Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate un...Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.展开更多
Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a phy...Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.展开更多
The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health r...The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health risks.In this study,we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories,low(minimal),moderate and high.Second,we compared the differences in attitudes towards FJBs in dietary guidelines.Third,we integrated the results of existing epidemiological surveys,randomized controlled trials,and animal experiments to explore the health risks associated with consuming FJBs.Deepening the processing of FJBs has been found to lead to an increased risk of diseases.Dietary pattern,nutrients,addition agents and consumer preferences may be influential factors.Finally,we investigated whether there were any changes in the health benefits of 100%fruit juices produced by different processing methods.In conclusion,minimally/moderately processed 100%fruit juices provide more health benefits than highly processed fruit beverages.The results support the need to consider the extent of FJBs processing in future studies to adjust official nutritional recommendations for beverage consumption.展开更多
The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life th...The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life through contaminated seafood. To better understand the effect of HAB and marine algal toxins on marine environment and human health in China, this paper overviews HAB occurrence and marine algal toxin incidents, as well as their environmental and health effects in this country. HAB has been increasing rapidly along the Chinese coast since the 1970s, and at least 512 documented HAB events have occurred from 1952 to 2002 in the Chinese mainland. It has been found that PSP and DSP toxins are distributed widely along both the northern and southern Chinese coasts. The HAB and marine algal toxin events during the 1990s in China were summarized, showing that the HAB and algal toxins resulted in great damages to local fisheries, marine culture, quality of marine environment, and human health. Therefore, to protect the coastal environment and human health, attention to HAB and marine algal toxins is urgently needed from the environmental and epidemiologicalview.展开更多
Forest bathing trip is a short, leisurely visit to forest. In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease （COPD）. The patients we...Forest bathing trip is a short, leisurely visit to forest. In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease （COPD）. The patients were randomly divided into two groups. One group was sent to forest, and the other was sent to an urban area as control. Flow cytometry, ELISA, and profile of mood states （POMS） evaluation were performed. In the forest group,展开更多
The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses...The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies.展开更多
A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR...A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR),-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control,but noγ-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs展开更多
In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentar...In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentary phosphate deposits samples from El-Hamraween, El-Quser and Safaga phosphate mines in Egypt. HPGe γ-spectrometry was used. This study was undertaken to estimate the radiation hazard indices in phosphate mining at the studied mines on their occupational workers, to establish correlation relationships between the some measured heavy metals such as As, Cd and Pb in blood workers and their concentration in phosphate rock ores and to determinate the biomarkers in the blood workers such as malondialdehyde (MDA) and superoxide dismutase (SOD). The phosphate mine sample of El-Hamrawein has the lowest activity concentration of <sup>226</sup>Ra, <sup>232</sup>Th and <sup>40</sup>K in comparison to the phosphate mine samples of El-Quseir and Safaga (El-Hamrawein kg<sup>-</sup>1</sup><sup></sup>, 122.4 to 188.3 Bq·kg<sup>-</sup>1</sup></sup> and 115.4 to 165.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>232</sup>Th activity concentrations varied from 135.6 to 212.3 Bq·kg<sup>-</sup>1</sup></sup>, 112.8 to 167.4 Bq·kg<sup>-</sup>1</sup></sup> and 132.8 to 188.6 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>40</sup>K activity concentrations varied from 225.2 to 312.8 Bq·kg<sup>-</sup>1</sup>, 168.7 to 268.9 Bq·kg<sup>-</sup>1</sup></sup> and 95.2 to 155.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. The workers of old ages have higher concentration of the investigated heavy metals than those of young ages. There is a good relation between the concentration of the investigated metals in phosphate mine samples and their concentration in blood of the occupational workers in these mines.展开更多
Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and s...Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and socio-economic processes. Addressing the question of the use of xanthates without considering their toxicity, and their decomposition process and products would be ecologically and healthily less sustainable. To date, related information is still dispersed and less known to the public. Therefore, this work provides a comprehensive overview of the existing information on the essentiality, fate, ecotoxicity, and health effects of xanthates and associated compounds. According to available information from scientific, technical, and professional circles, xanthates are diverse, usually with a carbon chain of two to six carbon atoms. They play a crucial role in the sectors of the mining and mineral processing industry, agriculture, wastewater treatment, metal protection, rubber vulcanization, the pharmaceutical industry, and medicine. Xanthates’ degradation under different factors and mechanisms, which determine their fate in the environment, leads to the formation of toxic substances, mainly carbon disulfide, carbonyl sulfide, hydrogen sulfide, and hydrogen peroxide. Xanthates and xanthates degradation products are seriously hazardous to humans, animals, soil and aquatic organisms, enzymatic system, etc. Simultaneous exposure to xanthates and metals results in the magnification or reduction of their toxicity level, depending on the exposed organisms. Such toxicological dimensions should attract more scientific and public attention for more safe production, use, storage, and disposal of xanthates. Due to the high affinity of xanthates for metal, xanthates-modified compounds are efficient metal chelating agents. Such a property should be explored to develop potentially low-cost and effective alternatives for metal removal and recovery from contaminated media. The same applies to developing appropriate methods for the evaluation and management of the simultaneous presence of xanthates and metals in the environment.展开更多
Objective:The Delphi method was used to propose health effect evaluation indicators to assess foods for special medical purposes(FSMPs).This lays the foundation for the formation of a big data model for human health t...Objective:The Delphi method was used to propose health effect evaluation indicators to assess foods for special medical purposes(FSMPs).This lays the foundation for the formation of a big data model for human health testing,as well as a big data platform for the health and safety evaluation of special medical foods.Methods:The Delphi method was used to conduct two rounds of expert consultation on the constructed FSMP health effect evaluation indicators.Results:Ten major items were identified after two rounds of expert consultation.Among these,there were 10 primary entries,32 secondary entries,50 tertiary entries,and 28 quaternary entries.Conclusion:The complete list of evaluation indicators contains 10 entries,which can comprehensively and systematically monitor adverse reactions to the use of FSMPs.The present findings lay the foundation for a big data platform to evaluate the health and safety of special foods.展开更多
Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To ...Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To investigate health effects related to STS in motor compressor workers. Methods: A cross sectional study of 464 motor compressor workers was conducted including hearing health examination by audiometer, and noise level in the workplace was monitored. Workers who reported having hobbies relating to noise, e.g. gun shooting, or a personal history of disease relating to the ear were excluded. The relationship between health effects and workers with STS was studied. Results: There were more men 81.90% (aged range 31-40 years old) than women working for the company. The average continuous noise level in the workplace was 84.14 ± 5.21 dB(A). The study showed that working at the factory for more than 14 years (OR= 3.84, 95%CI 1.54-9.56) and being exposed to noise at least 8 hours a day (OR = 2.12, 95%CI = 1.02-4.40) effected to STS. Workers with STS showed significant communication difficulties (OR = 1.89, 95%CI = 1.03-3.49) and stress/nausea more than workers without STS (OR = 1.54, 95%CI = 0.90-2.65) although not statistically significant. Conclusions: Workers exposed to continuous noise in the motor compressor industry are at risk of STS. Duration of exposure to noise is a key factor in respect of harm to hearing health. STS could be used as a tool to screen workers who have hearing health problems.展开更多
The objective of this paper is the valuation of radiological health effects of Yatagan Power Plant. To this aim the radiation dose calculations are carried out for the population living within 80 km radius of the plan...The objective of this paper is the valuation of radiological health effects of Yatagan Power Plant. To this aim the radiation dose calculations are carried out for the population living within 80 km radius of the plant. The average of the maximum measured specific isotopes 238U, 232Th and 226Ra in the flying ash samples are considered as radioactive sources. Based on the dose calculations, first the stochastic health effects and then monetary health effects are estimated. The estimated total collective dose and economic value of the pre-dicted health effects are 0.3098 man Sv/y and 14791 US$/y respectively. The results obtained from the dose calculations are lower than the limits of International Commission of Radiation Protection (ICRP) and it does not pose any risk for public health. Monetary value of health risks is also negligible in comparison to the av-erage yearly sales revenue of the plant which is 250 million US$.展开更多
