.However,as the aquaculture area expands,the seawater background becomes increasingly complex and spectral characteristics differ dramatically,making it difficult to determine the aquaculture area.In this study,we used a high-resolution remote-sensing satellite GF-2 image to introduce a deep-learning Richer Convolutional Features(RCF)network model to extract the aquaculture area.Then we used the density of aquaculture as an assessment index to assess the vulnerability of aquaculture areas in Sanduao.The results demonstrate that this method does not require land and water separation of the area in advance,and good extraction can be achieved in the areas with more sediment and waves,with an extraction accuracy>93%,which is suitable for large-scale aquaculture area extraction.Vulnerability assessment results indicate that the density of aquaculture in the eastern part of Sanduao is considerably high,reaching a higher vulnerability level than other parts.展开更多
To generate realistic three-dimensional animation of virtual character,capturing real facial expression is the primary task.Due to diverse facial expressions and complex background,facial landmarks recognized by exist...To generate realistic three-dimensional animation of virtual character,capturing real facial expression is the primary task.Due to diverse facial expressions and complex background,facial landmarks recognized by existing strategies have the problem of deviations and low accuracy.Therefore,a method for facial expression capture based on two-stage neural network is proposed in this paper which takes advantage of improved multi-task cascaded convolutional networks(MTCNN)and high-resolution network.Firstly,the convolution operation of traditional MTCNN is improved.The face information in the input image is quickly filtered by feature fusion in the first stage and Octave Convolution instead of the original ones is introduced into in the second stage to enhance the feature extraction ability of the network,which further rejects a large number of false candidates.The model outputs more accurate facial candidate windows for better landmarks recognition and locates the faces.Then the images cropped after face detection are input into high-resolution network.Multi-scale feature fusion is realized by parallel connection of multi-resolution streams,and rich high-resolution heatmaps of facial landmarks are obtained.Finally,the changes of facial landmarks recognized are tracked in real-time.The expression parameters are extracted and transmitted to Unity3D engine to drive the virtual character’s face,which can realize facial expression synchronous animation.Extensive experimental results obtained on the WFLW database demonstrate the superiority of the proposed method in terms of accuracy and robustness,especially for diverse expressions and complex background.The method can accurately capture facial expression and generate three-dimensional animation effects,making online entertainment and social interaction more immersive in shared virtual space.展开更多
Safety production is of great significance to the development of enterprises and society.Accidents often cause great losses because of the particularity environment of electric power.Therefore,it is important to impro...Safety production is of great significance to the development of enterprises and society.Accidents often cause great losses because of the particularity environment of electric power.Therefore,it is important to improve the safety supervision and protection in the electric power environment.In this paper,we simulate the actual electric power operation scenario by monitoring equipment and propose a real-time detection method of illegal actions based on human body key points to ensure safety behavior in real time.In this method,the human body key points in video frames were first extracted by the high-resolution network,and then classified in real time by spatial-temporal graph convolutional network.Experimental results show that this method can effectively detect illegal actions in the simulated scene.展开更多
基金financial support from the National Natural Science Foundation of China(Grant No.61971201)。
文摘High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-corrected transmission electron microscopy constrain resolution.A machine learning algorithm is developed to determine the aberration parameters with higher precision from small,lattice-periodic crystal images.The proposed algorithm is then validated with simulated HRTEM images of graphene and applied to the experimental images of a molybdenum disulfide(MoS_(2))monolayer with 25 variables(14 aberrations)resolved in wide ranges.Using these measured parameters,the phases of the exit-wave functions are reconstructed for each image in a focal series of MoS_(2)monolayers.The images were acquired due to the unexpected movement of the specimen holder.Four-dimensional data extraction reveals time-varying atomic structures and ripple.In particular,the atomic evolution of the sulfur-vacancy point and line defects,as well as the edge structure near the amorphous,is visualized as the resolution has been improved from about 1.75?to 0.9 A.This method can help salvage important transmission electron microscope images and is beneficial for the images obtained from electron microscopes with average stability.
