As a new type of production factor in healthcare,healthcare data elements have been rapidly integrated into various health production processes,such as clinical assistance,health management,biological testing,and oper...As a new type of production factor in healthcare,healthcare data elements have been rapidly integrated into various health production processes,such as clinical assistance,health management,biological testing,and operation and supervision[1,2].Healthcare data elements include biolog.ical and clinical data that are related to disease,environ-mental health data that are associated with life,and operational and healthcare management data that are related to healthcare activities(Figure 1).Activities such as the construction of a data value assessment system,the devel-opment of a data circulation and sharing platform,and the authorization of data compliance and operation products support the strong growth momentum of the market for health care data elements in China[3].展开更多
The growing demand for international travel has highlighted the critical need for reliable tools to verify travelers’healthcare status and meet entry requirements.Personal health passports,while essential,face signif...The growing demand for international travel has highlighted the critical need for reliable tools to verify travelers’healthcare status and meet entry requirements.Personal health passports,while essential,face significant challenges related to data silos,privacy protection,and forgery risks in global sharing.To address these issues,this study proposes a blockchain-based solution designed for the secure storage,sharing,and verification of personal health passports.This innovative approach combines on-chain and off-chain storage,leveraging searchable encryption to enhance data security and optimize blockchain storage efficiency.By reducing the storage burden on the blockchain,the system ensures both the secure handling and reliable sharing of sensitive personal health data.An optimized consensus mechanism streamlines the process into two stages,minimizing communication complexity among nodes and significantly improving the throughput of the blockchain system.Additionally,the introduction of advanced aggregate signature technology accommodates multi-user scenarios,reducing computational overhead for signature verification and enabling swift identification ofmalicious forgers.Comprehensive security analyses validate the system’s robustness and reliability.Simulation results demonstrate notable performance improvements over existing solutions,with reductions in computational overhead of up to 49.89%and communication overhead of up to 25.81%inmulti-user scenarios.Furthermore,the optimized consensus mechanism shows substantial efficiency gains across varying node configurations.This solution represents a significant step toward addressing the pressing challenges of health passport management in a secure,scalable,and efficient manner.展开更多
Nowadays,healthcare applications necessitate maximum volume of medical data to be fed to help the physicians,academicians,pathologists,doctors and other healthcare professionals.Advancements in the domain of Wireless ...Nowadays,healthcare applications necessitate maximum volume of medical data to be fed to help the physicians,academicians,pathologists,doctors and other healthcare professionals.Advancements in the domain of Wireless Sensor Networks(WSN)andMultimediaWireless Sensor Networks(MWSN)are tremendous.M-WMSN is an advanced form of conventional Wireless Sensor Networks(WSN)to networks that use multimedia devices.When compared with traditional WSN,the quantity of data transmission in M-WMSN is significantly high due to the presence of multimedia content.Hence,clustering techniques are deployed to achieve low amount of energy utilization.The current research work aims at introducing a new Density Based Clustering(DBC)technique to achieve energy efficiency inWMSN.The DBC technique is mainly employed for data collection in healthcare environment which primarily depends on three input parameters namely remaining energy level,distance,and node centrality.In addition,two static data collector points called Super Cluster Head(SCH)are placed,which collects the data from normal CHs and forwards it to the Base Station(BS)directly.SCH supports multi-hop data transmission that assists in effectively balancing the available energy.Adetailed simulation analysiswas conducted to showcase the superior performance of DBC technique and the results were examined under diverse aspects.The simulation outcomes concluded that the proposed DBC technique improved the network lifetime to a maximum of 16,500 rounds,which is significantly higher compared to existing methods.展开更多
A new era of data access and management has begun with the use of cloud computing in the healthcare industry.Despite the efficiency and scalability that the cloud provides, the security of private patient data is stil...A new era of data access and management has begun with the use of cloud computing in the healthcare industry.Despite the efficiency and scalability that the cloud provides, the security of private patient data is still a majorconcern. Encryption, network security, and adherence to data protection laws are key to ensuring the confidentialityand integrity of healthcare data in the cloud. The computational overhead of encryption technologies could leadto delays in data access and processing rates. To address these challenges, we introduced the Enhanced ParallelMulti-Key Encryption Algorithm (EPM-KEA), aiming to bolster healthcare data security and facilitate the securestorage of critical patient records in the cloud. The data was gathered from two categories Authorization forHospital Admission (AIH) and Authorization for High Complexity Operations.We use Z-score normalization forpreprocessing. The primary goal of implementing encryption techniques is to secure and store massive amountsof data on the cloud. It is feasible that cloud storage alternatives for protecting healthcare data will become morewidely available if security issues can be successfully fixed. As a result of our analysis using specific parametersincluding Execution time (42%), Encryption time (45%), Decryption time (40%), Security level (97%), and Energyconsumption (53%), the system demonstrated favorable performance when compared to the traditional method.This suggests that by addressing these security concerns, there is the potential for broader accessibility to cloudstorage solutions for safeguarding healthcare data.展开更多
