Sleep disorders,particularly insomnia,have emerged as a critical public health challenge,with the situation worsened by the coronavirus disease-2019 pandemic.Insomnia symptoms,which affected up to 45%of the population...Sleep disorders,particularly insomnia,have emerged as a critical public health challenge,with the situation worsened by the coronavirus disease-2019 pandemic.Insomnia symptoms,which affected up to 45%of the population during this period,highlight the urgent need to understand the mechanisms linking sleep disturbances to mental health outcomes.Recent findings suggest that cognitive failures,such as memory lapses and attentional deficits,mediate the relationship between insomnia and emotional disorders such as anxiety and depression.The role of personality traits,particularly neuroticism,adds further complexity,as it may either exacerbate or buffer these effects under specific conditions.This review explores the study by Li et al,which offers valuable insights into the cognitive-emotional pathways influenced by sleep disturbances.The study makes significant contributions by identifying key cognitive mechanisms and proposing the dual role of neuroticism in shaping emotional outcomes.To advance these findings,this letter advocates for future longitudinal research and the integration of targeted interventions,such as cognitive-behavioral therapy for insomnia,into public health frameworks.By addressing insomnia-induced cognitive dysfunction,these strategies can enhance emotional regulation and foster resilience,particularly in vulnerable populations facing the mental health impacts of the pandemic.展开更多
Predictive maintenance is essential for the implementation of an innovative and efficient structural health monitoring strategy.Models capable of accurately interpreting new data automatically collected by suitably pl...Predictive maintenance is essential for the implementation of an innovative and efficient structural health monitoring strategy.Models capable of accurately interpreting new data automatically collected by suitably placed sensors to assess the state of the infrastructure represent a fundamental step,particularly for the railway sector,whose safe and continuous operation plays a strategic role in the well-being and development of nations.In this scenario,the benefits of a digital twin of a bonded insu-lated rail joint(IRJ)with the predictive capabilities of advanced classification algorithms based on artificial intelligence have been explored.The digital model provides an accurate mechanical response of the infrastructure as a pair of wheels passes over the joint.As bolt preload conditions vary,four structural health classes were identified for the joint.Two parameters,i.e.gap value and vertical displacement,which are strongly correlated with bolt preload,are used in different combinations to train and test five predictive classifiers.Their classification effectiveness was assessed using several performance indica-tors.Finally,we compared the IRJ condition predictions of two trained classifiers with the available data,confirming their high accuracy.The approach presented provides an interesting solution for future predictive tools in SHM especially in the case of complex systems such as railways where the vehicle-infrastructure interaction is complex and always time varying.展开更多
The Systemic Arterial Hypertension (SAH) stands out among the chronic non-transmissible pathologies that impact the cause and/or aggravation of cardiovascular diseases (CVD) on a global level, as the disease is an und...The Systemic Arterial Hypertension (SAH) stands out among the chronic non-transmissible pathologies that impact the cause and/or aggravation of cardiovascular diseases (CVD) on a global level, as the disease is an underestimated disorder due to non-perceptive symptoms and associated with factors and risk markers of another CVD. Therefore, establishing the risk of progression and aggravation of the SAH, according the Framingham Risk Score (FRS), allows to reducing morbidity and improving preventative measures for DCVs. This observational and transversal study approaches the data collection of patient records at the Health Family Strategy of Senhor do Bonfim, BA, which established differences by descriptive and inferential statistical analysis (correlation and regression). The aspects of hypertension associated with risk factors for atherosclerosis were analyzed, determining the risk of developing cardiovascular events in 10 years by FRS. From 432 families, 746 patients were selected, of which 340 are hypertensive individuals (SAH = 45.57%) and 406 (NSAH = 54.42%) non-hypertensives. Among the SAH the majority (31.17%) was in the age range of 63 - 77, but, in both groups, women were in stronger number. There was greater prevalence in SAH for all the characteristics analyzed, smoking (13.20%), sedentary (29.41%) and cardiovascular accident (22.60%). The SAH group is more susceptive to the CVD progress in 10 years by FRS (P < 0.0001 ANOVA). In the NSAH group, there were significant associations among all the variables analyzed as was expected, without differences between the linear correlation and regression, indicating the physio-metabolic equilibrium of the factors and markers evaluated by FRS. Already in SAH group, despite the correlations have been significant too, the regression analysis revealed that only Total Cholesterol (P = 0.0086);LDL (P < 0.0001), Glucose (P < 0.0006) and Age (P < 0.0001) have significative association with FRS. So, these factors and markers deserve more attention upon the health staff of Health Family Strategy, in the SAH course at studied population, attempt the highest cardiovascular risk by FRS (2.5 to 2.8 times) to SAH. The monitoring of high-risk patients should prioritize the lifestyle changes, employing preventive measures to SAH and CVD and atherosclerosis.展开更多
