BACKGROUND Metachronous gastric cancer usually refers to a tumor that occurs in the stomach more than half a year after esophageal cancer surgery,and metastasis of primary esophageal cancer should be excluded.There ar...BACKGROUND Metachronous gastric cancer usually refers to a tumor that occurs in the stomach more than half a year after esophageal cancer surgery,and metastasis of primary esophageal cancer should be excluded.There are few reports of metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon after esophageal cancer surgery,which has a high degree of malignancy.This is also the reason for the poor treatment results.CASE SUMMARY A 54-year-old male patient was admitted to the hospital with“dysphagia obstruction”.Seven years ago,the patient was diagnosed with well-differentiated squamous cell carcinoma in the middle esophagus(T4N1M0 stage)and left gastric lymph node metastasis.In the final resection of the esophageal cancer,no residual cancer tissue was found in the esophageal and gastric stump.The patient’s medical history 7 years ago(preoperative gastroscopy and other examinations)revealed no gastric tumor.Combined with the patient’s history,the diagnosis of recurrent esophageal cancer was made on this admission.The final pathological results were surprising:Metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon.Considering the high malignancy of the tumor,the complexity of the second operation,and many complications,the patient received chemotherapy.CONCLUSION He had a history of esophageal cancer resection.Gastroenteroscopy should be performed simultaneously to avoid missed diagnosis and misdiagnosis.展开更多
BACKGROUND Endoscopic mucosal resection is an innovative method for treating early gastric cancer and has been widely used in clinical practice.AIM To analyze the factors associated with the development of heterochron...BACKGROUND Endoscopic mucosal resection is an innovative method for treating early gastric cancer and has been widely used in clinical practice.AIM To analyze the factors associated with the development of heterochronic gastric cancer in patients with early gastric cancer who had undergone endoscopic mucosal dissection(EMD).METHODS A cohort of patients with early gastric cancer treated using EMD was retrospectively analyzed,and patients who developed heterochronic gastric cancer after the surgery were compared with those who did not.The effects of patient age,sex,tumor size,pathological type,and surgical technique on the development of heterochronic gastric cancer were assessed using statistical analysis.RESULTS Of the 300 patients with early gastric cancer,150 patients developed heterochronic gastric cancer after EMD.Statistical analysis revealed that patient age(P value=XX),sex(P value=XX),tumor size(P value=XX),pathological type(P value=XX),and surgical technique(P value=XX)were significantly associated with the occurrence of heterochronic gastric cancer.CONCLUSION Age,sex,tumor size,pathological type,and surgical technique are key factors influencing the occurrence of heterochronic gastric cancer after EMD in patients with early gastric cancer.To address these factors,postoperative follow-up and management should be strengthened to improve the prognosis and survival rate of patients.展开更多
We have isolated a recessive rice mutant, designated as indeterminate growth （ing）, which displays creeping and apparent heterochronic phenotypes in the vegetative period with lanky and winding culms. Rough mapping ...We have isolated a recessive rice mutant, designated as indeterminate growth （ing）, which displays creeping and apparent heterochronic phenotypes in the vegetative period with lanky and winding culms. Rough mapping and subsequent molecular characterization revealed that the ing mutant carries a large deletion, which corresponds to a 103 kb region in the Nipponbare genome, containing nine annotated genes on chromosome 3. Of these annotated genes, the SLR1 gene encoding a DELLA protein is the only one that is well characterized in its function, and its null mutation, which is caused by a single base deletion in the middle of the intronless SLR1 gene, confers a slender phenotype that bears close resemblance to the ing mutant phenotype. The primary cause of the ing mutant phenotype is the deletion of the SLR1 gene, and the ing mutant appears to be the first characterized mutant having the entire SLR1 sequence deleted. Our results also suggest that the deleted region of 103 kb does not contain an indispensable gene, whose dysfunction must result in a lethal phenotype.展开更多