Patient privacy and data protection have been crucial concerns in Ehealthcare systems for many years.In modern-day applications,patient data usually holds clinical imagery,records,and other medical details.Lately,the ...Patient privacy and data protection have been crucial concerns in Ehealthcare systems for many years.In modern-day applications,patient data usually holds clinical imagery,records,and other medical details.Lately,the Internet of Medical Things(IoMT),equipped with cloud computing,has come out to be a beneficial paradigm in the healthcare field.However,the openness of networks and systems leads to security threats and illegal access.Therefore,reliable,fast,and robust security methods need to be developed to ensure the safe exchange of healthcare data generated from various image sensing and other IoMT-driven devices in the IoMT network.This paper presents an image protection scheme for healthcare applications to protect patients’medical image data exchanged in IoMT networks.The proposed security scheme depends on an enhanced 2D discrete chaotic map and allows dynamic substitution based on an optimized highly-nonlinear S-box and diffusion to gain an excellent security performance.The optimized S-box has an excellent nonlinearity score of 112.The new image protection scheme is efficient enough to exhibit correlation values less than 0.0022,entropy values higher than 7.999,and NPCR values around 99.6%.To reveal the efficacy of the scheme,several comparison studies are presented.These comparison studies reveal that the novel protection scheme is robust,efficient,and capable of securing healthcare imagery in IoMT systems.展开更多
The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessa...The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method.展开更多
Machine learning advancements in healthcare have made data collected through smartphones and wearable devices a vital source of public health and medical insights.While wearable device data help to monitor,detect,and ...Machine learning advancements in healthcare have made data collected through smartphones and wearable devices a vital source of public health and medical insights.While wearable device data help to monitor,detect,and predict diseases and health conditions,some data owners hesitate to share such sensitive data with companies or researchers due to privacy concerns.Moreover,wearable devices have been recently available as commercial products;thus large,diverse,and representative datasets are not available to most researchers.In this article,the authors propose an open marketplace where wearable device users securely monetize their wearable device records by sharing data with consumers(e.g.,researchers)to make wearable device data more available to healthcare researchers.To secure the data transactions in a privacy-preserving manner,the authors use a decentralized approach using Blockchain and Non-Fungible Tokens(NFTs).To ensure data originality and integrity with secure validation,the marketplace uses Trusted Execution Environments(TEE)in wearable devices to verify the correctness of health data.The marketplace also allows researchers to train models using Federated Learning with a TEE-backed secure aggregation of data users may not be willing to share.To ensure user participation,we model incentive mechanisms for the Federated Learning-based and anonymized data-sharing approaches using NFTs.The authors also propose using payment channels and batching to reduce smart contact gas fees and optimize user profits.If widely adopted,it’s believed that TEE and Blockchain-based incentives will promote the ethical use of machine learning with validated wearable device data in healthcare and improve user participation due to incentives.展开更多
Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific hea...Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.展开更多
As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in dat...As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,etc.To guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration Service System combining Blockchain with Federated Learning,termed FL-HMChain.This system is composed of three layers:Data extraction and storage,data management,and data application.Focusing on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and integrity.An improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training process.Furthermore,healthcare and medical data collaboration services in real-world scenarios have been discussed and developed.To further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image identification.This model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),respectively.Furthermore,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.展开更多
