Electrical discharges in or in contact with liquid can produce H2O2effectively.However,wound treatment requires not only high energy yield,but also low temperature,stability,safety and reproducibility in H2O2generatio...Electrical discharges in or in contact with liquid can produce H2O2effectively.However,wound treatment requires not only high energy yield,but also low temperature,stability,safety and reproducibility in H2O2generation.Thus a method of producing H2O2in saline solution reacting with He/H2O plasma jet is described in this paper.Two working modes(bullet and arc modes)are stable while keeping at low temperature in the H2O2production.The production is much faster under the arc mode,but has rather high production rate and energy efficiency under the bullet mode.Plus,the energy efficiency increases with treatment time and higher moist helium flow rate under both modes,but especially the bullet mode.Moreover,55 min after the plasma treatment,there is only 6%degradation of H2O2concentration in the saline solution,and this indicates the potential of He/H2O plasma jet in plasma pharmacy.展开更多
[Objectives] To prepare an acute myocardial infarction model for SD rats and conduct ventricular remodeling. [Methods] 45 male Sprague-Dawley( SD) rats were randomly selected in 60 male rats as the model group and the...[Objectives] To prepare an acute myocardial infarction model for SD rats and conduct ventricular remodeling. [Methods] 45 male Sprague-Dawley( SD) rats were randomly selected in 60 male rats as the model group and the rest rats were sham operation group. For the model group,the left anterior descending coronary artery was ligated,while the sham operation group was not ligated. 4 weeks after the operation,hemodynamics was used to measure the cardiac function of both groups. HE staining and Masson staining were used to observe the changes in myocardial histopathology and myocardial fibrosis of both groups. [Results] Compared with the sham operation group,the model group rats showed significant decrease in the left ventricular systolic pressure( LVSP) and left ventricular pressure maximum rising and dropping rate( ± d_p/d_(tmax)) and significant increase in the left ventricular end-diastolic pressure( LVEDP). HE staining showed that a large number of myocardial cell necrosis occured in the model group,while the morphology of myocardial cells of rats in the sham operation group was normal. Masson staining showed that myocardial collagen fibers in the model group were significantly increased compared with those in the sham operation group. Collagen fibers were scattered in the sham operation group. [Conclusions] It can be concluded that cardiac function of rats changed and ventricular remodeling occurred in 4 weeks after myocardial infarction.展开更多
基金Project supported by National Natural Science Foundation of China （51207027）, Scien- tific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China.
文摘Electrical discharges in or in contact with liquid can produce H2O2effectively.However,wound treatment requires not only high energy yield,but also low temperature,stability,safety and reproducibility in H2O2generation.Thus a method of producing H2O2in saline solution reacting with He/H2O plasma jet is described in this paper.Two working modes(bullet and arc modes)are stable while keeping at low temperature in the H2O2production.The production is much faster under the arc mode,but has rather high production rate and energy efficiency under the bullet mode.Plus,the energy efficiency increases with treatment time and higher moist helium flow rate under both modes,but especially the bullet mode.Moreover,55 min after the plasma treatment,there is only 6%degradation of H2O2concentration in the saline solution,and this indicates the potential of He/H2O plasma jet in plasma pharmacy.
基金Supported by Project of Natural Science Foundation of Hebei Province(C2011406009)Key Project of Hebei Provincial Education Department(ZD20131068)
文摘[Objectives] To prepare an acute myocardial infarction model for SD rats and conduct ventricular remodeling. [Methods] 45 male Sprague-Dawley( SD) rats were randomly selected in 60 male rats as the model group and the rest rats were sham operation group. For the model group,the left anterior descending coronary artery was ligated,while the sham operation group was not ligated. 4 weeks after the operation,hemodynamics was used to measure the cardiac function of both groups. HE staining and Masson staining were used to observe the changes in myocardial histopathology and myocardial fibrosis of both groups. [Results] Compared with the sham operation group,the model group rats showed significant decrease in the left ventricular systolic pressure( LVSP) and left ventricular pressure maximum rising and dropping rate( ± d_p/d_(tmax)) and significant increase in the left ventricular end-diastolic pressure( LVEDP). HE staining showed that a large number of myocardial cell necrosis occured in the model group,while the morphology of myocardial cells of rats in the sham operation group was normal. Masson staining showed that myocardial collagen fibers in the model group were significantly increased compared with those in the sham operation group. Collagen fibers were scattered in the sham operation group. [Conclusions] It can be concluded that cardiac function of rats changed and ventricular remodeling occurred in 4 weeks after myocardial infarction.
