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Harnessing autophagy: A potential breakthrough in digestive disease treatment
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作者 Mukaddes Esrefoglu 《World Journal of Gastroenterology》 SCIE CAS 2024年第24期3036-3043,共8页
Autophagy,a conserved cellular degradation process,is crucial for various cellular processes such as immune responses,inflammation,metabolic and oxidative stress adaptation,cell proliferation,development,and tissue re... Autophagy,a conserved cellular degradation process,is crucial for various cellular processes such as immune responses,inflammation,metabolic and oxidative stress adaptation,cell proliferation,development,and tissue repair and remodeling.Dysregulation of autophagy is suspected in numerous diseases,including cancer,neurodegenerative diseases,digestive disorders,metabolic syndromes,and infectious and inflammatory diseases.If autophagy is disrupted,for example,this can have serious consequences and lead to chronic inflammation and tissue damage,as occurs in diseases such as Chron's disease and ulcerative colitis.On the other hand,the influence of autophagy on the development and progression of cancer is not clear.Autophagy can both suppress and promote the progression and metastasis of cancer at various stages.From inflammatory bowel diseases to gastrointestinal cancer,researchers are discovering the intricate role of autophagy in maintaining gut health and its potential as a therapeutic target.Researchers should carefully consider the nature and progression of diseases such as cancer when trying to determine whether inhibiting or stimulating autophagy is likely to be beneficial.Multidisciplinary approaches that combine cutting-edge research with clinical expertise are key to unlocking the full therapeutic potential of autophagy in digestive diseases. 展开更多
关键词 AUTOPHAGY Digestive disease Inflammatory bowel disease Gastrointestinal cancer harnessing autophagy
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A new technology for harnessing the dye polluted water and dye collection in a chemical factory
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作者 PU Jiang-ping PU Pei-min +3 位作者 HU Chun-hua QIAN Jun-long PU Ju-xing HUA Ji-kang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2001年第2期198-200,共3页
A new technology for harnessing the dye polluted water and dye collection was developed. It is based on the enhanced evaporation by using solar, wind and air temperature energy and additional heat-electric energy. It ... A new technology for harnessing the dye polluted water and dye collection was developed. It is based on the enhanced evaporation by using solar, wind and air temperature energy and additional heat-electric energy. It consists of four parts: (1) evaporation carrier system (evaporation carrier and frame for evaporation carrier) for polluted water; (2)polluted water circulating system (pumping-spraying-collecting); (3)heating system; (4)workshop with polluted water reservoir-tanks and rainfall prevention roof. The polluted water was (heated in case necessary) sprayed to the evaporation carrier system and the water was evaporated when it moved in the space and downward along the carrier mainly by using natural (solar, wind and air temperature energy). In case, when there is no roof for the carrier system, the polluted water can be stored in the reservoirs (storage volume for about 20 days). The first 10-25 mm rainfall also need to be stored in the reservoirs to meet the state standard or discharging wastewater. The dye may be collected at the surface in the reservoir-tanks and the crystallized salt may be collected at the bottom plate. The black-color wastewater released by the factory is no more discharged to the surface water system of Taihu Lake Basin. About 2 kg dye and 200 kg industrial salt may be collected from each tone of the polluted water. The non-pollution production of dye may be realized by using this technology with environmental, economical and social benefits. 展开更多
关键词 dye polluted water harnessing dye collection technology
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Harnessing Technology
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作者 Xia Yuanyuan 《ChinAfrica》 2018年第8期18-19,共2页
In science fiction movies like Westworld, robots are awaking; in Blade Runner, the consciousness of robots is rising; and in The Matrix, people are trapped in a virtual world by robots.