Big data applications in healthcare have provided a variety of solutions to reduce costs,errors,and waste.This work aims to develop a real-time system based on big medical data processing in the cloud for the predicti...Big data applications in healthcare have provided a variety of solutions to reduce costs,errors,and waste.This work aims to develop a real-time system based on big medical data processing in the cloud for the prediction of health issues.In the proposed scalable system,medical parameters are sent to Apache Spark to extract attributes from data and apply the proposed machine learning algorithm.In this way,healthcare risks can be predicted and sent as alerts and recommendations to users and healthcare providers.The proposed work also aims to provide an effective recommendation system by using streaming medical data,historical data on a user’s profile,and a knowledge database to make themost appropriate real-time recommendations and alerts based on the sensor’s measurements.This proposed scalable system works by tweeting the health status attributes of users.Their cloud profile receives the streaming healthcare data in real time by extracting the health attributes via a machine learning prediction algorithm to predict the users’health status.Subsequently,their status can be sent on demand to healthcare providers.Therefore,machine learning algorithms can be applied to stream health care data from wearables and provide users with insights into their health status.These algorithms can help healthcare providers and individuals focus on health risks and health status changes and consequently improve the quality of life.展开更多
Datamining plays a crucial role in extractingmeaningful knowledge fromlarge-scale data repositories,such as data warehouses and databases.Association rule mining,a fundamental process in data mining,involves discoveri...Datamining plays a crucial role in extractingmeaningful knowledge fromlarge-scale data repositories,such as data warehouses and databases.Association rule mining,a fundamental process in data mining,involves discovering correlations,patterns,and causal structures within datasets.In the healthcare domain,association rules offer valuable opportunities for building knowledge bases,enabling intelligent diagnoses,and extracting invaluable information rapidly.This paper presents a novel approach called the Machine Learning based Association Rule Mining and Classification for Healthcare Data Management System(MLARMC-HDMS).The MLARMC-HDMS technique integrates classification and association rule mining(ARM)processes.Initially,the chimp optimization algorithm-based feature selection(COAFS)technique is employed within MLARMC-HDMS to select relevant attributes.Inspired by the foraging behavior of chimpanzees,the COA algorithm mimics their search strategy for food.Subsequently,the classification process utilizes stochastic gradient descent with a multilayer perceptron(SGD-MLP)model,while the Apriori algorithm determines attribute relationships.We propose a COA-based feature selection approach for medical data classification using machine learning techniques.This approach involves selecting pertinent features from medical datasets through COA and training machine learning models using the reduced feature set.We evaluate the performance of our approach on various medical datasets employing diverse machine learning classifiers.Experimental results demonstrate that our proposed approach surpasses alternative feature selection methods,achieving higher accuracy and precision rates in medical data classification tasks.The study showcases the effectiveness and efficiency of the COA-based feature selection approach in identifying relevant features,thereby enhancing the diagnosis and treatment of various diseases.To provide further validation,we conduct detailed experiments on a benchmark medical dataset,revealing the superiority of the MLARMCHDMS model over other methods,with a maximum accuracy of 99.75%.Therefore,this research contributes to the advancement of feature selection techniques in medical data classification and highlights the potential for improving healthcare outcomes through accurate and efficient data analysis.The presented MLARMC-HDMS framework and COA-based feature selection approach offer valuable insights for researchers and practitioners working in the field of healthcare data mining and machine learning.展开更多
Decision forest is a well-renowned machine learning technique to address the detection and prediction problems related to clinical data.But,the tra-ditional decision forest(DF)algorithms have lower classification accu...Decision forest is a well-renowned machine learning technique to address the detection and prediction problems related to clinical data.But,the tra-ditional decision forest(DF)algorithms have lower classification accuracy and cannot handle high-dimensional feature space effectively.In this work,we pro-pose a bootstrap decision forest using penalizing attributes(BFPA)algorithm to predict heart disease with higher accuracy.This work integrates a significance-based attribute selection(SAS)algorithm with the BFPA classifier to improve the performance of the diagnostic system in identifying cardiac illness.The pro-posed SAS algorithm is used to determine the correlation among attributes and to select the optimum subset of feature space for learning and testing processes.BFPA selects the optimal number of learning and testing data points as well as the density of trees in the forest to realize higher prediction accuracy in classifying imbalanced datasets effectively.The effectiveness of the developed classifier is cautiously verified on the real-world database(i.e.,Heart disease dataset from UCI repository)by relating its enactment with many advanced approaches with respect to the accuracy,sensitivity,specificity,precision,and intersection over-union(IoU).The empirical results demonstrate that the intended classification approach outdoes other approaches with superior enactment regarding the accu-racy,precision,sensitivity,specificity,and IoU of 94.7%,99.2%,90.1%,91.1%,and 90.4%,correspondingly.Additionally,we carry out Wilcoxon’s rank-sum test to determine whether our proposed classifier with feature selection method enables a noteworthy enhancement related to other classifiers or not.From the experimental results,we can conclude that the integration of SAS and BFPA outperforms other classifiers recently reported in the literature.展开更多
