Intratumoral heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst malignant cells originated within the same tumor.Both,cell differentiation hierarchy and stochasticity in...Intratumoral heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst malignant cells originated within the same tumor.Both,cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of cancer cells.Since a tumor consists of cancer cell clones that display distinct behaviours,changes in clonal proliferative behavior may also contribute to the phenotypic variability of tumor cells.There is a need to reveal molecular actions driving chemotherapeutic resistance in colon cancer cells.In general,it is widely hypothesized that therapeutic resistance in colorectal cancer is a consequence of the preferential survival of cancer stem cells.However,recent data regarding colorectal cancer suggest that resistance to anticancer therapy and post-therapeutic tumor reappearence could be related to variations of clonal dynamics.Understanding the interaction of genetic and nongenetic determinants influencing the functional diversity and therapy response of tumors should be a future direction for cancer research.展开更多
Eight new complexes were synthesize d for the first time.The compounds which have the general formula K x H 2 [PM(OH 2 )Mo 7 W 2 V 2 O 39 ]·nH 2 O(M=Cr 3+ ,Mn 2+ ,Fe 3+ ,Co 3+ ,Ni 2+ ,Cu 2+ ,Zn 2+ ,Cd 2+ ;x=4or 5...Eight new complexes were synthesize d for the first time.The compounds which have the general formula K x H 2 [PM(OH 2 )Mo 7 W 2 V 2 O 39 ]·nH 2 O(M=Cr 3+ ,Mn 2+ ,Fe 3+ ,Co 3+ ,Ni 2+ ,Cu 2+ ,Zn 2+ ,Cd 2+ ;x=4or 5)were de-termined by conductance titration a nd elemental analysis.The analysis of IR,UV,XRD and ESR show that the products hold the Keggin structure a nd TG-DTA,IR,XRD at various tempera tures and water solubility test also give the evidences that the range of pyrolysis temperature is 300～350℃.T he study on the substitutional reaction of coordinated water by optical ligand quinine shows that the S N 2nucleophilic substitution occure s when Ni is con-tained in the compound and S N 1nucleophilic substitution occure s when Cu is contained.These also con firmed that the transitional metals are in the in ner sphere of the complexes.展开更多
文摘Intratumoral heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst malignant cells originated within the same tumor.Both,cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of cancer cells.Since a tumor consists of cancer cell clones that display distinct behaviours,changes in clonal proliferative behavior may also contribute to the phenotypic variability of tumor cells.There is a need to reveal molecular actions driving chemotherapeutic resistance in colon cancer cells.In general,it is widely hypothesized that therapeutic resistance in colorectal cancer is a consequence of the preferential survival of cancer stem cells.However,recent data regarding colorectal cancer suggest that resistance to anticancer therapy and post-therapeutic tumor reappearence could be related to variations of clonal dynamics.Understanding the interaction of genetic and nongenetic determinants influencing the functional diversity and therapy response of tumors should be a future direction for cancer research.
文摘Eight new complexes were synthesize d for the first time.The compounds which have the general formula K x H 2 [PM(OH 2 )Mo 7 W 2 V 2 O 39 ]·nH 2 O(M=Cr 3+ ,Mn 2+ ,Fe 3+ ,Co 3+ ,Ni 2+ ,Cu 2+ ,Zn 2+ ,Cd 2+ ;x=4or 5)were de-termined by conductance titration a nd elemental analysis.The analysis of IR,UV,XRD and ESR show that the products hold the Keggin structure a nd TG-DTA,IR,XRD at various tempera tures and water solubility test also give the evidences that the range of pyrolysis temperature is 300～350℃.T he study on the substitutional reaction of coordinated water by optical ligand quinine shows that the S N 2nucleophilic substitution occure s when Ni is con-tained in the compound and S N 1nucleophilic substitution occure s when Cu is contained.These also con firmed that the transitional metals are in the in ner sphere of the complexes.
