With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pre...With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pressure,the traditional family-based elderly care model is facing significant challenges and can hardly meet the elderly care needs.At present,the geriatric nursing models are relatively backward,which directly affects the quality of daily life,physical health and mental well-being of the elderly.Therefore,it is necessary to explore an appropriate geriatric nursing model to address the aging problem.Based on this,this paper analyzes and studies the current situation of geriatric nursing models under the background of healthy aging,providing references for relevant research and practice.展开更多
As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings.Gut microbiota has become a key factor in the anti-aging p...As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings.Gut microbiota has become a key factor in the anti-aging process.Modulation of gut microbiota by fecal microbiota transplantation(FMT)to prevent frailty and unhealthy aging has been a hot topic of research.This narrative review summarizes the benefits of FMT for health span and lifespan,brains,eyes,productive systems,bones,and others.The mechanisms of FMT in improving healthy aging are discussed.The increased beneficial bacteria and decreased pathological bacteria decreased gut permeability and systemic inflammation,increased short-chain fatty acid(SCFA)and SCFA-producing bacteria,and other factors are listed as mechanisms of FMT to improve healthy aging.The points that need to be considered to ensure the optimal outcomes of FMT are also discussed,such as recipients’age,sex,genetic background,and gut microbiota after FMT.Although thisfield is still in its infancy,it has shown that FMT has great potential to improve healthy aging.展开更多
Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a society.This study aime...Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a society.This study aimed to investigate how older people are portrayed in televised food commercials from the approach of a healthy aging perspective in contemporary Chinese society.Methods:All televised advertising in the Ad Topic archive were screened against inclusion and exclusion criteria,and a total of 164 commercials from the years of 2016-2019 that portrayed Chinese older people were sampled.The association between the main older characters with the product categories,healthy vs.unhealthy foods,use of health claims,sex,type of spokesperson,companions,and tones and manners were included in the analysis.Results:Older people more frequently appeared in unhealthy food products than in healthy food products.Health claims involving older adults were portrayed adequately,whereas nursing professions as companions of older adults were overlooked.Positive advertising that delivered happy,caring,or warm tones was overwhelmingly represented.Thus,the advertising messages circulated in China represent a binary stereotype model of images of older adults'characteristics that reflect ageist and the so-called agelessism,referring to the new application of the look from the approach of social psychology and marketing field.Conclusions:This study examined aging discrimination reflected in advertisements.Studies exploring the impact of a crisis remain limited.Research is needed to improve the accuracy of advertised healthy older adults and normal aging.展开更多
In 2021,China became an aged society when the share of its elderly population(age 65 years and above)exceeded 14%.In China,as in other upper‐middle‐income and high‐income countries,life expectancy gains are increas...In 2021,China became an aged society when the share of its elderly population(age 65 years and above)exceeded 14%.In China,as in other upper‐middle‐income and high‐income countries,life expectancy gains are increasingly concentrated at older ages with below‐average health and economic activity.Governments worldwide are hence actively pursuing healthy and productive aging.Healthy aging by some measures is taking place.Similar with other upper‐middle‐income countries,China's young old in their 60s are healthier than the same age group two decades ago.The picture is more complex for the older age group(70 years and above).Although there is a substantial decline in leading disease burdens such as stroke and chronic obstructive pulmonary disease,diseases such as Alzheimer's and other dementia are on the rise.To meet the challenge of a rapidly aging population,China's healthy aging agenda should improve its multipronged approach that seeks to promote healthy lifestyles,enhance the healthcare system,create agefriendly communities,and tackle socioeconomic and health disparities.展开更多
aging is a natural and inevitable physiological process that poses a serious threat to physical health,leading to age-related diseases and placing a heavy burden on the public health system.this study explores interve...aging is a natural and inevitable physiological process that poses a serious threat to physical health,leading to age-related diseases and placing a heavy burden on the public health system.this study explores intervention measures to promote healthy aging and prolong lifespan.anthocyanins(aCNs),as a class of flavonoids widely presented in fruits,vegetables and grains,exhibit strong antioxidant and anti-inflammatory activities.recent studies indicate that aCNs exert health effects primarily by interacting with gut microbiota.Here,we introduced the digestion and absorption of aCNs,and mainly elaborated on the role of aCNs in delaying aging through gut microbiota.In addition,we described the changes in gut microbiota mediated by aCNs and their impact on age-related chronic diseases,including cardiovascular diseases,neurodegenerative diseases,cancer,and sarcopenia.therefore,aCNs have a broad application prospect in the development of functional foods with anti-aging effects by regulating gut microbiota.展开更多