Multimodal deep learning has emerged as a key paradigm in contemporary medical diagnostics,advancing precision medicine by enabling integration and learning from diverse data sources.The exponential growth of high-dim...Multimodal deep learning has emerged as a key paradigm in contemporary medical diagnostics,advancing precision medicine by enabling integration and learning from diverse data sources.The exponential growth of high-dimensional healthcare data,encompassing genomic,transcriptomic,and other omics profiles,as well as radiological imaging and histopathological slides,makes this approach increasingly important because,when examined separately,these data sources only offer a fragmented picture of intricate disease processes.Multimodal deep learning leverages the complementary properties of multiple data modalities to enable more accurate prognostic modeling,more robust disease characterization,and improved treatment decision-making.This review provides a comprehensive overview of the current state of multimodal deep learning approaches in medical diagnosis.We classify and examine important application domains,such as(1)radiology,where automated report generation and lesion detection are facilitated by image-text integration;(2)histopathology,where fusion models improve tumor classification and grading;and(3)multi-omics,where molecular subtypes and latent biomarkers are revealed through cross-modal learning.We provide an overview of representative research,methodological advancements,and clinical consequences for each domain.Additionally,we critically analyzed the fundamental issues preventing wider adoption,including computational complexity(particularly in training scalable,multi-branch networks),data heterogeneity(resulting from modality-specific noise,resolution variations,and inconsistent annotations),and the challenge of maintaining significant cross-modal correlations during fusion.These problems impede interpretability,which is crucial for clinical trust and use,in addition to performance and generalizability.Lastly,we outline important areas for future research,including the development of standardized protocols for harmonizing data,the creation of lightweight and interpretable fusion architectures,the integration of real-time clinical decision support systems,and the promotion of cooperation for federated multimodal learning.Our goal is to provide researchers and clinicians with a concise overview of the field’s present state,enduring constraints,and exciting directions for further research through this review.展开更多
Efficient data management in healthcare is essential for providing timely and accurate patient care, yet traditional partitioning methods in relational databases often struggle with the high volume, heterogeneity, and...Efficient data management in healthcare is essential for providing timely and accurate patient care, yet traditional partitioning methods in relational databases often struggle with the high volume, heterogeneity, and regulatory complexity of healthcare data. This research introduces a tailored partitioning strategy leveraging the MD5 hashing algorithm to enhance data insertion, query performance, and load balancing in healthcare systems. By applying a consistent hash function to patient IDs, our approach achieves uniform distribution of records across partitions, optimizing retrieval paths and reducing access latency while ensuring data integrity and compliance. We evaluated the method through experiments focusing on partitioning efficiency, scalability, and fault tolerance. The partitioning efficiency analysis compared our MD5-based approach with standard round-robin methods, measuring insertion times, query latency, and data distribution balance. Scalability tests assessed system performance across increasing dataset sizes and varying partition counts, while fault tolerance experiments examined data integrity and retrieval performance under simulated partition failures. The experimental results demonstrate that the MD5-based partitioning strategy significantly reduces query retrieval times by optimizing data access patterns, achieving up to X% better performance compared to round-robin methods. It also scales effectively with larger datasets, maintaining low latency and ensuring robust resilience under failure scenarios. This novel approach offers a scalable, efficient, and fault-tolerant solution for healthcare systems, facilitating faster clinical decision-making and improved patient care in complex data environments.展开更多
In the dynamic environment of hospitals, valuable real-world data often remain underutilised despite their potential to revolutionize cancer research and personalised medicine. This study explores the challenges and o...In the dynamic environment of hospitals, valuable real-world data often remain underutilised despite their potential to revolutionize cancer research and personalised medicine. This study explores the challenges and opportunities in managing hospital-generated data, particularly within the Masaryk Memorial Cancer Institute (MMCI) in Brno, Czech Republic. Utilizing Next-Generation Sequencing (NGS) technology, MMCI generates substantial volumes of genomic data. Due to inadequate curation, these data remain difficult to integrate with clinical records for secondary use (such as personalised treatment outcome prediction and patient stratification based on their genomic profiles). This paper proposes solutions based on the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) to enhance data sharing and reuse. The primary output of our work is the development of an automated pipeline that continuously processes and integrates NGS data with clinical and biobank information upon their creation. It stores the data in a special secured repository for sensitive data in a structured form to ensure smooth retrieval.展开更多
基金supported by National Natural Science Foundation of China(Grants 72474022,71974011,72174022,71972012,71874009)"BIT think tank"Promotion Plan of Science and Technology Innovation Program of Beijing Institute of Technology(Grants 2024CX14017,2023CX13029).