The first task in prevention of diseases after an earthquake is to quickly provide an adequate source of safe drinking water.Otherwise,the incidence of infectious intestinal diseases in the disaster area residents wil...The first task in prevention of diseases after an earthquake is to quickly provide an adequate source of safe drinking water.Otherwise,the incidence of infectious intestinal diseases in the disaster area residents will increase rapidly.Additional health measures,such as disinfecting drinking water,protecting the water source,and treating disaster area residents,must be taken at the same time.The sensory test of meat is a useful index of meat decomposition levels.Corpse alkali is a kind of toxic chemical,and personal protective measures must be taken in handling corpses.In general,all of these measures are important not only for achieving the goal of“no severe epidemic after strong earthquake disaster”in the affected areas,but also for enriching knowledge of disaster medicine.1989 Academic Press.Inc.展开更多
The manuscript by Agidew et al,evaluates the critical role of family background and socioeconomic status in shaping breast cancer awareness,attitudes,and preventive behaviors,particularly in low-resource settings.Brea...The manuscript by Agidew et al,evaluates the critical role of family background and socioeconomic status in shaping breast cancer awareness,attitudes,and preventive behaviors,particularly in low-resource settings.Breast cancer continues to be a leading cause of cancer-related deaths globally,with a disproportionate impact on women in low-and middle-income countries.Recent research by Agidew et al underscores a significant association between family history of breast cancer and elevated levels of knowledge,positive attitudes,and proactive behaviors among women in Northeast Ethiopia.Building upon these findings,this editorial explores the psychological mechanisms and behavioral tendencies that drive greater awareness among women with familial exposure to the disease.Additionally,it highlights persistent socioeconomic challenges—such as limited healthcare access,education disparities,and cultural stigmas-that impede widespread preventive action,especially among women without a known family history.The editorial emphasizes the necessity of integrated public health strategies that combine culturally sensitive education,community outreach,and accessible screening services.Drawing from clinical and policy perspectives,it offers guidance on how to strengthen early detection and preventive care in under-resourced environments.Ultimately,the piece advocates for a more inclusive approach to breast cancer education and prevention that addresses both familial influence and systemic socioeconomic barriers.展开更多
Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summ...Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summer in southern areas[1].The World Health Organization(WHO)emphasizes that early warning and epidemic intensity assessments are critical public health strategies for influenza prevention and control.Internet-based flu surveillance,with real-time data and low costs,effectively complements traditional methods.The Baidu Search Index,which reflects flu-related queries,strongly correlates with influenza trends,aiding in regional activity assessment and outbreak tracking[2].展开更多
BACKGROUND Child vaccination plays a great role in preventing infectious diseases in children.While Ethiopia has emphasized child vaccination,its effectiveness largely depends on efficient communication between health...BACKGROUND Child vaccination plays a great role in preventing infectious diseases in children.While Ethiopia has emphasized child vaccination,its effectiveness largely depends on efficient communication between health practitioners and mothers/caregivers.Thus,sufficient communication contributes to promoting child immunization and in turn improving child health.AIM To examine child vaccine communication practices and strategies as well as their relationship with sociodemographic characteristics of respondents in the Amhara region of Ethiopia.METHODS A quantitative cross-sectional survey was conducted using a pretested Likert scale questionnaire and distributed to 123 health workers in primary healthcare centers between April 2024 and June 2024.The data were analyzed using both descriptive and inferential statistics.RESULTS The results indicated that the most common vaccine communication activities included education and communication(mean score=24.1),vaccine data registration(mean score=8.86),and information exchange(mean score=8.3).A significant correlation was found between the implementation of interpersonal health communication principles and immunization communication training(F=341.756,P=0.000,P<0.05).However,no significant correlations were observed between age,education,work experience,and vaccine communication practices.Additionally,the study found that the application of interpersonal communication principles was associated with the perceived relevance of immunization communication(F=27.790,P=0.000,P<0.05).CONCLUSION Based on the findings the study concluded that communication practice in promoting child immunization is insufficient.To enhance vaccine acceptance,continuous immunization communication training for health workers is recommended.展开更多