关键词 AI harnessing Technology
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Harnessing the Wind
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作者 Francois Essomba 《ChinAfrica》 2011年第9期28-28,共1页
Morocco expands its wind energy program to provide much needed clean energy resource THINK of the Kingdom of Morocco and you would not imagine wind farms stretching into the horizon. But the North African country has ... Morocco expands its wind energy program to provide much needed clean energy resource THINK of the Kingdom of Morocco and you would not imagine wind farms stretching into the horizon. But the North African country has set itself a windfilled challenge,one that could be a model for sustainable development.Morocco aims to increase its electricity output from wind from its current 280 MW (megawatt) to 2,000 MW by 2020. 展开更多
关键词 harnessing the Wind
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Harnessing Demographic Dividends
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作者 Charles Onunaiju 《ChinAfrica》 2017年第8期30-31,共2页
THE history of all developed economies and even the emerging ones have been their abilities to harness human resource into capital and use its diverse multiplier effects to create value chains spanning all other resou... THE history of all developed economies and even the emerging ones have been their abilities to harness human resource into capital and use its diverse multiplier effects to create value chains spanning all other resources categories. In addition, this process unleashes outcomes that include a rise in national economic aggregates and more importantly, improved quality of living standards for citizens. 展开更多
关键词 harnessing Demographic Dividends
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Harnessing the Sun
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作者 Liu Jian 《ChinAfrica》 2016年第12期22-23,共2页
Chinese solar power company provides clean,affordable andsustainable energy solutions in AfricaIN most areas in Africa,poor infrastructure and unreliable power supply means life-saving vaccines are often spoiled,as th... Chinese solar power company provides clean,affordable andsustainable energy solutions in AfricaIN most areas in Africa,poor infrastructure and unreliable power supply means life-saving vaccines are often spoiled,as they need to keep cool from the point of manufacture all the way to the point of use. 展开更多
关键词 harnessing the Sun
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Renewable and Green Energy, Africa’s Pathway to Sustainable Development;Harnessing the Continent’s Natural Energy Sources
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作者 Nsikan Nkordeh Maroh Ejiro +2 位作者 Mba Okeoghene Morayo Awomoyi Ibinabo Bobmanuel 《Smart Grid and Renewable Energy》 2023年第7期131-151,共21页
Renewable energy includes all forms of energy produced from renewable sources in a sustainable manner, including bioenergy, geothermal energy, hydropower, ocean energy, solar energy, and wind energy. Less than one qua... Renewable energy includes all forms of energy produced from renewable sources in a sustainable manner, including bioenergy, geothermal energy, hydropower, ocean energy, solar energy, and wind energy. Less than one quarter of Africa’s renewable power generation potential is utilized. Africa’s natural endowments are enormous, yet the continent experiences high energy shortage. Amongst the classifications of energy sources, renewable and green energy sources are increasingly gaining popularity due to their sustainable nature and environmental concerns. This paper explores the continent’s natural energy sources and identifies pathways to sustainable development. The paper also narrows the renewable and green energy sources obtainable on the continent and presents their contribution to the development of the continent. The awareness level of Africans towards renewable energy is discussed and the challenges of renewable and green energy sources are highlighted. Finally, the roles to be played by the government and private organizations in the development of renewable and green energy sources in Africa are discussed. 展开更多
关键词 Green RENEWABLE CONTINENT HARNESS Sustainable Environmental
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Harnessing exceptional points for ultrahigh sensitive acoustic wave sensing
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作者 Xingyu Lu Yang Yuan +6 位作者 Fa Chen Xiaoxiao Hou Yanlong Guo Leonhard Reindl Yongqing Fu Wei Luo Degang Zhao 《Microsystems & Nanoengineering》 2025年第2期203-212,共10页
Exceptional point(EP)is referred to degeneracies in a non-Hermitian system where two or more eigenvalues and their corresponding eigenvectors coalesce.Recently there have been significantly increased interests in harn... Exceptional point(EP)is referred to degeneracies in a non-Hermitian system where two or more eigenvalues and their corresponding eigenvectors coalesce.Recently there have been significantly increased interests in harnessing EPs to enhance responsivities and achieve ultrasensitive detections in optics,electronics and acoustics,although there are few similar studies focused on using surface acoustic wave(SAW)sensing technologies,probably due to its great technical challenges.Herein,we proposed a scheme for accessing EPs in an on-chip architecture consisted of coupledSAW-resonators system,forming a passive parity-time(PT)symmetric system.We demonstrated that by tuning additional losses in one of resonators and regulating the system in the proximity of the EP,the sensor exhibited significantly enhanced responses.As an example,we present an EP-based SAW gas sensor,which showed a muchimproved sensitivity compared to that of a conventional delay-line SAW sensor.The fundamental mechanisms behind this excellent sensing performance have been elucidated. 展开更多
