Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-...Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.展开更多
High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-co...High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-corrected transmission electron microscopy constrain resolution.A machine learning algorithm is developed to determine the aberration parameters with higher precision from small,lattice-periodic crystal images.The proposed algorithm is then validated with simulated HRTEM images of graphene and applied to the experimental images of a molybdenum disulfide(MoS_(2))monolayer with 25 variables(14 aberrations)resolved in wide ranges.Using these measured parameters,the phases of the exit-wave functions are reconstructed for each image in a focal series of MoS_(2)monolayers.The images were acquired due to the unexpected movement of the specimen holder.Four-dimensional data extraction reveals time-varying atomic structures and ripple.In particular,the atomic evolution of the sulfur-vacancy point and line defects,as well as the edge structure near the amorphous,is visualized as the resolution has been improved from about 1.75?to 0.9 A.This method can help salvage important transmission electron microscope images and is beneficial for the images obtained from electron microscopes with average stability.展开更多
[Objective]The paper aimed to effectively reduce the occurrence of bacterial resistance associated with breeding practices and to mitigate food safety risks by controlling the illegal use of veterinary drugs in self-f...[Objective]The paper aimed to effectively reduce the occurrence of bacterial resistance associated with breeding practices and to mitigate food safety risks by controlling the illegal use of veterinary drugs in self-formulated feed at the source.[Method]A screening database comprising 274 illegally added chemical drugs in self-formulated feed was established utilizing ultra-performance liquid chromatography coupled with quadrupole/electrostatic field orbitrap high-resolution mass spectrometry(HPLC-Q-Exactive Focus/MS).Subsequently,253 batches of self-formulated feed samples from various farms in Hebei Province were screened and quantitatively analyzed.[Result]The screening results indicated the presence of 8 pharmaceutical components across 10 batches of self-formulated feed samples,with a detection rate of 3.2%and concentrations ranging from 0.06 to 28851.8μg/g.[Conclusion]The application of high-resolution mass spectrometry is feasible and highly significant for the risk monitoring of illegally added drugs in self-formulated feed.展开更多
While algorithms have been created for land usage in urban settings,there have been few investigations into the extraction of urban footprint(UF).To address this research gap,the study employs several widely used imag...While algorithms have been created for land usage in urban settings,there have been few investigations into the extraction of urban footprint(UF).To address this research gap,the study employs several widely used image classification method classified into three categories to evaluate their segmentation capabilities for extracting UF across eight cities.The results indicate that pixel-based methods only excel in clear urban environments,and their overall accuracy is not consistently high.RF and SVM perform well but lack stability in object-based UF extraction,influenced by feature selection and classifier performance.Deep learning enhances feature extraction but requires powerful computing and faces challenges with complex urban layouts.SAM excels in medium-sized urban areas but falters in intricate layouts.Integrating traditional and deep learning methods optimizes UF extraction,balancing accuracy and processing efficiency.Future research should focus on adapting algorithms for diverse urban landscapes to enhance UF extraction accuracy and applicability.展开更多
BACKGROUND Rectal cancer is a common malignant tumor of the digestive system,with older patients representing the predominantly affected population.Magnetic resonance imaging(MRI)has been widely applied in preoperativ...BACKGROUND Rectal cancer is a common malignant tumor of the digestive system,with older patients representing the predominantly affected population.Magnetic resonance imaging(MRI)has been widely applied in preoperative tumor assessment;however,the value of high-resolution MRI(HR-MRI)combined with dynamic contrast-enhanced(DCE)scanning in the preoperative diagnosis of rectal cancer in older patients remains unclear.AIM To evaluate the value of HR-MRI combined with DCE scanning in the preoperative diagnosis of rectal cancer in older patients.METHODS This retrospective study included 148 consecutive older female patients