Healthy aging is a common goal for humanity and society,and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration.However,the mechanistic understandin...Healthy aging is a common goal for humanity and society,and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration.However,the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive.Here,we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell(MSC)function and regeneration.Interestingly,replenishment of cell aggregates-derived extracellular vesicles(CA-EVs)rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5.Importantly,in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice,suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration.Collectively,our findings provide insights into Golgi regulation in stem cell senescence and bone aging,which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.展开更多
Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the...Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the entrepreneurship activities of Nepalese older adults. Data for this study were collected from the project Help Age International (HAI) implemented in Nepal. Qualitative data observations and interviews were used to collect data. The findings of this study show the formation of the Older People’s Association (OPA) has supported many older people to participate outside the home in various social activities. Moreover, regular deposits through OPAs offer little help. OPAs support older people in their need of financial support to implement minor entrepreneurship. Older people who received support were pleased and were actively involved in their activities and also regularly deposited money in them. Subsequently, older people’s participation in social activities has increased and also helped to lower elderly abuse, loneliness, and depression. Local governments should promote such activities which will help with healthy aging.展开更多
Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and can...Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.展开更多
Aging is a major risk factor for many human diseases,including cognitive impairment,which affects a large population of the elderly.In the past few decades,our understanding of the molecular and cellular mechanisms un...Aging is a major risk factor for many human diseases,including cognitive impairment,which affects a large population of the elderly.In the past few decades,our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly,shedding light on the potential role of these changes in cognitive impairment.In this article,we review recent advances in understanding of the mechanisms underlying brain aging under normal and pathological conditions,compare their similarities and differences,discuss the causative and adaptive mechanisms of brain aging,and finally attempt to find some rules to guide us on how to promote healthy aging and prevent age-related diseases.展开更多
About two thousand years ago,Hippocrates observed that“walking is man's best medicine”[1],a notion increasingly validated in modern society.The benefits of physical activity in preventing chronic diseases and in...About two thousand years ago,Hippocrates observed that“walking is man's best medicine”[1],a notion increasingly validated in modern society.The benefits of physical activity in preventing chronic diseases and in improving longevity have been extensively studied[2].展开更多
The world＇s population is ageing rapidly, which will have substantial consequences. According to WHO： ＂Process of optimizing opportunities for health, participation and security in order to enhance quality of life ...The world＇s population is ageing rapidly, which will have substantial consequences. According to WHO： ＂Process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age＂. The aim of this work is to make a literature review on key measures that contribute to healthy ageing. A search was conducted in the following databases： PubMed, Cochrane, National Guideline Clearinghouse, Trip Database, Guideline finders, NICE and WHO database, written in English and published in the last ten years. The following MeSH words were used： ＂healthy ageing＂. The search was conducted from July first till end of December 2015. Based on the articles searched there are many measures with potential to achieve gains in healthy ageing such as prevention of falls; vaccination; regular physical activity, eating fruits and vegetables daily, drinking alcohol moderately; never smoking; prevention of social isolation and social exclusion; prevention of elder maltreatment; public support for informal care giving and create strategies to ensure the quality of care for older people. Getting older can come with a variety of health challenges. In the daily practice of family doctor there are many effective interventions that can improve health and wellbeing in elderly people.展开更多
Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health statuses.Methods:Totally 485 older adults were recruited.Th...Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health statuses.Methods:Totally 485 older adults were recruited.They were divided into three groups based on their health status:healthy group(n=72),group with one disease(n=183)and group with multimorbidity(n=230).Lubben Social Network Scale-6 and Health-Promoting Lifestyle Profile II were used to measure their social isolation and health-promoting behaviors,respectively.Results:Among the aged with one disease or multimorbidity,30.6%(56/183)and 31.7%(73/230)were socially isolated,respectively,based on the score of the Lubben Social Network Scale-6.The three groups differed significantly in health-promoting behaviors and scores on several subscales.The group with multimorbidity exhibited more social isolation and fewer health-promoting behaviors than other groups.Social isolation was among the factors adversely affecting health-promoting behaviors in older adults.Conclusions:Health care providers should help older adults with multimorbidity preserve the remaining abilities to improve health-promoting behaviors.Meanwhile,it is important to support healthy older adults to increase self-responsibility to achieve healthy aging.展开更多
