Heterogeneous federated learning(HtFL)has gained significant attention due to its ability to accommodate diverse models and data from distributed combat units.The prototype-based HtFL methods were proposed to reduce t...Heterogeneous federated learning(HtFL)has gained significant attention due to its ability to accommodate diverse models and data from distributed combat units.The prototype-based HtFL methods were proposed to reduce the high communication cost of transmitting model parameters.These methods allow for the sharing of only class representatives between heterogeneous clients while maintaining privacy.However,existing prototype learning approaches fail to take the data distribution of clients into consideration,which results in suboptimal global prototype learning and insufficient client model personalization capabilities.To address these issues,we propose a fair trainable prototype federated learning(FedFTP)algorithm,which employs a fair sampling training prototype(FSTP)mechanism and a hyperbolic space constraints(HSC)mechanism to enhance the fairness and effectiveness of prototype learning on the server in heterogeneous environments.Furthermore,a local prototype stable update(LPSU)mechanism is proposed as a means of maintaining personalization while promoting global consistency,based on contrastive learning.Comprehensive experimental results demonstrate that FedFTP achieves state-of-the-art performance in HtFL scenarios.展开更多
Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different educ...Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different education stages is still limited.A new framework was established to evaluate the spatial heterogeneity and its influencing factors across all education stages(kindergarten,primary school,middle school,college)in 1100 schools at the urban scale of Xi’an,China.The research results show that:1)CGS is lower in the Baqiao district and higher in the Yanta and Xincheng districts of Xi’an City.‘Green wealthy schools are mainly concentrated in the Weiyang,Chang’an and Yanta districts.2)CGS of these schools in descending order is college(31.40%)>kindergarten(18.32%)>middle school(13.56%)>primary school(10.70%).3)Colleges have the most recreation sites(n(number)=2),the best education levels(11.93 yr),and the lowest housing prices(1.18×10^(4) yuan(RMB)/m^(2));middle schools have the highest public expenditures(3.97×10^(9) yuan/yr);primary schools have the highest CGS accessibility(travel time gap(TTG)=31.33).4)Multiscale Geographically Weighted Regression model and Spearman’s test prove that recreation sites have a significant positive impact on college green spaces(0.28–0.35),and education level has a significant positive impact on kindergarten green spaces(0.16–0.24).This research framework provides important insights for the assessment of school greening initiatives aimed at fostering healthier learning environments for future generations.展开更多
In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics...In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics,have enabled a detailed molecular comprehension of the complex regulation of cell fate.The insights obtained from these methodologies are anticipated to significantly contribute to the development of personalized medicine.Currently,single-cell technology is less frequently utilized for prostate cancer compared with other types of tumors.Start-ing from the perspective of RNA sequencing technology,this review outlined the signifcance of single-cell RNA sequencing(scRNA-seq)in prostate cancer research,encompassing preclinical medicine and clinical applications.We summarize the differences between mouse and human prostate cancer as revealed by scRNA-seq studies,as well as a combination of multi-omics methods involving scRNA-seq to highlight the key molecular targets for the diagnosis,treatment,and drug resistance characteristics of prostate cancer.These studies are expected to provide novel insights for the development of immunotherapy and other innovative treatment strategies for castration-resistant prostate cancer.Furthermore,we explore the potential clinical applications stemming from other single-cell technologies in this review,paving the way for future research in precision medicine.展开更多
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functio...Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.展开更多
Low-dose radiation therapy has emerged as a promising modality for cancer treatment because of its ability to stimulate antitumor immune responses while minimizing damage to healthy tissues.However,the significant het...Low-dose radiation therapy has emerged as a promising modality for cancer treatment because of its ability to stimulate antitumor immune responses while minimizing damage to healthy tissues.However,the significant heterogeneity in immune responses among patients complicates its clinical application,hindering outcome prediction and treatment personalization.Artificial intelligence(AI)offers a transformative solution by integrating multidimensional data such as immunomics,radiomics,and clinical features to decode complex immune pa-tterns and predict individual therapeutic outcomes.This editorial explored the potential of AI to address immune response heterogeneity in low-dose radiation therapy and proposed an AI-driven framework for precision immunotherapy.While promising,challenges,including data standardization,model interpre-tability,and clinical validation,must be overcome to ensure successful integration into oncological practice.展开更多
Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in signific...Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.展开更多
Due to severe mass transfer limitations,the remediation efficiency of low-permeability contaminated sites often fails to meet expectations.Hydraulic fracturing technology has been utilized to enhance amendment deliver...Due to severe mass transfer limitations,the remediation efficiency of low-permeability contaminated sites often fails to meet expectations.Hydraulic fracturing technology has been utilized to enhance amendment delivery,but the influence of soil heterogeneity is commonly overlooked.To address this issue,this study develops a numerical model to simulate the enhanced transport of amendments,incorporating convection,diffusion,adsorption,and degradation processes.Within the model,random permeability fields are generated based on geostatistical methods to explore how soil heterogeneity affects amendment injection efficiency,distribution characteristics,and the underlying physical mechanisms.The results indicate that(1)soil heterogeneity significantly reduces the amendment injection efficiency,with stronger heterogeneity correlating to lower efficiency,(2)soil heterogeneity markedly alters the amendment distribution characteristics,leading to the formation of localized“nodes”,(3)the mechanism by which heterogeneity reduces injection efficiency involves decreasing the density of preferential flow paths in the soil,and(4)the adverse effects of heterogeneity can be mitigated by employing pressure compensation or adjusting well spacing.展开更多
Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design...Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design/methodology/approach:An exploratory survey is administered to researchers at the Sapienza University of Rome,one of Europe’s oldest and largest generalist universities.To measure metric-wiseness,we use attitude statements that are evaluated by a 5-point Likert scale.Moreover,we analyze documents of recent initiatives on assessment reform to shed light on how researchers’heterogeneous attitudes regarding and knowledge of bibliometric indicators are taken into account.Findings:We found great heterogeneity in researchers’metric-wiseness across scientific disciplines.In addition,within each discipline,we observed both supporters and critics of bibliometric indicators.From the document analysis,we found no reference to individual heterogeneity concerning researchers’metric wiseness.Research limitations:We used a self-selected sample of researchers from one Italian university as an exploratory case.Further research is needed to check the generalizability of our findings.Practical implications:To gain sufficient support for research evaluation practices,it is key to consider researchers’diverse attitudes towards indicators.Originality/value:We contribute to the current debate on reforming research assessment by providing a novel empirical measurement of researchers’knowledge and attitudes towards bibliometric indicators and discussing the importance of the obtained results for improving current research evaluation systems.展开更多
Magnesium(Mg)alloys have attracted considerable attention as promising implant materials for biodegradable medical devices.In this study,we focused on investigating the effect of macroscopic environmental heterogeneit...Magnesium(Mg)alloys have attracted considerable attention as promising implant materials for biodegradable medical devices.In this study,we focused on investigating the effect of macroscopic environmental heterogeneity due to the degradation of Mg on its corrosion behavior.The immersion experiments using pure Mg plates,which were placed vertically in a culture medium(Dulbecco’s Modified Eagle’s Medium(DEME)+10%fetal bovine serum(FBS))for 1,5,and 10 days,were conducted.Surface analyses for the corrosion product layers and the measurements of the pH values and concentrations of eluted ions in the immersion medium around the upper and lower areas of the Mg plate were performed.The significant effect of the macroscopic environmental heterogeneity derived from Mg degradation on the corrosion behavior was demonstrated by in vitro tests.Additionally,the in vivo tests were carried out by implanting the pure Mg plates in the femur of rabbits.The in vivo results exhibited macroscopically heterogeneous Mg degradation,with areas of more severe corrosion compared to the in vitro test;it is especially noticeable during the early stage of degradation,even though the average corrosion rate was lower.展开更多
Although the spatial characteristics within the tumor microenvironment of lung adenocarcinoma(LUAD)have been identified,the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear....Although the spatial characteristics within the tumor microenvironment of lung adenocarcinoma(LUAD)have been identified,the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear.Using spatial transcriptomics and single-cell RNA-sequencing data from multi-regional LUAD biopsies consisting of tumor core,tumor edge,and normal area,we sought to delineate the spatial heterogeneity and driving factors of cell colocalization.Two cancer cell sub-clusters(Cancer_c1 and Cancer_c2),associated with LUAD initiation and metastasis,respectively,exhibit distinct spatial distributions and immune cell colocalizations.In particular,Cancer_c1,enriched within the tumor core,could directly interact with B cells or indirectly recruit B cells through macrophages.Conversely,Cancer_c2 enriched within the tumor edge exhibits colocalization with CD8^(+)T cells.Collectively,our work elucidates the spatial distribution of cancer cell subtypes and their interaction with immune cells in the core and edge of LUAD,providing insights for developing therapeutic strategies for cancer intervention.展开更多
Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-...Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound.The coexistence of weak interlayer van der Waals interactions,robust intralayer ionic bonding,and partial covalent bonding leads to remarkable bonding heterogeneity,which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction.The weakened chemical bonds induced by the antibonding states,together with the rattling-like behavior of the Zn atom,culminate in the profound anharmonicity in the layered NdZnSbO compound.The weakening bond and heavy element contribute to the softness of phonon modes,which significantly diminishes the phonon group velocity.The redistribution-dominated four-phonon scattering process spans a large optical gap,which effectively reduces the lattice thermal conductivity.The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06)functional in combination with spin–orbit coupling(SOC)effect.The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy,thus amplifying the power factor.Consequently,an optimal figure-of-merit(ZT)of 3.40 at 900 K is achieved for the n-type NdZnSbO compound.The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.展开更多
Reservoirs play a critical role in addressing water resources challenges.However,their vertical influence on the assembly mechanisms of different microbial communities,including prokaryotes and eukaryotes,remains uncl...Reservoirs play a critical role in addressing water resources challenges.However,their vertical influence on the assembly mechanisms of different microbial communities,including prokaryotes and eukaryotes,remains unclear.This study examined the vertical diversity patterns of abundant and rare subcommunities of prokaryotes and eukaryotes in an urban reservoir,using water depth as a geographical gradient and employing high-throughput sequencing.The impact of vertical environmental heterogeneity on community structure was quantified,and key drivers of these dynamics were identified.The results indicated that the urban reservoir exhibited statistically significant differences in the vertical distribution of water temperature and oxidation/reduction potential.The a-diversity of the abundant subcommunity displayed an opposing vertical pattern compared to that of the rare subcommunity,while the b-diversity for both subcommunities of prokaryotes and eukaryotes increased with water depth.Moreover,the distinct diversity patterns of abundant and rare subcommunities were associated with environmental heterogeneity and species adaptability.Notably,the b-diversity of the rare subcommunity of eukaryotes was primarily driven by species turnover in surface water,whereas nestedness became the dominant factor in deeper water.Furthermore,eukaryotic microbes exhibited a more pronounced response to changes in water depth than prokaryotes,consistent with the importance of heterogeneous selection to the eukaryotic community.Water temperature significantly affected the community composition of all groups,highlighting its importance in shaping community dynamics.This study provides valuable insights into the vertical distribution and assembly mechanisms of microbial communities in urban reservoirs,contributing to the protection and management of aquatic ecosystems under river regulation.展开更多
