Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate un...Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.展开更多
Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a phy...Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.展开更多
The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health r...The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health risks.In this study,we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories,low(minimal),moderate and high.Second,we compared the differences in attitudes towards FJBs in dietary guidelines.Third,we integrated the results of existing epidemiological surveys,randomized controlled trials,and animal experiments to explore the health risks associated with consuming FJBs.Deepening the processing of FJBs has been found to lead to an increased risk of diseases.Dietary pattern,nutrients,addition agents and consumer preferences may be influential factors.Finally,we investigated whether there were any changes in the health benefits of 100%fruit juices produced by different processing methods.In conclusion,minimally/moderately processed 100%fruit juices provide more health benefits than highly processed fruit beverages.The results support the need to consider the extent of FJBs processing in future studies to adjust official nutritional recommendations for beverage consumption.展开更多
A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR...A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR),-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control,but noγ-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs展开更多
In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentar...In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentary phosphate deposits samples from El-Hamraween, El-Quser and Safaga phosphate mines in Egypt. HPGe γ-spectrometry was used. This study was undertaken to estimate the radiation hazard indices in phosphate mining at the studied mines on their occupational workers, to establish correlation relationships between the some measured heavy metals such as As, Cd and Pb in blood workers and their concentration in phosphate rock ores and to determinate the biomarkers in the blood workers such as malondialdehyde (MDA) and superoxide dismutase (SOD). The phosphate mine sample of El-Hamrawein has the lowest activity concentration of <sup>226</sup>Ra, <sup>232</sup>Th and <sup>40</sup>K in comparison to the phosphate mine samples of El-Quseir and Safaga (El-Hamrawein kg<sup>-</sup>1</sup><sup></sup>, 122.4 to 188.3 Bq·kg<sup>-</sup>1</sup></sup> and 115.4 to 165.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>232</sup>Th activity concentrations varied from 135.6 to 212.3 Bq·kg<sup>-</sup>1</sup></sup>, 112.8 to 167.4 Bq·kg<sup>-</sup>1</sup></sup> and 132.8 to 188.6 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>40</sup>K activity concentrations varied from 225.2 to 312.8 Bq·kg<sup>-</sup>1</sup>, 168.7 to 268.9 Bq·kg<sup>-</sup>1</sup></sup> and 95.2 to 155.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. The workers of old ages have higher concentration of the investigated heavy metals than those of young ages. There is a good relation between the concentration of the investigated metals in phosphate mine samples and their concentration in blood of the occupational workers in these mines.展开更多
Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and s...Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and socio-economic processes. Addressing the question of the use of xanthates without considering their toxicity, and their decomposition process and products would be ecologically and healthily less sustainable. To date, related information is still dispersed and less known to the public. Therefore, this work provides a comprehensive overview of the existing information on the essentiality, fate, ecotoxicity, and health effects of xanthates and associated compounds. According to available information from scientific, technical, and professional circles, xanthates are diverse, usually with a carbon chain of two to six carbon atoms. They play a crucial role in the sectors of the mining and mineral processing industry, agriculture, wastewater treatment, metal protection, rubber vulcanization, the pharmaceutical industry, and medicine. Xanthates’ degradation under different factors and mechanisms, which determine their fate in the environment, leads to the formation of toxic substances, mainly carbon disulfide, carbonyl sulfide, hydrogen sulfide, and hydrogen peroxide. Xanthates and xanthates degradation products are seriously hazardous to humans, animals, soil and aquatic organisms, enzymatic system, etc. Simultaneous exposure to xanthates and metals results in the magnification or reduction of their toxicity level, depending on the exposed organisms. Such toxicological dimensions should attract more scientific and public attention for more safe production, use, storage, and disposal of xanthates. Due to the high affinity of xanthates for metal, xanthates-modified compounds are efficient metal chelating agents. Such a property should be explored to develop potentially low-cost and effective alternatives for metal removal and recovery from contaminated media. The same applies to developing appropriate methods for the evaluation and management of the simultaneous presence of xanthates and metals in the environment.展开更多