Objective:This study aimed to revise the Constitution in Chinese Medicine Questionnaire(Elderly Edition)(CCMQ-EE),as well as evaluate its reliability and validity.The objective was to provide a more accurate Chinese m...Objective:This study aimed to revise the Constitution in Chinese Medicine Questionnaire(Elderly Edition)(CCMQ-EE),as well as evaluate its reliability and validity.The objective was to provide a more accurate Chinese medicine constitution identification tool for geriatric health management and help further research on the relationship between geriatric diseases and constitution type,etc.Methods:The Delphi method and a cross-sectional survey of the elderly population were used.From April to October 2021,experts in different fields were invited to participate in the questionnaire,and items were revised through the experts'ratings and feedback.From December 2021 to February 2022,the revised CCMQ-EE was validated in the elderly population.Results:The coefficients of variation of rationality and importance scores decreased to less than 0.25 in the third round of Delphi.The Kendall coordination coefficients of rationality and importance in the third round were 0.15 and 0.17(P=.031 and P=.007,respectively).The revised CCMQ-EE was established with 34 items.The factor loadings of subscales were between 0.39 and 0.92,and the fitting effects of other subscales were acceptable,except for the inherited special constitution.The Cronbach alpha and test-retest reliability coefficients of each subscale ranged from 0.65 to 0.83,and 0.66 to 0.96,respectively.The composite reliability and average variance extraction were between 0.66 and 0.84,and between 0.32 and 0.57,respectively.The reliability and validity of the revised CCMQ-EE were acceptable or satisfactory.Conclusion:The revised CCMQ-EE was developed through a three-round Delphi process and internal team discussion.After the verification in the elderly in Beijing area,its measurement performance was good.The updated questionnaire can probably replace the initial version to better promote health management and help healthy aging by identifying the constitution type of the elderly.展开更多
Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longevity hallmarks to defining mechanisms of gut microbiota influe...Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longevity hallmarks to defining mechanisms of gut microbiota influencing it.Importantly,the role of gut microbiota in the healthy longevity of the host may provide unprecedented opportunities to decipher the plasticity of lifespan on a natural evolutionary scale and shed light on using microbiota-targeted strategies to promote healthy aging and combat age-related diseases.This review investigates how gut microbiota affects healthy longevity,focusing on the mechanisms through which gut microbiota modulates it.Specifically,we focused on the ability of gut microbiota to enhance the intestinal barrier integrity,provide protection from inflammaging,ameliorate nutrientsensing pathways,optimize mitochondrial function,and improve defense against age-related diseases,thus participating in enhancing longevity and healthspan.展开更多
Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between co...Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan（i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates）. Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer＇s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.展开更多
Background: The balance of autonomic nervous system activity and its relationship with body composition, sleep quality, and activities of daily living among older people is still unclear. Purpose: This comparative cas...Background: The balance of autonomic nervous system activity and its relationship with body composition, sleep quality, and activities of daily living among older people is still unclear. Purpose: This comparative case study examined the characteristics of body composition, sleep quality, and autonomic nerve activity in active older adults with a younger body age-calculated from age trends in body composition and basal metabolic rate. Methods: We selected two cases with a metabolic age younger than their actual age. They had good sleep quality, no sarcopenia, strong muscle and grip strength, and balanced autonomic nervous system activity. They were compared with two other age- and gender-matched cases, who had poor sleep quality, unbalanced autonomic nervous system activity, and had a physical age closer to their actual age. Results: Older adults with more muscle mass and higher basal metabolism were younger than their actual age, had a better sleep status, and had a good balance of autonomic nervous activity during exercise stimulation. They also had lower percentages of body and visceral fat and higher percentages of body water. Conclusion: Two cases had a metabolic age younger than their actual age were found to be much younger than their actual age. However, the older adults with normal muscle mass and basal metabolic rate had poor sleep status and no sympathetic hyperactivity during exercise simulation.展开更多
Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from ...Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from 29 cities in China.Questionnaires were used to collect demographic information,presence of chronic disease,and the use of nutritional supplements and fortified foods.24-hour food intake was recorded using the Eat-Right Assistant,a validated digital service.Results:Fiber(56.7%),calcium(66.3%)and selenium(67.0%)were the nutrients with the highest insufficient intake.The foods with the highest inadequate consumption were dairy products(91%),fruits(84.3%),tubers(76.3%),soybeans and nuts(70%),and whole grains(65%).Even though 95.7%of the study population showed medium-high level of dietary diversity,dietary imbalance was present among 99%of the subjects.Higher socioeconomic status,passive health awareness,or the use of nutritional supplements or fortified foods showed positive influence on nutrient intake and dietary quality.Conclusions:This research provided insights into the dietary intake status and its influencing factors of 300 urban residents aged 40-69.The adult population still face a challenge of inadequate nutrient intake and imbalanced diet.In addition,this study supported the feasibility of using a digital service in research.Further studies with a larger sample size are needed to confirm current findings.This will help to clarify the unmet nutritional needs of adults in China and thus help to achieve healthy aging.展开更多