关键词 EIGENVECTORS surface acoustic wave harnessing eps ultrahigh sensitive sensing parity time symmetry exceptional points enhance responsivities ultrasensitive detections
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Ant Lion Algorithm for Optimized Controller Gains for Power Quality Enrichment of Off-grid Wind Power Harnessing Units 被引量:3
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作者 Kodakkal Amritha Veramalla Rajagopal +1 位作者 Kuthuri Narasimha Raju Sabha Raj Arya 《Chinese Journal of Electrical Engineering》 CSCD 2020年第3期85-97,共13页
The proposed system uses an algorithm that works on the admittance of the system,for estimating the reference values of generated currents for an off-grid wind power harnessing unit(WPHU).The controller controls the v... The proposed system uses an algorithm that works on the admittance of the system,for estimating the reference values of generated currents for an off-grid wind power harnessing unit(WPHU).The controller controls the voltage and maintains the frequency within the limits while working with both linear and nonlinear loads for varying wind speeds.The admittance algorithm is simple and easy to implement and works very efficiently to generate the triggering signals for the controller of the WPHU.The wind power harnessing unit comprising of a squirrel cage induction generator,a star-delta transformer,a battery storage system and the control unit are modeled using Matlab/Simulink R2019.An isolated transformer with a star-delta configuration connects the load and the generator circuit with the controller to reduce the dc bus voltage and mitigate current in the neutral line.The response of the system during the dynamic loading depends on the best possible compensator proportional-integral(PI)gains.The antlion optimization algorithm is compared with particle swarm optimization and grey wolf optimization and is found to have the advantages of good convergence,high efficiency and fast calculating speed.It is therefore used to extract the optimal values of frequency and voltage PI gains.The simulation results of the control algorithm for the WPHU are validated in a real-time environment in a dSpace1104 laboratory set up.This algorithm is proven to have a quick response,maintain the required frequency,suppress the current harmonics,regulate voltage,help in balancing the load and compensating for the neutral current. 展开更多
关键词 Wind power harnessing unit induction generator admittance based control algorithm ant lion optimization algorithm voltage and frequency control battery energy storage system
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Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development 被引量:1
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作者 Wakana Yamashita Shinjiro Ojima +10 位作者 Azumi Tamura Aa Haeruman Azam Kohei Kondo Zhang Yuancheng Longzhu Cui Masaki Shintani Masato Suzuki Yoshimasa Takahashi Koichi Watashi Satoshi Tsuneda Kotaro Kiga 《BioDesign Research》 CAS 2024年第1期28-38,共11页
The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial agents.Using bacteriophage-derived lytic enzym... The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial agents.Using bacteriophage-derived lytic enzymes in antibacterial therapy shows promise;however,a thorough comparison and evaluation of their bactericidal efficacy are lacking.This study aimed to compare and investigate the bactericidal activity and spectrum of such lytic enzymes,with the goal of harnessing them for antibacterial therapy.First,we examined the bactericidal activity of spanins,endolysins,and holins derived from 2 Escherichia coli model phages,T1 and T7.Among these,T1-spanin exhibited the highest bactericidal activity against E.coli.Subsequently,we expressed T1-spanin within bacterial cells and assessed its bactericidal activity.T1-spanin showed potent bactericidal activity against all clinical isolates tested,including bacterial strains of 111 E.coli,2 Acinetobacter spp.,3 Klebsiella spp.,and 3 Pseudomonas aeruginosa.In contrast,T1 phage-derived endolysin showed bactericidal activity against E.coli and P.aeruginosa,yet its efficacy against other bacteria was inferior to that of T1-spanin.Finally,we developed a phage-based technology to introduce the T1-spanin gene into target bacteria.The synthesized non-proliferative phage exhibited strong antibacterial activity against the targeted bacteria.The potent bactericidal activity exhibited by spanins,combined with the novel phage synthetic technology,holds promise for the development of innovative antimicrobial agents. 展开更多
关键词 DEVELOPMENT ANTIMICROBIAL DEVELOPING harnessing phage-based phage-derived spanin
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MFCCT:A Robust Spectral-Temporal Fusion Method with DeepConvLSTM for Human Activity Recognition
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作者 Rashid Jahangir Nazik Alturki +1 位作者 Muhammad Asif Nauman Faiqa Hanif 《Computers, Materials & Continua》 2026年第2期852-871,共20页
