<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in ...<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in men than in women. Serum UA has been identified as a predictive biomarker for metabolic syndrome (MetS);however, the gender differences in the association between UA levels and MetS-related conditions in a Japanese population have not been completely assessed. <strong><em>Objective</em></strong> To examine gender and age differences in the associations between serum UA levels and other biomarkers within a health-screened Japanese population and to evaluate the usefulness of serum UA as a predictor of MetS between the two genders. <strong><em>Methods</em></strong> A cross-sectional study of healthy individuals in Japan (16,391 men;16,656 women) was conducted. Associations between UA and several biomarkers were analyzed for each gender type and for age- and serum UA level-stratified groups. Logistic regression was used to analyze the association of age and serum UA levels with MetS-related conditions. Receiver operating characteristic (ROC) curve analysis was performed to identify the UA cut-off value for predicting the risk of the MetS-related conditions. <strong><em>Results</em></strong> Serum UA levels in women had stronger correlations with MetS-related biomarkers than in men. After adjusting for age, the odds ratios for a 1-mg/dL serum UA increase for diabetes mellitus and dyslipidemia in women were 1.13 (95% confidence interval, 1.04 - 1.23) and 1.30 (1.25 - 1.34), respectively. In ROC analysis, women had significantly higher area under the curve (AUC) values for MetS prediction than men. <em><strong>Conclusion</strong></em> An elevated serum UA level has a higher predictive ability for the risk of MetS-related conditions in Japanese women than in men. The optimal serum UA cut-off value for MetS in women was suggested to be approximately 5 mg/dL, remarkably lower than that in men.展开更多
Health checks are key features of primary and secondary disease prevention. The aim of this study was to examine the sex- and age-specific association of social status and health-related behaviors with health check at...Health checks are key features of primary and secondary disease prevention. The aim of this study was to examine the sex- and age-specific association of social status and health-related behaviors with health check attendance in eligible persons. Data were derived from the Kanazawa Study 2011 (n = 12,781), a cross-sectional study which investigated all the residents in model areas of Kanazawa City, Ishikawa Prefecture, Japan. We selected participants aged 23 years or older with National Health Insurance (n = 4920). Attendance at health checks was the outcome. We used social status and health-related behaviors as predictor variables. We analyzed them by sex and applied stratified analyses by age groups for each sex. The bivariate analyses were conducted by means of cross-tabs. We calculated health check attendance rates by each variable. We used Pearson’s χ2-test to examine statistically significant differences. We fitted logistic regression models to estimate adjusted odds ratios (ORs) of attendance in the past one year. We computed ORs in a logistic regression model containing all variables described above. Workingmen and women aged 23 to 39 years and aged 40 to 64 years had significantly increased ORs for health check attendance compared with non-working persons. Men, men aged 23 to 39 years and men aged 65 years or older with more physical activity had significantly increased ORs for health check attendance. Male ex-smokers, female ex- and non-smokers, male ex-smokers aged 65 years or older, and female non-smokers aged 40 to 64 years had significantly increased ORs. The findings suggest that population groups with lower social status or increased risks of adverse health effects are less likely to attend health checks than those with higher social status or decreased risks in particular sex and age groups. It indicates that diverse approaches are required to realize the full benefit of health checks.展开更多