Purpose: Diabetes Mellitus (DM) is a prevalent metabolic disorder associated with significant complications, including visual impairment. This study aimed to assess the prevalence and severity of visual impairment and...Purpose: Diabetes Mellitus (DM) is a prevalent metabolic disorder associated with significant complications, including visual impairment. This study aimed to assess the prevalence and severity of visual impairment and its associated factors in diabetic patients in Libya. Methods: This cross-sectional study included 2365 DM patients (4730 eyes). Most participants were aged 30 - 49 (38.3%) and 50 - 69 (50.8%) with a nearly equal gender distribution (47.8% males, 52.2% females). Type 2 diabetes was predominant (92.6%), and 62.9% had HbA1c levels of 7.5% or higher. Results: Diabetic retinopathy (DR) was present in 2068 eyes (43.8%), with mild non-proliferative diabetic retinopathy (NPDR) affecting 1178 eyes (25%), moderate NPDR 476 eyes (10.1%), severe NPDR 228 eyes (4.8%), and proliferative diabetic retinopathy (PDR) 186 eyes (3.9%). Diabetic maculopathy was observed in 621 eyes (13.1%), with CSME in 287 eyes (6.07%) and non-CSME in 334 eyes (7.06%). Non-retinal conditions included cataracts in 1938 eyes (41%) and glaucoma in 252 eyes (5.3%). Visual impairment was observed in 1159 patients (49%), with 534 (23%) experiencing mild impairment, 382 (18%) moderate impairment, and 243 (12%) severe impairment;142 patients (6%) were classified as legally blind. DR showed a strong association with visual impairment severity (p Conclusions: These findings underscore the urgency for targeted public health interventions to mitigate visual impairment in Libyan individuals with DM.展开更多
Respiratory viral co-infections present significant challenges in clinical settings due to their impact on disease severity and patient outcomes.Current diagnostic methods often miss these co-infections,complicating t...Respiratory viral co-infections present significant challenges in clinical settings due to their impact on disease severity and patient outcomes.Current diagnostic methods often miss these co-infections,complicating the epidemiology and management of these cases.Research,primarily conducted in vitro and in vivo,suggests that co-infections can lead to more severe illnesses,increased hospitalization rates,and greater healthcare utilization,especially in high-risk groups such as children,the elderly,and immunocompromised individuals.Common coinfection patterns,risk factors,and their impact on disease dynamics highlight the need for advanced diagnostic techniques and tailored therapeutic strategies.Understanding the virological interactions and immune response modulation during co-infections is crucial for developing effective public health interventions and improving patient outcomes.Future research should focus on the molecular mechanisms of co-infection and the development of specific therapies to mitigate the adverse effects of these complex infections.展开更多
Globally, over 300 million people are living with viral he-patitis with approximately 1.3 million deaths per year. In 2016, World Health Assembly adopted the Global Health Sector Strategy on viral hepatitis to elimina...Globally, over 300 million people are living with viral he-patitis with approximately 1.3 million deaths per year. In 2016, World Health Assembly adopted the Global Health Sector Strategy on viral hepatitis to eliminate hepatitis by 2030. Different World Health Organization member countries are working on hepatitis control strategies to achieve hepatitis elimination. So far, only 12 countries are on track to achieve hepatitis elimination targets. The aim of the study was to give an update about the progress and challenges to achieving hepatitis elimination by 2030. According to the latest data, 87% of infants had received the three doses of hepatitis B virus （HBV） vaccination in the frst year of their life and 46% of infants had received a timely birth dose of HBV vaccination.There is a strong need to improve blood and injection safety. Rates of hepatitis B and C diagnosis are very low and only 11% of hepatitis B and C cases are diagnosed. There is a dire need to speed up hepatitis diagnosis and find the missing millions of people living with viral hepatitis. Up to 2016, only 3 million hepatitis C cases have been treated. Pricing of hepatitis C virus drugs is also reduced in many countries. The major hurdle to ach-ieve hepatitis elimination is lack of finances to support hepatitis programs. None of the major global donors are committed to invest in the fght against hepatitis. It will be very diffcult for the low and middle-income countries to fund their hepatitis control program. Hepatitis elimination needs strong fnancial and political commitment, support from civil societies, and support from pharmaceutical and medical companies around the globe.展开更多
To improve the inefficient prevention caused by customers unwillingness to adopt prevention strategies in health management,an incentive feedback mechanism that is based on game theory and contract design theory is in...To improve the inefficient prevention caused by customers unwillingness to adopt prevention strategies in health management,an incentive feedback mechanism that is based on game theory and contract design theory is introduced.The conditions for making customers and health maintenance organizations(HMOs)willing to participate in the proposed mechanism are given.A dual nonlinear programming model is used to identify the optimal prevention effort of customers and the pricing strategy of HMOs.Results show that to generate increased benefits,HMOs need to consider cost sharing when customers are not familiar with the proposed health services.When health services are gradually accepted,the cost sharing factor can be gradually reduced.Simulation shows that under random circumstances in which the market reaches a certain size,the proposed method exhibits a positive network externality.Motivated by network externality,HMOs only need to make their customers understand that the larger the number of participants,the greater the utility of each person.Such customers may then spontaneously invite others to purchase insurance.展开更多