文摘As a new type of production factor in healthcare,healthcare data elements have been rapidly integrated into various health production processes,such as clinical assistance,health management,biological testing,and operation and supervision[1,2].Healthcare data elements include biolog.ical and clinical data that are related to disease,environ-mental health data that are associated with life,and operational and healthcare management data that are related to healthcare activities(Figure 1).Activities such as the construction of a data value assessment system,the devel-opment of a data circulation and sharing platform,and the authorization of data compliance and operation products support the strong growth momentum of the market for health care data elements in China[3].
文摘The growing demand for international travel has highlighted the critical need for reliable tools to verify travelers’healthcare status and meet entry requirements.Personal health passports,while essential,face significant challenges related to data silos,privacy protection,and forgery risks in global sharing.To address these issues,this study proposes a blockchain-based solution designed for the secure storage,sharing,and verification of personal health passports.This innovative approach combines on-chain and off-chain storage,leveraging searchable encryption to enhance data security and optimize blockchain storage efficiency.By reducing the storage burden on the blockchain,the system ensures both the secure handling and reliable sharing of sensitive personal health data.An optimized consensus mechanism streamlines the process into two stages,minimizing communication complexity among nodes and significantly improving the throughput of the blockchain system.Additionally,the introduction of advanced aggregate signature technology accommodates multi-user scenarios,reducing computational overhead for signature verification and enabling swift identification ofmalicious forgers.Comprehensive security analyses validate the system’s robustness and reliability.Simulation results demonstrate notable performance improvements over existing solutions,with reductions in computational overhead of up to 49.89%and communication overhead of up to 25.81%inmulti-user scenarios.Furthermore,the optimized consensus mechanism shows substantial efficiency gains across varying node configurations.This solution represents a significant step toward addressing the pressing challenges of health passport management in a secure,scalable,and efficient manner.
文摘Nowadays,healthcare applications necessitate maximum volume of medical data to be fed to help the physicians,academicians,pathologists,doctors and other healthcare professionals.Advancements in the domain of Wireless Sensor Networks(WSN)andMultimediaWireless Sensor Networks(MWSN)are tremendous.M-WMSN is an advanced form of conventional Wireless Sensor Networks(WSN)to networks that use multimedia devices.When compared with traditional WSN,the quantity of data transmission in M-WMSN is significantly high due to the presence of multimedia content.Hence,clustering techniques are deployed to achieve low amount of energy utilization.The current research work aims at introducing a new Density Based Clustering(DBC)technique to achieve energy efficiency inWMSN.The DBC technique is mainly employed for data collection in healthcare environment which primarily depends on three input parameters namely remaining energy level,distance,and node centrality.In addition,two static data collector points called Super Cluster Head(SCH)are placed,which collects the data from normal CHs and forwards it to the Base Station(BS)directly.SCH supports multi-hop data transmission that assists in effectively balancing the available energy.Adetailed simulation analysiswas conducted to showcase the superior performance of DBC technique and the results were examined under diverse aspects.The simulation outcomes concluded that the proposed DBC technique improved the network lifetime to a maximum of 16,500 rounds,which is significantly higher compared to existing methods.