The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life th...The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life through contaminated seafood. To better understand the effect of HAB and marine algal toxins on marine environment and human health in China, this paper overviews HAB occurrence and marine algal toxin incidents, as well as their environmental and health effects in this country. HAB has been increasing rapidly along the Chinese coast since the 1970s, and at least 512 documented HAB events have occurred from 1952 to 2002 in the Chinese mainland. It has been found that PSP and DSP toxins are distributed widely along both the northern and southern Chinese coasts. The HAB and marine algal toxin events during the 1990s in China were summarized, showing that the HAB and algal toxins resulted in great damages to local fisheries, marine culture, quality of marine environment, and human health. Therefore, to protect the coastal environment and human health, attention to HAB and marine algal toxins is urgently needed from the environmental and epidemiologicalview.展开更多
The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses...The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies.展开更多
Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationsh...Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationship between animal exposure to MPs and their health effects,revealing that MP contamination affects a broad spectrum of animal species across terrestrial and aquatic habitats.Crucially,interspecies differences in ingestion,accumulation,and responses to MPs emerge as central themes arising from various factors,including feeding behavior,physiology,and ecological niches.The health implications of MP exposure are multifarious;animals may suffer physical harm,endure chemical exposure to adsorbed contaminants,provoke inflammatory responses,and undergo behavioral modifi-cations.Chronic exposure to MPs raises concerns about their long-term health consequences,and the ability of MPs to adsorb and transport chemicals has implications for the bioaccumulation of pollutants within food webs.The ecological ramifications of MP contamination are profound,impacting animal behavior,population dynamics,and ecosystem processes.The intricate interplay between animals and MPs underscores the need for interdisciplinary research that unites fields such as biology,ecology,chemistry,and toxicology.Recognizing the relationship between animal exposure to MPs and their health effects has significant implications,particularly as the potential for MPs to enter the human food chain through animals underscores the need for research on human health risks.展开更多
Shijiazhuang is one of the cities in the North China Plain.In recent decades,this city has experienced high levels of fine particulate matter(PM_(2.5)),which have potentially significant effects on human health.In thi...Shijiazhuang is one of the cities in the North China Plain.In recent decades,this city has experienced high levels of fine particulate matter(PM_(2.5)),which have potentially significant effects on human health.In this study,the health effects of PM_(2.5)exposure in Shijiazhuang were estimated by applying an integrated exposure-response model.Premature mortality,years of life lost(YLL),and the mortality benefits linked to reduced levels of PM_(2.5)were quantified for the period 2015–2017.In 2015,2016,and 2017,cerebrovascular diseases caused the highest premature mortality(2432,2449,and 2483,respectively),followed by ischemic heart diseases(1391,1479,and 1493,respectively),lung cancer(639,660,and 639,respectively),and chronic obstructive pulmonary diseases(533,519,and 473,respectively).Notably,the total number of premature deaths caused by PM_(2.5)exposure in Shijiazhuang in 2015,2016,and 2017 were 4994,5107,and 5088,respectively.Moreover,the YLL in the same years were 47001,47880 and 47381,respectively.Interestingly,the YLL per 1000 females was lower than that per 1000 males.Finally,we noted that premature mortality and YLL decreased by 84.2%and 84.6%when the PM_(2.5)levels diminished to 10µg/m^(3).Overall,the results of this study improve our understanding of how high PM_(2.5)concentrations affect human health and suggest the application of more stringent measures in Shijiazhuang to alleviate the associated health risks.展开更多
Cultivated hawthorn(Crataegus pinnatifida var.major),the principal cultivated hawthorn species in China,is rich in phenolic compounds.These phytochemicals are considered essential bioactive ingredients in different or...Cultivated hawthorn(Crataegus pinnatifida var.major),the principal cultivated hawthorn species in China,is rich in phenolic compounds.These phytochemicals are considered essential bioactive ingredients in different organs of cultivated hawthorn,contributing to its health effects.However,there is lack of a comprehensive review that systematically summarizes the chemistry,health effects,and stability of phenolic substances.This review summarizes recent progress in the characterization,classification,and distribution of phenolic compounds in C.pinnatifida var.major,including procyanidins,flavonoids,phenolic acids,lignans,and others.Importantly,the stability of these compounds was found to be influenced by factors such as the hawthorn development process,postharvest storage,postharvest processing,and the gastrointestinal tract environment.Additionally,the health effects of phenolic compounds in cultivated hawthorn and their underlying mechanisms were discussed.This review provides valuable insights into the utilization of hawthorn resources and the development of the hawthorn industry.展开更多
