Objective: To explore the effects of ligustrazine on proteinuria, serumcreati-nine, urinary thromboxane A_2(TxA_2), metabolism of prostacyclinI_2(PGI_2)―6-keto-PGF_(1α), and renal pathological changes of SD rats wit...Objective: To explore the effects of ligustrazine on proteinuria, serumcreati-nine, urinary thromboxane A_2(TxA_2), metabolism of prostacyclinI_2(PGI_2)―6-keto-PGF_(1α), and renal pathological changes of SD rats with passive Hermannnephritis (PHN). Methods: The PHN model was induced by intravenous injection of rabbit anti-ratrenal tubular epithelial antigen (Tub―Ag) an-tiserum to SD rats. I. P. administration ofligustrazine to rats was given every 2 d for 1 to 5 weeks. The proteinuria, creatinine, TxA_2 and6-keto-PGF_(1α) were measured by sulfosaticylic acid, picric acid, and direct radioimmunoassayrespectively. The renal pathological changes were observed under light microscope, electronicmicroscope and by direct immunofluorescence staining rabbit and rat IgG. Results: The PHN ratstreated with ligustrazine had significantly less proteinuria, serum creatinine, urinary TxA_2 andpathological changes of kidney, and more urinary 6-keto-PGF_(1α) than those without administrationof ligustrazine. Conclusion: Ligustrazine decreases proteinuria, urinary TxA_2, and renal tissueinjury and increases urinary 6-keto-PGF_(1α). These data indicate that ligustrazine may modulatethe balance of TxA_2 and PG I_2 in rat PHN model and can be used for preventing and treatingmembranous glomerulonephritis.展开更多
By virtue of the generalised Hermann-Feynmam theorem we re-derive the energy average formula of photon gas. This is another useful application of the theorem.
Hermann Weyl在其“关于数学的新基础危机”(On the New Fundations Crisis in Mathematics)[Weyl 1921]中宣告：“Brouwer计划乃是一场彻底的改革!”，并随之一头扎进了数学界关于集合论和分析基础的不断升级的大论战．Weyl作此决定并...Hermann Weyl在其“关于数学的新基础危机”(On the New Fundations Crisis in Mathematics)[Weyl 1921]中宣告：“Brouwer计划乃是一场彻底的改革!”，并随之一头扎进了数学界关于集合论和分析基础的不断升级的大论战．Weyl作此决定并非轻而易举——展开更多
[目的]对比人工股骨头置换与动力髋螺钉（dynamic hip screw,DHS）治疗高龄股骨粗隆间骨折的临床效果,并分析两者的优缺点。[方法]收治72岁以上高龄股骨粗隆间骨折76例,其中采用DHS 49例,人工股骨头置换27例,记录手术时间、术中和术后...[目的]对比人工股骨头置换与动力髋螺钉（dynamic hip screw,DHS）治疗高龄股骨粗隆间骨折的临床效果,并分析两者的优缺点。[方法]收治72岁以上高龄股骨粗隆间骨折76例,其中采用DHS 49例,人工股骨头置换27例,记录手术时间、术中和术后出血量、下床活动时间、早期Harris评分以及半年、2年后Harris评分及术后并发症。[结果]随访24~48个月。人工股骨头置换组可有较早的下床活动和早期良好的Harris评分,但是,无论在手术时间上,还是在手术中和术后出血量比较上人工股骨头置换组均明显高于DHS内固定组;6个月后的Harris评分两者无明显差异。[结论]高龄股骨粗隆间骨折仍应以内固定治疗为首选措施,应慎重选用人工股骨头置换术,严格掌握其适应证。展开更多
文摘Objective: To explore the effects of ligustrazine on proteinuria, serumcreati-nine, urinary thromboxane A_2(TxA_2), metabolism of prostacyclinI_2(PGI_2)―6-keto-PGF_(1α), and renal pathological changes of SD rats with passive Hermannnephritis (PHN). Methods: The PHN model was induced by intravenous injection of rabbit anti-ratrenal tubular epithelial antigen (Tub―Ag) an-tiserum to SD rats. I. P. administration ofligustrazine to rats was given every 2 d for 1 to 5 weeks. The proteinuria, creatinine, TxA_2 and6-keto-PGF_(1α) were measured by sulfosaticylic acid, picric acid, and direct radioimmunoassayrespectively. The renal pathological changes were observed under light microscope, electronicmicroscope and by direct immunofluorescence staining rabbit and rat IgG. Results: The PHN ratstreated with ligustrazine had significantly less proteinuria, serum creatinine, urinary TxA_2 andpathological changes of kidney, and more urinary 6-keto-PGF_(1α) than those without administrationof ligustrazine. Conclusion: Ligustrazine decreases proteinuria, urinary TxA_2, and renal tissueinjury and increases urinary 6-keto-PGF_(1α). These data indicate that ligustrazine may modulatethe balance of TxA_2 and PG I_2 in rat PHN model and can be used for preventing and treatingmembranous glomerulonephritis.
基金supported by the Special Funds of the National Natural Science Foundation of China (Grant No.10947017/A05)
文摘By virtue of the generalised Hermann-Feynmam theorem we re-derive the energy average formula of photon gas. This is another useful application of the theorem.
文摘Hermann Weyl在其“关于数学的新基础危机”(On the New Fundations Crisis in Mathematics)[Weyl 1921]中宣告：“Brouwer计划乃是一场彻底的改革!”，并随之一头扎进了数学界关于集合论和分析基础的不断升级的大论战．Weyl作此决定并非轻而易举——
文摘[目的]对比人工股骨头置换与动力髋螺钉（dynamic hip screw,DHS）治疗高龄股骨粗隆间骨折的临床效果,并分析两者的优缺点。[方法]收治72岁以上高龄股骨粗隆间骨折76例,其中采用DHS 49例,人工股骨头置换27例,记录手术时间、术中和术后出血量、下床活动时间、早期Harris评分以及半年、2年后Harris评分及术后并发症。[结果]随访24~48个月。人工股骨头置换组可有较早的下床活动和早期良好的Harris评分,但是,无论在手术时间上,还是在手术中和术后出血量比较上人工股骨头置换组均明显高于DHS内固定组;6个月后的Harris评分两者无明显差异。[结论]高龄股骨粗隆间骨折仍应以内固定治疗为首选措施,应慎重选用人工股骨头置换术,严格掌握其适应证。