Introduction: Khat chewing is believed to be rapidly increasing worldwide. Worldwide, it is estimated that 10 million people consume khat daily. Khat chewing practice renders certain influence on physical and psycholo...Introduction: Khat chewing is believed to be rapidly increasing worldwide. Worldwide, it is estimated that 10 million people consume khat daily. Khat chewing practice renders certain influence on physical and psychological well being of the community and it can cause more serious adverse psychiatric, cardiovascular, dental and gastrointestinal effects. The recent sharp increase in khat consumption may not only affect the health of individuals but could also have serious socio-economic consequences. This study was conducted to assess prevalence of khat chewing practice, its associated factors and perceived health effects among communities in Dera woreda, Amhara region, Ethiopia 2013. Methods: Community-based cross-sectional study was conducted by using both quantitative and qualitative method of data. The sample size for quantitative was determined by using single population proportion formula and the households were selected by systematic sampling method and in the selected household, one respondent was selected by lottery among members of household aged 15 years and above. Data were collected by means of a pretested questionnaire;analysis was carried out using SPSS version 16. For the qualitative part ten in-depth interviews were conducted on purposely selected individuals and sample size for this method was determined through continuing to interview participants until no new information was obtained. Results: The response rate was 98.3%. Current prevalence of khat chewing practice was 17%. Males were more likely to chew khat (AOR, 18.53;95%CI, 7.20-47.66) compared to females. Muslims were more likely to chew khat (AOR, 4.34;95%CI, 2.07-9.11) compared to Orthodox Christians. Respondents who had family member chewing khat were more likely to chew khat (AOR, 2.67;95%CI, 1.15-6.21) compared to family member without a chewer. Among all the respondents, 92.8% perceived the health effects of khat chewing practice. Respondents who did not perceive health effect of khat were 5 times more likely to chew khat (AOR = 5.10, 95%CI;1.64-15.5) compared to those who perceived health effect of khat. Conclusions: The prevalence of khat chewing practice was 17% with high proportion of the khat chewers found in the urban setting. Sex, religion, residence, family chewing habit and perceived health effect were significantly associated factors with khat chewing practice. In this study 92.8% of the respondents perceived that khat chewing practice had harmful effects on health and the perceived health effects reported were sleeping disorder, hallucination, tooth staining, anxiety, and loss of appetite, depression, constipation, gastritis, hypertension and psychosis.展开更多
Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationsh...Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationship between animal exposure to MPs and their health effects,revealing that MP contamination affects a broad spectrum of animal species across terrestrial and aquatic habitats.Crucially,interspecies differences in ingestion,accumulation,and responses to MPs emerge as central themes arising from various factors,including feeding behavior,physiology,and ecological niches.The health implications of MP exposure are multifarious;animals may suffer physical harm,endure chemical exposure to adsorbed contaminants,provoke inflammatory responses,and undergo behavioral modifi-cations.Chronic exposure to MPs raises concerns about their long-term health consequences,and the ability of MPs to adsorb and transport chemicals has implications for the bioaccumulation of pollutants within food webs.The ecological ramifications of MP contamination are profound,impacting animal behavior,population dynamics,and ecosystem processes.The intricate interplay between animals and MPs underscores the need for interdisciplinary research that unites fields such as biology,ecology,chemistry,and toxicology.Recognizing the relationship between animal exposure to MPs and their health effects has significant implications,particularly as the potential for MPs to enter the human food chain through animals underscores the need for research on human health risks.展开更多
Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have b...Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have been observed at much lower pollution levels than previously studied.China has experienced periods of severe air pollution over the past few decades.To improve air quality and safeguard public health,the government has implemented several progressively tightened policies.Emission control policies were first proposed in 2005.展开更多
Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients...Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.展开更多