The present study aims to determine the gynecologic health status of asymptomatic women at a unique Japanese Health Check-up Institute, Ningen Dock. Medical records of Japanese women, who underwent gynecological medic...The present study aims to determine the gynecologic health status of asymptomatic women at a unique Japanese Health Check-up Institute, Ningen Dock. Medical records of Japanese women, who underwent gynecological medical (health) examinations between January 2011 and December 2016, were retrospectively reviewed. Of the cervical smears from 8927 women aged 18 - 85 years, 50 (0.6%) were classified as dysplastic and malignant changes: 18 of low-grade squamous intraepithelial lesion, 10 high-grade squamous intraepithelial lesion, 21 atypical squamous cells of undetermined significance and 1 cervical squamous cell carcinoma. No case of cervical adenocarcinoma was found. Ultrasonographic examination detected uterus enlargements and ovary tumors in 2.0% and 0.9% of cases, respectively. Most of participants (95.6%) revealed no gynecologic abnormalities. The present study based on the records of Ningen Dock, where asymptomatic participants undergo a medical examination at their own expense, showed very low incidence of abnormal cytologic and/or ultrasonographic findings.展开更多
Objective: In Japan, there are unique facilities (namely Ningen Dock) of health check-up, where asymptomatic participants undergo a medical examination at their own expense. The earlier occurrence of cervical cancer a...Objective: In Japan, there are unique facilities (namely Ningen Dock) of health check-up, where asymptomatic participants undergo a medical examination at their own expense. The earlier occurrence of cervical cancer and the concern on screening prompted us compare to the age distribution in the self-covered system with that of free physical check-up programs at public expense. Methods: We analyzed medical records of Japanese women, who underwent gynecological examinations at self-covered expense and at public expense between for the periods 2002-2011 and 2005-2009, respectively, restricting examinee’s age group. Results: For self-covered system, approximately 80% of the overall examinee population was occupied with three age groups 30-39, 40-49 and 50-59. The participants was extremely fewer in the over 60 years age group accounting for 10%, compared to those for the public expense-covered system, the over 60 years age group being 25%. Participant under the age of 30 years seemed to increase in chronological order in both systems. Conclusion: The level of knowledge on sexually transmitted infections may contribute to screening promotion for the younger women, while the elderly over 60 years’ attitudes toward screening may be mainly related to social-economic status and/or public expense support.展开更多
Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological condi...Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological conditions in China remains limited.Methods:This nationwide cross-sectional study analyzed health check-up data from the Dian laboratory network across China in 2023.The study included 238,807 women aged≥20 years from 23 PLADs who underwent both HPV genotyping and LBC testing.The rates of abnormal cytology and HPV infection were weighted and standardized according to the Seventh National Population Census(2020).Results:The overall weighted rates of HR-HPV infection and abnormal cytology were 12.30%and 9.25%,respectively.Among women with abnormal cervical cytology,HPV-16 was the most prevalent HRHPV genotype,followed by HPV-58 and HPV-52.Conclusions:The detection rates of HR-HPV and abnormal cytology remain relatively high in China.Both single and multiple HR-HPV infections were associated with increased risk of abnormal cervical cytology.These findings may inform the development of HPV genotype-specific vaccination and screening strategies to reduce cervical cancer burden.展开更多
Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qi...Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qixingguan district (township, town) , so as to clarify the shortcomings in this work, and effectively promote the development of magnetic project. Methods: questionnaire survey and telephone survey were carried out among the service subjects in the health center. The content mainly included the channels of policy knowledge, the evaluation of the situation of policy knowledge and advice information, as well as the degree of satisfaction, and the pregnancy outcome, early pregnancy follow-up and follow-up. Results: the coverage rate of the scientific knowledge of eugenics and the awareness rate of the married couples at childbearing age were all above 90%, especially the channels of awareness were higher. According to the analysis of follow-up, the rate of pregnancy outcome, early pregnancy follow-up and high-risk group follow-up is low, and there is no significant difference in the population satisfaction and follow-up willingness according to the population age, but there is significant difference in the population satisfaction and follow-up willingness according to different regions (P < 0.05). Conclusion: according to the results of the study, we can know that publicity and training should be strengthened, and follow-up services should be further improved. According to different groups of people, different ways should be used to do the work well before pregnancy, so that people's satisfaction can be improved.展开更多
目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS...目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)于2020年开展的第五轮调查数据,共筛选中老年高血糖、血脂异常、高血压患者8227人作为研究对象,基于安德森模型框架,采用χ2检验和多因素Logistic回归分析影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结果研究对象体检服务利用率为54.13%。多因素Logistic回归分析结果显示年龄(≥65岁:OR=2.024,95%CI=1.831~2.236,P<0.001)、受教育程度(高中及以上:OR=1.303,95%CI=1.123~1.511,P<0.001)、个人收入(有:OR=1.440,95%CI=1.285~1.614,P<0.001)、养老保险类别(企业职工养老保险:OR=0.655,95%CI=0.516~0.833,P<0.001;城镇居民/城乡居民养老保险:OR=0.633,95%CI=0.493~0.813,P<0.001;新型农村居民社会养老保险:OR=0.602,95%CI=0.466~0.778,P<0.001;其他养老保险:OR=0.549,95%CI=0.390~0.772,P<0.001;无养老保险:OR=0.473,95%CI=0.361~0.619,P<0.001)、医保类别(新农合、其他医保、无医保:OR=0.834,95%CI=0.726~0.959,P=0.011)、抑郁症状(是:OR=0.885,95%CI=0.804~0.975,P=0.014)、慢性病患病数量(2种:OR=1.158,95%CI=1.004~1.337,P=0.045;3种:OR=1.273,95%CI=1.099~1.475,P=0.001;≥4种:OR=1.282,95%CI=1.117~1.472,P<0.001)、社交情况(有:OR=1.396,95%CI=1.274~1.530,P<0.001)、住院服务利用(利用/需求:OR=1.207,95%CI:1.080~1.348,P<0.001)、饮酒(是:OR=1.127,95%CI=1.019~1.246,P=0.020)及吸烟(是:OR=0.761,95%CI=0.681~0.849,P<0.001)是影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结论我国中老年高血糖、血脂异常、高血压人群体检服务利用率有待提高,建议将45~64岁人群纳入弹性体检补贴范围,推动体检费用医保报销,减轻贫困人群经费负担;深化医防融合机制,创新技术赋能,简化体检流程;加强慢性病防控政策及健康宣教,提升居民健康素养水平和健康管理依从性;针对低收入、低教育水平、有抑郁症状等人群,制定定向干预方案,实现慢性病防控关口前移,促进健康老龄化。展开更多
文摘<strong><em>Background</em></strong> A serum uric acid (UA) level of 7.0 mg/dL has been used as the criterion for hyperuricemia in Japan regardless of gender, despite higher serum UA levels in men than in women. Serum UA has been identified as a predictive biomarker for metabolic syndrome (MetS);however, the gender differences in the association between UA levels and MetS-related conditions in a Japanese population have not been completely assessed. <strong><em>Objective</em></strong> To examine gender and age differences in the associations between serum UA levels and other biomarkers within a health-screened Japanese population and to evaluate the usefulness of serum UA as a predictor of MetS between the two genders. <strong><em>Methods</em></strong> A cross-sectional study of healthy individuals in Japan (16,391 men;16,656 women) was conducted. Associations between UA and several biomarkers were analyzed for each gender type and for age- and serum UA level-stratified groups. Logistic regression was used to analyze the association of age and serum UA levels with MetS-related conditions. Receiver operating characteristic (ROC) curve analysis was performed to identify the UA cut-off value for predicting the risk of the MetS-related conditions. <strong><em>Results</em></strong> Serum UA levels in women had stronger correlations with MetS-related biomarkers than in men. After adjusting for age, the odds ratios for a 1-mg/dL serum UA increase for diabetes mellitus and dyslipidemia in women were 1.13 (95% confidence interval, 1.04 - 1.23) and 1.30 (1.25 - 1.34), respectively. In ROC analysis, women had significantly higher area under the curve (AUC) values for MetS prediction than men. <em><strong>Conclusion</strong></em> An elevated serum UA level has a higher predictive ability for the risk of MetS-related conditions in Japanese women than in men. The optimal serum UA cut-off value for MetS in women was suggested to be approximately 5 mg/dL, remarkably lower than that in men.