Background:It is of great challenge to raise the public coronavirus disease 2019(COVID-19)related health literacy(CRHL)in impoverished regions due to the limits of poor infrastructure,large proportion of vulnerable gr...Background:It is of great challenge to raise the public coronavirus disease 2019(COVID-19)related health literacy(CRHL)in impoverished regions due to the limits of poor infrastructure,large proportion of vulnerable groups,etc.However,those limits cannot be solved in the short term.Therefore,this study chose Liangshan Yi Autonomous Prefecture,one of the poorest areas in China,as a pilot,to reveal the quantitative relationships among diferent dimensions under the COVID-19 health education framework,clarify the key points for health promotion,and provide specifc suggestions for COVID-19 health education strategy in impoverished regions.Methods:A cross-sectional questionnaire survey was conducted in fve regions of Liangshan Yi Autonomous Prefecture in 2020.There were 2,100 individuals sampled by multi-stage method.This survey mainly measured the four dimensions:CRHL,COVID-19 related tense psychological reactions(CRTPR),COVID-19 related information report acquisition(CRIRA),and general health literacy(GHL).The multivariate logistic regression was used to explore the infuence of demographic characteristics on each dimension.Furthermore,to quantify the relationships among different dimensions,this study employed the structural equation model(SEM),and analyzed the mediating efects of CRHL and CRIRA as well as the moderating efects of regional characteristic variables.Results:The CRHL played an important role in promoting COVID-19 health education,reaching 52.5%in Liangshan Yi Autonomous Prefecture.The GHL(β=0.336)and age(β=0.136)had statistically positive impacts on CRHL.The CRHL afected CRTPR negatively(β=−0.198)and CRIRA positively(β=0.052).The CRHL played signifcant mediating roles among the four dimensions(P<0.05).Efectiveness of government prevention and control as well as the ethnicity moderated not only the relationships between CRHL and other dimensions,but also the mediating efect of CRHL(P<0.05).People with lower income and education levels had lower GHL(β=0.286,1.292).The youth were more likely to show CRTPR(β=−0.080).Conclusions:By proposing and verifying the theoretical framework,this study put forward specifc suggestions on how to improve COVID-19 health education strategies in impoverished regions via implementation methods,key groups and efect evaluation,which also provided references about future public health emergencies for other impoverished regions of the world.展开更多
Interactions among zoonotic pathogens play a critical role in shaping disease transmission,severity,and public health responses.However,the mechanisms and population-level consequences of these interactions remain und...Interactions among zoonotic pathogens play a critical role in shaping disease transmission,severity,and public health responses.However,the mechanisms and population-level consequences of these interactions remain underexplored in current modelling frameworks.This review aims to synthesize emerging evidence and address key scientific challenges in understanding how pathogen interactions influence transmission dynamics and mathematical modelling,with a focus on zoonotic and other cocirculating pathogens.In this review,we synthesize current evidence on synergistic,antagonistic,and neutral interactions between zoonotic and other cocirculating pathogens.We explore the underlying mechanisms of these interactions,such as transmission enhancement,immune modulation,and resource competition,at both the individual and population levels.We further review mathematical models to illustrate how these interaction features,such as transmission pathways,coinfection histories,cross-immunity,and superspreading potential,could be incorporated into epidemiological frameworks to increase our understanding of the community transmission of infections.Particular attention is given to the challenges of parameter estimation,incomplete surveillance data,and the difficulty of modelling interactions across scales and pathogen types.Understanding and modelling these interactions is essential for predicting outbreak trajectories,designing effective vaccination strategies,and improving early-warning systems.We conclude by calling for enhanced integration of empirical data and mechanistic modelling,especially in the context of emerging zoonoses and postpandemic preparedness.This review provides a structured perspective to support future interdisciplinary efforts aimed at managing cocirculating pathogens and mitigating their public health impact.展开更多
Introduction:Wild rodents serve as important reservoir hosts of Schistosoma japonicum in certain endemic regions.Although a One Health strategy integrating human,animal,and environmental health measures has been propo...Introduction:Wild rodents serve as important reservoir hosts of Schistosoma japonicum in certain endemic regions.Although a One Health strategy integrating human,animal,and environmental health measures has been proposed,evidence demonstrating its effectiveness in reducing wildlife reservoir infection remains limited.Methods:A preplanned intervention study was conducted from 2022 to 2024 across 12 villages in two endemic counties of Anhui Province.Villages were assigned to receive either routine control measures or an enhanced One Health intervention package that included deratization,drone-based surveillance,microenvironment modification,and health education.Annual rodent surveys were conducted using trapnight methods,and multiple diagnostic tests were employed to detect S.japonicum infection.Results:A total of 2,084 rodents were captured and examined.The S.japonicum infection rate in intervention villages decreased from 69.15%(278/402)at baseline to 22.09%(146/661)after two years of intervention(χ^(2)=230.950,P<0.01),whereas the infection rate in control villages increased from 39.07%(143/366)to 45.65%(299/655)(χ^(2)=4.138,P=0.04).Adjusted analysis demonstrated an 88.46%reduction in infection odds within the intervention group[adjusted odds ratio(aOR)=0.115,95%confidence interval(CI):0.078,0.172].Conclusion:A comprehensive One Health intervention package is significantly associated with reduced S.japonicum infection in wild rodents.Integrating rodent-targeted measures into schistosomiasis control programs may substantially decrease transmission risk and accelerate progress toward nationwide schistosomiasis elimination.展开更多
基金Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287.