Ectopic pregnancy is identified with the widely-applied assisted reproductive technology （ART）. Bilateral ectopic pregnancy is a rare form of ectopic pregnancy which is difficult to be diagnosed at the pre-operation...Ectopic pregnancy is identified with the widely-applied assisted reproductive technology （ART）. Bilateral ectopic pregnancy is a rare form of ectopic pregnancy which is difficult to be diagnosed at the pre-operation stage. In this paper, we presented an unusual case of heterochronic bilateral ectopic pregnancy after stimulated intrauterine insemination （IUI）, where there has been a delay of 22 d between the diagnoses of the two ectopic pregnancies. Literature was reviewed on the occurrence of bilateral ectopic pregnancy during the past four years in the MEDLINE database. We found 16 cases of bilateral ectopic pregnancy reported since 2008, and analyzed the characteristics of those cases of bilateral ectopic pregnancy. We emphasize that ovulation induction and other ARTs may increase the risk of bilateral ectopic pregnancy. Because of the difficulty in identification of bilateral ectopic pregnancy by ultraso- nography, the clinician should be aware that the treatment of one ectopic pregnancy does not preclude the occurrence of a second ectopic pregnancy in the same patient and should pay attention to the intra-operation inspection of both side fallopian tubes in any ectopic pregnancy case.展开更多
BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)and intraductal papillary mucinous neoplasm(IPMN)of the pancreas have similar pathological manifestations.However,they often develop separately and it is...BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)and intraductal papillary mucinous neoplasm(IPMN)of the pancreas have similar pathological manifestations.However,they often develop separately and it is rare for both to occur together.Patients presenting with heterochronic IPMN after IPNB are prone to be misdiagnosed with tumor recurrence.CASE SUMMARY A 67-year-old male patient was admitted 8.5 years after IPNB carcinoma and 4 years after the discovery of a pancreatic tumor.A left hepatic bile duct tumor with distal bile duct dilatation was found 8.5 years ago by the computed tomography;therefore,a left hepatectomy was performed.The postoperative pathological diagnosis was malignant IPNB with negative cutting edge and pathological stage T1N0M0.Magnetic resonance imaging 4 years ago showed cystic lesions in the pancreatic head with pancreatic duct dilatation,and carcinoembryonic antigen continued to increase.Positron emission tomography showed a maximum standard uptake value of 11.8 in the soft tissue mass in the pancreatic head,and a malignant tumor was considered.Radical pancreatoduodenectomy was performed.Postoperative pathological diagnosis was pancreatic head IPMN with negative cutting edge,pancreaticobiliary type,stage T3N0M0.He was discharged 15 d after the operation.Follow-up for 6 mo showed no tumor recurrence,and quality of life was good.CONCLUSION IPNB and IPMN are precancerous lesions with similar pathological characteristics and require active surgery and long-term follow-up.展开更多
BACKGROUND The incidence of multiple primary carcinomas(MPC)varies greatly,ranging from 0.73%to 11.70%in foreign countries,with duo-duplex carcinoma being the most common,trio-duplex carcinoma and above being rare,and...BACKGROUND The incidence of multiple primary carcinomas(MPC)varies greatly,ranging from 0.73%to 11.70%in foreign countries,with duo-duplex carcinoma being the most common,trio-duplex carcinoma and above being rare,and simultaneous multigenic carcinoma being even rarer,accounting for 18.4%to 25.3%of the incidence of MPC.However,there is no report regarding patients presenting with simultaneous dual-origin carcinoma of the liver and colon and heterochronous pancreatic cancer.CASE SUMMARY We report a special case of multifocal carcinoma,in which one patient had a medical condition of primary liver and colon cancer and pancreatic cystadenocarcinoma 2 years after surgery.Through aggressive advanced fluorescent laparoscopic techniques,standardized immunotherapy,targeting,and chemotherapy,a better prognosis and a desirable survival period were achieved for the patient.CONCLUSION There is a need to clarify the nature of MPC through advanced surgical means to ensure better diagnosis and treatment.展开更多
The comparative morphology and anatomy of leaves between the coastal ecotype and the normal type of Adenophora triphylla (Thunb.) A.DC. var. japonica (Regel) H.Hara (Campanulaceae) were examined to clarify the differe...The comparative morphology and anatomy of leaves between the coastal ecotype and the normal type of Adenophora triphylla (Thunb.) A.DC. var. japonica (Regel) H.Hara (Campanulaceae) were examined to clarify the differences in morphological characters between the 2 groups. Morphological and anatomical analyses revealed that the coastal ecotype had a thicker leaf than the normal type, because of the increased size of epidermal and spongy cells. Thus, the main morphological change from the normal type into the coastal ecotype of A. triphylla var. japonica is the increase in leaf size, suggesting that the coastal ecotype may have evolved from the normal type via a heterochronic process.展开更多
基金Scientific Research Fund of Sichuan Health and Wellness,China,No.21PJ113.