文摘A new era of data access and management has begun with the use of cloud computing in the healthcare industry.Despite the efficiency and scalability that the cloud provides, the security of private patient data is still a majorconcern. Encryption, network security, and adherence to data protection laws are key to ensuring the confidentialityand integrity of healthcare data in the cloud. The computational overhead of encryption technologies could leadto delays in data access and processing rates. To address these challenges, we introduced the Enhanced ParallelMulti-Key Encryption Algorithm (EPM-KEA), aiming to bolster healthcare data security and facilitate the securestorage of critical patient records in the cloud. The data was gathered from two categories Authorization forHospital Admission (AIH) and Authorization for High Complexity Operations.We use Z-score normalization forpreprocessing. The primary goal of implementing encryption techniques is to secure and store massive amountsof data on the cloud. It is feasible that cloud storage alternatives for protecting healthcare data will become morewidely available if security issues can be successfully fixed. As a result of our analysis using specific parametersincluding Execution time (42%), Encryption time (45%), Decryption time (40%), Security level (97%), and Energyconsumption (53%), the system demonstrated favorable performance when compared to the traditional method.This suggests that by addressing these security concerns, there is the potential for broader accessibility to cloudstorage solutions for safeguarding healthcare data.
基金funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University,through the Research Funding Program,Grant No.(FRP-1443-11).
文摘Patient privacy and data protection have been crucial concerns in Ehealthcare systems for many years.In modern-day applications,patient data usually holds clinical imagery,records,and other medical details.Lately,the Internet of Medical Things(IoMT),equipped with cloud computing,has come out to be a beneficial paradigm in the healthcare field.However,the openness of networks and systems leads to security threats and illegal access.Therefore,reliable,fast,and robust security methods need to be developed to ensure the safe exchange of healthcare data generated from various image sensing and other IoMT-driven devices in the IoMT network.This paper presents an image protection scheme for healthcare applications to protect patients’medical image data exchanged in IoMT networks.The proposed security scheme depends on an enhanced 2D discrete chaotic map and allows dynamic substitution based on an optimized highly-nonlinear S-box and diffusion to gain an excellent security performance.The optimized S-box has an excellent nonlinearity score of 112.The new image protection scheme is efficient enough to exhibit correlation values less than 0.0022,entropy values higher than 7.999,and NPCR values around 99.6%.To reveal the efficacy of the scheme,several comparison studies are presented.These comparison studies reveal that the novel protection scheme is robust,efficient,and capable of securing healthcare imagery in IoMT systems.
文摘The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method.
文摘Machine learning advancements in healthcare have made data collected through smartphones and wearable devices a vital source of public health and medical insights.While wearable device data help to monitor,detect,and predict diseases and health conditions,some data owners hesitate to share such sensitive data with companies or researchers due to privacy concerns.Moreover,wearable devices have been recently available as commercial products;thus large,diverse,and representative datasets are not available to most researchers.In this article,the authors propose an open marketplace where wearable device users securely monetize their wearable device records by sharing data with consumers(e.g.,researchers)to make wearable device data more available to healthcare researchers.To secure the data transactions in a privacy-preserving manner,the authors use a decentralized approach using Blockchain and Non-Fungible Tokens(NFTs).To ensure data originality and integrity with secure validation,the marketplace uses Trusted Execution Environments(TEE)in wearable devices to verify the correctness of health data.The marketplace also allows researchers to train models using Federated Learning with a TEE-backed secure aggregation of data users may not be willing to share.To ensure user participation,we model incentive mechanisms for the Federated Learning-based and anonymized data-sharing approaches using NFTs.The authors also propose using payment channels and batching to reduce smart contact gas fees and optimize user profits.If widely adopted,it’s believed that TEE and Blockchain-based incentives will promote the ethical use of machine learning with validated wearable device data in healthcare and improve user participation due to incentives.
基金supported by the National Natural Science Foundation of China(82225049,72104155)the Sichuan Provincial Central Government Guides Local Science and Technology Development Special Project(2022ZYD0127)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD23004).
文摘Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.
基金We are thankful for the funding support fromthe Science and Technology Projects of the National Archives Administration of China(Grant Number 2022-R-031)the Fundamental Research Funds for the Central Universities,Central China Normal University(Grant Number CCNU24CG014).
文摘As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,etc.To guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration Service System combining Blockchain with Federated Learning,termed FL-HMChain.This system is composed of three layers:Data extraction and storage,data management,and data application.Focusing on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and integrity.An improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training process.Furthermore,healthcare and medical data collaboration services in real-world scenarios have been discussed and developed.To further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image identification.This model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),respectively.Furthermore,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.
基金This study was financially supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),the Ministry of Health and Welfare(HI18C1216),and the Soonchunhyang University Research Fund.