文摘Sleep disorders,particularly insomnia,have emerged as a critical public health challenge,with the situation worsened by the coronavirus disease-2019 pandemic.Insomnia symptoms,which affected up to 45%of the population during this period,highlight the urgent need to understand the mechanisms linking sleep disturbances to mental health outcomes.Recent findings suggest that cognitive failures,such as memory lapses and attentional deficits,mediate the relationship between insomnia and emotional disorders such as anxiety and depression.The role of personality traits,particularly neuroticism,adds further complexity,as it may either exacerbate or buffer these effects under specific conditions.This review explores the study by Li et al,which offers valuable insights into the cognitive-emotional pathways influenced by sleep disturbances.The study makes significant contributions by identifying key cognitive mechanisms and proposing the dual role of neuroticism in shaping emotional outcomes.To advance these findings,this letter advocates for future longitudinal research and the integration of targeted interventions,such as cognitive-behavioral therapy for insomnia,into public health frameworks.By addressing insomnia-induced cognitive dysfunction,these strategies can enhance emotional regulation and foster resilience,particularly in vulnerable populations facing the mental health impacts of the pandemic.
基金the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.4-Call for tender No. 3138 of 16/12/2021 of Italian Ministry of University and Research funded by the European Union-Next Generation EU. Award Number: Project code CN00000023Concession Decree No. 1033 of 17/06/2022 adopted by the Italian Ministry of University and Research, CUP D93C22000400001, “Sustainable Mobility Center” (CNMS). Spoke 4-Rail Transportation
文摘Predictive maintenance is essential for the implementation of an innovative and efficient structural health monitoring strategy.Models capable of accurately interpreting new data automatically collected by suitably placed sensors to assess the state of the infrastructure represent a fundamental step,particularly for the railway sector,whose safe and continuous operation plays a strategic role in the well-being and development of nations.In this scenario,the benefits of a digital twin of a bonded insu-lated rail joint(IRJ)with the predictive capabilities of advanced classification algorithms based on artificial intelligence have been explored.The digital model provides an accurate mechanical response of the infrastructure as a pair of wheels passes over the joint.As bolt preload conditions vary,four structural health classes were identified for the joint.Two parameters,i.e.gap value and vertical displacement,which are strongly correlated with bolt preload,are used in different combinations to train and test five predictive classifiers.Their classification effectiveness was assessed using several performance indica-tors.Finally,we compared the IRJ condition predictions of two trained classifiers with the available data,confirming their high accuracy.The approach presented provides an interesting solution for future predictive tools in SHM especially in the case of complex systems such as railways where the vehicle-infrastructure interaction is complex and always time varying.
文摘The Systemic Arterial Hypertension (SAH) stands out among the chronic non-transmissible pathologies that impact the cause and/or aggravation of cardiovascular diseases (CVD) on a global level, as the disease is an underestimated disorder due to non-perceptive symptoms and associated with factors and risk markers of another CVD. Therefore, establishing the risk of progression and aggravation of the SAH, according the Framingham Risk Score (FRS), allows to reducing morbidity and improving preventative measures for DCVs. This observational and transversal study approaches the data collection of patient records at the Health Family Strategy of Senhor do Bonfim, BA, which established differences by descriptive and inferential statistical analysis (correlation and regression). The aspects of hypertension associated with risk factors for atherosclerosis were analyzed, determining the risk of developing cardiovascular events in 10 years by FRS. From 432 families, 746 patients were selected, of which 340 are hypertensive individuals (SAH = 45.57%) and 406 (NSAH = 54.42%) non-hypertensives. Among the SAH the majority (31.17%) was in the age range of 63 - 77, but, in both groups, women were in stronger number. There was greater prevalence in SAH for all the characteristics analyzed, smoking (13.20%), sedentary (29.41%) and cardiovascular accident (22.60%). The SAH group is more susceptive to the CVD progress in 10 years by FRS (P < 0.0001 ANOVA). In the NSAH group, there were significant associations among all the variables analyzed as was expected, without differences between the linear correlation and regression, indicating the physio-metabolic equilibrium of the factors and markers evaluated by FRS. Already in SAH group, despite the correlations have been significant too, the regression analysis revealed that only Total Cholesterol (P = 0.0086);LDL (P < 0.0001), Glucose (P < 0.0006) and Age (P < 0.0001) have significative association with FRS. So, these factors and markers deserve more attention upon the health staff of Health Family Strategy, in the SAH course at studied population, attempt the highest cardiovascular risk by FRS (2.5 to 2.8 times) to SAH. The monitoring of high-risk patients should prioritize the lifestyle changes, employing preventive measures to SAH and CVD and atherosclerosis.