with rectal cancer who were treated at our hospital between December 2020 and December 2024.Clinical data and HR-MRI and DCE scan findings were collected.Histopathological examination after surgical resection served as the gold standard.The diagnostic accuracy of MRI for preoperative T and N staging was calculated.Consistency,sensitivity,and specificity between HR-MRI combined with DCE scanning and pathological staging were analyzed using the k test.Among the 148 patients,the overall accuracy of T staging was 84.5%.Sensitivity for T1,T2,T3,and T4 staging was 75.00%,62.50%,89.47%,and 90.48%,respectively,whereas specificity was 100.00%,94.35%,79.25%,and 96.06%,respectively.T staging based on HR-MRI combined with DCE scanning showed good agreement with pathological staging(k=0.8176,P<0.001).For N staging,sensitivity and specificity were 54.88%and 84.85%for N0,36.96%and 72.55%for N1,and 70.00%and 73.44%for N2,respectively;agreement with pathological N staging was poor(k=0.259,P<0.001).CONCLUSION HR-MRI combined with DCE scanning demonstrates high diagnostic accuracy for T staging of rectal cancer in older patients and can provide a theoretical basis for treatment planning.However,its diagnostic accuracy for N staging requires improvement.展开更多
Severe acute respiratory syndrome (SARS) is an acute respiratory infectious disease caused by a novel coronavirus, firstly broke out in November 2002 in Guangdong and prevailed quickly in Beijing, Hong Kong, Taiwan an...Severe acute respiratory syndrome (SARS) is an acute respiratory infectious disease caused by a novel coronavirus, firstly broke out in November 2002 in Guangdong and prevailed quickly in Beijing, Hong Kong, Taiwan and other regions of China. It was one of the most potential pandemic diseases and had affected more than 20 other countries.^(1,2) There have been a lot of resear-ches^(2-7) in terms of its etiology, epidemiology, pathogenesis, clinical characteristics, diagnostics, treatment and prevention, vaccines and so on.Along with control of the epidemic situation, a great number of SARS patients were in the recovery phase, therefore, we undertook a half-year follow-up investigation on their clinical, laboratory and image situations.展开更多
Projections of future precipitation change over China are studied based on the output of a global AGCM, ECHAM5, with a high resolution of T319 （equivalent to 40 km）. Evaluation of the model’s performance in simulat...Projections of future precipitation change over China are studied based on the output of a global AGCM, ECHAM5, with a high resolution of T319 （equivalent to 40 km）. Evaluation of the model’s performance in simulating present-day precipitation shows encouraging results. The spatial distributions of both mean and extreme precipitation, especially the locations of main precipitation centers, are reproduced reasonably. The simulated annual cycle of precipitation is close to the observed. The performance of the model over eastern China is generally better than that over western China. A weakness of the model is the overestimation of precipitation over northern and western China. Analyses on the potential change in precipitation projected under the A1B scenario show that both annual mean precipitation intensity and extreme precipitation would increase significantly over southeastern China. The percentage increase in extreme precipitation is larger than that of mean precipitation. Meanwhile, decreases in mean and extreme precipitation are evident over the southern Tibetan Plateau. For precipitation days, extreme precipitation days are projected to increase over all of China. Both consecutive dry days over northern China and consecutive wet days over southern China would decrease.展开更多
Objective: To test the feasibility of measuring fine temporal bone structures using a newly established cone-beam computed tomography(CBCT)system.Materials and methods: Six formalin-fixed human cadaver temporal bones ...Objective: To test the feasibility of measuring fine temporal bone structures using a newly established cone-beam computed tomography(CBCT)system.Materials and methods: Six formalin-fixed human cadaver temporal bones were imaged using a high-resolution CBCT system that has 900 frames and copper t aluminum filtration. Fine temporal bone structures, including those of the facial nerve canal and vestibular structures, were identified and measured.Results: The fine structures of the middle ear, including the tympanic membrane, tendon of the tensor tympani, cochleariform process of the semicanal of the tensor tympani, pyramidal eminence, footplate of the stapes, full path of the facial nerve within the temporal bone, supralabyrinthine space, semicircular canals, pathway of the subarcuate canal, and full path of the vestibular aqueduct, were clearly demonstrated. The vestibular aqueduct has a midpoint width of 0.4 ± 0.0 mm and opercular width of 0.5 ± 0.1 mm(mean ± SD). The length of the internal acoustic meatus was 10.6 ± 1.2 mm(mean ± SD), and the diameter of the internal acoustic meatus was 3.7 ± 0.3 mm(mean ± SD).Conclusion: This novel high-resolution CBCT system has potentially broad applications in the diagnosis of inner ear disease and in monitoring associated pathological changes, surgical planning, navigation for the ear surgery, and temporal bone training.展开更多