With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative ...With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative disease of neurodegenerative diseases,has become a major challenge,affecting the health and quality of life of the elderly population severely.In recent years,the incidence,prevalence and mortality rates of AD have increased in China,imposing substantial economic burdens on families,society and the entire healthcare system.To proactively address this challenge and respond to the national‘Healthy China Action’initiative,leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025.Building on previous editions,this report updates epidemiological data on AD in China,thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.Its release reflects China’s progress in AD research and prevention,underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention,diagnosis and treatment.It also facilitates academic exchanges and cooperation,enhancing public awareness and promoting active participation in elderly healthcare,towards achieving‘healthy ageing’in China.展开更多
This study compares the associators of healthy ageing in China and the United States,using the 2005-2014 Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the 2004-2014 Health and Retirement Study(HRS).Health ag...This study compares the associators of healthy ageing in China and the United States,using the 2005-2014 Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the 2004-2014 Health and Retirement Study(HRS).Health ageing is measured using an overall healthy ageing index(HAI),defined according to five dimensions:no major chronic diseases,free of physical functional impairment,free of cognitive impairment,no depressive symptoms,and socially active engagement.Multilevel logistic regression analysis is adopted to explore the association of demographic characteristics,socioeconomic status,and healthy lifestyles with the odds ratios of healthy ageing in China and the United States.Results indicate that the proportion of individuals experiencing healthy ageing is slightly higher in US than Chinese older adults aged 65-100(25.67%vs 23.27%).Nevertheless,Chinese oldest-old(80-100)have a higher proportion of healthy ageing than American oldest-old(15.05%vs.12.19%).Our results indicate that the odds of healthy ageing decrease with age,whereas they increase with education,income,marriage,and health behaviours.The odds of healthy ageing are lower for older Chinese women than men,whereas the odds are higher for older US women.Moreover,non-white elders in the United States have significantly lower odds of healthy ageing than their white counterparts.These findings suggest certain similar patterns of healthy ageing across two countries,but distinct patterns do exist.Promoting gender and racial equalities in healthy ageing are crucial for Chinese and American policymakers,respectively.展开更多
Adapting systems and technology for an aging population has benefits for older people,the consumer market industry itself and all of society.To promote knowledge sharing on innovations for healthy ageing and digital i...Adapting systems and technology for an aging population has benefits for older people,the consumer market industry itself and all of society.To promote knowledge sharing on innovations for healthy ageing and digital inclusion of older people in the Western Pacific Region,a hybrid conference on“Digital inclusion of older peo-ple:harnessing digital technologies to promote healthy ageing in the Western Pacific Region”was held on 23 June 2021 by China Academy of Information and Communications Technology,a WHO Collaborating Centre for Digital Health.Barriers from demand side include:(1)unaffordability;(2)poor Information and Communication technology(ICT)knowledge and skills for navigation;and(3)low self-efficacy and motivation.Supply barriers include:(1)youth-centred design;(2)ageism;and(3)anti-facilitative environment including infrastructure and age-biased technology.Existing practices to overcome digital inclusion barriers were shared:(1)landmark ini-tiatives related to the health and social welfare;(2)laws and policies to improve aged care services,strengthen social services,enrich spiritual and cultural life for older people;(3)ICT infrastructure and residential care facil-ities based on the philosophy of family care and supported by community care;(4)affordable digital application and adaptive feature design to better enable and motivate their desire to use digital technology;and(5)com-munity activities such as trainings and tutorials to enhance digital capacity and literacy of older people.Main principles highlighted include market motivation,human-centered design,creating enabling environments,and multi-stakeholder collaborations to provide guidance to customize strategy under context of different regions and countries,instead of a one-size-fits-all solution,to avoid the risk of exacerbating inequalities experienced by older people,caused by accelerated ICT innovation,and advocate for more affordable products in the silver market.展开更多
文摘With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pressure,the traditional family-based elderly care model is facing significant challenges and can hardly meet the elderly care needs.At present,the geriatric nursing models are relatively backward,which directly affects the quality of daily life,physical health and mental well-being of the elderly.Therefore,it is necessary to explore an appropriate geriatric nursing model to address the aging problem.Based on this,this paper analyzes and studies the current situation of geriatric nursing models under the background of healthy aging,providing references for relevant research and practice.