BACKGROUND Gastroenteropancreatic neuroendocrine tumors(GEP-NETs)frequently metasta-size to the liver,with heterogeneity in tumor grade impacting patient prognosis and treatment.The Ki-67 index,a key prognostic marker...BACKGROUND Gastroenteropancreatic neuroendocrine tumors(GEP-NETs)frequently metasta-size to the liver,with heterogeneity in tumor grade impacting patient prognosis and treatment.The Ki-67 index,a key prognostic marker,often varies between primary and metastatic sites;however,routine liver biopsy remains controversial.Although percutaneous computed tomography-guided core needle biopsy(PCT-CNB)is safe and effective for focal lesions,its role in detecting intertumor grading discrepancies and survival implications in GEP-NETs is underexplored.Conflic-ting survival associations with grade shifts have been reported in previous stu-dies.We hypothesized that PCT-CNB could identify clinically significant grading heterogeneity in liver metastases,correlating with survival outcomes,thereby refining risk stratification and therapeutic strategies.METHODS We retrospectively investigated 92 patients with liver metastases from GEP-NETs via PCT-CNB,76 patient samples from the liver and primary sites,and 16 from the liver and secondary liver sites.Ki-67 immunohistochemistry was performed for tissue sampling,and grading classifications were determined.Intertumor grading classification heterogeneity and associated changes in patient survival outcomes were also evaluated.RESULTS No procedure-related mortality was recorded during or after biopsy.In 37/92 patients(40.2%),the grading classi-fications changed:The grading increased from G1 to G2 in 13 patients,from G1 to G3 in 2,and from G2 to G3 in 14;the grading decreased from G2 to G1 in 5 patients,from G3 to G1 in 1,and from G3 to G2 in 2.Patients with G1 or G2 disease had better progression-free survival and overall survival(OS)outcomes than those with G3 disease did(P=0.001 and P<0.001,respectively).The 5-year and 10-year OS rates for stable G2 patients were 67.5%and 26.0%,respectively,decreasing to 46.4%and 23.2%,respectively,among G2 patients whose grade increased(P=0.016).CONCLUSION The PCT-CNB of liver metastases from GEP-NETs differed in grade between the liver tumor and primary site/secondary liver metastases.Additionally,when grading increased from G2,the OS rate significantly de-creased.展开更多
CO_(2) emissions(CEs)pose a growing threat to environmental changes and global warming,attracting extensive attention.Here,we leveraged near-real-time monitoring data spanning 2019 to 2022 to investigate spatiotempora...CO_(2) emissions(CEs)pose a growing threat to environmental changes and global warming,attracting extensive attention.Here,we leveraged near-real-time monitoring data spanning 2019 to 2022 to investigate spatiotemporal heterogeneity,sectoral contributions,provincial spatial correlation,and driving factors influencing CEs at the provincial level in China.Our analysis,integrating Moran’s Index analysis,Spearman correlation analysis,and the Geographically Weighted Regression model,unveiled China’s consistent world-leading CEs,surpassing 10,000 Mt over the study period.Spatially,CEs exhibited a heterogeneous distribution,with markedly higher emissions in eastern and northern regions compared to western and southern areas.Temporally,CEs displayed significant fluctuations,peaking in the fourth quarter before declining in subsequent quarters.Chinese NewYear and COVID-19 had the biggest effects on CEs,with average daily reductions of-20.8%and-18.9%,respectively,compared to the four-year average and the same period in 2019.Sectoral analysis highlighted the power and industry sectors as primary contributors to CEs in China,jointly accounting for 37.9%-40.2%and 43.5%-46.4%of total CEs,respectively.Spatial clustering analysis identified a distinct High-High agglomeration region,predominantly encompassing provinces such as Inner Mongolia,Shandong and Jiangsu.Furthermore,total energy consumption and electricity consumption emerged as significant drivers of CEs,exhibiting correlation coefficients exceeding 0.9,followed by exhaust emissions,population size,and gross domestic product.Moreover,the influence of drivers on provincial CEs exhibited notable spatial heterogeneity,with regression coefficients displaying a decreasing gradient from north to south.These findings provide scientific and technological support to realize the provincial dual-carbon goals in China.展开更多
The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the diffic...The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the difficulty and time consumption of OLT sample collection,accurately predicting OLT distribution remains a challenging.To address this,a novel framework has been developed.First,OLT samples are collected through field surveys,remote sensing,and geological drilling.Next,the heterogeneity of OLT’s spatial distribution is analyzed using the probability distribution of OLT samples and their horizontal and vertical distributions.The OLT samples are categorized and the small sample categories are expanded using the synthetic minority over-sampling technique(SMOTE).The slope position is selected as a key conditioning factor.Subsequently,16 conditioning factors are applied to construct OLT prediction model using the random forest regression algorithm.Weights are assigned to each OLT sample category to balance the uneven distribution of sample sizes.Finally,the Pearson correlation coefficient,mean absolute error(MAE),root mean square error(RMSE),and Lin’s concordance correlation coefficient(Lin’s CCC)are employed to validate the OLT prediction results.The Huangtan town serves as the case study.Results show:(1)heterogeneity analysis,SMOTE-based OLT sample expansion strategy and slope position selection can significantly mitigate the effect of spatial heterogeneity on OLT prediction.(2)The Pearson correlation coefficient,RMSE,MAE and Lin’s CCC values are 0.84,1.173,1.378 and 0.804,respectively,indicating excellent prediction performance.This research provides an effective solution for predicting OLT distribution in hillslope regions.展开更多
Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in t...Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in three coastal cities in Jiangsu Province,China.Seasonal and Trend decomposition using Loess(STL)together with wavelet analysis and empirical mode decomposition were applied to identify tide-influenced wells while remaining wells were grouped by hierarchical clustering analysis(HCA).Machine learning models were developed to predict GWD,then their response to natural conditions and human activities was assessed by the Shapley Additive exPlanations(SHAP)method.Results showed that eXtreme Gradient Boosting(XGB)was superior to other models in terms of prediction performance and computational efficiency(R^(2)>0.95).GWD in Yancheng and southern Lianyungang were greater than those in Nantong,exhibiting larger fluctuations.Groundwater within 5 km of the coastline was affected by tides,with more pronounced effects in agricultural areas compared to urban areas.Shallow groundwater(3-7 m depth)responded immediately(0-1 day)to rainfall,primarily influenced by farmland and topography(slope and distance from rivers).Rainfall recharge to groundwater peaked at 50%farmland coverage,but this effect was suppressed by high temperatures(>30℃)which intensified as distance from rivers increased,especially in forest and grassland.Deep groundwater(>10 m)showed delayed responses to rainfall(1-4 days)and temperature(10-15 days),with GDP as the primary influence,followed by agricultural irrigation and population density.Farmland helped to maintain stable GWD in low population density regions,while excessive farmland coverage(>90%)led to overexploitation.In the early stages of GDP development,increased industrial and agricultural water demand led to GWD decline,but as GDP levels significantly improved,groundwater consumption pressure gradually eased.This methodological framework is applicable not only to coastal cities in China but also could be extended to coastal regions worldwide.展开更多
The trade-off between strength and ductility has long been a challenge for Mg alloy.To address this issue,bimodal-structured AZ80 Mg alloys with varying heterogeneity levels were fabricated via low-temperature extrusi...The trade-off between strength and ductility has long been a challenge for Mg alloy.To address this issue,bimodal-structured AZ80 Mg alloys with varying heterogeneity levels were fabricated via low-temperature extrusion in this work.The results reveal the microstructure comprising second-phase particle(SP_(p),β-Mg_(17)Al_(12)and Mg_(3) Mn_(2) Al_(18))-reinforced fine grains(FGs)FGs and SP_(p)-free coarse grains(CGs),with the heterogeneity level decreasing as extrusion temperature increases.As the heterogeneity level decreases,the synergistic deformation capacity initially improves,reaching a maximum at the moderate heterogeneity level of 0.31 GPa and 0.238,and then declines.This exceptional capacity is attributed to the hetero-deformation induced(HDI)stress,which effectively alleviates the strain gradients by activating〈c+a〉dislocations and non-basal〈a〉dislocations during deformation.An optimal combination of 287 MPa in yield strength,393 MPa in ultimate tensile strength,and 14.96%in elongation is achieved in the alloy with a moderate heterogeneity level.The excellent strength-ductility synergy originates from the enhanced capacity of dislocations accumulation driven by remarkable capacity of synergistic deformation and the synergistic strengthening mechanisms.This work provides a new insight into the design of bimodal structure to produce high-performance Mg alloys.展开更多
Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More recently,advances in the development of Lecanemab,an anti-amyloid-βmonoclonal antibody,have shown positive results in reducing brain A burden and slowing cognitive decline in patients with early-stage Alzheimer’s disease in the Phase Ⅲ clinical trial(Clarity Alzheimer’s disease).Despite these promising results,side effects such as amyloid-related imaging abnormalities(ARIA)may limit its usage.ARIA can manifest as ARIA-E(cerebral edema or effusions)and ARIA-H(microhemorrhages or superficial siderosis)and is thought to be caused by increased vascular permeability due to inflammatory responses,leading to leakages of blood products and protein-rich fluid into brain parenchyma.Endothelial dysfunction is an early pathological feature of Alzheimer’s disease,and the blood-brain barrier becomes increasingly leaky as the disease progresses.In addition,APOE4,the strongest genetic risk factor for Alzheimer’s disease,is associated with higher vascular amyloid burden,increased ARIA incidence,and accelerated blood-brain barrier disruptions.These interconnected vascular abnormalities highlight the importance of vascular contributions to the pathophysiology of Alzheimer’s disease.Here,we will closely examine recent research evaluating the heterogeneity of brain endothelial cells in the microvasculature of different brain regions and their relationships with Alzheimer’s disease progression.展开更多
Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump mate...Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1.展开更多
ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning ...ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning from 2019 to 2022,coupled with measures of corporate transformation and upgrading,this study introduces green innovation as a mediating variable to dissect the impact of ESG ratings on corporate transformation and upgrading.The key findings of this research are as follows:(1)ESG ratings positively influence corporate transformation and upgrading,a conclusion that retains robustness after a comprehensive series of tests and discussions on endogeneity.(2)Mechanism analysis reveals that ESG ratings foster corporate transformation and upgrading by enhancing corporate green innovation.(3)In comparison with other industries,the influence of ESG ratings on corporate transformation and upgrading is notably more pronounced among heavily polluting industries among listed companies in China.Additionally,ESG ratings exhibit a more significant promotional effect on non-state-owned enterprises compared to state-owned enterprises.Larger enterprises play a more substantial role in transformation and upgrading than small and medium-sized enterprises.The promotional effect of ESG ratings is more evident in enterprises with poor information disclosure quality.Furthermore,as media attention increases,so does the impact of ESG ratings on corporate transformation.This study offers valuable policy insights from the ESG rating perspective,aiming to propel corporate transformation and upgrading,thereby contributing to economic high-quality and sustainable development.展开更多
基金supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01B187).
文摘Heterogeneous federated learning(HtFL)has gained significant attention due to its ability to accommodate diverse models and data from distributed combat units.The prototype-based HtFL methods were proposed to reduce the high communication cost of transmitting model parameters.These methods allow for the sharing of only class representatives between heterogeneous clients while maintaining privacy.However,existing prototype learning approaches fail to take the data distribution of clients into consideration,which results in suboptimal global prototype learning and insufficient client model personalization capabilities.To address these issues,we propose a fair trainable prototype federated learning(FedFTP)algorithm,which employs a fair sampling training prototype(FSTP)mechanism and a hyperbolic space constraints(HSC)mechanism to enhance the fairness and effectiveness of prototype learning on the server in heterogeneous environments.Furthermore,a local prototype stable update(LPSU)mechanism is proposed as a means of maintaining personalization while promoting global consistency,based on contrastive learning.Comprehensive experimental results demonstrate that FedFTP achieves state-of-the-art performance in HtFL scenarios.