Objective: By the end of 2021, the aging rate of China’s population is 18.9%, and the prevalence rate of chronic diseases in the elderly population is increasing year by year, and chronic diseases have become the mai...Objective: By the end of 2021, the aging rate of China’s population is 18.9%, and the prevalence rate of chronic diseases in the elderly population is increasing year by year, and chronic diseases have become the main causes of death and health threats of Chinese residents. Therefore, how to manage this huge group well is crucial. This paper analyzes the value of health education in the process of health management for patients with chronic diseases. Methods: 102 patients with chronic diseases treated from January 2021 to December 2021 were divided into control group and experimental group by random number table method. The control group was given routine health management while the experimental group was given health education based on the control group, and the implementation effect was analyzed. Results: After management, the scores of chronic disease knowledge in the experimental group were significantly higher than those in the control group, and the dimensions of ESCA were higher than those in the control group, and P < 0.05;Conclusion: The implementation of health education in the process of chronic disease health management is helpful to improve patients’ self-care ability and better control disease progression.展开更多
Charcoal marketing is the main activity in the Gbegamey district of Cotonou. The aim of the study was to determine the effects of charcoal marketing on the environment and health of the Gbegamey population. A mixed de...Charcoal marketing is the main activity in the Gbegamey district of Cotonou. The aim of the study was to determine the effects of charcoal marketing on the environment and health of the Gbegamey population. A mixed descriptive and evaluative design was adopted. Data were collected using an interview guide, a structured non-participatory observation grid and air quality analysis equipment (PCE RCM 8 air quality detector;Carbon monoxide meter AS 87000A and Anemometer AM 4812) among charcoal traders, food vendors and residents living near charcoal sales outlets, selected by non-probabilistic purposive sampling, and were analysed with reference to national regulatory provisions and WHO recommendations (2022). 57 people, including 26 shopkeepers, were surveyed. Their average age was 45, with extremes of 25 and 65. The effects of charcoal marketing on health and the environment were known to 23 traders, who unfortunately did not adopt any protective measures. Some of the health effects mentioned were rheumatic and cardiovascular diseases. Pollutants (PM1: 96 µg/m3, PM2.5: 161 µg/m3, PM10: 206 µg/m3, CO: 185 mg/m3) were present in the coal-selling environment at Gbegamey. According to the respondents, respiratory diseases (42.31%), rheumatic diseases (30.77%) and cardiovascular diseases (11.54%) affected the traders, while respiratory diseases (51.61%) affected the general population. The marketing of charcoal in the Gbegamey district generates a high concentration of pollutants in the atmosphere. The activity needs to be monitored in order to limit its effects.展开更多
Cement is made by grinding several raw materials. The cement industry contributes to the development of any society. Benin has four cement companies, including Sèkandji. Exposure to cement dust can cause a number...Cement is made by grinding several raw materials. The cement industry contributes to the development of any society. Benin has four cement companies, including Sèkandji. Exposure to cement dust can cause a number of ailments. Cement production also contributes to the emission of greenhouse gases (GHGs), which contribute to global warming. The study aims to assess the effects of cement dust on the environment and on the health of the population of Sekandji. This was a cross-sectional study with descriptive and quantitative aims, conducted from May 21 to June 23, 2024. Data were collected using an interview guide from people living in the vicinity of the cement plant, who gave their informed consent to participate in the study. An observation grid was used to assess the environment. Particulate matter was sampled in the immediate vicinity of the cement plant using an AM-4812 anemometer and an air quality monitor. Sampling was non-probabilistic and purposive. Targets were selected for reliability and accuracy of data collection. Data collection was carried out using Kobo Collect software for data collected with the interview guide. Excel 2013 was used for data analysis, tables and graphs, and Microsoft Word 2013 for data entry. A total of 105 residents were selected in the vicinity of the cement plant. The average age of respondents was 35, with a minimum of 20 and a maximum of 50. The dominant age group was between 30 and 39. Males (70) dominated, with a sex ratio equal to 2. The vast majority of respondents (92.38%) said they had noticed or heard about an increase in health problems since the cement plant was set up. However, 70.48% of respondents claimed to have no information on the effects of cement production on the environment. Few respondents (29.52%) were aware of the effects of cement production on the environment. Respiratory, dermatological and ocular disorders were cited as being linked to cement. PM2.5 and PM10 particles were present in very high proportions in the air. The implementation of a serious industrialization policy that takes urbanization into account will guarantee the health safety of the population.展开更多
基金supported by the Key Research and Development Plan of Zhejiang Province(No.2021C03176)Zhejiang Provincial Natural Science Foundation of China(No.LY23B070001)+2 种基金the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20230009)the National Natural Science Foundation of China(No.22106032)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000).
