Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later tr...Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later transitions to secondary progressive MS. Currently available disease-modifying therapies（DMTs） for relapsing MS have been demonstrated to reduce disease activity, however most patients require a change in therapy over the course of their disease. Treatment goals include the prevention of relapses and disability accumulation and to achieve this objective requires careful planning. Sequencing of DMTs for individual patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.展开更多
The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to ...The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to heat and pH range of ethyl lauroyl arginate HCI have been introduced. The new preservatives have been developed, they are the compounds containing ethyl lauroyl arginate HCI. The high efficacy of antimicrobial of Ethyl lauroyl arginate HCI series products ha been described while added into the formulations of amino acid shampoo and toner. It has been proved that ethyl lauroyl arginate HCI series products can be the optimized option for the alternative of traditional preservatives for cosmetic products.展开更多
An aqueous nanosuspension of agrochemicals unlike pharmaceutics has to achieve massive production in an effective way,capable to ensure sufficient profits in commercialization.This work implements the flash nanoprecip...An aqueous nanosuspension of agrochemicals unlike pharmaceutics has to achieve massive production in an effective way,capable to ensure sufficient profits in commercialization.This work implements the flash nanoprecipitation(FNP)technique to effectively generate agrochemical nanosuspension,anticipatedly overcoming such an obstacle.Azoxystrobin,a broad spectrum fungicide,in either acetone or ethanol is used herein as a mode agrochemical.To ensure a green and practical utilization,three kinds of commercially available and eco-friendly surfactants,i.e.,poly(ethylene glycol)-block-poly(lactic-co-glycolic acid)(PEG-b-PLGA),Tween 80 and alkyl polyglucosides(APGs),are employed for stabilizing the nanoparticles.The results show that the polymeric stabilizer,PEG-b-PLGA,has the best stabilization efficiency,and can maintain the particles below 100 nm for at least three weeks.The azoxystrobin load of the nanoparticles reaches as high as 77 wt.%,beneficial to enhancing the biological potency.Moreover,the FNP brings the particles a much smaller size,narrower size distribution,better size stability,and higher biological efficacy than the ones made via a traditional method of the drop and stir(DS).The nanosuspensions present superior fungicidal performances over a prevailing counterpart from Syngenta.This study proves an enhanced biological potency and reduced dosage of agrochemical nanosuspension made via the FNP,indicating a remarkable advantage of the FNP over the conventional preparation.The integration of a super-high load,eco-friendly excipients,intensified preparation process,enhanced potency,and reduced dosage creates a promising pathway to generate a green aqueous nanosuspension of agrochemicals.展开更多
文摘Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later transitions to secondary progressive MS. Currently available disease-modifying therapies（DMTs） for relapsing MS have been demonstrated to reduce disease activity, however most patients require a change in therapy over the course of their disease. Treatment goals include the prevention of relapses and disability accumulation and to achieve this objective requires careful planning. Sequencing of DMTs for individual patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.
文摘The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to heat and pH range of ethyl lauroyl arginate HCI have been introduced. The new preservatives have been developed, they are the compounds containing ethyl lauroyl arginate HCI. The high efficacy of antimicrobial of Ethyl lauroyl arginate HCI series products ha been described while added into the formulations of amino acid shampoo and toner. It has been proved that ethyl lauroyl arginate HCI series products can be the optimized option for the alternative of traditional preservatives for cosmetic products.
基金The work was financially supported by the National Natural Science Foundation of China(No.21544005)the Basic Research Program(Natural Science Foundation for Young Scholars)of Jiangsu Province(No.BK20170489)+3 种基金the Materials and Chemical Engineering Research Center of Xinjiang Production and Construction Corps(No.2018BTRC003)the Joint Project of Yangzhou City and Higher Education Institutions(No.YZ2019127)the Innovation Incubation Project of Yangzhou University(No.2019CXJ025)the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘An aqueous nanosuspension of agrochemicals unlike pharmaceutics has to achieve massive production in an effective way,capable to ensure sufficient profits in commercialization.This work implements the flash nanoprecipitation(FNP)technique to effectively generate agrochemical nanosuspension,anticipatedly overcoming such an obstacle.Azoxystrobin,a broad spectrum fungicide,in either acetone or ethanol is used herein as a mode agrochemical.To ensure a green and practical utilization,three kinds of commercially available and eco-friendly surfactants,i.e.,poly(ethylene glycol)-block-poly(lactic-co-glycolic acid)(PEG-b-PLGA),Tween 80 and alkyl polyglucosides(APGs),are employed for stabilizing the nanoparticles.The results show that the polymeric stabilizer,PEG-b-PLGA,has the best stabilization efficiency,and can maintain the particles below 100 nm for at least three weeks.The azoxystrobin load of the nanoparticles reaches as high as 77 wt.%,beneficial to enhancing the biological potency.Moreover,the FNP brings the particles a much smaller size,narrower size distribution,better size stability,and higher biological efficacy than the ones made via a traditional method of the drop and stir(DS).The nanosuspensions present superior fungicidal performances over a prevailing counterpart from Syngenta.This study proves an enhanced biological potency and reduced dosage of agrochemical nanosuspension made via the FNP,indicating a remarkable advantage of the FNP over the conventional preparation.The integration of a super-high load,eco-friendly excipients,intensified preparation process,enhanced potency,and reduced dosage creates a promising pathway to generate a green aqueous nanosuspension of agrochemicals.