基金supported by the Natural Science Foundation of Hubei Provincial Department of Education(D20232101)Shandong Second Medical University 2024 Affiliated Hospital(Teaching Hospital)Scientific Research Development Fund Project(2024FYQ026)+3 种基金the innovative Research Programme of Xiangyang No.1 People’s Hospital(XYY2023ZY01)Faculty Development Grants of Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine(XYY2023D05)Joint supported by Hubei Provincial Natural Science Foundation and Xiangyang of China(2025AFD091)Traditional Chinese Medicine Scientific Research Project of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2025D019).
文摘Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.
基金supported in part by the National Natural Science Foundation of China 6167246662011530130,Joint Fund of Zhejiang Provincial Natural Science Foundation LSZ19F010001.
文摘Scale variation is amajor challenge inmulti-person pose estimation.In scenes where persons are present at various distances,models tend to perform better on larger-scale persons,while the performance for smaller-scale persons often falls short of expectations.Therefore,effectively balancing the persons of different scales poses a significant challenge.So this paper proposes a newmulti-person pose estimation model called FSANet to improve themodel’s performance in complex scenes.Our model utilizes High-Resolution Network(HRNet)as the backbone and feeds the outputs of the last stage’s four branches into the DCB module.The dilated convolution-based(DCB)module employs a parallel structure that incorporates dilated convolutions with different rates to expand the receptive field of each branch.Subsequently,the attention operation-based(AOB)module performs attention operations at both branch and channel levels to enhance high-frequency features and reduce the influence of noise.Finally,predictions are made using the heatmap representation.The model can recognize images with diverse scales and more complex semantic information.Experimental results demonstrate that FSA Net achieves competitive results on the MSCOCO and MPII datasets,validating the effectiveness of our proposed approach.
基金funded by the Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia through research group No.(RG-NBU-2022-1234).
文摘The integration of Unmanned Aerial Vehicles(UAVs)into Intelligent Transportation Systems(ITS)holds trans-formative potential for real-time traffic monitoring,a critical component of emerging smart city infrastructure.UAVs offer unique advantages over stationary traffic cameras,including greater flexibility in monitoring large and dynamic urban areas.However,detecting small,densely packed vehicles in UAV imagery remains a significant challenge due to occlusion,variations in lighting,and the complexity of urban landscapes.Conventional models often struggle with these issues,leading to inaccurate detections and reduced performance in practical applications.To address these challenges,this paper introduces CFEMNet,an advanced deep learning model specifically designed for high-precision vehicle detection in complex urban environments.CFEMNet is built on the High-Resolution Network(HRNet)architecture and integrates a Context-aware Feature Extraction Module(CFEM),which combines multi-scale feature learning with a novel Self-Attention and Convolution layer setup within a Multi-scale Feature Block(MFB).This combination allows CFEMNet to accurately capture fine-grained details across varying scales,crucial for detecting small or partially occluded vehicles.Furthermore,the model incorporates an Equivalent Feed-Forward Network(EFFN)Block to ensure robust extraction of both spatial and semantic features,enhancing its ability to distinguish vehicles from similar objects.To optimize computational efficiency,CFEMNet employs a local window adaptation of Multi-head Self-Attention(MSA),which reduces memory overhead without sacrificing detection accuracy.Extensive experimental evaluations on the UAVDT and VisDrone-DET2018 datasets confirm CFEMNet’s superior performance in vehicle detection compared to existing models.This new architecture establishes CFEMNet as a benchmark for UAV-enabled traffic management,offering enhanced precision,reduced computational demands,and scalability for deployment in smart city applications.The advancements presented in CFEMNet contribute significantly to the evolution of smart city technologies,providing a foundation for intelligent and responsive traffic management systems that can adapt to the dynamic demands of urban environments.