文摘Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.
基金supported by the National Natural Science Foundation of China(Nos.42020104001,42327806 and 42177354).
文摘Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.
基金funded by the National Natural Science Foundation Program of China(31901707)the 2115 Talent Development Program of China Agricultural University。
文摘The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health risks.In this study,we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories,low(minimal),moderate and high.Second,we compared the differences in attitudes towards FJBs in dietary guidelines.Third,we integrated the results of existing epidemiological surveys,randomized controlled trials,and animal experiments to explore the health risks associated with consuming FJBs.Deepening the processing of FJBs has been found to lead to an increased risk of diseases.Dietary pattern,nutrients,addition agents and consumer preferences may be influential factors.Finally,we investigated whether there were any changes in the health benefits of 100%fruit juices produced by different processing methods.In conclusion,minimally/moderately processed 100%fruit juices provide more health benefits than highly processed fruit beverages.The results support the need to consider the extent of FJBs processing in future studies to adjust official nutritional recommendations for beverage consumption.
基金This study was supported by National Basic Research Project No. 2001CB4097 NSFC Projects No.20177023+2 种基金 40076030 CAS Innovation Project No. KZCX2-206 Project of Shandong Province Science Committee No.012110115.
文摘The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life through contaminated seafood. To better understand the effect of HAB and marine algal toxins on marine environment and human health in China, this paper overviews HAB occurrence and marine algal toxin incidents, as well as their environmental and health effects in this country. HAB has been increasing rapidly along the Chinese coast since the 1970s, and at least 512 documented HAB events have occurred from 1952 to 2002 in the Chinese mainland. It has been found that PSP and DSP toxins are distributed widely along both the northern and southern Chinese coasts. The HAB and marine algal toxin events during the 1990s in China were summarized, showing that the HAB and algal toxins resulted in great damages to local fisheries, marine culture, quality of marine environment, and human health. Therefore, to protect the coastal environment and human health, attention to HAB and marine algal toxins is urgently needed from the environmental and epidemiologicalview.
基金supported by funds from the National Natural Science Foundation of China(31301139&31201040)funds from Science Technology Department of Zhejiang Province(2012C24005&2014C33130)+2 种基金Health Bureau of Zhejiang Province(11-CX01&2013ZDA002)Zhejiang Provincial Key Disciplinary Fields of Geriatrics Program
文摘Forest bathing trip is a short, leisurely visit to forest. In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease （COPD）. The patients were randomly divided into two groups. One group was sent to forest, and the other was sent to an urban area as control. Flow cytometry, ELISA, and profile of mood states （POMS） evaluation were performed. In the forest group,
文摘The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies.
文摘A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR),-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control,but noγ-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs
文摘In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentary phosphate deposits samples from El-Hamraween, El-Quser and Safaga phosphate mines in Egypt. HPGe γ-spectrometry was used. This study was undertaken to estimate the radiation hazard indices in phosphate mining at the studied mines on their occupational workers, to establish correlation relationships between the some measured heavy metals such as As, Cd and Pb in blood workers and their concentration in phosphate rock ores and to determinate the biomarkers in the blood workers such as malondialdehyde (MDA) and superoxide dismutase (SOD). The phosphate mine sample of El-Hamrawein has the lowest activity concentration of <sup>226</sup>Ra, <sup>232</sup>Th and <sup>40</sup>K in comparison to the phosphate mine samples of El-Quseir and Safaga (El-Hamrawein kg<sup>-</sup>1</sup><sup></sup>, 122.4 to 188.3 Bq·kg<sup>-</sup>1</sup></sup> and 115.4 to 165.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>232</sup>Th activity concentrations varied from 135.6 to 212.3 Bq·kg<sup>-</sup>1</sup></sup>, 112.8 to 167.4 Bq·kg<sup>-</sup>1</sup></sup> and 132.8 to 188.6 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>40</sup>K activity concentrations varied from 225.2 to 312.8 Bq·kg<sup>-</sup>1</sup>, 168.7 to 268.9 Bq·kg<sup>-</sup>1</sup></sup> and 95.2 to 155.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. The workers of old ages have higher concentration of the investigated heavy metals than those of young ages. There is a good relation between the concentration of the investigated metals in phosphate mine samples and their concentration in blood of the occupational workers in these mines.