基金Under the auspices of Natural Science Basic Research Plan in Shaanxi Province of China(No.2024JC-YBMS-196)。
文摘Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different education stages is still limited.A new framework was established to evaluate the spatial heterogeneity and its influencing factors across all education stages(kindergarten,primary school,middle school,college)in 1100 schools at the urban scale of Xi’an,China.The research results show that:1)CGS is lower in the Baqiao district and higher in the Yanta and Xincheng districts of Xi’an City.‘Green wealthy schools are mainly concentrated in the Weiyang,Chang’an and Yanta districts.2)CGS of these schools in descending order is college(31.40%)>kindergarten(18.32%)>middle school(13.56%)>primary school(10.70%).3)Colleges have the most recreation sites(n(number)=2),the best education levels(11.93 yr),and the lowest housing prices(1.18×10^(4) yuan(RMB)/m^(2));middle schools have the highest public expenditures(3.97×10^(9) yuan/yr);primary schools have the highest CGS accessibility(travel time gap(TTG)=31.33).4)Multiscale Geographically Weighted Regression model and Spearman’s test prove that recreation sites have a significant positive impact on college green spaces(0.28–0.35),and education level has a significant positive impact on kindergarten green spaces(0.16–0.24).This research framework provides important insights for the assessment of school greening initiatives aimed at fostering healthier learning environments for future generations.
基金Chinese Scholarship Council(202206240086)National Natural Science Foundation of China(81974099,82170785,81974098,82170784)+4 种基金National Key Research and Development Program of China(2021YFC2009303)programs from Science and Technology Department of Sichuan Province(2021YFH0172)Young Investigator Award of Sichuan University 2017(2017SCU04A17)Technology Innovation Research and Development Project of Chengdu Science and Technology Bureau(2019-YF05-00296-SN)Sichuan University-Panzhihua science and technology cooperation special fund(2020CDPZH-4).
文摘In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics,have enabled a detailed molecular comprehension of the complex regulation of cell fate.The insights obtained from these methodologies are anticipated to significantly contribute to the development of personalized medicine.Currently,single-cell technology is less frequently utilized for prostate cancer compared with other types of tumors.Start-ing from the perspective of RNA sequencing technology,this review outlined the signifcance of single-cell RNA sequencing(scRNA-seq)in prostate cancer research,encompassing preclinical medicine and clinical applications.We summarize the differences between mouse and human prostate cancer as revealed by scRNA-seq studies,as well as a combination of multi-omics methods involving scRNA-seq to highlight the key molecular targets for the diagnosis,treatment,and drug resistance characteristics of prostate cancer.These studies are expected to provide novel insights for the development of immunotherapy and other innovative treatment strategies for castration-resistant prostate cancer.Furthermore,we explore the potential clinical applications stemming from other single-cell technologies in this review,paving the way for future research in precision medicine.
基金supported by a grant from the Progressive MS Alliance(BRAVE in MS)Le Grand Portage Fund。
文摘Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.
文摘Low-dose radiation therapy has emerged as a promising modality for cancer treatment because of its ability to stimulate antitumor immune responses while minimizing damage to healthy tissues.However,the significant heterogeneity in immune responses among patients complicates its clinical application,hindering outcome prediction and treatment personalization.Artificial intelligence(AI)offers a transformative solution by integrating multidimensional data such as immunomics,radiomics,and clinical features to decode complex immune pa-tterns and predict individual therapeutic outcomes.This editorial explored the potential of AI to address immune response heterogeneity in low-dose radiation therapy and proposed an AI-driven framework for precision immunotherapy.While promising,challenges,including data standardization,model interpre-tability,and clinical validation,must be overcome to ensure successful integration into oncological practice.
基金funded by the National Key Research and Development Program of China(grant number 2023YFC3009204)the National Natural Science Foundation of China(grant number 52174015).
文摘Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.
基金supported by the National Natural Science Foundation of China(Grant Nos.42227804 and 42402279)the Natural Science Foundation of Shanghai(Grant No.24ZR1467500).
文摘Due to severe mass transfer limitations,the remediation efficiency of low-permeability contaminated sites often fails to meet expectations.Hydraulic fracturing technology has been utilized to enhance amendment delivery,but the influence of soil heterogeneity is commonly overlooked.To address this issue,this study develops a numerical model to simulate the enhanced transport of amendments,incorporating convection,diffusion,adsorption,and degradation processes.Within the model,random permeability fields are generated based on geostatistical methods to explore how soil heterogeneity affects amendment injection efficiency,distribution characteristics,and the underlying physical mechanisms.The results indicate that(1)soil heterogeneity significantly reduces the amendment injection efficiency,with stronger heterogeneity correlating to lower efficiency,(2)soil heterogeneity markedly alters the amendment distribution characteristics,leading to the formation of localized“nodes”,(3)the mechanism by which heterogeneity reduces injection efficiency involves decreasing the density of preferential flow paths in the soil,and(4)the adverse effects of heterogeneity can be mitigated by employing pressure compensation or adjusting well spacing.
基金supported by the Sapienza Universitàdi Roma Sapienza Awards no.6H15XNFS.
文摘Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design/methodology/approach:An exploratory survey is administered to researchers at the Sapienza University of Rome,one of Europe’s oldest and largest generalist universities.To measure metric-wiseness,we use attitude statements that are evaluated by a 5-point Likert scale.Moreover,we analyze documents of recent initiatives on assessment reform to shed light on how researchers’heterogeneous attitudes regarding and knowledge of bibliometric indicators are taken into account.Findings:We found great heterogeneity in researchers’metric-wiseness across scientific disciplines.In addition,within each discipline,we observed both supporters and critics of bibliometric indicators.From the document analysis,we found no reference to individual heterogeneity concerning researchers’metric wiseness.Research limitations:We used a self-selected sample of researchers from one Italian university as an exploratory case.Further research is needed to check the generalizability of our findings.Practical implications:To gain sufficient support for research evaluation practices,it is key to consider researchers’diverse attitudes towards indicators.Originality/value:We contribute to the current debate on reforming research assessment by providing a novel empirical measurement of researchers’knowledge and attitudes towards bibliometric indicators and discussing the importance of the obtained results for improving current research evaluation systems.
