<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in ...<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in men than in women. Serum UA has been identified as a predictive biomarker for metabolic syndrome (MetS);however, the gender differences in the association between UA levels and MetS-related conditions in a Japanese population have not been completely assessed. <strong><em>Objective</em></strong> To examine gender and age differences in the associations between serum UA levels and other biomarkers within a health-screened Japanese population and to evaluate the usefulness of serum UA as a predictor of MetS between the two genders. <strong><em>Methods</em></strong> A cross-sectional study of healthy individuals in Japan (16,391 men;16,656 women) was conducted. Associations between UA and several biomarkers were analyzed for each gender type and for age- and serum UA level-stratified groups. Logistic regression was used to analyze the association of age and serum UA levels with MetS-related conditions. Receiver operating characteristic (ROC) curve analysis was performed to identify the UA cut-off value for predicting the risk of the MetS-related conditions. <strong><em>Results</em></strong> Serum UA levels in women had stronger correlations with MetS-related biomarkers than in men. After adjusting for age, the odds ratios for a 1-mg/dL serum UA increase for diabetes mellitus and dyslipidemia in women were 1.13 (95% confidence interval, 1.04 - 1.23) and 1.30 (1.25 - 1.34), respectively. In ROC analysis, women had significantly higher area under the curve (AUC) values for MetS prediction than men. <em><strong>Conclusion</strong></em> An elevated serum UA level has a higher predictive ability for the risk of MetS-related conditions in Japanese women than in men. The optimal serum UA cut-off value for MetS in women was suggested to be approximately 5 mg/dL, remarkably lower than that in men.展开更多
Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qi...Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qixingguan district (township, town) , so as to clarify the shortcomings in this work, and effectively promote the development of magnetic project. Methods: questionnaire survey and telephone survey were carried out among the service subjects in the health center. The content mainly included the channels of policy knowledge, the evaluation of the situation of policy knowledge and advice information, as well as the degree of satisfaction, and the pregnancy outcome, early pregnancy follow-up and follow-up. Results: the coverage rate of the scientific knowledge of eugenics and the awareness rate of the married couples at childbearing age were all above 90%, especially the channels of awareness were higher. According to the analysis of follow-up, the rate of pregnancy outcome, early pregnancy follow-up and high-risk group follow-up is low, and there is no significant difference in the population satisfaction and follow-up willingness according to the population age, but there is significant difference in the population satisfaction and follow-up willingness according to different regions (P < 0.05). Conclusion: according to the results of the study, we can know that publicity and training should be strengthened, and follow-up services should be further improved. According to different groups of people, different ways should be used to do the work well before pregnancy, so that people's satisfaction can be improved.展开更多
Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological condi...Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological conditions in China remains limited.Methods:This nationwide cross-sectional study analyzed health check-up data from the Dian laboratory network across China in 2023.The study included 238,807 women aged≥20 years from 23 PLADs who underwent both HPV genotyping and LBC testing.The rates of abnormal cytology and HPV infection were weighted and standardized according to the Seventh National Population Census(2020).Results:The overall weighted rates of HR-HPV infection and abnormal cytology were 12.30%and 9.25%,respectively.Among women with abnormal cervical cytology,HPV-16 was the most prevalent HRHPV genotype,followed by HPV-58 and HPV-52.Conclusions:The detection rates of HR-HPV and abnormal cytology remain relatively high in China.Both single and multiple HR-HPV infections were associated with increased risk of abnormal cervical cytology.These findings may inform the development of HPV genotype-specific vaccination and screening strategies to reduce cervical cancer burden.展开更多
文摘<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in men than in women. Serum UA has been identified as a predictive biomarker for metabolic syndrome (MetS);however, the gender differences in the association between UA levels and MetS-related conditions in a Japanese population have not been completely assessed. <strong><em>Objective</em></strong> To examine gender and age differences in the associations between serum UA levels and other biomarkers within a health-screened Japanese population and to evaluate the usefulness of serum UA as a predictor of MetS between the two genders. <strong><em>Methods</em></strong> A cross-sectional study of healthy individuals in Japan (16,391 men;16,656 women) was conducted. Associations between UA and several biomarkers were analyzed for each gender type and for age- and serum UA level-stratified groups. Logistic regression was used to analyze the association of age and serum UA levels with MetS-related conditions. Receiver operating characteristic (ROC) curve analysis was performed to identify the UA cut-off value for predicting the risk of the MetS-related conditions. <strong><em>Results</em></strong> Serum UA levels in women had stronger correlations with MetS-related biomarkers than in men. After adjusting for age, the odds ratios for a 1-mg/dL serum UA increase for diabetes mellitus and dyslipidemia in women were 1.13 (95% confidence interval, 1.04 - 1.23) and 1.30 (1.25 - 1.34), respectively. In ROC analysis, women had significantly higher area under the curve (AUC) values for MetS prediction than men. <em><strong>Conclusion</strong></em> An elevated serum UA level has a higher predictive ability for the risk of MetS-related conditions in Japanese women than in men. The optimal serum UA cut-off value for MetS in women was suggested to be approximately 5 mg/dL, remarkably lower than that in men.
文摘Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qixingguan district (township, town) , so as to clarify the shortcomings in this work, and effectively promote the development of magnetic project. Methods: questionnaire survey and telephone survey were carried out among the service subjects in the health center. The content mainly included the channels of policy knowledge, the evaluation of the situation of policy knowledge and advice information, as well as the degree of satisfaction, and the pregnancy outcome, early pregnancy follow-up and follow-up. Results: the coverage rate of the scientific knowledge of eugenics and the awareness rate of the married couples at childbearing age were all above 90%, especially the channels of awareness were higher. According to the analysis of follow-up, the rate of pregnancy outcome, early pregnancy follow-up and high-risk group follow-up is low, and there is no significant difference in the population satisfaction and follow-up willingness according to the population age, but there is significant difference in the population satisfaction and follow-up willingness according to different regions (P < 0.05). Conclusion: according to the results of the study, we can know that publicity and training should be strengthened, and follow-up services should be further improved. According to different groups of people, different ways should be used to do the work well before pregnancy, so that people's satisfaction can be improved.
基金Supported by the Scientific Research Seed Fund of Peking University First Hospital(grant number 2024SF47)(D.G.)Regular Resources from Peking University First Hospital(X.Z.).
文摘Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological conditions in China remains limited.Methods:This nationwide cross-sectional study analyzed health check-up data from the Dian laboratory network across China in 2023.The study included 238,807 women aged≥20 years from 23 PLADs who underwent both HPV genotyping and LBC testing.The rates of abnormal cytology and HPV infection were weighted and standardized according to the Seventh National Population Census(2020).Results:The overall weighted rates of HR-HPV infection and abnormal cytology were 12.30%and 9.25%,respectively.Among women with abnormal cervical cytology,HPV-16 was the most prevalent HRHPV genotype,followed by HPV-58 and HPV-52.Conclusions:The detection rates of HR-HPV and abnormal cytology remain relatively high in China.Both single and multiple HR-HPV infections were associated with increased risk of abnormal cervical cytology.These findings may inform the development of HPV genotype-specific vaccination and screening strategies to reduce cervical cancer burden.