The First UMN-CAS Bilateral Seminar was successfully con- cluded with all the goals met. The meeting in Xi＇an was informative, stimulating and enjoyable, thanks to the local host, Prof. Junji Cao, and his capable sta...The First UMN-CAS Bilateral Seminar was successfully con- cluded with all the goals met. The meeting in Xi＇an was informative, stimulating and enjoyable, thanks to the local host, Prof. Junji Cao, and his capable staff. The Bilateral Seminar was organized by Prof. David Y.H. Pui of the University of Minnesota and Prof. Junji Cao of the Institute of Earth Environment, Chinese Academy of Sci- ences. It was attended by approximately 100 delegates from the University of Minnesota （UMN）, the Center for Filtration Research （CFR）, the Chinese Academy of Sciences （CAS） and other famous Chinese universities. We are grateful for the opening remarks given by UMN President Eric hai Li on behalf of President Kaler and CAS Vice President Jing- Chunli Bai.展开更多
The world’s climate,particularly in Africa,has changed substantially during the past few decades,contributed by several human activities.Africa is one of the continents that is most vulnerable to climate change globa...The world’s climate,particularly in Africa,has changed substantially during the past few decades,contributed by several human activities.Africa is one of the continents that is most vulnerable to climate change globally.Since the beginning of 2022,extreme weather events in Africa have affected about 19 million people and killed at least 4,000 individuals.Cyclones,floods,heatwaves,wildfires,droughts,and famine were among the severe weather occurrences.Natural disasters and extreme weather events brought on by climate change may compromise access to clean water,sanitation systems,and healthcare facilities,making people more vulnerable to a number of illnesses.Floods and drought can lead to both communicable and non-communicable diseases.The African population is more likely to experience more mental health disorders than before because of natural disasters,which result in the loss of property and sometimes loss of lives more frequently.We,therefore,call for an improved implementation of strategies to prevent the health effects of climate change so that the health of the people in Africa can be maintained.展开更多
The seeds and sprouts of mung bean are very common cruise in Asia.Evidence showed that bioactive compounds in mung bean have emerged as an increasing scientific interest due to their role in the prevention of degenera...The seeds and sprouts of mung bean are very common cruise in Asia.Evidence showed that bioactive compounds in mung bean have emerged as an increasing scientific interest due to their role in the prevention of degenerative diseases.All data of in vitro,in vivo and clinical studies of mung bean and its impact on human health were collected from a library database and electronic search.Botanical,phytochemical and pharmacological information was gathered and orchestrated.Remarkable studies have been demonstrated,showing the enhancement of metabolites in mung bean during the sprouting process,which possesses various health benefiting bioactive compounds.These compounds have been frequently attributed to their antioxidant,anti-diabetic,antimicrobial,anti-hyperlipidemic and antihypertensive effect,anti-inflammatory,and anticancer,anti-tumor and anti-mutagenic properties.In this critical review,we aimed to study the insight of the nutritional compositions,phytochemistry,and healthpromoting effects of mung bean and its sprouts.The various curative potential of mung bean provides successive preclinical outcomes in the field of drug discovery and this review strongly recommends that mung bean is an excellent nutritive legume,which modulates or prevents chronic degenerative diseases.展开更多
Due to climate change,the heatwave has become a more serious public health threat with aging as an aggravating factor in recent years.There is a pressing need to detect the most effective prevention and response measu...Due to climate change,the heatwave has become a more serious public health threat with aging as an aggravating factor in recent years.There is a pressing need to detect the most effective prevention and response measures.However,the specific health effects of interventions have not been characterized on an individual scale.In this study,an intervention experiment was designed to explore the health effects of heat exposure at the individual level and assess the effects of different interventions based on a comprehensive health sensitivity index(CHSI)in Xinyi,China.Forty-one subjects were recruited randomly,and divided into one control group and three intervention groups.Interventions included education(Educate by lecturing,offering relative materials,and communication),subsidy support(offer subsidy to offset the cost of running air conditioning),and cooling-spray(install a piece of cooling-spray equipment in the yard).Results showed that systolic blood pressure(SBP)and deep sleep duration(DSD)were significantly affected by short-term heat exposure,and the effects could be alleviated by three types of interventions.The estimated CHSI indicated that the effective days of the education group were longer than other groups,while the lower CHSI of the subsidy group showed lower sensitivity than the control group.These findings provide feasible implementation strategies to optimize Heat-health action plans and evaluate the intervention performance.展开更多