A profile of shallow crustal velocity structure(1–2 km) may greatly enhance interpretation of the sedimentary environment and shallow tectonic deformation.Recent advances in surface wave tomography, using ambient noi...A profile of shallow crustal velocity structure(1–2 km) may greatly enhance interpretation of the sedimentary environment and shallow tectonic deformation.Recent advances in surface wave tomography, using ambient noise data recorded with high-density seismic arrays, have improved the understanding of regional crustal structure. As the interest in detailed shallow crustal structure imaging has increased, dense seismic array methods have become increasingly efficient. This study used a high-density seismic array deployed in the Xinjiang basin in southeastern China, to record seismic data, which was then processed with the ambient noise tomography method. The high-density seismic array contained 203 short-period seismometers, spaced at short intervals(～ 400 m). The array collected continuous records of ambient noise for 32 days. Data preprocessing,cross correlation calculation, and Rayleigh surface wave phase-velocity dispersion curve extraction, yielded more than 16,000 Rayleigh surface wave phase-velocity dispersion curves, which were then analyzed using the direct-inversion method. Checkerboard tests indicate that the shear wave velocity is recovered in the study area, at depths of 0–1.4 km,with a lateral image resolution of ～ 400 m. Model test results show that the seismic array effectively images a 50 m thick slab at a depth of 0–300 m, a 150 m thick anomalous body at a depth of 300–600 m, and a 400 m thick anomalous body at a depth of 0.6–1.4 km. The shear wave velocity profile reveals features very similar to those detected by a deep seismic reflection profile across the study area. This demonstrates that analysis of shallow crustal velocity structure provides high-resolution imaging of crustal features.Thus, ambient noise tomography with a high-density seismic array may play an important role in imaging shallow crustal structure.展开更多
Using the Community Earth System Model framework, the authors build a very-high-resolution quasi-global coupled model by coupling an eddy-resolving quasi-global ocean model with a high-resolution atmospheric model. Th...Using the Community Earth System Model framework, the authors build a very-high-resolution quasi-global coupled model by coupling an eddy-resolving quasi-global ocean model with a high-resolution atmospheric model. The model is successfully run for six years under present climate conditions, and the simulations are evaluated against observational and reanalysis data.The model is capable of simulating large-scale oceanic and atmospheric circulation patterns, sea surface temperature(SST) fronts, oceanic eddy kinetic energy, and fine-scale structures of surface winds. The ocean mesoscale structure–induced air–sea interaction characteristics are explored in detail. The model can effectively reproduce positive correlations between SST and surface wind stress induced by mesoscale structures through comparison with observations. The positive correlation is particularly significant over regions with strong oceanic fronts and eddies.However, the responses of wind stress to eddy-induced SST are weaker in the simulation than in the observations, although different magnitudes exist in different areas. Associated with weak wind responses, surface sensible heat flux responses to eddy-induced SST are underestimated slightly, while surface latent heat flux responses are overestimated because of the drier atmospheric boundary layers in the model. Both momentum mixing and pressure adjustment mechanisms play important roles in surface wind changes over oceanic fronts and eddies in the high-resolution model.展开更多