基金supported by JSPS KAKENHI Grant Number 22K12903.
文摘Magnesium(Mg)alloys have attracted considerable attention as promising implant materials for biodegradable medical devices.In this study,we focused on investigating the effect of macroscopic environmental heterogeneity due to the degradation of Mg on its corrosion behavior.The immersion experiments using pure Mg plates,which were placed vertically in a culture medium(Dulbecco’s Modified Eagle’s Medium(DEME)+10%fetal bovine serum(FBS))for 1,5,and 10 days,were conducted.Surface analyses for the corrosion product layers and the measurements of the pH values and concentrations of eluted ions in the immersion medium around the upper and lower areas of the Mg plate were performed.The significant effect of the macroscopic environmental heterogeneity derived from Mg degradation on the corrosion behavior was demonstrated by in vitro tests.Additionally,the in vivo tests were carried out by implanting the pure Mg plates in the femur of rabbits.The in vivo results exhibited macroscopically heterogeneous Mg degradation,with areas of more severe corrosion compared to the in vitro test;it is especially noticeable during the early stage of degradation,even though the average corrosion rate was lower.
基金supported by the National Natural Science Foundation of China(82002432 to J.W.,82302068 to M.Z.,and 32300568 to T.W.)the Natural Science Foundation of Shandong Province(ZR2024MH159 to Y.Z.,ZR2020QH179 to J.W.,ZR2022QH057 to M.Z.,and ZR2021QH005 to T.W.)the China Postdoctoral Science Foundation(2024M752006 to S.M.)。
文摘Although the spatial characteristics within the tumor microenvironment of lung adenocarcinoma(LUAD)have been identified,the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear.Using spatial transcriptomics and single-cell RNA-sequencing data from multi-regional LUAD biopsies consisting of tumor core,tumor edge,and normal area,we sought to delineate the spatial heterogeneity and driving factors of cell colocalization.Two cancer cell sub-clusters(Cancer_c1 and Cancer_c2),associated with LUAD initiation and metastasis,respectively,exhibit distinct spatial distributions and immune cell colocalizations.In particular,Cancer_c1,enriched within the tumor core,could directly interact with B cells or indirectly recruit B cells through macrophages.Conversely,Cancer_c2 enriched within the tumor edge exhibits colocalization with CD8^(+)T cells.Collectively,our work elucidates the spatial distribution of cancer cell subtypes and their interaction with immune cells in the core and edge of LUAD,providing insights for developing therapeutic strategies for cancer intervention.
基金Financial supports from the National Natural Science Foundation of China(21503039)Department of Science and Technology of Liaoning Province(2019MS164)+1 种基金Department of Education of Liaoning Province(LJ2020JCL034)Discipline Innovation Team of Liaoning Technical University(LNTU20TD-16)are greatly acknowledged。
文摘Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound.The coexistence of weak interlayer van der Waals interactions,robust intralayer ionic bonding,and partial covalent bonding leads to remarkable bonding heterogeneity,which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction.The weakened chemical bonds induced by the antibonding states,together with the rattling-like behavior of the Zn atom,culminate in the profound anharmonicity in the layered NdZnSbO compound.The weakening bond and heavy element contribute to the softness of phonon modes,which significantly diminishes the phonon group velocity.The redistribution-dominated four-phonon scattering process spans a large optical gap,which effectively reduces the lattice thermal conductivity.The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06)functional in combination with spin–orbit coupling(SOC)effect.The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy,thus amplifying the power factor.Consequently,an optimal figure-of-merit(ZT)of 3.40 at 900 K is achieved for the n-type NdZnSbO compound.The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.
基金supported by the Key Program of the National Natural Science Foundation of China(Grant No.92047201)the Fundamental Research Funds for the Central Universities(Grant No.B230201026)+1 种基金the National Natural Science Foundation of China(Grants No.42377054 and 42007149)the Open Project of Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake(Grant No.HZHLAB2301).
文摘Reservoirs play a critical role in addressing water resources challenges.However,their vertical influence on the assembly mechanisms of different microbial communities,including prokaryotes and eukaryotes,remains unclear.This study examined the vertical diversity patterns of abundant and rare subcommunities of prokaryotes and eukaryotes in an urban reservoir,using water depth as a geographical gradient and employing high-throughput sequencing.The impact of vertical environmental heterogeneity on community structure was quantified,and key drivers of these dynamics were identified.The results indicated that the urban reservoir exhibited statistically significant differences in the vertical distribution of water temperature and oxidation/reduction potential.The a-diversity of the abundant subcommunity displayed an opposing vertical pattern compared to that of the rare subcommunity,while the b-diversity for both subcommunities of prokaryotes and eukaryotes increased with water depth.Moreover,the distinct diversity patterns of abundant and rare subcommunities were associated with environmental heterogeneity and species adaptability.Notably,the b-diversity of the rare subcommunity of eukaryotes was primarily driven by species turnover in surface water,whereas nestedness became the dominant factor in deeper water.Furthermore,eukaryotic microbes exhibited a more pronounced response to changes in water depth than prokaryotes,consistent with the importance of heterogeneous selection to the eukaryotic community.Water temperature significantly affected the community composition of all groups,highlighting its importance in shaping community dynamics.This study provides valuable insights into the vertical distribution and assembly mechanisms of microbial communities in urban reservoirs,contributing to the protection and management of aquatic ecosystems under river regulation.