Purpose： This study investigates how online user intention in searching health information is affected by problematic situations.Design/methodology/approach： Based on the Theory of Reasoned Action, the Technology Ac...Purpose： This study investigates how online user intention in searching health information is affected by problematic situations.Design/methodology/approach： Based on the Theory of Reasoned Action, the Technology Acceptance Model, and Sense-making theory, we propose two dimensions of problematic situations： urgency and severity of health issues being searched online. Data were collected through a questionnaire survey among 214 Wuhan University students and analyzed using hierarchical regression analysis.Findings： Perceived usefulness, perceived ease of use, and subjective norm can influence user intention to seek health information online. The urgency of problematic situations has a negative moderating effect on the relationship between perceived ease of use and user intention and the relationship between subjective norm and user intention. The severity of problematic situations has a negative moderating effect on the relationship between subjective norm and user intention.Research limitations： The respondents of the survey are limited to students in one Chinese university, so whether this study＇s results can be applied to another population or not remains to be verified. In addition, only two dimensions of problematic situations are considered in this study. Practical implications： The paper puts forward the moderating effect of problematic situations and verifies it, which is the compensation for online health information-seeking behavior research. Besides, our analyses have implications for professional design of health care systems and related consumer information searches, and improve their performance. Originality/value： Previous work has reported the effects of problematic situation on user intention to seek health information online, ignoring its influence on other factors. This empirical study extends that work to identify the influence of problematic situation when seeking intention-behavior data in two dimensions, urgency and severity.展开更多
Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic value.However,abundant antinutritional factors(ANFs)reduces its health benefits.As reported,germination can improve the nu...Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic value.However,abundant antinutritional factors(ANFs)reduces its health benefits.As reported,germination can improve the nutritional profile of grains.In this study,we systematically evaluate the safety of Tartary buckwheat seeds(TB)and Tartary buckwheat sprouts(TBS)used as high active ingredients.After evaluating nutrition levels,bioactive compounds and ANFs in TBS during germinating,5^(th)-day TBS were selected as the raw material.C57BL/6J mice were gavaged daily with distilled water,TB,or TBS for 6 weeks.The physiological indices related to ANFs were determined.Results showed that the TB intake tends to generate negative effects on the gut microbiota,and organs.Additionally,upon TB intake,the Fe^(3+)content in serum,trypsin activity in pancreas and jejunum decreased,while the cytokine,IgE,and histamine levels in serum,water content in faeces,cytokine levels in liver and jejunum increased.Conversely,TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering effect.Altogether,TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia.展开更多
Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients...Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.展开更多
Lonicera japonica(honeysuckle)is a traditional Chinese medicinal food,in which the main active ingredients are phenolic acids,polysaccharides,flavonoids,and volatile oils.They have various biological activities,includ...Lonicera japonica(honeysuckle)is a traditional Chinese medicinal food,in which the main active ingredients are phenolic acids,polysaccharides,flavonoids,and volatile oils.They have various biological activities,including antiviral,antibacterial,antioxidant,hypoglycemic and lipid-lowering,and anti-inflammatory effects.This review summarizes the health effects and pharmacodynamic mechanisms of L.japonica extracts and the major active ingredients in these extracts,and the structures,metabolic process in vivo,and biotransformation processes of these compounds.In addition,the current status of the development of L.japonica-related functional foods is summarized.The aim is to provide a theoretical basis and reference for the further development and use of the active ingredients in L.japonica as functional foods for disease prevention and treatment.展开更多
Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have b...Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have been observed at much lower pollution levels than previously studied.China has experienced periods of severe air pollution over the past few decades.To improve air quality and safeguard public health,the government has implemented several progressively tightened policies.Emission control policies were first proposed in 2005.展开更多
基金supported by the Key Research and Development Plan of Zhejiang Province(No.2021C03176)Zhejiang Provincial Natural Science Foundation of China(No.LY23B070001)+2 种基金the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20230009)the National Natural Science Foundation of China(No.22106032)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000).
文摘Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.
基金supported by the National Natural Science Foundation of China(Nos.42020104001,42327806 and 42177354).
文摘Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.