文摘The first task in prevention of diseases after an earthquake is to quickly provide an adequate source of safe drinking water.Otherwise,the incidence of infectious intestinal diseases in the disaster area residents will increase rapidly.Additional health measures,such as disinfecting drinking water,protecting the water source,and treating disaster area residents,must be taken at the same time.The sensory test of meat is a useful index of meat decomposition levels.Corpse alkali is a kind of toxic chemical,and personal protective measures must be taken in handling corpses.In general,all of these measures are important not only for achieving the goal of“no severe epidemic after strong earthquake disaster”in the affected areas,but also for enriching knowledge of disaster medicine.1989 Academic Press.Inc.
文摘The manuscript by Agidew et al,evaluates the critical role of family background and socioeconomic status in shaping breast cancer awareness,attitudes,and preventive behaviors,particularly in low-resource settings.Breast cancer continues to be a leading cause of cancer-related deaths globally,with a disproportionate impact on women in low-and middle-income countries.Recent research by Agidew et al underscores a significant association between family history of breast cancer and elevated levels of knowledge,positive attitudes,and proactive behaviors among women in Northeast Ethiopia.Building upon these findings,this editorial explores the psychological mechanisms and behavioral tendencies that drive greater awareness among women with familial exposure to the disease.Additionally,it highlights persistent socioeconomic challenges—such as limited healthcare access,education disparities,and cultural stigmas-that impede widespread preventive action,especially among women without a known family history.The editorial emphasizes the necessity of integrated public health strategies that combine culturally sensitive education,community outreach,and accessible screening services.Drawing from clinical and policy perspectives,it offers guidance on how to strengthen early detection and preventive care in under-resourced environments.Ultimately,the piece advocates for a more inclusive approach to breast cancer education and prevention that addresses both familial influence and systemic socioeconomic barriers.
基金supported by the National Key Research and Development Program of China(Project No.2023YFC2307500).
文摘Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summer in southern areas[1].The World Health Organization(WHO)emphasizes that early warning and epidemic intensity assessments are critical public health strategies for influenza prevention and control.Internet-based flu surveillance,with real-time data and low costs,effectively complements traditional methods.The Baidu Search Index,which reflects flu-related queries,strongly correlates with influenza trends,aiding in regional activity assessment and outbreak tracking[2].
文摘BACKGROUND Child vaccination plays a great role in preventing infectious diseases in children.While Ethiopia has emphasized child vaccination,its effectiveness largely depends on efficient communication between health practitioners and mothers/caregivers.Thus,sufficient communication contributes to promoting child immunization and in turn improving child health.AIM To examine child vaccine communication practices and strategies as well as their relationship with sociodemographic characteristics of respondents in the Amhara region of Ethiopia.METHODS A quantitative cross-sectional survey was conducted using a pretested Likert scale questionnaire and distributed to 123 health workers in primary healthcare centers between April 2024 and June 2024.The data were analyzed using both descriptive and inferential statistics.RESULTS The results indicated that the most common vaccine communication activities included education and communication(mean score=24.1),vaccine data registration(mean score=8.86),and information exchange(mean score=8.3).A significant correlation was found between the implementation of interpersonal health communication principles and immunization communication training(F=341.756,P=0.000,P<0.05).However,no significant correlations were observed between age,education,work experience,and vaccine communication practices.Additionally,the study found that the application of interpersonal communication principles was associated with the perceived relevance of immunization communication(F=27.790,P=0.000,P<0.05).CONCLUSION Based on the findings the study concluded that communication practice in promoting child immunization is insufficient.To enhance vaccine acceptance,continuous immunization communication training for health workers is recommended.