文摘Big data applications in healthcare have provided a variety of solutions to reduce costs,errors,and waste.This work aims to develop a real-time system based on big medical data processing in the cloud for the prediction of health issues.In the proposed scalable system,medical parameters are sent to Apache Spark to extract attributes from data and apply the proposed machine learning algorithm.In this way,healthcare risks can be predicted and sent as alerts and recommendations to users and healthcare providers.The proposed work also aims to provide an effective recommendation system by using streaming medical data,historical data on a user’s profile,and a knowledge database to make themost appropriate real-time recommendations and alerts based on the sensor’s measurements.This proposed scalable system works by tweeting the health status attributes of users.Their cloud profile receives the streaming healthcare data in real time by extracting the health attributes via a machine learning prediction algorithm to predict the users’health status.Subsequently,their status can be sent on demand to healthcare providers.Therefore,machine learning algorithms can be applied to stream health care data from wearables and provide users with insights into their health status.These algorithms can help healthcare providers and individuals focus on health risks and health status changes and consequently improve the quality of life.
基金Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia for funding this research work through the Project Number RI-44-0444.
文摘Datamining plays a crucial role in extractingmeaningful knowledge fromlarge-scale data repositories,such as data warehouses and databases.Association rule mining,a fundamental process in data mining,involves discovering correlations,patterns,and causal structures within datasets.In the healthcare domain,association rules offer valuable opportunities for building knowledge bases,enabling intelligent diagnoses,and extracting invaluable information rapidly.This paper presents a novel approach called the Machine Learning based Association Rule Mining and Classification for Healthcare Data Management System(MLARMC-HDMS).The MLARMC-HDMS technique integrates classification and association rule mining(ARM)processes.Initially,the chimp optimization algorithm-based feature selection(COAFS)technique is employed within MLARMC-HDMS to select relevant attributes.Inspired by the foraging behavior of chimpanzees,the COA algorithm mimics their search strategy for food.Subsequently,the classification process utilizes stochastic gradient descent with a multilayer perceptron(SGD-MLP)model,while the Apriori algorithm determines attribute relationships.We propose a COA-based feature selection approach for medical data classification using machine learning techniques.This approach involves selecting pertinent features from medical datasets through COA and training machine learning models using the reduced feature set.We evaluate the performance of our approach on various medical datasets employing diverse machine learning classifiers.Experimental results demonstrate that our proposed approach surpasses alternative feature selection methods,achieving higher accuracy and precision rates in medical data classification tasks.The study showcases the effectiveness and efficiency of the COA-based feature selection approach in identifying relevant features,thereby enhancing the diagnosis and treatment of various diseases.To provide further validation,we conduct detailed experiments on a benchmark medical dataset,revealing the superiority of the MLARMCHDMS model over other methods,with a maximum accuracy of 99.75%.Therefore,this research contributes to the advancement of feature selection techniques in medical data classification and highlights the potential for improving healthcare outcomes through accurate and efficient data analysis.The presented MLARMC-HDMS framework and COA-based feature selection approach offer valuable insights for researchers and practitioners working in the field of healthcare data mining and machine learning.
文摘Decision forest is a well-renowned machine learning technique to address the detection and prediction problems related to clinical data.But,the tra-ditional decision forest(DF)algorithms have lower classification accuracy and cannot handle high-dimensional feature space effectively.In this work,we pro-pose a bootstrap decision forest using penalizing attributes(BFPA)algorithm to predict heart disease with higher accuracy.This work integrates a significance-based attribute selection(SAS)algorithm with the BFPA classifier to improve the performance of the diagnostic system in identifying cardiac illness.The pro-posed SAS algorithm is used to determine the correlation among attributes and to select the optimum subset of feature space for learning and testing processes.BFPA selects the optimal number of learning and testing data points as well as the density of trees in the forest to realize higher prediction accuracy in classifying imbalanced datasets effectively.The effectiveness of the developed classifier is cautiously verified on the real-world database(i.e.,Heart disease dataset from UCI repository)by relating its enactment with many advanced approaches with respect to the accuracy,sensitivity,specificity,precision,and intersection over-union(IoU).The empirical results demonstrate that the intended classification approach outdoes other approaches with superior enactment regarding the accu-racy,precision,sensitivity,specificity,and IoU of 94.7%,99.2%,90.1%,91.1%,and 90.4%,correspondingly.Additionally,we carry out Wilcoxon’s rank-sum test to determine whether our proposed classifier with feature selection method enables a noteworthy enhancement related to other classifiers or not.From the experimental results,we can conclude that the integration of SAS and BFPA outperforms other classifiers recently reported in the literature.