基金funded by the National Natural Science Foundation Program of China(31901707)the 2115 Talent Development Program of China Agricultural University。
文摘The degree of processing is rarely considered an independent factor in the health effects of fruit juices and beverages(FJBs)consumption.In fact,the consumption of ultra-processed foods has been shown to pose health risks.In this study,we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories,low(minimal),moderate and high.Second,we compared the differences in attitudes towards FJBs in dietary guidelines.Third,we integrated the results of existing epidemiological surveys,randomized controlled trials,and animal experiments to explore the health risks associated with consuming FJBs.Deepening the processing of FJBs has been found to lead to an increased risk of diseases.Dietary pattern,nutrients,addition agents and consumer preferences may be influential factors.Finally,we investigated whether there were any changes in the health benefits of 100%fruit juices produced by different processing methods.In conclusion,minimally/moderately processed 100%fruit juices provide more health benefits than highly processed fruit beverages.The results support the need to consider the extent of FJBs processing in future studies to adjust official nutritional recommendations for beverage consumption.
文摘A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR),-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control,but noγ-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs
文摘In this work, the specific activities of natural radionuclides, namely <sup>238</sup>U series, <sup>232</sup>Th series and <sup>40</sup>K, have been measured in collected sedimentary phosphate deposits samples from El-Hamraween, El-Quser and Safaga phosphate mines in Egypt. HPGe γ-spectrometry was used. This study was undertaken to estimate the radiation hazard indices in phosphate mining at the studied mines on their occupational workers, to establish correlation relationships between the some measured heavy metals such as As, Cd and Pb in blood workers and their concentration in phosphate rock ores and to determinate the biomarkers in the blood workers such as malondialdehyde (MDA) and superoxide dismutase (SOD). The phosphate mine sample of El-Hamrawein has the lowest activity concentration of <sup>226</sup>Ra, <sup>232</sup>Th and <sup>40</sup>K in comparison to the phosphate mine samples of El-Quseir and Safaga (El-Hamrawein kg<sup>-</sup>1</sup><sup></sup>, 122.4 to 188.3 Bq·kg<sup>-</sup>1</sup></sup> and 115.4 to 165.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>232</sup>Th activity concentrations varied from 135.6 to 212.3 Bq·kg<sup>-</sup>1</sup></sup>, 112.8 to 167.4 Bq·kg<sup>-</sup>1</sup></sup> and 132.8 to 188.6 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. For <sup>40</sup>K activity concentrations varied from 225.2 to 312.8 Bq·kg<sup>-</sup>1</sup>, 168.7 to 268.9 Bq·kg<sup>-</sup>1</sup></sup> and 95.2 to 155.8 Bq·kg<sup>-</sup>1</sup></sup> for Safaga, El-Quseir and El-Hamrawein, respectively. The workers of old ages have higher concentration of the investigated heavy metals than those of young ages. There is a good relation between the concentration of the investigated metals in phosphate mine samples and their concentration in blood of the occupational workers in these mines.
文摘Xanthates are organic synthesized substances with a potentially wide range of applications. They may serve as essential components of many compounds or materials that also play a vital role in various industrial and socio-economic processes. Addressing the question of the use of xanthates without considering their toxicity, and their decomposition process and products would be ecologically and healthily less sustainable. To date, related information is still dispersed and less known to the public. Therefore, this work provides a comprehensive overview of the existing information on the essentiality, fate, ecotoxicity, and health effects of xanthates and associated compounds. According to available information from scientific, technical, and professional circles, xanthates are diverse, usually with a carbon chain of two to six carbon atoms. They play a crucial role in the sectors of the mining and mineral processing industry, agriculture, wastewater treatment, metal protection, rubber vulcanization, the pharmaceutical industry, and medicine. Xanthates’ degradation under different factors and mechanisms, which determine their fate in the environment, leads to the formation of toxic substances, mainly carbon disulfide, carbonyl sulfide, hydrogen sulfide, and hydrogen peroxide. Xanthates and xanthates degradation products are seriously hazardous to humans, animals, soil and aquatic organisms, enzymatic system, etc. Simultaneous exposure to xanthates and metals results in the magnification or reduction of their toxicity level, depending on the exposed organisms. Such toxicological dimensions should attract more scientific and public attention for more safe production, use, storage, and disposal of xanthates. Due to the high affinity of xanthates for metal, xanthates-modified compounds are efficient metal chelating agents. Such a property should be explored to develop potentially low-cost and effective alternatives for metal removal and recovery from contaminated media. The same applies to developing appropriate methods for the evaluation and management of the simultaneous presence of xanthates and metals in the environment.
基金This study was supported by National Basic Research Project No. 2001CB4097 NSFC Projects No.20177023+2 种基金 40076030 CAS Innovation Project No. KZCX2-206 Project of Shandong Province Science Committee No.012110115.