High-resolution ro-vibrational spectroscopy of ^15N2^16O in 1650-3450 cm-1 region is studied using highly enriched isotopologue sample. The positions of more than 7300 lines of ^15N2^16O isotopologue were measured wit...High-resolution ro-vibrational spectroscopy of ^15N2^16O in 1650-3450 cm-1 region is studied using highly enriched isotopologue sample. The positions of more than 7300 lines of ^15N2^16O isotopologue were measured with a typical accuracy of 5.0×10-4 cm-1. The transitions were rovibrationally assigned on the basis of the global effective Hamiltonian model. The band by band analysis allowed for the determination of the rovibrational parameters of a total of 73 bands. 29 of them are newly reported and more rotational transitions have been observed for the others. The maximum deviation of the preidictions of the effective Hamiltonian model is up to 0.70 cm-1 for the ^15N2^16O species.展开更多
Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses...Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.展开更多
Aiming at a novel missile-borne detector in the optional burst height proximity fuze, a self-adaptive high-resolution forward-looking imaging algorithm (SAHRFL-IA) is presented. The echo data are captured by the missi...Aiming at a novel missile-borne detector in the optional burst height proximity fuze, a self-adaptive high-resolution forward-looking imaging algorithm (SAHRFL-IA) is presented. The echo data are captured by the missile-borne detector in the target regions;thereby the azimuth angulation accuracy at the same distance dimension is improved dynamically. Thus, azimuth information of the targets in the detection area may be obtained accurately. The proposed imaging algorithm breaks through the conventional misconception of merely using azimuth discrimination curves under ideal conditions during monopulse angulation. The real-time echo data from the target region are used to perform error correction for this discrimination curve, and finally the accuracy of the azimuth angulation may reach the optimum at the same distance dimension. A series of experiments demonstrate the validity, reliability and high performance of the proposed imaging algorithm. Azimuth angulation accuracy may reach ten times that of the detection beam width. Meanwhile, the running time of this algorithm satisfies the requirements of missile-borne platforms.展开更多
BACKGROUND The quality of life in patients who develop low anterior resection syndrome(LARS)after surgery for mid-low rectal cancer is seriously impaired.The underlying pathophysiological mechanism of LARS has not bee...BACKGROUND The quality of life in patients who develop low anterior resection syndrome(LARS)after surgery for mid-low rectal cancer is seriously impaired.The underlying pathophysiological mechanism of LARS has not been fully investigated.AIM To assess anorectal function of mid-low rectal cancer patients developing LARS perioperatively.METHODS Patients diagnosed with mid-low rectal cancer were included.The LARS score was used to evaluate defecation symptoms 3 and 6 mo after anterior resection or a stoma reversal procedure.Anorectal functions were assessed by threedimensional high resolution anorectal manometry preoperatively and 3-6 mo after surgery.RESULTS The study population consisted of 24 patients.The total LARS score was decreased at 6 mo compared with 3 mo after surgery(P<0.05),but 58.3%(14/24)lasted as major LARS at 6 mo after surgery.The length of the high-pressure zone of the anal sphincter was significantly shorter,the mean resting pressure and maximal squeeze pressure of the anus were significantly lower than those before surgery in allpatients (P < 0.05), especially in the neoadjuvant therapy group after surgery (n = 18). The focalpressure defects of the anal canal were detected in 70.8% of patients, and those patients had higherLARS scores at 3 mo postoperatively than those without focal pressure defects (P < 0.05). Spasticperistaltic contractions from the new rectum to anus were detected in 45.8% of patients, whichwere associated with a higher LARS score at 3 mo postoperatively (P < 0.05).CONCLUSIONThe LARS score decreases over time after surgery in the majority of patients with mid-low rectalcancer. Anorectal dysfunctions, especially focal pressure defects of the anal canal and spasticperistaltic contractions from the new rectum to anus postoperatively, might be the majorpathophysiological mechanisms of LARS.展开更多
基金supported by the Natural Science Foundation of Hubei Provincial Department of Education(D20232101)Shandong Second Medical University 2024 Affiliated Hospital(Teaching Hospital)Scientific Research Development Fund Project(2024FYQ026)+3 种基金the innovative Research Programme of Xiangyang No.1 People’s Hospital(XYY2023ZY01)Faculty Development Grants of Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine(XYY2023D05)Joint supported by Hubei Provincial Natural Science Foundation and Xiangyang of China(2025AFD091)Traditional Chinese Medicine Scientific Research Project of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2025D019).