文摘Multimodal deep learning has emerged as a key paradigm in contemporary medical diagnostics,advancing precision medicine by enabling integration and learning from diverse data sources.The exponential growth of high-dimensional healthcare data,encompassing genomic,transcriptomic,and other omics profiles,as well as radiological imaging and histopathological slides,makes this approach increasingly important because,when examined separately,these data sources only offer a fragmented picture of intricate disease processes.Multimodal deep learning leverages the complementary properties of multiple data modalities to enable more accurate prognostic modeling,more robust disease characterization,and improved treatment decision-making.This review provides a comprehensive overview of the current state of multimodal deep learning approaches in medical diagnosis.We classify and examine important application domains,such as(1)radiology,where automated report generation and lesion detection are facilitated by image-text integration;(2)histopathology,where fusion models improve tumor classification and grading;and(3)multi-omics,where molecular subtypes and latent biomarkers are revealed through cross-modal learning.We provide an overview of representative research,methodological advancements,and clinical consequences for each domain.Additionally,we critically analyzed the fundamental issues preventing wider adoption,including computational complexity(particularly in training scalable,multi-branch networks),data heterogeneity(resulting from modality-specific noise,resolution variations,and inconsistent annotations),and the challenge of maintaining significant cross-modal correlations during fusion.These problems impede interpretability,which is crucial for clinical trust and use,in addition to performance and generalizability.Lastly,we outline important areas for future research,including the development of standardized protocols for harmonizing data,the creation of lightweight and interpretable fusion architectures,the integration of real-time clinical decision support systems,and the promotion of cooperation for federated multimodal learning.Our goal is to provide researchers and clinicians with a concise overview of the field’s present state,enduring constraints,and exciting directions for further research through this review.
文摘Efficient data management in healthcare is essential for providing timely and accurate patient care, yet traditional partitioning methods in relational databases often struggle with the high volume, heterogeneity, and regulatory complexity of healthcare data. This research introduces a tailored partitioning strategy leveraging the MD5 hashing algorithm to enhance data insertion, query performance, and load balancing in healthcare systems. By applying a consistent hash function to patient IDs, our approach achieves uniform distribution of records across partitions, optimizing retrieval paths and reducing access latency while ensuring data integrity and compliance. We evaluated the method through experiments focusing on partitioning efficiency, scalability, and fault tolerance. The partitioning efficiency analysis compared our MD5-based approach with standard round-robin methods, measuring insertion times, query latency, and data distribution balance. Scalability tests assessed system performance across increasing dataset sizes and varying partition counts, while fault tolerance experiments examined data integrity and retrieval performance under simulated partition failures. The experimental results demonstrate that the MD5-based partitioning strategy significantly reduces query retrieval times by optimizing data access patterns, achieving up to X% better performance compared to round-robin methods. It also scales effectively with larger datasets, maintaining low latency and ensuring robust resilience under failure scenarios. This novel approach offers a scalable, efficient, and fault-tolerant solution for healthcare systems, facilitating faster clinical decision-making and improved patient care in complex data environments.
基金funding from the project SALVAGE(P JACreg.no.CZ.02.01.01/00/22_008/0004644)-funded by the European Union and by the State Budget of the Czech Republic,from MH CZ-DRO(MMCI,00209805)+1 种基金BBMRI.cz(no.LM2023033)Computational resources were provided by the e-INFRA CZ project(no.LM2023054).
文摘In the dynamic environment of hospitals, valuable real-world data often remain underutilised despite their potential to revolutionize cancer research and personalised medicine. This study explores the challenges and opportunities in managing hospital-generated data, particularly within the Masaryk Memorial Cancer Institute (MMCI) in Brno, Czech Republic. Utilizing Next-Generation Sequencing (NGS) technology, MMCI generates substantial volumes of genomic data. Due to inadequate curation, these data remain difficult to integrate with clinical records for secondary use (such as personalised treatment outcome prediction and patient stratification based on their genomic profiles). This paper proposes solutions based on the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) to enhance data sharing and reuse. The primary output of our work is the development of an automated pipeline that continuously processes and integrates NGS data with clinical and biobank information upon their creation. It stores the data in a special secured repository for sensitive data in a structured form to ensure smooth retrieval.