文摘BACKGROUND Metachronous gastric cancer usually refers to a tumor that occurs in the stomach more than half a year after esophageal cancer surgery,and metastasis of primary esophageal cancer should be excluded.There are few reports of metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon after esophageal cancer surgery,which has a high degree of malignancy.This is also the reason for the poor treatment results.CASE SUMMARY A 54-year-old male patient was admitted to the hospital with“dysphagia obstruction”.Seven years ago,the patient was diagnosed with well-differentiated squamous cell carcinoma in the middle esophagus(T4N1M0 stage)and left gastric lymph node metastasis.In the final resection of the esophageal cancer,no residual cancer tissue was found in the esophageal and gastric stump.The patient’s medical history 7 years ago(preoperative gastroscopy and other examinations)revealed no gastric tumor.Combined with the patient’s history,the diagnosis of recurrent esophageal cancer was made on this admission.The final pathological results were surprising:Metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon.Considering the high malignancy of the tumor,the complexity of the second operation,and many complications,the patient received chemotherapy.CONCLUSION He had a history of esophageal cancer resection.Gastroenteroscopy should be performed simultaneously to avoid missed diagnosis and misdiagnosis.
文摘BACKGROUND Endoscopic mucosal resection is an innovative method for treating early gastric cancer and has been widely used in clinical practice.AIM To analyze the factors associated with the development of heterochronic gastric cancer in patients with early gastric cancer who had undergone endoscopic mucosal dissection(EMD).METHODS A cohort of patients with early gastric cancer treated using EMD was retrospectively analyzed,and patients who developed heterochronic gastric cancer after the surgery were compared with those who did not.The effects of patient age,sex,tumor size,pathological type,and surgical technique on the development of heterochronic gastric cancer were assessed using statistical analysis.RESULTS Of the 300 patients with early gastric cancer,150 patients developed heterochronic gastric cancer after EMD.Statistical analysis revealed that patient age(P value=XX),sex(P value=XX),tumor size(P value=XX),pathological type(P value=XX),and surgical technique(P value=XX)were significantly associated with the occurrence of heterochronic gastric cancer.CONCLUSION Age,sex,tumor size,pathological type,and surgical technique are key factors influencing the occurrence of heterochronic gastric cancer after EMD in patients with early gastric cancer.To address these factors,postoperative follow-up and management should be strengthened to improve the prognosis and survival rate of patients.
基金supported by a grant from the Program for Promotion of Basic Research Activities for Innovative Biosciences(PROBRAIN to S.I.) from Bio-oriented Technology Research Advancement Institution(BRAIN) in Japangrants from the Ministry of Education,Culture,Sports, Science,and Technology of Japan(No.17207002 to S.I.and 22780007 to K.T.)+1 种基金supported by the Global COE Program(to H.K.and S.I.)the NIBB Cooperative Research Program(9-151 to H.K.and 9-153 to M.M.),and the Graduate University for Advanced Studies(Sokendai)
文摘We have isolated a recessive rice mutant, designated as indeterminate growth （ing）, which displays creeping and apparent heterochronic phenotypes in the vegetative period with lanky and winding culms. Rough mapping and subsequent molecular characterization revealed that the ing mutant carries a large deletion, which corresponds to a 103 kb region in the Nipponbare genome, containing nine annotated genes on chromosome 3. Of these annotated genes, the SLR1 gene encoding a DELLA protein is the only one that is well characterized in its function, and its null mutation, which is caused by a single base deletion in the middle of the intronless SLR1 gene, confers a slender phenotype that bears close resemblance to the ing mutant phenotype. The primary cause of the ing mutant phenotype is the deletion of the SLR1 gene, and the ing mutant appears to be the first characterized mutant having the entire SLR1 sequence deleted. Our results also suggest that the deleted region of 103 kb does not contain an indispensable gene, whose dysfunction must result in a lethal phenotype.