文摘Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and socio-economic processes. Addressing the question of the use of xanthates without considering their toxicity, and their decomposition process and products would be ecologically and healthily less sustainable. To date, related information is still dispersed and less known to the public. Therefore, this work provides a comprehensive overview of the existing information on the essentiality, fate, ecotoxicity, and health effects of xanthates and associated compounds. According to available information from scientific, technical, and professional circles, xanthates are diverse, usually with a carbon chain of two to six carbon atoms. They play a crucial role in the sectors of the mining and mineral processing industry, agriculture, wastewater treatment, metal protection, rubber vulcanization, the pharmaceutical industry, and medicine. Xanthates’ degradation under different factors and mechanisms, which determine their fate in the environment, leads to the formation of toxic substances, mainly carbon disulfide, carbonyl sulfide, hydrogen sulfide, and hydrogen peroxide. Xanthates and xanthates degradation products are seriously hazardous to humans, animals, soil and aquatic organisms, enzymatic system, etc. Simultaneous exposure to xanthates and metals results in the magnification or reduction of their toxicity level, depending on the exposed organisms. Such toxicological dimensions should attract more scientific and public attention for more safe production, use, storage, and disposal of xanthates. Due to the high affinity of xanthates for metal, xanthates-modified compounds are efficient metal chelating agents. Such a property should be explored to develop potentially low-cost and effective alternatives for metal removal and recovery from contaminated media. The same applies to developing appropriate methods for the evaluation and management of the simultaneous presence of xanthates and metals in the environment.
基金This research was supported by the National Key Research and Development Program of China(2019YFC1606400).
文摘Objective:The Delphi method was used to propose health effect evaluation indicators to assess foods for special medical purposes(FSMPs).This lays the foundation for the formation of a big data model for human health testing,as well as a big data platform for the health and safety evaluation of special medical foods.Methods:The Delphi method was used to conduct two rounds of expert consultation on the constructed FSMP health effect evaluation indicators.Results:Ten major items were identified after two rounds of expert consultation.Among these,there were 10 primary entries,32 secondary entries,50 tertiary entries,and 28 quaternary entries.Conclusion:The complete list of evaluation indicators contains 10 entries,which can comprehensively and systematically monitor adverse reactions to the use of FSMPs.The present findings lay the foundation for a big data platform to evaluate the health and safety of special foods.
文摘Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To investigate health effects related to STS in motor compressor workers. Methods: A cross sectional study of 464 motor compressor workers was conducted including hearing health examination by audiometer, and noise level in the workplace was monitored. Workers who reported having hobbies relating to noise, e.g. gun shooting, or a personal history of disease relating to the ear were excluded. The relationship between health effects and workers with STS was studied. Results: There were more men 81.90% (aged range 31-40 years old) than women working for the company. The average continuous noise level in the workplace was 84.14 ± 5.21 dB(A). The study showed that working at the factory for more than 14 years (OR= 3.84, 95%CI 1.54-9.56) and being exposed to noise at least 8 hours a day (OR = 2.12, 95%CI = 1.02-4.40) effected to STS. Workers with STS showed significant communication difficulties (OR = 1.89, 95%CI = 1.03-3.49) and stress/nausea more than workers without STS (OR = 1.54, 95%CI = 0.90-2.65) although not statistically significant. Conclusions: Workers exposed to continuous noise in the motor compressor industry are at risk of STS. Duration of exposure to noise is a key factor in respect of harm to hearing health. STS could be used as a tool to screen workers who have hearing health problems.