Human activity recognition(HAR)is a method to predict human activities from sensor signals using machine learning(ML)techniques.HAR systems have several applications in various domains,including medicine,surveillance,... Human activity recognition(HAR)is a method to predict human activities from sensor signals using machine learning(ML)techniques.HAR systems have several applications in various domains,including medicine,surveillance,behavioral monitoring,and posture analysis.Extraction of suitable information from sensor data is an important part of the HAR process to recognize activities accurately.Several research studies on HAR have utilizedMel frequency cepstral coefficients(MFCCs)because of their effectiveness in capturing the periodic pattern of sensor signals.However,existing MFCC-based approaches often fail to capture sufficient temporal variability,which limits their ability to distinguish between complex or imbalanced activity classes robustly.To address this gap,this study proposes a feature fusion strategy that merges time-based and MFCC features(MFCCT)to enhance activity representation.The merged features were fed to a convolutional neural network(CNN)integrated with long shortterm memory(LSTM)—DeepConvLSTM to construct the HAR model.The MFCCT features with DeepConvLSTM achieved better performance as compared to MFCCs and time-based features on PAMAP2,UCI-HAR,and WISDM by obtaining an accuracy of 97%,98%,and 97%,respectively.In addition,DeepConvLSTM outperformed the deep learning(DL)algorithms that have recently been employed in HAR.These results confirm that the proposed hybrid features are not only practical but also generalizable,making them applicable across diverse HAR datasets for accurate activity classification. 展开更多
关键词 DeepConvLSTM human activity recognition(HAR) MFCCT feature fusion wearable sensors
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Harnessing chaos for broadband coupling
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《Science Foundation in China》 CAS 2017年第4期38-,共1页
With the support by the National Natural Science Foundation of China,a team led by Professor Xiao Yunfeng(肖云峰)from Peking University demonstrates that the angular momentum of the photon refracted into a microresona... With the support by the National Natural Science Foundation of China,a team led by Professor Xiao Yunfeng(肖云峰)from Peking University demonstrates that the angular momentum of the photon refracted into a microresonator can be transformed dynamically by the chaotic motion,which was 展开更多
关键词 THG harnessing chaos for broadband coupling WGM
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Harnessing Wind
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作者 LIU YUNYUN 《Beijing Review》 2009年第29期24-27,共4页
China’s wind power industry shifts into full gear The global oil crunch and environmental degradation have given rise to an ardent search for alternative and green energies throughout the world. For China, wind power... China’s wind power industry shifts into full gear The global oil crunch and environmental degradation have given rise to an ardent search for alternative and green energies throughout the world. For China, wind power is a choice one and its development is sizzling hot backed 展开更多
关键词 harnessing Wind NEA
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Harnessing the Hongshuihe
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作者 LAN XINZHEN 《Beijing Review》 2008年第44期26-27,共2页
The construction of China’s third largest hydropower station sets four world records In southwest China, there is a river called Hongshuihe, which originates in
关键词 harnessing the Hongshuihe
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Harnessing the power of mosquito gut microbiome in disease control
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作者 Huicheng Shi Yingyi Cao Gong Cheng 《Medicine Plus》 2024年第2期6-10,共5页
Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is ... Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is un-derscored by some staggering statistics:over 3.9 billion people in more than 120 countries confront the imminent threat of some of the most epidemiologically significant mosquito-borne viruses;in 2021 alone,malaria accounted for 247 million cases,resulting in an estimated 619,000 deaths globally. 展开更多
关键词 CONTROL POWER DISEASE harnessing MICROBIOME MOSQUITO
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Harnessing Opportunities of Our Times To Jointly Pursue Prosperity in the Asia-Pacific
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作者 Xi Jinping 《Peace》 2018年第4期9-11,共3页
At the APEC Summit, Port Moresby, 18 November 2018 Honorable Prime Minister Peter O’Neill,Dear Colleagues,It gives me great pleasure to join you in the beautiful city of Port Moresby. This is the first time for us AP... At the APEC Summit, Port Moresby, 18 November 2018 Honorable Prime Minister Peter O’Neill,Dear Colleagues,It gives me great pleasure to join you in the beautiful city of Port Moresby. This is the first time for us APEC economic leaders to meet in the Pacific Islands region. We gather under the theme'HarnessingInclusiveOpportunities,Embracing the Digital Future'to review what we have achieved in our cooperation and chart the course for the future of the Asia-Pacific. 展开更多
关键词 harnessing OPPORTUNITIES ASIA-PACIFIC
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Harnessing science,technology,and innovation to drive synergy between climate goals and the SDGs 被引量:2
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作者 Lei Huang Ranjula Bali Swain +11 位作者 Erik Jeppesen Hai Cheng Panmao Zhai Baojing Gu DamiàBarceló Jianhua Lu Ke Wei Lei Luo Fang Wang Haijun Wang Jiangyuan Zeng Huadong Guo 《The Innovation》 EI 2024年第6期1-2,共2页