基金supported by the National Basic Research Program(973)of China(No.2013CB967404)the National Natural Science Foundation of China(Nos.81170310 and 81270664)+1 种基金the Science Foundation for Distinguished Young Scholars of Zhejiang Province(No.LR14H040001)the Talent Project of Zhejiang Province(No.2011RCA028),China
文摘Ectopic pregnancy is identified with the widely-applied assisted reproductive technology （ART）. Bilateral ectopic pregnancy is a rare form of ectopic pregnancy which is difficult to be diagnosed at the pre-operation stage. In this paper, we presented an unusual case of heterochronic bilateral ectopic pregnancy after stimulated intrauterine insemination （IUI）, where there has been a delay of 22 d between the diagnoses of the two ectopic pregnancies. Literature was reviewed on the occurrence of bilateral ectopic pregnancy during the past four years in the MEDLINE database. We found 16 cases of bilateral ectopic pregnancy reported since 2008, and analyzed the characteristics of those cases of bilateral ectopic pregnancy. We emphasize that ovulation induction and other ARTs may increase the risk of bilateral ectopic pregnancy. Because of the difficulty in identification of bilateral ectopic pregnancy by ultraso- nography, the clinician should be aware that the treatment of one ectopic pregnancy does not preclude the occurrence of a second ectopic pregnancy in the same patient and should pay attention to the intra-operation inspection of both side fallopian tubes in any ectopic pregnancy case.
文摘BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)and intraductal papillary mucinous neoplasm(IPMN)of the pancreas have similar pathological manifestations.However,they often develop separately and it is rare for both to occur together.Patients presenting with heterochronic IPMN after IPNB are prone to be misdiagnosed with tumor recurrence.CASE SUMMARY A 67-year-old male patient was admitted 8.5 years after IPNB carcinoma and 4 years after the discovery of a pancreatic tumor.A left hepatic bile duct tumor with distal bile duct dilatation was found 8.5 years ago by the computed tomography;therefore,a left hepatectomy was performed.The postoperative pathological diagnosis was malignant IPNB with negative cutting edge and pathological stage T1N0M0.Magnetic resonance imaging 4 years ago showed cystic lesions in the pancreatic head with pancreatic duct dilatation,and carcinoembryonic antigen continued to increase.Positron emission tomography showed a maximum standard uptake value of 11.8 in the soft tissue mass in the pancreatic head,and a malignant tumor was considered.Radical pancreatoduodenectomy was performed.Postoperative pathological diagnosis was pancreatic head IPMN with negative cutting edge,pancreaticobiliary type,stage T3N0M0.He was discharged 15 d after the operation.Follow-up for 6 mo showed no tumor recurrence,and quality of life was good.CONCLUSION IPNB and IPMN are precancerous lesions with similar pathological characteristics and require active surgery and long-term follow-up.
基金Supported by the Education Project of Yunnan Province,No.2023J767the High-level Talent Training Support Project of Yunnan Province,No.YNWR-MY-2020-053.
文摘BACKGROUND The incidence of multiple primary carcinomas(MPC)varies greatly,ranging from 0.73%to 11.70%in foreign countries,with duo-duplex carcinoma being the most common,trio-duplex carcinoma and above being rare,and simultaneous multigenic carcinoma being even rarer,accounting for 18.4%to 25.3%of the incidence of MPC.However,there is no report regarding patients presenting with simultaneous dual-origin carcinoma of the liver and colon and heterochronous pancreatic cancer.CASE SUMMARY We report a special case of multifocal carcinoma,in which one patient had a medical condition of primary liver and colon cancer and pancreatic cystadenocarcinoma 2 years after surgery.Through aggressive advanced fluorescent laparoscopic techniques,standardized immunotherapy,targeting,and chemotherapy,a better prognosis and a desirable survival period were achieved for the patient.CONCLUSION There is a need to clarify the nature of MPC through advanced surgical means to ensure better diagnosis and treatment.
文摘The comparative morphology and anatomy of leaves between the coastal ecotype and the normal type of Adenophora triphylla (Thunb.) A.DC. var. japonica (Regel) H.Hara (Campanulaceae) were examined to clarify the differences in morphological characters between the 2 groups. Morphological and anatomical analyses revealed that the coastal ecotype had a thicker leaf than the normal type, because of the increased size of epidermal and spongy cells. Thus, the main morphological change from the normal type into the coastal ecotype of A. triphylla var. japonica is the increase in leaf size, suggesting that the coastal ecotype may have evolved from the normal type via a heterochronic process.