文摘Purpose: Diabetes Mellitus (DM) is a prevalent metabolic disorder associated with significant complications, including visual impairment. This study aimed to assess the prevalence and severity of visual impairment and its associated factors in diabetic patients in Libya. Methods: This cross-sectional study included 2365 DM patients (4730 eyes). Most participants were aged 30 - 49 (38.3%) and 50 - 69 (50.8%) with a nearly equal gender distribution (47.8% males, 52.2% females). Type 2 diabetes was predominant (92.6%), and 62.9% had HbA1c levels of 7.5% or higher. Results: Diabetic retinopathy (DR) was present in 2068 eyes (43.8%), with mild non-proliferative diabetic retinopathy (NPDR) affecting 1178 eyes (25%), moderate NPDR 476 eyes (10.1%), severe NPDR 228 eyes (4.8%), and proliferative diabetic retinopathy (PDR) 186 eyes (3.9%). Diabetic maculopathy was observed in 621 eyes (13.1%), with CSME in 287 eyes (6.07%) and non-CSME in 334 eyes (7.06%). Non-retinal conditions included cataracts in 1938 eyes (41%) and glaucoma in 252 eyes (5.3%). Visual impairment was observed in 1159 patients (49%), with 534 (23%) experiencing mild impairment, 382 (18%) moderate impairment, and 243 (12%) severe impairment;142 patients (6%) were classified as legally blind. DR showed a strong association with visual impairment severity (p Conclusions: These findings underscore the urgency for targeted public health interventions to mitigate visual impairment in Libyan individuals with DM.
文摘Respiratory viral co-infections present significant challenges in clinical settings due to their impact on disease severity and patient outcomes.Current diagnostic methods often miss these co-infections,complicating the epidemiology and management of these cases.Research,primarily conducted in vitro and in vivo,suggests that co-infections can lead to more severe illnesses,increased hospitalization rates,and greater healthcare utilization,especially in high-risk groups such as children,the elderly,and immunocompromised individuals.Common coinfection patterns,risk factors,and their impact on disease dynamics highlight the need for advanced diagnostic techniques and tailored therapeutic strategies.Understanding the virological interactions and immune response modulation during co-infections is crucial for developing effective public health interventions and improving patient outcomes.Future research should focus on the molecular mechanisms of co-infection and the development of specific therapies to mitigate the adverse effects of these complex infections.
文摘Globally, over 300 million people are living with viral he-patitis with approximately 1.3 million deaths per year. In 2016, World Health Assembly adopted the Global Health Sector Strategy on viral hepatitis to eliminate hepatitis by 2030. Different World Health Organization member countries are working on hepatitis control strategies to achieve hepatitis elimination. So far, only 12 countries are on track to achieve hepatitis elimination targets. The aim of the study was to give an update about the progress and challenges to achieving hepatitis elimination by 2030. According to the latest data, 87% of infants had received the three doses of hepatitis B virus （HBV） vaccination in the frst year of their life and 46% of infants had received a timely birth dose of HBV vaccination.There is a strong need to improve blood and injection safety. Rates of hepatitis B and C diagnosis are very low and only 11% of hepatitis B and C cases are diagnosed. There is a dire need to speed up hepatitis diagnosis and find the missing millions of people living with viral hepatitis. Up to 2016, only 3 million hepatitis C cases have been treated. Pricing of hepatitis C virus drugs is also reduced in many countries. The major hurdle to ach-ieve hepatitis elimination is lack of finances to support hepatitis programs. None of the major global donors are committed to invest in the fght against hepatitis. It will be very diffcult for the low and middle-income countries to fund their hepatitis control program. Hepatitis elimination needs strong fnancial and political commitment, support from civil societies, and support from pharmaceutical and medical companies around the globe.
基金The National Natural Science Foundation of China(No.71531004,72071042).
文摘To improve the inefficient prevention caused by customers unwillingness to adopt prevention strategies in health management,an incentive feedback mechanism that is based on game theory and contract design theory is introduced.The conditions for making customers and health maintenance organizations(HMOs)willing to participate in the proposed mechanism are given.A dual nonlinear programming model is used to identify the optimal prevention effort of customers and the pricing strategy of HMOs.Results show that to generate increased benefits,HMOs need to consider cost sharing when customers are not familiar with the proposed health services.When health services are gradually accepted,the cost sharing factor can be gradually reduced.Simulation shows that under random circumstances in which the market reaches a certain size,the proposed method exhibits a positive network externality.Motivated by network externality,HMOs only need to make their customers understand that the larger the number of participants,the greater the utility of each person.Such customers may then spontaneously invite others to purchase insurance.