文摘The frequency and scale of Harmful Algal Bloom (HAB) and marine algal toxin incidents have been increasing and spreading in the past two decades, causing damages to the marine environment and threatening human life through contaminated seafood. To better understand the effect of HAB and marine algal toxins on marine environment and human health in China, this paper overviews HAB occurrence and marine algal toxin incidents, as well as their environmental and health effects in this country. HAB has been increasing rapidly along the Chinese coast since the 1970s, and at least 512 documented HAB events have occurred from 1952 to 2002 in the Chinese mainland. It has been found that PSP and DSP toxins are distributed widely along both the northern and southern Chinese coasts. The HAB and marine algal toxin events during the 1990s in China were summarized, showing that the HAB and algal toxins resulted in great damages to local fisheries, marine culture, quality of marine environment, and human health. Therefore, to protect the coastal environment and human health, attention to HAB and marine algal toxins is urgently needed from the environmental and epidemiologicalview.
文摘The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2019R1A6A1A03033167).
文摘Microplastic(MP)contamination has become a pervasive global issue,affecting terrestrial and aquatic environments,and its potential health hazards are of widespread concern.This review examined the intricate relationship between animal exposure to MPs and their health effects,revealing that MP contamination affects a broad spectrum of animal species across terrestrial and aquatic habitats.Crucially,interspecies differences in ingestion,accumulation,and responses to MPs emerge as central themes arising from various factors,including feeding behavior,physiology,and ecological niches.The health implications of MP exposure are multifarious;animals may suffer physical harm,endure chemical exposure to adsorbed contaminants,provoke inflammatory responses,and undergo behavioral modifi-cations.Chronic exposure to MPs raises concerns about their long-term health consequences,and the ability of MPs to adsorb and transport chemicals has implications for the bioaccumulation of pollutants within food webs.The ecological ramifications of MP contamination are profound,impacting animal behavior,population dynamics,and ecosystem processes.The intricate interplay between animals and MPs underscores the need for interdisciplinary research that unites fields such as biology,ecology,chemistry,and toxicology.Recognizing the relationship between animal exposure to MPs and their health effects has significant implications,particularly as the potential for MPs to enter the human food chain through animals underscores the need for research on human health risks.
基金Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(KHK1906)Science and Technology Project of Hebei Education Department(ZD2020135)+3 种基金Overseas Talents Introduction Funded Project of Hebei Province(C20200308)National Innovation and Entrepreneurship Training Program for College Students(202010077001)Scientific Pre-Research Fund of Hebei GEO University in 2015(YK201501)the Young Talent Plan of Hebei Province 2016.
文摘Shijiazhuang is one of the cities in the North China Plain.In recent decades,this city has experienced high levels of fine particulate matter(PM_(2.5)),which have potentially significant effects on human health.In this study,the health effects of PM_(2.5)exposure in Shijiazhuang were estimated by applying an integrated exposure-response model.Premature mortality,years of life lost(YLL),and the mortality benefits linked to reduced levels of PM_(2.5)were quantified for the period 2015–2017.In 2015,2016,and 2017,cerebrovascular diseases caused the highest premature mortality(2432,2449,and 2483,respectively),followed by ischemic heart diseases(1391,1479,and 1493,respectively),lung cancer(639,660,and 639,respectively),and chronic obstructive pulmonary diseases(533,519,and 473,respectively).Notably,the total number of premature deaths caused by PM_(2.5)exposure in Shijiazhuang in 2015,2016,and 2017 were 4994,5107,and 5088,respectively.Moreover,the YLL in the same years were 47001,47880 and 47381,respectively.Interestingly,the YLL per 1000 females was lower than that per 1000 males.Finally,we noted that premature mortality and YLL decreased by 84.2%and 84.6%when the PM_(2.5)levels diminished to 10µg/m^(3).Overall,the results of this study improve our understanding of how high PM_(2.5)concentrations affect human health and suggest the application of more stringent measures in Shijiazhuang to alleviate the associated health risks.
基金supported by the Natural Science Foundation of Shandong Province(No.ZR2023QC228)the Key Research and Development Program of Zhejiang Province(No.2021C02001)+1 种基金the Shandong(Linyi)Institute of Modern Agriculture of Zhejiang University to Serve the Local Economic Development(Integration of Two Institutes)(No.ZDNY-2021-FWLY01004)the Fundamental Research Funds for the Central Universities(No.226-2022-00215),China.