基金This work was sponsored by Natural Science Foundation of Chongqing,China(cstc2021jcyjbshX0176 to Ting Gong)National Natural Science Foundation of China(81900980 to Huifen Ding).
文摘As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings.Gut microbiota has become a key factor in the anti-aging process.Modulation of gut microbiota by fecal microbiota transplantation(FMT)to prevent frailty and unhealthy aging has been a hot topic of research.This narrative review summarizes the benefits of FMT for health span and lifespan,brains,eyes,productive systems,bones,and others.The mechanisms of FMT in improving healthy aging are discussed.The increased beneficial bacteria and decreased pathological bacteria decreased gut permeability and systemic inflammation,increased short-chain fatty acid(SCFA)and SCFA-producing bacteria,and other factors are listed as mechanisms of FMT to improve healthy aging.The points that need to be considered to ensure the optimal outcomes of FMT are also discussed,such as recipients’age,sex,genetic background,and gut microbiota after FMT.Although thisfield is still in its infancy,it has shown that FMT has great potential to improve healthy aging.
基金the University of Macao(Grant No.:MYRG2019-00079-FSS).
文摘Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a society.This study aimed to investigate how older people are portrayed in televised food commercials from the approach of a healthy aging perspective in contemporary Chinese society.Methods:All televised advertising in the Ad Topic archive were screened against inclusion and exclusion criteria,and a total of 164 commercials from the years of 2016-2019 that portrayed Chinese older people were sampled.The association between the main older characters with the product categories,healthy vs.unhealthy foods,use of health claims,sex,type of spokesperson,companions,and tones and manners were included in the analysis.Results:Older people more frequently appeared in unhealthy food products than in healthy food products.Health claims involving older adults were portrayed adequately,whereas nursing professions as companions of older adults were overlooked.Positive advertising that delivered happy,caring,or warm tones was overwhelmingly represented.Thus,the advertising messages circulated in China represent a binary stereotype model of images of older adults'characteristics that reflect ageist and the so-called agelessism,referring to the new application of the look from the approach of social psychology and marketing field.Conclusions:This study examined aging discrimination reflected in advertisements.Studies exploring the impact of a crisis remain limited.Research is needed to improve the accuracy of advertised healthy older adults and normal aging.
基金Humanities and Social Sciences(HSS)Seed Fund,National University of Singapore。
文摘In 2021,China became an aged society when the share of its elderly population(age 65 years and above)exceeded 14%.In China,as in other upper‐middle‐income and high‐income countries,life expectancy gains are increasingly concentrated at older ages with below‐average health and economic activity.Governments worldwide are hence actively pursuing healthy and productive aging.Healthy aging by some measures is taking place.Similar with other upper‐middle‐income countries,China's young old in their 60s are healthier than the same age group two decades ago.The picture is more complex for the older age group(70 years and above).Although there is a substantial decline in leading disease burdens such as stroke and chronic obstructive pulmonary disease,diseases such as Alzheimer's and other dementia are on the rise.To meet the challenge of a rapidly aging population,China's healthy aging agenda should improve its multipronged approach that seeks to promote healthy lifestyles,enhance the healthcare system,create agefriendly communities,and tackle socioeconomic and health disparities.
基金supported by the National Key research and Development Program of China(2022YFF1100103)the Youth talent Support Program by the National Food and Strategic reserves administration(QN2022401).