文摘Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.
基金financial support from the National Natural Science Foundation of China(Grant No.61971201)。
文摘High-resolution transmission electron microscopy(HRTEM)promises rapid atomic-scale dynamic structure imaging.Yet,the precision limitations of aberration parameters and the challenge of eliminating aberrations in Cs-corrected transmission electron microscopy constrain resolution.A machine learning algorithm is developed to determine the aberration parameters with higher precision from small,lattice-periodic crystal images.The proposed algorithm is then validated with simulated HRTEM images of graphene and applied to the experimental images of a molybdenum disulfide(MoS_(2))monolayer with 25 variables(14 aberrations)resolved in wide ranges.Using these measured parameters,the phases of the exit-wave functions are reconstructed for each image in a focal series of MoS_(2)monolayers.The images were acquired due to the unexpected movement of the specimen holder.Four-dimensional data extraction reveals time-varying atomic structures and ripple.In particular,the atomic evolution of the sulfur-vacancy point and line defects,as well as the edge structure near the amorphous,is visualized as the resolution has been improved from about 1.75?to 0.9 A.This method can help salvage important transmission electron microscope images and is beneficial for the images obtained from electron microscopes with average stability.
基金Supported by the Earmarked Fund for Hebei Agriculture Research System(HBCT2024260407)。
文摘[Objective]The paper aimed to effectively reduce the occurrence of bacterial resistance associated with breeding practices and to mitigate food safety risks by controlling the illegal use of veterinary drugs in self-formulated feed at the source.[Method]A screening database comprising 274 illegally added chemical drugs in self-formulated feed was established utilizing ultra-performance liquid chromatography coupled with quadrupole/electrostatic field orbitrap high-resolution mass spectrometry(HPLC-Q-Exactive Focus/MS).Subsequently,253 batches of self-formulated feed samples from various farms in Hebei Province were screened and quantitatively analyzed.[Result]The screening results indicated the presence of 8 pharmaceutical components across 10 batches of self-formulated feed samples,with a detection rate of 3.2%and concentrations ranging from 0.06 to 28851.8μg/g.[Conclusion]The application of high-resolution mass spectrometry is feasible and highly significant for the risk monitoring of illegally added drugs in self-formulated feed.
文摘While algorithms have been created for land usage in urban settings,there have been few investigations into the extraction of urban footprint(UF).To address this research gap,the study employs several widely used image classification method classified into three categories to evaluate their segmentation capabilities for extracting UF across eight cities.The results indicate that pixel-based methods only excel in clear urban environments,and their overall accuracy is not consistently high.RF and SVM perform well but lack stability in object-based UF extraction,influenced by feature selection and classifier performance.Deep learning enhances feature extraction but requires powerful computing and faces challenges with complex urban layouts.SAM excels in medium-sized urban areas but falters in intricate layouts.Integrating traditional and deep learning methods optimizes UF extraction,balancing accuracy and processing efficiency.Future research should focus on adapting algorithms for diverse urban landscapes to enhance UF extraction accuracy and applicability.
基金Supported by Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-3-012B.
