The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axona...The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.展开更多
The chaos in Iraq poses a great threat to the U.S. plan in the Middle East While the fighting between Israel and Lebanon-based Hezbollah becomes fiercer, security in Iraq also keeps deteriorating, making the region a ...The chaos in Iraq poses a great threat to the U.S. plan in the Middle East While the fighting between Israel and Lebanon-based Hezbollah becomes fiercer, security in Iraq also keeps deteriorating, making the region a petrol can that may blow up anytime.展开更多
On April 14,the Changji Hui Autonomous PrefectureofXinjiangissuedthe Announcement on Halting the Illegal AluminumProductionCapacityunder Construction,inwhichthePeople’s Government of the Prefecture decides to halt th...On April 14,the Changji Hui Autonomous PrefectureofXinjiangissuedthe Announcement on Halting the Illegal AluminumProductionCapacityunder Construction,inwhichthePeople’s Government of the Prefecture decides to halt the illegal 2-million-ton aluminum projects under construction of 3 enterprises including Xinjiang East Hope Nonferrous Metals Co.,展开更多
Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary ...Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.展开更多
基金supported by NIH(R01 NS094402 and R21 EY029386)Shriners Children’s(#85190 PHI and#87400 PHI)by BrightFocus Foundation(G2019267)(to GMT).
文摘The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.
文摘The chaos in Iraq poses a great threat to the U.S. plan in the Middle East While the fighting between Israel and Lebanon-based Hezbollah becomes fiercer, security in Iraq also keeps deteriorating, making the region a petrol can that may blow up anytime.
文摘On April 14,the Changji Hui Autonomous PrefectureofXinjiangissuedthe Announcement on Halting the Illegal AluminumProductionCapacityunder Construction,inwhichthePeople’s Government of the Prefecture decides to halt the illegal 2-million-ton aluminum projects under construction of 3 enterprises including Xinjiang East Hope Nonferrous Metals Co.,
基金supported by the National Natural Science Foundation of China(82120108010 and 81930028).
文摘Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.