The United Nations passed two important resolutions,Transforming our World:The 2030 Agenda for Sustainable Development and the Paris Agreement,in 2015 to change our world.The 17 Sustainable Development Goals(SDGs)were... The United Nations passed two important resolutions,Transforming our World:The 2030 Agenda for Sustainable Development and the Paris Agreement,in 2015 to change our world.The 17 Sustainable Development Goals(SDGs)were adopted as the core of the 2030 Agenda for Sustainable Development,which set out a 15-year plan to achieve the goals. 展开更多
关键词 SUSTAINABLE SDGs HARNESS
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Harnessing the holobiont to alleviate the stress of aluminum toxicity to rice
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作者 Hong-Zhe Li Yong-Guan Zhu 《Soil Ecology Letters》 CSCD 2024年第1期7-9,共3页
Plant microbiome(including the microbiomes in the rhizosphere,phyllosphere,and endosphere)has been hailed as the second genome of the host,and plays a critical role in the health and fitness of the host.Similar to cli... Plant microbiome(including the microbiomes in the rhizosphere,phyllosphere,and endosphere)has been hailed as the second genome of the host,and plays a critical role in the health and fitness of the host.Similar to clinical medicine,microbiome transplant has been suggested to improve ecosystem restoration and crop production in degraded environment(Jurburg et al.,2022).This concept aligns with recent findings that emphasize the significant impact of soil and plant-associated microbiomes in agricultural productivity and the health of host plants(Wubs et al.,2016;Carthey et al.,2020;Mazza Rodrigues and Melotto,2023). 展开更多
关键词 finding HARNESS SOIL
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Eco-Friendly Particleboards Produced with Banana Tree(Musa paradisiaca)Pseudostem Fibers Bonded with Cassava Starch and Urea-Formaldehyde Adhesives
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作者 Prosper Mensah Rafael Rodolfode Melo +3 位作者 Edgley Alves de Oliveira Paula Alexandre Santos Pimenta Julianade Moura Fernando Rusch 《Journal of Renewable Materials》 2025年第7期1475-1489,共15页
The increase in wood and wood-based products in the construction and furniture sectors has grown exponentially,generating severe environmental and socioeconomic impacts.Particleboard panels have been the main cost-ben... The increase in wood and wood-based products in the construction and furniture sectors has grown exponentially,generating severe environmental and socioeconomic impacts.Particleboard panels have been the main cost-benefit option on the market due to their lightness and lower cost compared to solid wood.However,the synthetic adhesives used in producing traditional particleboard panels cause serious harm to human health.Developing particleboard panels with fibrous waste and natural adhesives could be a sustainable alternative for these sectors.The work aimed to create particleboards with fibrous wastes from the pseudostem of the banana tree(Musa paradisiaca)and different proportions of the natural adhesive cassava starch-CS in replacement of synthetic adhesive urea-formaldehyde-UF.Five experimental groups were manufactured with banana trees and different percentages of UF and CS adhesives,namely(100UF–0%CS),(50%UF–50%CS),(30%UF–70%CS),(10%UF–90%CS)and(0%UF–100%CS).The particleboards had their physical-mechanical properties determined.The apparent density values did not show significant variation between the assessed treatments.Regarding the water absorption and thickness swelling,the best performances were observed for the panels made without the addition of CS(100%UF).For the mechanical properties of static bending strength and Janka hardness,it was identified that adding up to 50%CS did not interfere with the quality of the panels.These analyses show that the particleboard panels produced with wastes of the banana tree bonded with natural CS adhesivemay be an economically viable and environmentally correct alternative,positively strengthening the development of sustainable strategies. 展开更多
关键词 Plant fibers vegetable waste harnessing bioadhesives physical and technological properties sustainable development
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Loss of CsPOD7 triggers ROS-induced metabolic collapse and male sterility in cucumber
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作者 Sen Li Yuming Dong +11 位作者 Xi Zhao Li Shan Lin Yang Menghang An Tiantian Pei Muhammad Ahmad Yifan Xu Yibing Zhao Hao Xue Xinyue Ma Xingwang Liu Huazhong Ren 《Horticultural Plant Journal》 2025年第6期2292-2296,共5页
Male sterile lines serve as a pivotal tool in plant breeding,offering an effective strategy for developing hybrid cultivars.In cucumber(Cucumis sativus L.),the creation of male sterile lines,most of which exhibit abno... Male sterile lines serve as a pivotal tool in plant breeding,offering an effective strategy for developing hybrid cultivars.In cucumber(Cucumis sativus L.),the creation of male sterile lines,most of which exhibit abnormal pollen development,is essential for harnessing heterosis.Accumulating evidence suggests that male sterility in plants is linked to the overaccumulation of Reactive Oxygen Species(ROS),which causes oxidative damage to biomolecules and cellular structures,ultimately leading to aberrant anther development(Li et al.,2004). 展开更多
关键词 creation male sterile linesmost abnormal pollen developmentis male sterility reactive oxygen species ros which cspod harnessing heterosisaccumulating male sterile lines developing hybrid cultivarsin
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