文摘Background:It is of great challenge to raise the public coronavirus disease 2019(COVID-19)related health literacy(CRHL)in impoverished regions due to the limits of poor infrastructure,large proportion of vulnerable groups,etc.However,those limits cannot be solved in the short term.Therefore,this study chose Liangshan Yi Autonomous Prefecture,one of the poorest areas in China,as a pilot,to reveal the quantitative relationships among diferent dimensions under the COVID-19 health education framework,clarify the key points for health promotion,and provide specifc suggestions for COVID-19 health education strategy in impoverished regions.Methods:A cross-sectional questionnaire survey was conducted in fve regions of Liangshan Yi Autonomous Prefecture in 2020.There were 2,100 individuals sampled by multi-stage method.This survey mainly measured the four dimensions:CRHL,COVID-19 related tense psychological reactions(CRTPR),COVID-19 related information report acquisition(CRIRA),and general health literacy(GHL).The multivariate logistic regression was used to explore the infuence of demographic characteristics on each dimension.Furthermore,to quantify the relationships among different dimensions,this study employed the structural equation model(SEM),and analyzed the mediating efects of CRHL and CRIRA as well as the moderating efects of regional characteristic variables.Results:The CRHL played an important role in promoting COVID-19 health education,reaching 52.5%in Liangshan Yi Autonomous Prefecture.The GHL(β=0.336)and age(β=0.136)had statistically positive impacts on CRHL.The CRHL afected CRTPR negatively(β=−0.198)and CRIRA positively(β=0.052).The CRHL played signifcant mediating roles among the four dimensions(P<0.05).Efectiveness of government prevention and control as well as the ethnicity moderated not only the relationships between CRHL and other dimensions,but also the mediating efect of CRHL(P<0.05).People with lower income and education levels had lower GHL(β=0.286,1.292).The youth were more likely to show CRTPR(β=−0.080).Conclusions:By proposing and verifying the theoretical framework,this study put forward specifc suggestions on how to improve COVID-19 health education strategies in impoverished regions via implementation methods,key groups and efect evaluation,which also provided references about future public health emergencies for other impoverished regions of the world.
基金National Natural Science Foundation of China(82304207)Science and Technology Projects of Xizang Autonomous Region,China(XZ202501JD0012)+4 种基金Beijing Natural Science Foundation(L232014)Research on Key Technologies of Plague Prevention and Control in Inner Mongolia Autonomous Region(2021ZD0006)Fundamental Research Funds for the Central Universities(2233300001)National Key Research and Development Program of China(2023YFC2307500)supported by the Beijing Research Center for Respiratory Infectious Diseases Project(BJRID2025-001).
文摘Interactions among zoonotic pathogens play a critical role in shaping disease transmission,severity,and public health responses.However,the mechanisms and population-level consequences of these interactions remain underexplored in current modelling frameworks.This review aims to synthesize emerging evidence and address key scientific challenges in understanding how pathogen interactions influence transmission dynamics and mathematical modelling,with a focus on zoonotic and other cocirculating pathogens.In this review,we synthesize current evidence on synergistic,antagonistic,and neutral interactions between zoonotic and other cocirculating pathogens.We explore the underlying mechanisms of these interactions,such as transmission enhancement,immune modulation,and resource competition,at both the individual and population levels.We further review mathematical models to illustrate how these interaction features,such as transmission pathways,coinfection histories,cross-immunity,and superspreading potential,could be incorporated into epidemiological frameworks to increase our understanding of the community transmission of infections.Particular attention is given to the challenges of parameter estimation,incomplete surveillance data,and the difficulty of modelling interactions across scales and pathogen types.Understanding and modelling these interactions is essential for predicting outbreak trajectories,designing effective vaccination strategies,and improving early-warning systems.We conclude by calling for enhanced integration of empirical data and mechanistic modelling,especially in the context of emerging zoonoses and postpandemic preparedness.This review provides a structured perspective to support future interdisciplinary efforts aimed at managing cocirculating pathogens and mitigating their public health impact.
基金supported by the National Key Research and Development Program of China(grant numbers 2021YFC2300800,2021YFC2300804)the National Science Foundation of China(Grant No.82073619).
文摘Introduction:Wild rodents serve as important reservoir hosts of Schistosoma japonicum in certain endemic regions.Although a One Health strategy integrating human,animal,and environmental health measures has been proposed,evidence demonstrating its effectiveness in reducing wildlife reservoir infection remains limited.Methods:A preplanned intervention study was conducted from 2022 to 2024 across 12 villages in two endemic counties of Anhui Province.Villages were assigned to receive either routine control measures or an enhanced One Health intervention package that included deratization,drone-based surveillance,microenvironment modification,and health education.Annual rodent surveys were conducted using trapnight methods,and multiple diagnostic tests were employed to detect S.japonicum infection.Results:A total of 2,084 rodents were captured and examined.The S.japonicum infection rate in intervention villages decreased from 69.15%(278/402)at baseline to 22.09%(146/661)after two years of intervention(χ^(2)=230.950,P<0.01),whereas the infection rate in control villages increased from 39.07%(143/366)to 45.65%(299/655)(χ^(2)=4.138,P=0.04).Adjusted analysis demonstrated an 88.46%reduction in infection odds within the intervention group[adjusted odds ratio(aOR)=0.115,95%confidence interval(CI):0.078,0.172].Conclusion:A comprehensive One Health intervention package is significantly associated with reduced S.japonicum infection in wild rodents.Integrating rodent-targeted measures into schistosomiasis control programs may substantially decrease transmission risk and accelerate progress toward nationwide schistosomiasis elimination.