基金Supported by the National Natural Science Foundation of China,No.82072034.
文摘BACKGROUND Gastroenteropancreatic neuroendocrine tumors(GEP-NETs)frequently metasta-size to the liver,with heterogeneity in tumor grade impacting patient prognosis and treatment.The Ki-67 index,a key prognostic marker,often varies between primary and metastatic sites;however,routine liver biopsy remains controversial.Although percutaneous computed tomography-guided core needle biopsy(PCT-CNB)is safe and effective for focal lesions,its role in detecting intertumor grading discrepancies and survival implications in GEP-NETs is underexplored.Conflic-ting survival associations with grade shifts have been reported in previous stu-dies.We hypothesized that PCT-CNB could identify clinically significant grading heterogeneity in liver metastases,correlating with survival outcomes,thereby refining risk stratification and therapeutic strategies.METHODS We retrospectively investigated 92 patients with liver metastases from GEP-NETs via PCT-CNB,76 patient samples from the liver and primary sites,and 16 from the liver and secondary liver sites.Ki-67 immunohistochemistry was performed for tissue sampling,and grading classifications were determined.Intertumor grading classification heterogeneity and associated changes in patient survival outcomes were also evaluated.RESULTS No procedure-related mortality was recorded during or after biopsy.In 37/92 patients(40.2%),the grading classi-fications changed:The grading increased from G1 to G2 in 13 patients,from G1 to G3 in 2,and from G2 to G3 in 14;the grading decreased from G2 to G1 in 5 patients,from G3 to G1 in 1,and from G3 to G2 in 2.Patients with G1 or G2 disease had better progression-free survival and overall survival(OS)outcomes than those with G3 disease did(P=0.001 and P<0.001,respectively).The 5-year and 10-year OS rates for stable G2 patients were 67.5%and 26.0%,respectively,decreasing to 46.4%and 23.2%,respectively,among G2 patients whose grade increased(P=0.016).CONCLUSION The PCT-CNB of liver metastases from GEP-NETs differed in grade between the liver tumor and primary site/secondary liver metastases.Additionally,when grading increased from G2,the OS rate significantly de-creased.
基金supported by the National Natural Science Foundation of China(No.52200120)the R&D Program of Beijing Municipal Education Commission(No.KM202310011003).
文摘CO_(2) emissions(CEs)pose a growing threat to environmental changes and global warming,attracting extensive attention.Here,we leveraged near-real-time monitoring data spanning 2019 to 2022 to investigate spatiotemporal heterogeneity,sectoral contributions,provincial spatial correlation,and driving factors influencing CEs at the provincial level in China.Our analysis,integrating Moran’s Index analysis,Spearman correlation analysis,and the Geographically Weighted Regression model,unveiled China’s consistent world-leading CEs,surpassing 10,000 Mt over the study period.Spatially,CEs exhibited a heterogeneous distribution,with markedly higher emissions in eastern and northern regions compared to western and southern areas.Temporally,CEs displayed significant fluctuations,peaking in the fourth quarter before declining in subsequent quarters.Chinese NewYear and COVID-19 had the biggest effects on CEs,with average daily reductions of-20.8%and-18.9%,respectively,compared to the four-year average and the same period in 2019.Sectoral analysis highlighted the power and industry sectors as primary contributors to CEs in China,jointly accounting for 37.9%-40.2%and 43.5%-46.4%of total CEs,respectively.Spatial clustering analysis identified a distinct High-High agglomeration region,predominantly encompassing provinces such as Inner Mongolia,Shandong and Jiangsu.Furthermore,total energy consumption and electricity consumption emerged as significant drivers of CEs,exhibiting correlation coefficients exceeding 0.9,followed by exhaust emissions,population size,and gross domestic product.Moreover,the influence of drivers on provincial CEs exhibited notable spatial heterogeneity,with regression coefficients displaying a decreasing gradient from north to south.These findings provide scientific and technological support to realize the provincial dual-carbon goals in China.
基金funded by the Natural Science Foundation of China(No.42407241,42272326 and 52222905)Jiangxi Provincial Natural Science Foundation(Nos.20242BAB20241,20242BAB23052 and 20242BAB24001).
文摘The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the difficulty and time consumption of OLT sample collection,accurately predicting OLT distribution remains a challenging.To address this,a novel framework has been developed.First,OLT samples are collected through field surveys,remote sensing,and geological drilling.Next,the heterogeneity of OLT’s spatial distribution is analyzed using the probability distribution of OLT samples and their horizontal and vertical distributions.The OLT samples are categorized and the small sample categories are expanded using the synthetic minority over-sampling technique(SMOTE).The slope position is selected as a key conditioning factor.Subsequently,16 conditioning factors are applied to construct OLT prediction model using the random forest regression algorithm.Weights are assigned to each OLT sample category to balance the uneven distribution of sample sizes.Finally,the Pearson correlation coefficient,mean absolute error(MAE),root mean square error(RMSE),and Lin’s concordance correlation coefficient(Lin’s CCC)are employed to validate the OLT prediction results.The Huangtan town serves as the case study.Results show:(1)heterogeneity analysis,SMOTE-based OLT sample expansion strategy and slope position selection can significantly mitigate the effect of spatial heterogeneity on OLT prediction.(2)The Pearson correlation coefficient,RMSE,MAE and Lin’s CCC values are 0.84,1.173,1.378 and 0.804,respectively,indicating excellent prediction performance.This research provides an effective solution for predicting OLT distribution in hillslope regions.
基金supported by the Natural Science Foundation of Jiangsu province,China(BK20240937)the Belt and Road Special Foundation of the National Key Laboratory of Water Disaster Prevention(2022491411,2021491811)the Basal Research Fund of Central Public Welfare Scientific Institution of Nanjing Hydraulic Research Institute(Y223006).