文摘Cultivated hawthorn(Crataegus pinnatifida var.major),the principal cultivated hawthorn species in China,is rich in phenolic compounds.These phytochemicals are considered essential bioactive ingredients in different organs of cultivated hawthorn,contributing to its health effects.However,there is lack of a comprehensive review that systematically summarizes the chemistry,health effects,and stability of phenolic substances.This review summarizes recent progress in the characterization,classification,and distribution of phenolic compounds in C.pinnatifida var.major,including procyanidins,flavonoids,phenolic acids,lignans,and others.Importantly,the stability of these compounds was found to be influenced by factors such as the hawthorn development process,postharvest storage,postharvest processing,and the gastrointestinal tract environment.Additionally,the health effects of phenolic compounds in cultivated hawthorn and their underlying mechanisms were discussed.This review provides valuable insights into the utilization of hawthorn resources and the development of the hawthorn industry.
文摘The First UMN-CAS Bilateral Seminar was successfully con- cluded with all the goals met. The meeting in Xi＇an was informative, stimulating and enjoyable, thanks to the local host, Prof. Junji Cao, and his capable staff. The Bilateral Seminar was organized by Prof. David Y.H. Pui of the University of Minnesota and Prof. Junji Cao of the Institute of Earth Environment, Chinese Academy of Sci- ences. It was attended by approximately 100 delegates from the University of Minnesota （UMN）, the Center for Filtration Research （CFR）, the Chinese Academy of Sciences （CAS） and other famous Chinese universities. We are grateful for the opening remarks given by UMN President Eric hai Li on behalf of President Kaler and CAS Vice President Jing- Chunli Bai.
文摘The world’s climate,particularly in Africa,has changed substantially during the past few decades,contributed by several human activities.Africa is one of the continents that is most vulnerable to climate change globally.Since the beginning of 2022,extreme weather events in Africa have affected about 19 million people and killed at least 4,000 individuals.Cyclones,floods,heatwaves,wildfires,droughts,and famine were among the severe weather occurrences.Natural disasters and extreme weather events brought on by climate change may compromise access to clean water,sanitation systems,and healthcare facilities,making people more vulnerable to a number of illnesses.Floods and drought can lead to both communicable and non-communicable diseases.The African population is more likely to experience more mental health disorders than before because of natural disasters,which result in the loss of property and sometimes loss of lives more frequently.We,therefore,call for an improved implementation of strategies to prevent the health effects of climate change so that the health of the people in Africa can be maintained.
基金The work was jointly supported by two grants(Project code:UIC 201624 and UIC 201714)from Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,Guangdong,China.
文摘The seeds and sprouts of mung bean are very common cruise in Asia.Evidence showed that bioactive compounds in mung bean have emerged as an increasing scientific interest due to their role in the prevention of degenerative diseases.All data of in vitro,in vivo and clinical studies of mung bean and its impact on human health were collected from a library database and electronic search.Botanical,phytochemical and pharmacological information was gathered and orchestrated.Remarkable studies have been demonstrated,showing the enhancement of metabolites in mung bean during the sprouting process,which possesses various health benefiting bioactive compounds.These compounds have been frequently attributed to their antioxidant,anti-diabetic,antimicrobial,anti-hyperlipidemic and antihypertensive effect,anti-inflammatory,and anticancer,anti-tumor and anti-mutagenic properties.In this critical review,we aimed to study the insight of the nutritional compositions,phytochemistry,and healthpromoting effects of mung bean and its sprouts.The various curative potential of mung bean provides successive preclinical outcomes in the field of drug discovery and this review strongly recommends that mung bean is an excellent nutritive legume,which modulates or prevents chronic degenerative diseases.
基金supported by the National Key Research and Development Program of China(No.2020YFC1807502)the National Natural Science Foundation of China(No.41822709)。
文摘Due to climate change,the heatwave has become a more serious public health threat with aging as an aggravating factor in recent years.There is a pressing need to detect the most effective prevention and response measures.However,the specific health effects of interventions have not been characterized on an individual scale.In this study,an intervention experiment was designed to explore the health effects of heat exposure at the individual level and assess the effects of different interventions based on a comprehensive health sensitivity index(CHSI)in Xinyi,China.Forty-one subjects were recruited randomly,and divided into one control group and three intervention groups.Interventions included education(Educate by lecturing,offering relative materials,and communication),subsidy support(offer subsidy to offset the cost of running air conditioning),and cooling-spray(install a piece of cooling-spray equipment in the yard).Results showed that systolic blood pressure(SBP)and deep sleep duration(DSD)were significantly affected by short-term heat exposure,and the effects could be alleviated by three types of interventions.The estimated CHSI indicated that the effective days of the education group were longer than other groups,while the lower CHSI of the subsidy group showed lower sensitivity than the control group.These findings provide feasible implementation strategies to optimize Heat-health action plans and evaluate the intervention performance.