文摘aging is a natural and inevitable physiological process that poses a serious threat to physical health,leading to age-related diseases and placing a heavy burden on the public health system.this study explores intervention measures to promote healthy aging and prolong lifespan.anthocyanins(aCNs),as a class of flavonoids widely presented in fruits,vegetables and grains,exhibit strong antioxidant and anti-inflammatory activities.recent studies indicate that aCNs exert health effects primarily by interacting with gut microbiota.Here,we introduced the digestion and absorption of aCNs,and mainly elaborated on the role of aCNs in delaying aging through gut microbiota.In addition,we described the changes in gut microbiota mediated by aCNs and their impact on age-related chronic diseases,including cardiovascular diseases,neurodegenerative diseases,cancer,and sarcopenia.therefore,aCNs have a broad application prospect in the development of functional foods with anti-aging effects by regulating gut microbiota.
基金supported by grants from the National Natural Science Foundation of China(81930025,82201013,82371020,82370949,82100992)the Young Science and Technology Rising Star Project of Shaanxi Province(2023KJXX-027)the China Postdoctoral Science Foundation(BX20230485).
文摘Healthy aging is a common goal for humanity and society,and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration.However,the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive.Here,we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell(MSC)function and regeneration.Interestingly,replenishment of cell aggregates-derived extracellular vesicles(CA-EVs)rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5.Importantly,in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice,suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration.Collectively,our findings provide insights into Golgi regulation in stem cell senescence and bone aging,which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.
文摘Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the entrepreneurship activities of Nepalese older adults. Data for this study were collected from the project Help Age International (HAI) implemented in Nepal. Qualitative data observations and interviews were used to collect data. The findings of this study show the formation of the Older People’s Association (OPA) has supported many older people to participate outside the home in various social activities. Moreover, regular deposits through OPAs offer little help. OPAs support older people in their need of financial support to implement minor entrepreneurship. Older people who received support were pleased and were actively involved in their activities and also regularly deposited money in them. Subsequently, older people’s participation in social activities has increased and also helped to lower elderly abuse, loneliness, and depression. Local governments should promote such activities which will help with healthy aging.
文摘Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.
文摘Aging is a major risk factor for many human diseases,including cognitive impairment,which affects a large population of the elderly.In the past few decades,our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly,shedding light on the potential role of these changes in cognitive impairment.In this article,we review recent advances in understanding of the mechanisms underlying brain aging under normal and pathological conditions,compare their similarities and differences,discuss the causative and adaptive mechanisms of brain aging,and finally attempt to find some rules to guide us on how to promote healthy aging and prevent age-related diseases.
基金supported by grants from the National Natural Science Foundation of China(Nos.92057207,92357303,92254308,32271223,and 32021003)the National Key Research and Development Program of China(No.2024YFA1306102).
文摘About two thousand years ago,Hippocrates observed that“walking is man's best medicine”[1],a notion increasingly validated in modern society.The benefits of physical activity in preventing chronic diseases and in improving longevity have been extensively studied[2].
文摘The world＇s population is ageing rapidly, which will have substantial consequences. According to WHO： ＂Process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age＂. The aim of this work is to make a literature review on key measures that contribute to healthy ageing. A search was conducted in the following databases： PubMed, Cochrane, National Guideline Clearinghouse, Trip Database, Guideline finders, NICE and WHO database, written in English and published in the last ten years. The following MeSH words were used： ＂healthy ageing＂. The search was conducted from July first till end of December 2015. Based on the articles searched there are many measures with potential to achieve gains in healthy ageing such as prevention of falls; vaccination; regular physical activity, eating fruits and vegetables daily, drinking alcohol moderately; never smoking; prevention of social isolation and social exclusion; prevention of elder maltreatment; public support for informal care giving and create strategies to ensure the quality of care for older people. Getting older can come with a variety of health challenges. In the daily practice of family doctor there are many effective interventions that can improve health and wellbeing in elderly people.
文摘Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health statuses.Methods:Totally 485 older adults were recruited.They were divided into three groups based on their health status:healthy group(n=72),group with one disease(n=183)and group with multimorbidity(n=230).Lubben Social Network Scale-6 and Health-Promoting Lifestyle Profile II were used to measure their social isolation and health-promoting behaviors,respectively.Results:Among the aged with one disease or multimorbidity,30.6%(56/183)and 31.7%(73/230)were socially isolated,respectively,based on the score of the Lubben Social Network Scale-6.The three groups differed significantly in health-promoting behaviors and scores on several subscales.The group with multimorbidity exhibited more social isolation and fewer health-promoting behaviors than other groups.Social isolation was among the factors adversely affecting health-promoting behaviors in older adults.Conclusions:Health care providers should help older adults with multimorbidity preserve the remaining abilities to improve health-promoting behaviors.Meanwhile,it is important to support healthy older adults to increase self-responsibility to achieve healthy aging.