文摘BACKGROUND Rectal cancer is a common malignant tumor of the digestive system,with older patients representing the predominantly affected population.Magnetic resonance imaging(MRI)has been widely applied in preoperative tumor assessment;however,the value of high-resolution MRI(HR-MRI)combined with dynamic contrast-enhanced(DCE)scanning in the preoperative diagnosis of rectal cancer in older patients remains unclear.AIM To evaluate the value of HR-MRI combined with DCE scanning in the preoperative diagnosis of rectal cancer in older patients.METHODS This retrospective study included 148 consecutive older female patients with rectal cancer who were treated at our hospital between December 2020 and December 2024.Clinical data and HR-MRI and DCE scan findings were collected.Histopathological examination after surgical resection served as the gold standard.The diagnostic accuracy of MRI for preoperative T and N staging was calculated.Consistency,sensitivity,and specificity between HR-MRI combined with DCE scanning and pathological staging were analyzed using the k test.Among the 148 patients,the overall accuracy of T staging was 84.5%.Sensitivity for T1,T2,T3,and T4 staging was 75.00%,62.50%,89.47%,and 90.48%,respectively,whereas specificity was 100.00%,94.35%,79.25%,and 96.06%,respectively.T staging based on HR-MRI combined with DCE scanning showed good agreement with pathological staging(k=0.8176,P<0.001).For N staging,sensitivity and specificity were 54.88%and 84.85%for N0,36.96%and 72.55%for N1,and 70.00%and 73.44%for N2,respectively;agreement with pathological N staging was poor(k=0.259,P<0.001).CONCLUSION HR-MRI combined with DCE scanning demonstrates high diagnostic accuracy for T staging of rectal cancer in older patients and can provide a theoretical basis for treatment planning.However,its diagnostic accuracy for N staging requires improvement.
文摘Severe acute respiratory syndrome (SARS) is an acute respiratory infectious disease caused by a novel coronavirus, firstly broke out in November 2002 in Guangdong and prevailed quickly in Beijing, Hong Kong, Taiwan and other regions of China. It was one of the most potential pandemic diseases and had affected more than 20 other countries.^(1,2) There have been a lot of resear-ches^(2-7) in terms of its etiology, epidemiology, pathogenesis, clinical characteristics, diagnostics, treatment and prevention, vaccines and so on.Along with control of the epidemic situation, a great number of SARS patients were in the recovery phase, therefore, we undertook a half-year follow-up investigation on their clinical, laboratory and image situations.
基金supported by the National Key Technologies R&D Program(Grant No. 2007BAC29B03)China-UK-Swiss Adaptingto Climate Change in China Project (ACCC)-Climate Sciencethe National Natural Science Foundation of China (Grant No. 40890054)
文摘Projections of future precipitation change over China are studied based on the output of a global AGCM, ECHAM5, with a high resolution of T319 （equivalent to 40 km）. Evaluation of the model’s performance in simulating present-day precipitation shows encouraging results. The spatial distributions of both mean and extreme precipitation, especially the locations of main precipitation centers, are reproduced reasonably. The simulated annual cycle of precipitation is close to the observed. The performance of the model over eastern China is generally better than that over western China. A weakness of the model is the overestimation of precipitation over northern and western China. Analyses on the potential change in precipitation projected under the A1B scenario show that both annual mean precipitation intensity and extreme precipitation would increase significantly over southeastern China. The percentage increase in extreme precipitation is larger than that of mean precipitation. Meanwhile, decreases in mean and extreme precipitation are evident over the southern Tibetan Plateau. For precipitation days, extreme precipitation days are projected to increase over all of China. Both consecutive dry days over northern China and consecutive wet days over southern China would decrease.