文摘The objective of this paper is the valuation of radiological health effects of Yatagan Power Plant. To this aim the radiation dose calculations are carried out for the population living within 80 km radius of the plant. The average of the maximum measured specific isotopes 238U, 232Th and 226Ra in the flying ash samples are considered as radioactive sources. Based on the dose calculations, first the stochastic health effects and then monetary health effects are estimated. The estimated total collective dose and economic value of the pre-dicted health effects are 0.3098 man Sv/y and 14791 US$/y respectively. The results obtained from the dose calculations are lower than the limits of International Commission of Radiation Protection (ICRP) and it does not pose any risk for public health. Monetary value of health risks is also negligible in comparison to the av-erage yearly sales revenue of the plant which is 250 million US$.
文摘Introduction: Khat chewing is believed to be rapidly increasing worldwide. Worldwide, it is estimated that 10 million people consume khat daily. Khat chewing practice renders certain influence on physical and psychological well being of the community and it can cause more serious adverse psychiatric, cardiovascular, dental and gastrointestinal effects. The recent sharp increase in khat consumption may not only affect the health of individuals but could also have serious socio-economic consequences. This study was conducted to assess prevalence of khat chewing practice, its associated factors and perceived health effects among communities in Dera woreda, Amhara region, Ethiopia 2013. Methods: Community-based cross-sectional study was conducted by using both quantitative and qualitative method of data. The sample size for quantitative was determined by using single population proportion formula and the households were selected by systematic sampling method and in the selected household, one respondent was selected by lottery among members of household aged 15 years and above. Data were collected by means of a pretested questionnaire;analysis was carried out using SPSS version 16. For the qualitative part ten in-depth interviews were conducted on purposely selected individuals and sample size for this method was determined through continuing to interview participants until no new information was obtained. Results: The response rate was 98.3%. Current prevalence of khat chewing practice was 17%. Males were more likely to chew khat (AOR, 18.53;95%CI, 7.20-47.66) compared to females. Muslims were more likely to chew khat (AOR, 4.34;95%CI, 2.07-9.11) compared to Orthodox Christians. Respondents who had family member chewing khat were more likely to chew khat (AOR, 2.67;95%CI, 1.15-6.21) compared to family member without a chewer. Among all the respondents, 92.8% perceived the health effects of khat chewing practice. Respondents who did not perceive health effect of khat were 5 times more likely to chew khat (AOR = 5.10, 95%CI;1.64-15.5) compared to those who perceived health effect of khat. Conclusions: The prevalence of khat chewing practice was 17% with high proportion of the khat chewers found in the urban setting. Sex, religion, residence, family chewing habit and perceived health effect were significantly associated factors with khat chewing practice. In this study 92.8% of the respondents perceived that khat chewing practice had harmful effects on health and the perceived health effects reported were sleeping disorder, hallucination, tooth staining, anxiety, and loss of appetite, depression, constipation, gastritis, hypertension and psychosis.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2019R1A6A1A03033167).
文摘Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationship between animal exposure to MPs and their health effects,revealing that MP contamination affects a broad spectrum of animal species across terrestrial and aquatic habitats.Crucially,interspecies differences in ingestion,accumulation,and responses to MPs emerge as central themes arising from various factors,including feeding behavior,physiology,and ecological niches.The health implications of MP exposure are multifarious;animals may suffer physical harm,endure chemical exposure to adsorbed contaminants,provoke inflammatory responses,and undergo behavioral modifi-cations.Chronic exposure to MPs raises concerns about their long-term health consequences,and the ability of MPs to adsorb and transport chemicals has implications for the bioaccumulation of pollutants within food webs.The ecological ramifications of MP contamination are profound,impacting animal behavior,population dynamics,and ecosystem processes.The intricate interplay between animals and MPs underscores the need for interdisciplinary research that unites fields such as biology,ecology,chemistry,and toxicology.Recognizing the relationship between animal exposure to MPs and their health effects has significant implications,particularly as the potential for MPs to enter the human food chain through animals underscores the need for research on human health risks.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3702702)National Natural Science Foundation of China(Grant No.82103871).