基金supported by the National Key Research and Development Program of China(2020YFC2003100&2020YFC2003102)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202001)。
文摘Objective:This study aimed to revise the Constitution in Chinese Medicine Questionnaire(Elderly Edition)(CCMQ-EE),as well as evaluate its reliability and validity.The objective was to provide a more accurate Chinese medicine constitution identification tool for geriatric health management and help further research on the relationship between geriatric diseases and constitution type,etc.Methods:The Delphi method and a cross-sectional survey of the elderly population were used.From April to October 2021,experts in different fields were invited to participate in the questionnaire,and items were revised through the experts'ratings and feedback.From December 2021 to February 2022,the revised CCMQ-EE was validated in the elderly population.Results:The coefficients of variation of rationality and importance scores decreased to less than 0.25 in the third round of Delphi.The Kendall coordination coefficients of rationality and importance in the third round were 0.15 and 0.17(P=.031 and P=.007,respectively).The revised CCMQ-EE was established with 34 items.The factor loadings of subscales were between 0.39 and 0.92,and the fitting effects of other subscales were acceptable,except for the inherited special constitution.The Cronbach alpha and test-retest reliability coefficients of each subscale ranged from 0.65 to 0.83,and 0.66 to 0.96,respectively.The composite reliability and average variance extraction were between 0.66 and 0.84,and between 0.32 and 0.57,respectively.The reliability and validity of the revised CCMQ-EE were acceptable or satisfactory.Conclusion:The revised CCMQ-EE was developed through a three-round Delphi process and internal team discussion.After the verification in the elderly in Beijing area,its measurement performance was good.The updated questionnaire can probably replace the initial version to better promote health management and help healthy aging by identifying the constitution type of the elderly.
基金supported by the Sichuan Key Research Base Program of Mental Health Education,Southwest Jiaotong University (XLJKJY2015B)Foundation of Sichuan Research Center of Applied Psychology of Chengdu Medical College (CSXL-202A03)。
文摘Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longevity hallmarks to defining mechanisms of gut microbiota influencing it.Importantly,the role of gut microbiota in the healthy longevity of the host may provide unprecedented opportunities to decipher the plasticity of lifespan on a natural evolutionary scale and shed light on using microbiota-targeted strategies to promote healthy aging and combat age-related diseases.This review investigates how gut microbiota affects healthy longevity,focusing on the mechanisms through which gut microbiota modulates it.Specifically,we focused on the ability of gut microbiota to enhance the intestinal barrier integrity,provide protection from inflammaging,ameliorate nutrientsensing pathways,optimize mitochondrial function,and improve defense against age-related diseases,thus participating in enhancing longevity and healthspan.
文摘Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan（i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates）. Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer＇s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.
文摘Background: The balance of autonomic nervous system activity and its relationship with body composition, sleep quality, and activities of daily living among older people is still unclear. Purpose: This comparative case study examined the characteristics of body composition, sleep quality, and autonomic nerve activity in active older adults with a younger body age-calculated from age trends in body composition and basal metabolic rate. Methods: We selected two cases with a metabolic age younger than their actual age. They had good sleep quality, no sarcopenia, strong muscle and grip strength, and balanced autonomic nervous system activity. They were compared with two other age- and gender-matched cases, who had poor sleep quality, unbalanced autonomic nervous system activity, and had a physical age closer to their actual age. Results: Older adults with more muscle mass and higher basal metabolism were younger than their actual age, had a better sleep status, and had a good balance of autonomic nervous activity during exercise stimulation. They also had lower percentages of body and visceral fat and higher percentages of body water. Conclusion: Two cases had a metabolic age younger than their actual age were found to be much younger than their actual age. However, the older adults with normal muscle mass and basal metabolic rate had poor sleep status and no sympathetic hyperactivity during exercise simulation.