基金supported by EC FP7 collaborative project NANOCI(grant agreement number:281056)National Natural Science Foundation of China(81170914/H1304)
文摘Objective: To test the feasibility of measuring fine temporal bone structures using a newly established cone-beam computed tomography(CBCT)system.Materials and methods: Six formalin-fixed human cadaver temporal bones were imaged using a high-resolution CBCT system that has 900 frames and copper t aluminum filtration. Fine temporal bone structures, including those of the facial nerve canal and vestibular structures, were identified and measured.Results: The fine structures of the middle ear, including the tympanic membrane, tendon of the tensor tympani, cochleariform process of the semicanal of the tensor tympani, pyramidal eminence, footplate of the stapes, full path of the facial nerve within the temporal bone, supralabyrinthine space, semicircular canals, pathway of the subarcuate canal, and full path of the vestibular aqueduct, were clearly demonstrated. The vestibular aqueduct has a midpoint width of 0.4 ± 0.0 mm and opercular width of 0.5 ± 0.1 mm(mean ± SD). The length of the internal acoustic meatus was 10.6 ± 1.2 mm(mean ± SD), and the diameter of the internal acoustic meatus was 3.7 ± 0.3 mm(mean ± SD).Conclusion: This novel high-resolution CBCT system has potentially broad applications in the diagnosis of inner ear disease and in monitoring associated pathological changes, surgical planning, navigation for the ear surgery, and temporal bone training.
基金supported by the China Geological Survey Project“Deep Geological Survey of the Qin-Hang Belt”(No.DD20160082)the National Natural Science Foundation of China(No.41574048)
文摘A profile of shallow crustal velocity structure(1–2 km) may greatly enhance interpretation of the sedimentary environment and shallow tectonic deformation.Recent advances in surface wave tomography, using ambient noise data recorded with high-density seismic arrays, have improved the understanding of regional crustal structure. As the interest in detailed shallow crustal structure imaging has increased, dense seismic array methods have become increasingly efficient. This study used a high-density seismic array deployed in the Xinjiang basin in southeastern China, to record seismic data, which was then processed with the ambient noise tomography method. The high-density seismic array contained 203 short-period seismometers, spaced at short intervals(～ 400 m). The array collected continuous records of ambient noise for 32 days. Data preprocessing,cross correlation calculation, and Rayleigh surface wave phase-velocity dispersion curve extraction, yielded more than 16,000 Rayleigh surface wave phase-velocity dispersion curves, which were then analyzed using the direct-inversion method. Checkerboard tests indicate that the shear wave velocity is recovered in the study area, at depths of 0–1.4 km,with a lateral image resolution of ～ 400 m. Model test results show that the seismic array effectively images a 50 m thick slab at a depth of 0–300 m, a 150 m thick anomalous body at a depth of 300–600 m, and a 400 m thick anomalous body at a depth of 0.6–1.4 km. The shear wave velocity profile reveals features very similar to those detected by a deep seismic reflection profile across the study area. This demonstrates that analysis of shallow crustal velocity structure provides high-resolution imaging of crustal features.Thus, ambient noise tomography with a high-density seismic array may play an important role in imaging shallow crustal structure.
基金supported by the National Key R&D Program for Developing Basic Sciences [grant numbers2016YFC1401401 and 2016YFC1401601]the National Natural Science Foundation of China [grant numbers41376026 and 41576025]
文摘Using the Community Earth System Model framework, the authors build a very-high-resolution quasi-global coupled model by coupling an eddy-resolving quasi-global ocean model with a high-resolution atmospheric model. The model is successfully run for six years under present climate conditions, and the simulations are evaluated against observational and reanalysis data.The model is capable of simulating large-scale oceanic and atmospheric circulation patterns, sea surface temperature(SST) fronts, oceanic eddy kinetic energy, and fine-scale structures of surface winds. The ocean mesoscale structure–induced air–sea interaction characteristics are explored in detail. The model can effectively reproduce positive correlations between SST and surface wind stress induced by mesoscale structures through comparison with observations. The positive correlation is particularly significant over regions with strong oceanic fronts and eddies.However, the responses of wind stress to eddy-induced SST are weaker in the simulation than in the observations, although different magnitudes exist in different areas. Associated with weak wind responses, surface sensible heat flux responses to eddy-induced SST are underestimated slightly, while surface latent heat flux responses are overestimated because of the drier atmospheric boundary layers in the model. Both momentum mixing and pressure adjustment mechanisms play important roles in surface wind changes over oceanic fronts and eddies in the high-resolution model.