文摘Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in three coastal cities in Jiangsu Province,China.Seasonal and Trend decomposition using Loess(STL)together with wavelet analysis and empirical mode decomposition were applied to identify tide-influenced wells while remaining wells were grouped by hierarchical clustering analysis(HCA).Machine learning models were developed to predict GWD,then their response to natural conditions and human activities was assessed by the Shapley Additive exPlanations(SHAP)method.Results showed that eXtreme Gradient Boosting(XGB)was superior to other models in terms of prediction performance and computational efficiency(R^(2)>0.95).GWD in Yancheng and southern Lianyungang were greater than those in Nantong,exhibiting larger fluctuations.Groundwater within 5 km of the coastline was affected by tides,with more pronounced effects in agricultural areas compared to urban areas.Shallow groundwater(3-7 m depth)responded immediately(0-1 day)to rainfall,primarily influenced by farmland and topography(slope and distance from rivers).Rainfall recharge to groundwater peaked at 50%farmland coverage,but this effect was suppressed by high temperatures(>30℃)which intensified as distance from rivers increased,especially in forest and grassland.Deep groundwater(>10 m)showed delayed responses to rainfall(1-4 days)and temperature(10-15 days),with GDP as the primary influence,followed by agricultural irrigation and population density.Farmland helped to maintain stable GWD in low population density regions,while excessive farmland coverage(>90%)led to overexploitation.In the early stages of GDP development,increased industrial and agricultural water demand led to GWD decline,but as GDP levels significantly improved,groundwater consumption pressure gradually eased.This methodological framework is applicable not only to coastal cities in China but also could be extended to coastal regions worldwide.
基金funded by the Guangdong Province general university Young Innovative Talents Program Project(2024KQNCX153)Postdoctoral Research Start-up Funds of Dongguan University of Technology。
文摘The trade-off between strength and ductility has long been a challenge for Mg alloy.To address this issue,bimodal-structured AZ80 Mg alloys with varying heterogeneity levels were fabricated via low-temperature extrusion in this work.The results reveal the microstructure comprising second-phase particle(SP_(p),β-Mg_(17)Al_(12)and Mg_(3) Mn_(2) Al_(18))-reinforced fine grains(FGs)FGs and SP_(p)-free coarse grains(CGs),with the heterogeneity level decreasing as extrusion temperature increases.As the heterogeneity level decreases,the synergistic deformation capacity initially improves,reaching a maximum at the moderate heterogeneity level of 0.31 GPa and 0.238,and then declines.This exceptional capacity is attributed to the hetero-deformation induced(HDI)stress,which effectively alleviates the strain gradients by activating〈c+a〉dislocations and non-basal〈a〉dislocations during deformation.An optimal combination of 287 MPa in yield strength,393 MPa in ultimate tensile strength,and 14.96%in elongation is achieved in the alloy with a moderate heterogeneity level.The excellent strength-ductility synergy originates from the enhanced capacity of dislocations accumulation driven by remarkable capacity of synergistic deformation and the synergistic strengthening mechanisms.This work provides a new insight into the design of bimodal structure to produce high-performance Mg alloys.
基金supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ)the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ+2 种基金the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH)the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ)the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).
文摘Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More recently,advances in the development of Lecanemab,an anti-amyloid-βmonoclonal antibody,have shown positive results in reducing brain A burden and slowing cognitive decline in patients with early-stage Alzheimer’s disease in the Phase Ⅲ clinical trial(Clarity Alzheimer’s disease).Despite these promising results,side effects such as amyloid-related imaging abnormalities(ARIA)may limit its usage.ARIA can manifest as ARIA-E(cerebral edema or effusions)and ARIA-H(microhemorrhages or superficial siderosis)and is thought to be caused by increased vascular permeability due to inflammatory responses,leading to leakages of blood products and protein-rich fluid into brain parenchyma.Endothelial dysfunction is an early pathological feature of Alzheimer’s disease,and the blood-brain barrier becomes increasingly leaky as the disease progresses.In addition,APOE4,the strongest genetic risk factor for Alzheimer’s disease,is associated with higher vascular amyloid burden,increased ARIA incidence,and accelerated blood-brain barrier disruptions.These interconnected vascular abnormalities highlight the importance of vascular contributions to the pathophysiology of Alzheimer’s disease.Here,we will closely examine recent research evaluating the heterogeneity of brain endothelial cells in the microvasculature of different brain regions and their relationships with Alzheimer’s disease progression.
基金the financial support provided by MHRD,Govt.of IndiaCoal India Limited for providing financial assistance for the research(Project No.CIL/R&D/01/73/2021)the partial financial support provided by the Ministry of Education,Government of India,under SPARC project(Project No.P1207)。
文摘Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1.
文摘ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning from 2019 to 2022,coupled with measures of corporate transformation and upgrading,this study introduces green innovation as a mediating variable to dissect the impact of ESG ratings on corporate transformation and upgrading.The key findings of this research are as follows:(1)ESG ratings positively influence corporate transformation and upgrading,a conclusion that retains robustness after a comprehensive series of tests and discussions on endogeneity.(2)Mechanism analysis reveals that ESG ratings foster corporate transformation and upgrading by enhancing corporate green innovation.(3)In comparison with other industries,the influence of ESG ratings on corporate transformation and upgrading is notably more pronounced among heavily polluting industries among listed companies in China.Additionally,ESG ratings exhibit a more significant promotional effect on non-state-owned enterprises compared to state-owned enterprises.Larger enterprises play a more substantial role in transformation and upgrading than small and medium-sized enterprises.The promotional effect of ESG ratings is more evident in enterprises with poor information disclosure quality.Furthermore,as media attention increases,so does the impact of ESG ratings on corporate transformation.This study offers valuable policy insights from the ESG rating perspective,aiming to propel corporate transformation and upgrading,thereby contributing to economic high-quality and sustainable development.