基金funded by Danone Open Science Research Center,Shanghai,China。
文摘Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from 29 cities in China.Questionnaires were used to collect demographic information,presence of chronic disease,and the use of nutritional supplements and fortified foods.24-hour food intake was recorded using the Eat-Right Assistant,a validated digital service.Results:Fiber(56.7%),calcium(66.3%)and selenium(67.0%)were the nutrients with the highest insufficient intake.The foods with the highest inadequate consumption were dairy products(91%),fruits(84.3%),tubers(76.3%),soybeans and nuts(70%),and whole grains(65%).Even though 95.7%of the study population showed medium-high level of dietary diversity,dietary imbalance was present among 99%of the subjects.Higher socioeconomic status,passive health awareness,or the use of nutritional supplements or fortified foods showed positive influence on nutrient intake and dietary quality.Conclusions:This research provided insights into the dietary intake status and its influencing factors of 300 urban residents aged 40-69.The adult population still face a challenge of inadequate nutrient intake and imbalanced diet.In addition,this study supported the feasibility of using a digital service in research.Further studies with a larger sample size are needed to confirm current findings.This will help to clarify the unmet nutritional needs of adults in China and thus help to achieve healthy aging.
基金supported by a grant from Brain Science and BrainLike Intelligence Technology of the Ministry of Science and Technology of China(2021ZD0201804).
文摘With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative disease of neurodegenerative diseases,has become a major challenge,affecting the health and quality of life of the elderly population severely.In recent years,the incidence,prevalence and mortality rates of AD have increased in China,imposing substantial economic burdens on families,society and the entire healthcare system.To proactively address this challenge and respond to the national‘Healthy China Action’initiative,leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025.Building on previous editions,this report updates epidemiological data on AD in China,thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.Its release reflects China’s progress in AD research and prevention,underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention,diagnosis and treatment.It also facilitates academic exchanges and cooperation,enhancing public awareness and promoting active participation in elderly healthcare,towards achieving‘healthy ageing’in China.
文摘This study compares the associators of healthy ageing in China and the United States,using the 2005-2014 Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the 2004-2014 Health and Retirement Study(HRS).Health ageing is measured using an overall healthy ageing index(HAI),defined according to five dimensions:no major chronic diseases,free of physical functional impairment,free of cognitive impairment,no depressive symptoms,and socially active engagement.Multilevel logistic regression analysis is adopted to explore the association of demographic characteristics,socioeconomic status,and healthy lifestyles with the odds ratios of healthy ageing in China and the United States.Results indicate that the proportion of individuals experiencing healthy ageing is slightly higher in US than Chinese older adults aged 65-100(25.67%vs 23.27%).Nevertheless,Chinese oldest-old(80-100)have a higher proportion of healthy ageing than American oldest-old(15.05%vs.12.19%).Our results indicate that the odds of healthy ageing decrease with age,whereas they increase with education,income,marriage,and health behaviours.The odds of healthy ageing are lower for older Chinese women than men,whereas the odds are higher for older US women.Moreover,non-white elders in the United States have significantly lower odds of healthy ageing than their white counterparts.These findings suggest certain similar patterns of healthy ageing across two countries,but distinct patterns do exist.Promoting gender and racial equalities in healthy ageing are crucial for Chinese and American policymakers,respectively.
文摘Adapting systems and technology for an aging population has benefits for older people,the consumer market industry itself and all of society.To promote knowledge sharing on innovations for healthy ageing and digital inclusion of older people in the Western Pacific Region,a hybrid conference on“Digital inclusion of older peo-ple:harnessing digital technologies to promote healthy ageing in the Western Pacific Region”was held on 23 June 2021 by China Academy of Information and Communications Technology,a WHO Collaborating Centre for Digital Health.Barriers from demand side include:(1)unaffordability;(2)poor Information and Communication technology(ICT)knowledge and skills for navigation;and(3)low self-efficacy and motivation.Supply barriers include:(1)youth-centred design;(2)ageism;and(3)anti-facilitative environment including infrastructure and age-biased technology.Existing practices to overcome digital inclusion barriers were shared:(1)landmark ini-tiatives related to the health and social welfare;(2)laws and policies to improve aged care services,strengthen social services,enrich spiritual and cultural life for older people;(3)ICT infrastructure and residential care facil-ities based on the philosophy of family care and supported by community care;(4)affordable digital application and adaptive feature design to better enable and motivate their desire to use digital technology;and(5)com-munity activities such as trainings and tutorials to enhance digital capacity and literacy of older people.Main principles highlighted include market motivation,human-centered design,creating enabling environments,and multi-stakeholder collaborations to provide guidance to customize strategy under context of different regions and countries,instead of a one-size-fits-all solution,to avoid the risk of exacerbating inequalities experienced by older people,caused by accelerated ICT innovation,and advocate for more affordable products in the silver market.