文摘Health checks are key features of primary and secondary disease prevention. The aim of this study was to examine the sex- and age-specific association of social status and health-related behaviors with health check attendance in eligible persons. Data were derived from the Kanazawa Study 2011 (n = 12,781), a cross-sectional study which investigated all the residents in model areas of Kanazawa City, Ishikawa Prefecture, Japan. We selected participants aged 23 years or older with National Health Insurance (n = 4920). Attendance at health checks was the outcome. We used social status and health-related behaviors as predictor variables. We analyzed them by sex and applied stratified analyses by age groups for each sex. The bivariate analyses were conducted by means of cross-tabs. We calculated health check attendance rates by each variable. We used Pearson’s χ2-test to examine statistically significant differences. We fitted logistic regression models to estimate adjusted odds ratios (ORs) of attendance in the past one year. We computed ORs in a logistic regression model containing all variables described above. Workingmen and women aged 23 to 39 years and aged 40 to 64 years had significantly increased ORs for health check attendance compared with non-working persons. Men, men aged 23 to 39 years and men aged 65 years or older with more physical activity had significantly increased ORs for health check attendance. Male ex-smokers, female ex- and non-smokers, male ex-smokers aged 65 years or older, and female non-smokers aged 40 to 64 years had significantly increased ORs. The findings suggest that population groups with lower social status or increased risks of adverse health effects are less likely to attend health checks than those with higher social status or decreased risks in particular sex and age groups. It indicates that diverse approaches are required to realize the full benefit of health checks.
文摘The present study aims to determine the gynecologic health status of asymptomatic women at a unique Japanese Health Check-up Institute, Ningen Dock. Medical records of Japanese women, who underwent gynecological medical (health) examinations between January 2011 and December 2016, were retrospectively reviewed. Of the cervical smears from 8927 women aged 18 - 85 years, 50 (0.6%) were classified as dysplastic and malignant changes: 18 of low-grade squamous intraepithelial lesion, 10 high-grade squamous intraepithelial lesion, 21 atypical squamous cells of undetermined significance and 1 cervical squamous cell carcinoma. No case of cervical adenocarcinoma was found. Ultrasonographic examination detected uterus enlargements and ovary tumors in 2.0% and 0.9% of cases, respectively. Most of participants (95.6%) revealed no gynecologic abnormalities. The present study based on the records of Ningen Dock, where asymptomatic participants undergo a medical examination at their own expense, showed very low incidence of abnormal cytologic and/or ultrasonographic findings.
文摘Objective: In Japan, there are unique facilities (namely Ningen Dock) of health check-up, where asymptomatic participants undergo a medical examination at their own expense. The earlier occurrence of cervical cancer and the concern on screening prompted us compare to the age distribution in the self-covered system with that of free physical check-up programs at public expense. Methods: We analyzed medical records of Japanese women, who underwent gynecological examinations at self-covered expense and at public expense between for the periods 2002-2011 and 2005-2009, respectively, restricting examinee’s age group. Results: For self-covered system, approximately 80% of the overall examinee population was occupied with three age groups 30-39, 40-49 and 50-59. The participants was extremely fewer in the over 60 years age group accounting for 10%, compared to those for the public expense-covered system, the over 60 years age group being 25%. Participant under the age of 30 years seemed to increase in chronological order in both systems. Conclusion: The level of knowledge on sexually transmitted infections may contribute to screening promotion for the younger women, while the elderly over 60 years’ attitudes toward screening may be mainly related to social-economic status and/or public expense support.
基金Supported by the Scientific Research Seed Fund of Peking University First Hospital(grant number 2024SF47)(D.G.)Regular Resources from Peking University First Hospital(X.Z.).
文摘Introduction:Human papillomaviruses(HPV)testing and liquid-based cytology(LBC)are the primary screening methods for cervical cancer.However,recent nationwide data on HPV distribution across different cytological conditions in China remains limited.Methods:This nationwide cross-sectional study analyzed health check-up data from the Dian laboratory network across China in 2023.The study included 238,807 women aged≥20 years from 23 PLADs who underwent both HPV genotyping and LBC testing.The rates of abnormal cytology and HPV infection were weighted and standardized according to the Seventh National Population Census(2020).Results:The overall weighted rates of HR-HPV infection and abnormal cytology were 12.30%and 9.25%,respectively.Among women with abnormal cervical cytology,HPV-16 was the most prevalent HRHPV genotype,followed by HPV-58 and HPV-52.Conclusions:The detection rates of HR-HPV and abnormal cytology remain relatively high in China.Both single and multiple HR-HPV infections were associated with increased risk of abnormal cervical cytology.These findings may inform the development of HPV genotype-specific vaccination and screening strategies to reduce cervical cancer burden.