基金This work is supported by the National Natural Science Foundation of China （No.20903085）, the NKBRSF 2010CB9230, and RFBR-Russia （No.06-05- 39016）. The support of the Groupement de Recherche International SAMIA （Spectroscopie d＇Absorption des Mol@cules d＇Interet Atmospherique） between CNRS （France）, RFBR （Russia） and CAS （China） is also acknowledged.
文摘High-resolution ro-vibrational spectroscopy of ^15N2^16O in 1650-3450 cm-1 region is studied using highly enriched isotopologue sample. The positions of more than 7300 lines of ^15N2^16O isotopologue were measured with a typical accuracy of 5.0×10-4 cm-1. The transitions were rovibrationally assigned on the basis of the global effective Hamiltonian model. The band by band analysis allowed for the determination of the rovibrational parameters of a total of 73 bands. 29 of them are newly reported and more rotational transitions have been observed for the others. The maximum deviation of the preidictions of the effective Hamiltonian model is up to 0.70 cm-1 for the ^15N2^16O species.
基金supported by the National Key Research&Development Program of China(Grant Nos.2017YFC1404100 and 2017YFC1404104)the National Natural Science Foundation of China(Grant Nos.41775100 and 41830964)。
文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.
基金supported by the Key Army Pre-research Projects of China(30107030803)
文摘Aiming at a novel missile-borne detector in the optional burst height proximity fuze, a self-adaptive high-resolution forward-looking imaging algorithm (SAHRFL-IA) is presented. The echo data are captured by the missile-borne detector in the target regions;thereby the azimuth angulation accuracy at the same distance dimension is improved dynamically. Thus, azimuth information of the targets in the detection area may be obtained accurately. The proposed imaging algorithm breaks through the conventional misconception of merely using azimuth discrimination curves under ideal conditions during monopulse angulation. The real-time echo data from the target region are used to perform error correction for this discrimination curve, and finally the accuracy of the azimuth angulation may reach the optimum at the same distance dimension. A series of experiments demonstrate the validity, reliability and high performance of the proposed imaging algorithm. Azimuth angulation accuracy may reach ten times that of the detection beam width. Meanwhile, the running time of this algorithm satisfies the requirements of missile-borne platforms.
基金Supported by the National High-tech R&D Program (“863” Program) of China,No. 2010AA023007
文摘BACKGROUND The quality of life in patients who develop low anterior resection syndrome(LARS)after surgery for mid-low rectal cancer is seriously impaired.The underlying pathophysiological mechanism of LARS has not been fully investigated.AIM To assess anorectal function of mid-low rectal cancer patients developing LARS perioperatively.METHODS Patients diagnosed with mid-low rectal cancer were included.The LARS score was used to evaluate defecation symptoms 3 and 6 mo after anterior resection or a stoma reversal procedure.Anorectal functions were assessed by threedimensional high resolution anorectal manometry preoperatively and 3-6 mo after surgery.RESULTS The study population consisted of 24 patients.The total LARS score was decreased at 6 mo compared with 3 mo after surgery(P<0.05),but 58.3%(14/24)lasted as major LARS at 6 mo after surgery.The length of the high-pressure zone of the anal sphincter was significantly shorter,the mean resting pressure and maximal squeeze pressure of the anus were significantly lower than those before surgery in allpatients (P < 0.05), especially in the neoadjuvant therapy group after surgery (n = 18). The focalpressure defects of the anal canal were detected in 70.8% of patients, and those patients had higherLARS scores at 3 mo postoperatively than those without focal pressure defects (P < 0.05). Spasticperistaltic contractions from the new rectum to anus were detected in 45.8% of patients, whichwere associated with a higher LARS score at 3 mo postoperatively (P < 0.05).CONCLUSIONThe LARS score decreases over time after surgery in the majority of patients with mid-low rectalcancer. Anorectal dysfunctions, especially focal pressure defects of the anal canal and spasticperistaltic contractions from the new rectum to anus postoperatively, might be the majorpathophysiological mechanisms of LARS.