文摘针对因遮挡和自相似性导致的从单张RGB图像估计三维手部姿态不精确的问题,提出结合注意力机制和多尺度特征融合的三维手部姿态估计算法。首先,提出结合扩张卷积和CBAM(Convolutional Block Attention Module)注意力机制的感受强化模块(SEM),以替换沙漏网络(HGNet)中的基本块(Basicblock),在扩大感受野的同时增强对空间信息的敏感性,从而提高手部特征的提取能力;其次,设计一种结合SPCNet(Spatial Preserve and Contentaware Network)和Soft-Attention改进的多尺度信息融合模块SS-MIFM(SPCNet and Soft-attention-Multi-scale Information Fusion Module),在充分考虑空间内容感知机制的情况下,有效地聚合多级特征,并显著提高二维手部关键点检测的准确性;最后,利用2.5D姿态转换模块将二维姿态转换为三维姿态,从而避免二维关键点坐标直接回归计算三维姿态信息导致的空间丢失问题。实验结果表明,在InterHand2.6M数据集上,所提算法的双手关节点平均误差(MPJPE)、单手MPJPE和根节点平均误差(MRRPE)分别达到了12.32、9.96和29.57 mm;在RHD(Rendered Hand pose Dataset)上,与InterNet和QMGR-Net算法相比,所提算法的终点误差(EPE)分别降低了2.68和0.38 mm。以上结果说明了所提算法能够更准确地估计手部姿态,且在一些双手交互和遮挡的场景下有更高的鲁棒性。
基金Supported by the National Key Research and Development Program of China(No.2016YFC1402003)the National Natural Science Foundation of China(No.41671436)the Innovation Project of LREIS(No.O88RAA01YA)
文摘Sanduao is an important sea-breeding bay in Fujian,South China and holds a high economic status in aquaculture.Quickly and accurately obtaining information including the distribution area,quantity,and aquaculture area is important for breeding area planning,production value estimation,ecological survey,and storm surge prevention.However,as the aquaculture area expands,the seawater background becomes increasingly complex and spectral characteristics differ dramatically,making it difficult to determine the aquaculture area.In this study,we used a high-resolution remote-sensing satellite GF-2 image to introduce a deep-learning Richer Convolutional Features(RCF)network model to extract the aquaculture area.Then we used the density of aquaculture as an assessment index to assess the vulnerability of aquaculture areas in Sanduao.The results demonstrate that this method does not require land and water separation of the area in advance,and good extraction can be achieved in the areas with more sediment and waves,with an extraction accuracy>93%,which is suitable for large-scale aquaculture area extraction.Vulnerability assessment results indicate that the density of aquaculture in the eastern part of Sanduao is considerably high,reaching a higher vulnerability level than other parts.
基金This research was funded by College Student Innovation and Entrepreneurship Training Program,grant number 2021055Z and S202110082031the Special Project for Cultivating Scientific and Technological Innovation Ability of College and Middle School Students in Hebei Province,Grant Number 2021H011404.
文摘To generate realistic three-dimensional animation of virtual character,capturing real facial expression is the primary task.Due to diverse facial expressions and complex background,facial landmarks recognized by existing strategies have the problem of deviations and low accuracy.Therefore,a method for facial expression capture based on two-stage neural network is proposed in this paper which takes advantage of improved multi-task cascaded convolutional networks(MTCNN)and high-resolution network.Firstly,the convolution operation of traditional MTCNN is improved.The face information in the input image is quickly filtered by feature fusion in the first stage and Octave Convolution instead of the original ones is introduced into in the second stage to enhance the feature extraction ability of the network,which further rejects a large number of false candidates.The model outputs more accurate facial candidate windows for better landmarks recognition and locates the faces.Then the images cropped after face detection are input into high-resolution network.Multi-scale feature fusion is realized by parallel connection of multi-resolution streams,and rich high-resolution heatmaps of facial landmarks are obtained.Finally,the changes of facial landmarks recognized are tracked in real-time.The expression parameters are extracted and transmitted to Unity3D engine to drive the virtual character’s face,which can realize facial expression synchronous animation.Extensive experimental results obtained on the WFLW database demonstrate the superiority of the proposed method in terms of accuracy and robustness,especially for diverse expressions and complex background.The method can accurately capture facial expression and generate three-dimensional animation effects,making online entertainment and social interaction more immersive in shared virtual space.
基金the Science and Technology Program of State Grid Corporation of China(No.5211TZ1900S6)。
文摘Safety production is of great significance to the development of enterprises and society.Accidents often cause great losses because of the particularity environment of electric power.Therefore,it is important to improve the safety supervision and protection in the electric power environment.In this paper,we simulate the actual electric power operation scenario by monitoring equipment and propose a real-time detection method of illegal actions based on human body key points to ensure safety behavior in real time.In this method,the human body key points in video frames were first extracted by the high-resolution network,and then classified in real time by spatial-temporal graph convolutional network.Experimental results show that this method can effectively detect illegal actions in the simulated scene.