文摘Objective: to comprehensively evaluate the quality of health examination service for pre-pregnancy healthy births, and to comprehensively understand the results of pre-pregnancy healthy births health examination in Qixingguan district (township, town) , so as to clarify the shortcomings in this work, and effectively promote the development of magnetic project. Methods: questionnaire survey and telephone survey were carried out among the service subjects in the health center. The content mainly included the channels of policy knowledge, the evaluation of the situation of policy knowledge and advice information, as well as the degree of satisfaction, and the pregnancy outcome, early pregnancy follow-up and follow-up. Results: the coverage rate of the scientific knowledge of eugenics and the awareness rate of the married couples at childbearing age were all above 90%, especially the channels of awareness were higher. According to the analysis of follow-up, the rate of pregnancy outcome, early pregnancy follow-up and high-risk group follow-up is low, and there is no significant difference in the population satisfaction and follow-up willingness according to the population age, but there is significant difference in the population satisfaction and follow-up willingness according to different regions (P < 0.05). Conclusion: according to the results of the study, we can know that publicity and training should be strengthened, and follow-up services should be further improved. According to different groups of people, different ways should be used to do the work well before pregnancy, so that people's satisfaction can be improved.
文摘目的了解我国中老年高血糖、血脂异常、高血压人群健康体检服务利用现状并分析其影响因素,为优化“三高共管”策略和卫生服务体系改革提供依据。方法依托中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)于2020年开展的第五轮调查数据,共筛选中老年高血糖、血脂异常、高血压患者8227人作为研究对象,基于安德森模型框架,采用χ2检验和多因素Logistic回归分析影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结果研究对象体检服务利用率为54.13%。多因素Logistic回归分析结果显示年龄(≥65岁:OR=2.024,95%CI=1.831~2.236,P<0.001)、受教育程度(高中及以上:OR=1.303,95%CI=1.123~1.511,P<0.001)、个人收入(有:OR=1.440,95%CI=1.285~1.614,P<0.001)、养老保险类别(企业职工养老保险:OR=0.655,95%CI=0.516~0.833,P<0.001;城镇居民/城乡居民养老保险:OR=0.633,95%CI=0.493~0.813,P<0.001;新型农村居民社会养老保险:OR=0.602,95%CI=0.466~0.778,P<0.001;其他养老保险:OR=0.549,95%CI=0.390~0.772,P<0.001;无养老保险:OR=0.473,95%CI=0.361~0.619,P<0.001)、医保类别(新农合、其他医保、无医保:OR=0.834,95%CI=0.726~0.959,P=0.011)、抑郁症状(是:OR=0.885,95%CI=0.804~0.975,P=0.014)、慢性病患病数量(2种:OR=1.158,95%CI=1.004~1.337,P=0.045;3种:OR=1.273,95%CI=1.099~1.475,P=0.001;≥4种:OR=1.282,95%CI=1.117~1.472,P<0.001)、社交情况(有:OR=1.396,95%CI=1.274~1.530,P<0.001)、住院服务利用(利用/需求:OR=1.207,95%CI:1.080~1.348,P<0.001)、饮酒(是:OR=1.127,95%CI=1.019~1.246,P=0.020)及吸烟(是:OR=0.761,95%CI=0.681~0.849,P<0.001)是影响我国中老年高血糖、血脂异常、高血压人群健康体检服务利用的主要因素。结论我国中老年高血糖、血脂异常、高血压人群体检服务利用率有待提高,建议将45~64岁人群纳入弹性体检补贴范围,推动体检费用医保报销,减轻贫困人群经费负担;深化医防融合机制,创新技术赋能,简化体检流程;加强慢性病防控政策及健康宣教,提升居民健康素养水平和健康管理依从性;针对低收入、低教育水平、有抑郁症状等人群,制定定向干预方案,实现慢性病防控关口前移,促进健康老龄化。