基金supported in part by the Key Projects of Philosophy and Social Sciences Research supported by the Ministry of Education of the People’s Republic of China(Grant No.:15JJD870001)Luo Jia Youth Scholar of Wuhan University
文摘Purpose： This study investigates how online user intention in searching health information is affected by problematic situations.Design/methodology/approach： Based on the Theory of Reasoned Action, the Technology Acceptance Model, and Sense-making theory, we propose two dimensions of problematic situations： urgency and severity of health issues being searched online. Data were collected through a questionnaire survey among 214 Wuhan University students and analyzed using hierarchical regression analysis.Findings： Perceived usefulness, perceived ease of use, and subjective norm can influence user intention to seek health information online. The urgency of problematic situations has a negative moderating effect on the relationship between perceived ease of use and user intention and the relationship between subjective norm and user intention. The severity of problematic situations has a negative moderating effect on the relationship between subjective norm and user intention.Research limitations： The respondents of the survey are limited to students in one Chinese university, so whether this study＇s results can be applied to another population or not remains to be verified. In addition, only two dimensions of problematic situations are considered in this study. Practical implications： The paper puts forward the moderating effect of problematic situations and verifies it, which is the compensation for online health information-seeking behavior research. Besides, our analyses have implications for professional design of health care systems and related consumer information searches, and improve their performance. Originality/value： Previous work has reported the effects of problematic situation on user intention to seek health information online, ignoring its influence on other factors. This empirical study extends that work to identify the influence of problematic situation when seeking intention-behavior data in two dimensions, urgency and severity.
基金Supported by the Opening Project of Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural AffairsSichuan Engineering and Technology Research Center of Coarse Cereal Industralization,Chengdu University(2022CC013)。
文摘Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic value.However,abundant antinutritional factors(ANFs)reduces its health benefits.As reported,germination can improve the nutritional profile of grains.In this study,we systematically evaluate the safety of Tartary buckwheat seeds(TB)and Tartary buckwheat sprouts(TBS)used as high active ingredients.After evaluating nutrition levels,bioactive compounds and ANFs in TBS during germinating,5^(th)-day TBS were selected as the raw material.C57BL/6J mice were gavaged daily with distilled water,TB,or TBS for 6 weeks.The physiological indices related to ANFs were determined.Results showed that the TB intake tends to generate negative effects on the gut microbiota,and organs.Additionally,upon TB intake,the Fe^(3+)content in serum,trypsin activity in pancreas and jejunum decreased,while the cytokine,IgE,and histamine levels in serum,water content in faeces,cytokine levels in liver and jejunum increased.Conversely,TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering effect.Altogether,TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia.
文摘Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.
基金supports from the National Natural Science Foundation of China(82130112,U24A20789)Beijing Hospitals Authority Ascent Plan(DFL20190702)Youth Beijing Scholar(2022-051)。
文摘Lonicera japonica(honeysuckle)is a traditional Chinese medicinal food,in which the main active ingredients are phenolic acids,polysaccharides,flavonoids,and volatile oils.They have various biological activities,including antiviral,antibacterial,antioxidant,hypoglycemic and lipid-lowering,and anti-inflammatory effects.This review summarizes the health effects and pharmacodynamic mechanisms of L.japonica extracts and the major active ingredients in these extracts,and the structures,metabolic process in vivo,and biotransformation processes of these compounds.In addition,the current status of the development of L.japonica-related functional foods is summarized.The aim is to provide a theoretical basis and reference for the further development and use of the active ingredients in L.japonica as functional foods for disease prevention and treatment.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3702702)National Natural Science Foundation of China(Grant No.82103871).
文摘Clean air is fundamental to human health.Approximately 99%of the global population has been exposed to concentrations higher than the World Health Organization’s recommendations.Moreover,adverse health effects have been observed at much lower pollution levels than previously studied.China has experienced periods of severe air pollution over the past few decades.To improve air quality and safeguard public health,the government has implemented several progressively tightened policies.Emission control policies were first proposed in 2005.