文摘Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have been observed at much lower pollution levels than previously studied.China has experienced periods of severe air pollution over the past few decades.To improve air quality and safeguard public health,the government has implemented several progressively tightened policies.Emission control policies were first proposed in 2005.
文摘Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.
文摘Objective: By the end of 2021, the aging rate of China’s population is 18.9%, and the prevalence rate of chronic diseases in the elderly population is increasing year by year, and chronic diseases have become the main causes of death and health threats of Chinese residents. Therefore, how to manage this huge group well is crucial. This paper analyzes the value of health education in the process of health management for patients with chronic diseases. Methods: 102 patients with chronic diseases treated from January 2021 to December 2021 were divided into control group and experimental group by random number table method. The control group was given routine health management while the experimental group was given health education based on the control group, and the implementation effect was analyzed. Results: After management, the scores of chronic disease knowledge in the experimental group were significantly higher than those in the control group, and the dimensions of ESCA were higher than those in the control group, and P < 0.05;Conclusion: The implementation of health education in the process of chronic disease health management is helpful to improve patients’ self-care ability and better control disease progression.
文摘Charcoal marketing is the main activity in the Gbegamey district of Cotonou. The aim of the study was to determine the effects of charcoal marketing on the environment and health of the Gbegamey population. A mixed descriptive and evaluative design was adopted. Data were collected using an interview guide, a structured non-participatory observation grid and air quality analysis equipment (PCE RCM 8 air quality detector;Carbon monoxide meter AS 87000A and Anemometer AM 4812) among charcoal traders, food vendors and residents living near charcoal sales outlets, selected by non-probabilistic purposive sampling, and were analysed with reference to national regulatory provisions and WHO recommendations (2022). 57 people, including 26 shopkeepers, were surveyed. Their average age was 45, with extremes of 25 and 65. The effects of charcoal marketing on health and the environment were known to 23 traders, who unfortunately did not adopt any protective measures. Some of the health effects mentioned were rheumatic and cardiovascular diseases. Pollutants (PM1: 96 µg/m3, PM2.5: 161 µg/m3, PM10: 206 µg/m3, CO: 185 mg/m3) were present in the coal-selling environment at Gbegamey. According to the respondents, respiratory diseases (42.31%), rheumatic diseases (30.77%) and cardiovascular diseases (11.54%) affected the traders, while respiratory diseases (51.61%) affected the general population. The marketing of charcoal in the Gbegamey district generates a high concentration of pollutants in the atmosphere. The activity needs to be monitored in order to limit its effects.
文摘Cement is made by grinding several raw materials. The cement industry contributes to the development of any society. Benin has four cement companies, including Sèkandji. Exposure to cement dust can cause a number of ailments. Cement production also contributes to the emission of greenhouse gases (GHGs), which contribute to global warming. The study aims to assess the effects of cement dust on the environment and on the health of the population of Sekandji. This was a cross-sectional study with descriptive and quantitative aims, conducted from May 21 to June 23, 2024. Data were collected using an interview guide from people living in the vicinity of the cement plant, who gave their informed consent to participate in the study. An observation grid was used to assess the environment. Particulate matter was sampled in the immediate vicinity of the cement plant using an AM-4812 anemometer and an air quality monitor. Sampling was non-probabilistic and purposive. Targets were selected for reliability and accuracy of data collection. Data collection was carried out using Kobo Collect software for data collected with the interview guide. Excel 2013 was used for data analysis, tables and graphs, and Microsoft Word 2013 for data entry. A total of 105 residents were selected in the vicinity of the cement plant. The average age of respondents was 35, with a minimum of 20 and a maximum of 50. The dominant age group was between 30 and 39. Males (70) dominated, with a sex ratio equal to 2. The vast majority of respondents (92.38%) said they had noticed or heard about an increase in health problems since the cement plant was set up. However, 70.48% of respondents claimed to have no information on the effects of cement production on the environment. Few respondents (29.52%) were aware of the effects of cement production on the environment. Respiratory, dermatological and ocular disorders were cited as being linked to cement. PM2.5 and PM10 particles were present in very high proportions in the air. The implementation of a serious industrialization policy that takes urbanization into account will guarantee the health safety of the population.
